Abstracts tagged "macrophages"

Abstract Number: LB12 • ACR Convergence 2025
Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial of an Innovative Intra-Articular Apoptotic Cell Therapy in Knee Osteoarthritis (OA): 3-Month Positive Outcomes and Identification of Responder Population (NCT06233474)
Philip Conaghan¹, Bernt Husøy², Cecilie Rovsing³, Sidsel L Boll⁴, Liliana Groppa⁵, Amir Oron⁶, Asger Bihlet⁷, Ali Mobasheri⁸, Tobias Winkler⁹, Dror Mevorach¹⁰, Einat Galamidi¹¹, Lital Weinfeld-Bergman¹², Lior Binder¹² and Oren Hershkovitz¹¹, ¹University of Leeds, Leeds, United Kingdom, ²Sanos Clinic, Herlev, Denmark, ³Sanos Clinic, Gandrup, Denmark, ⁴Sanos Clinic, Vejle, Denmark, ⁵T. Mosneaga Republican Clinical Hospital, Chisinau, Moldova, ⁶Kaplan MC, Rehovot, Israel, ⁷NBCD A/S, Soeborg, Denmark, ⁸University of Oulu, Oulu, Finland, ⁹Charité - Universitätsmedizin Berlin, Berlin, Germany, ¹⁰Hadassah-University Hospital, Jerusalem, Israel, ¹¹Enlivex Therapeutics, Ness Ziona, Israel, ¹²Enlivex Therapeutics, Nes Ziona, Israel
Background/Purpose: OA is a prevalent disabling disease growing globally due to aging populations and rising obesity. In primary OA, the effects of joint tissue damage accumulate with age,…
Abstract Number: 2464 • ACR Convergence 2025
IMC-002 (IMM0306), a First-in-Class Bi-specific Fusion Protein, Demonstrates Improvements in Systemic Lupus Erythematosus (SLE) Disease Activity Measures and Biomarkers in Patients with Moderate to Severe Active SLE in the Open-label Phase 1b/2 Study
Haihong Yao¹, Wenzhi Tian², Qian Zheng², Min Chen², Guoping Jiang³, Zhichun Liu⁴, Yingkun Nie⁵, Rui Wu⁶, Zhaohui Zheng⁷ and Zhanguo Li¹, ¹Peking University People's Hospital, Beijing, China (People's Republic), ²ImmuneCare Biopharmaceuticals (Shanghai) Co.,Ltd, Shanghai, China (People's Republic), ³Jilin Province People's Hospital, Changchun, China (People's Republic), ⁴The Second Affiliated Hospital of Soochow, Suzhou, China (People's Republic), ⁵The Second Affiliated Hospital of Harbin Medical University, Haerbin, China (People's Republic), ⁶The First Affiliated Hospital of Nanchang University, Nanchang, China (People's Republic), ⁷The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China (People's Republic)
Background/Purpose: Deep B cell depletion has been confirmed to be the main mechanism for complete clinical response of SLE patients. We analyzed the peripheral blood…
Abstract Number: 0973 • ACR Convergence 2025
Effects of a Novel Hybrid Protein Based on S100 on Macrophage Polarization and Its Therapeutic Efficacy in a Bleomycin-Induced Systemic Sclerosis Mouse Model.
Takuya Kotani¹, Takayasu Suzuka², Shogo Matsuda³ and Tohru Takeuchi⁴, ¹Division of Rheumatology, Department of Internal Medicine IV, Osaka Medical and Pharmaceutical University, Osaka, Japan, ²Division of Rheumatology, Department of Internal Medicine IV, Osaka Medical and Pharmaceutical University, Takatsuki, Japan, ³Department of Internal Medicine IV, Division of Rheumatology, Osaka Medical and Pharmaceutical University, Osaka, Japan, ⁴Department of Internal Medicine (IV), Osaka Medical and Pharmaceutical University, Takatsuki, Japan
Background/Purpose: S100 proteins are involved in the inflammatory responses of autoimmune diseases. We previously showed that S100 proteins regulate macrophage function via CD68. Based on…
Abstract Number: 2078 • ACR Convergence 2025
Neutrophil Extracellular Traps from Patients with Idiopathic Inflammatory Myopathies Induce Interferogenic Responses in Macrophages and Myeloid Dendritic Cells
Yatzil Reyna Juárez¹, Jennifer Tiaré Balderas Miranda², Beatriz Alcalá Carmona³, María José Ostos Prado⁴, karina santana⁵, Diana Gómez-Martín⁶ and Jiram Torres Ruiz⁷, ¹Instituto Politècnico Nacional, Tultitlán de Mariano Escobedo, Mexico State, Mexico, ²Universidad Nacional Autónoma de México, Coyoacán, Federal District, Mexico, ³INCMNSZ, Cdmx, Distrito Federal, Mexico, ⁴Instituto Nacional De Ciencias Médicas Y Nutrición Salvador Zubirán, Mexico City, Distrito Federal, Mexico, ⁵INCMNSZ, Ciudad de México, Federal District, Mexico, ⁶INCMNSZ, Mexico city, Federal District, Mexico, ⁷INCMNSZ, Mexico, Federal District, Mexico
Background/Purpose: Dermatomyositis (DM) and anti-synthetase syndrome (AS) are idiopathic inflammatory myopathies (IIM) with perifascicular pathology involving vasculopathy, macrophages, dendritic cells and an overexpression of interferon-stimulated…
Abstract Number: 0963 • ACR Convergence 2025
Increased expression of M2 pro-fibrotic markers in circulating monocytes and cultured monocyte-derived macrophages from systemic sclerosis patients with progressive interstitial lung disease (ILD)
Vanessa Smith¹, Stefano Soldano², Rosanna Campitiello³, Emanuele Gotelli³, Paola Montagna⁴, Tamara Vojinovic⁴, Sabrina Paolino², Carmen Pizzorni², Alberto Sulli² and Maurizio Cutolo⁵, ¹Ghent University Hospital, Gent, Belgium, ²University of Genoa, Genova, Italy, ³University of Genoa, Genoa, Liguria, Italy, ⁴University of Genoa, Genova, ⁵University of Genova, Genova, Italy
Background/Purpose: In the complex pathogenesis of systemic sclerosis (SSc), macrophages are mainly involved in mechanism of progressive tissue fibrosis of skin and internal organs, particularly…
Abstract Number: 2011 • ACR Convergence 2025
A Phase 1 placebo controlled, single (SAD) and multiple dose escalation (MAD) safety and pharmacokinetic (PK) study of a novel colchicine analogue ABP-745 in healthy volunteers (HV)
ullrich schwertschlag¹, Roy Wu², yan yang³ and William Shi⁴, ¹Atom Therapeutics, PALO ALTO, CA, ²Atom Bioscience, San Francisco, CA, ³Atom Therapeutics, Suzhou, China (People's Republic), ⁴Atom Therapeutics, Newark, CA
Background/Purpose: ABP-745 is a novel colchicine analogue in development as an anti-inflammatory agent for the treatment of acute gout and other chronic inflammatory conditions. In…
Abstract Number: 0945 • ACR Convergence 2025
Nerve Injury-Induced Protein-1 (Ninj1) Deficiency Aggravates Murine Lupus Through Modulation of Macrophage Polarization
Jorge Romo-Tena¹, Luz Blanco², Shuichiro Nakabo³, Victoria Hoffman⁴, Norio Hanata⁵, Mingzeng Zhang², Carmelo Carmona-Rivera⁵, Eduardo Patino-Martinez⁶, Dillon Claybaugh², Zu-Xi Yu² and Mariana Kaplan⁵, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, ²NIH, Bethesda, MD, ³NIAMS, NIH, Bethesda, MD, ⁴Diagnostic and Research Services Branch, Division of Veterinary Resources, Office of Research Services, National Institutes of Health, Bethesda, MD, Bethesda, ⁵Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, Bethesda, MD, ⁶NIH/NIAMS, Bethesda, MD
Background/Purpose: Nerve injury-induced protein-1 (Ninj1) is an adhesion molecule that plays various roles in immune and stromal cells, including the modulation of inflammation and a…
Abstract Number: 1870 • ACR Convergence 2025
Paracrine WNT Signaling Modulates Profibrotic Macrophage Metabolic Activation in Systemic Sclerosis
emily Morris¹, Helen Jarnagin¹, Chen-Yu Wang¹, Michael Whitfield² and Patricia Pioli³, ¹Dartmouth College, Lebanon, NH, ²Geisel School of Medicine, Lebanon, NH, ³Geisel School of Medicine at Dartmouth, Lebanon, NH
Background/Purpose: An immune fibrotic axis consisting of activated macrophages (MØs) and fibroblasts has been identified in autoimmune systemic sclerosis (SSc) that drives disease across affected…
Abstract Number: 0940 • ACR Convergence 2025
Resident Macrophages Localize Near Fibroblasts and Drive Reprogramming in Lupus Nephritis Through Direct and Soluble Signaling
Chirag Raparia¹, Paul Hoover², Arnon Arazi³, Nir Hacohen⁴ and Anne Davidson¹, ¹Feinstein Institutes for Medical Research, Manhasset, NY, ²Brigham and Women's Hospital, Boston, MA, ³Feinstein Institutes for Medical Research, Acton, MA, ⁴Broad Institute of MIT Harvard, Cambridge, MA
Background/Purpose: Lupus nephritis (LN) is a severe manifestation of SLE that can progress to renal fibrosis, and eventual renal failure. In LN, tubulointerstitial inflammation and…
Abstract Number: 1844 • ACR Convergence 2025
Disease-Associated Macrophages Express an Injury-Associated Gene Program and Localize to Distinct Compartments in Proliferative and Mixed Histologic Classes of Lupus Nephritis
Paul Hoover¹, Rollin Leavitt², Jill Buyon³, Jennifer Anolik⁴, Jennifer Barnas⁵, Judith James⁶, Joel Guthridge⁶, Michelle Petri⁷, Betty Diamond⁸, Soumya Raychaudhuri¹, Nir Hacohen⁹, Anne Davidson¹⁰ and Arnon Arazi¹¹, ¹Brigham and Women's Hospital, Boston, MA, ²Broad Institute, Boston, MA, ³NYU Grossman School of Medicine, New York, NY, ⁴University of Rochester Medical Center, Rochester, NY, ⁵University of Rochester, Rochester, NY, ⁶Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Johns Hopkins University School of Medicine, Timonium, MD, ⁸The Feinstein Institutes for Medical Research, Manhasset, NY, ⁹Broad Institute, Cambridge, MA, ¹⁰Feinstein Institutes for Medical Research, Manhasset, NY, ¹¹The Feinstein Institutes for Medical Research, Manhasset
Background/Purpose: In collaboration with the AMP-RA/SLE network, we identified disease-associated macrophages (D-Macs) in kidney biopsies from 155 patients with active lupus nephritis (LN) and 30…
Abstract Number: 0925 • ACR Convergence 2025
Pathogenic role of SPP1+ macrophages in Rheumatoid Arthritis
Megan M. Hanlon¹, Catherine Manning¹, Kevin Wei¹, Ursula Fearon² and Ellen M. Gravallese³, ¹Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ²Trinity College Dublin, Dublin, Dublin, Ireland, ³Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA
Background/Purpose: Synovial tissue macrophages (STMs) represent a mixed population of cells contributing to the pathogenesis of rheumatoid arthritis (RA). We identified an enrichment of Secreted…
Abstract Number: 1793 • ACR Convergence 2025
Sex-associated changes to synovial macrophages in the aging joint
Matthew Dapas¹, Erica De Jong², Yidan Wang³, Cally Mills³, Samuel Dowling⁴, Tyler Therron⁵, Carla Marie Cuda³, Dawn Bowdish⁶ and Deborah Rachelle Winter⁷, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²McMaster Immunology Research Centre, Hamilton, ON, Canada, ³Northwestern University, Chicago, IL, ⁴Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Northwestern Feinberg School of Medicine, Chicago, IL, ⁶McMaster University, Hamilton, ON, Canada, ⁷Northwestern University, Skokie, IL
Background/Purpose: Macrophages are found in nearly every tissue of the body where they maintain homeostasis and drive healthy immune response. However, macrophages are dysregulated with…
Abstract Number: 0921 • ACR Convergence 2025
Fibrinogen Co-Modified with Malondialdehyde-Acetaldehyde and Citrulline Promotes Pro-Inflammatory Macrophage Differentiation Through p38 and NF-κB Signaling
Hannah Johnson¹, Wenxian Zhou², Michael Duryee¹, Carlos Hunter¹, Geoffrey Thiele¹ and Ted Mikuls¹, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Bellevue, NE
Background/Purpose: Citrulline (CIT) and malondialdehyde-acetaldehyde (MAA) co-adduct native proteins in RA tissues to create a dual pro-inflammatory and pro-fibrotic milieu. Our previous work demonstrated that…
Abstract Number: 1787 • ACR Convergence 2025
Spatial and Quantitative Semiautomated Image Analysis of Synovial Biopsies Studied Using a Novel High-Plex Immunofluorescence Platform
Estefania Quesada-Masachs¹, Luis Peñaranda Bolaño¹, Aakriti Arora², Jessica Murillo-Saich³, Edward Lo⁴, Tad George⁴, Daniel Tanoeihusada⁴, Sara McArdle⁵ and Monica Guma⁶, ¹University of Miami, Miami, FL, ²University of Miami / Jackson Memorial Hospital, Miami, FL, ³University of California, San Diego, San Diego, CA, ⁴RareCyte, Seattle, WA, ⁵La Jolla Institute for Immunology, La Jolla, CA, ⁶University of California San Diego, San Diego, CA
Background/Purpose: Although not part of the formal ACR criteria for RA, PsA, or OA, synovial pathology can be a helpful tool in clinical practice. Histopathologic…
Abstract Number: 0908 • ACR Convergence 2025
E-602 (Efgitasialase alfa) Enhances Memory B Cell Depletion and Reduces Profibrotic Macrophages via Desialylation in Autoimmune Disease
Hrishikesh Mehta¹, Vijayashree Mysore¹, Chih-Hsing Chou¹, Lizhi Cao¹, Rui Liu², Tianrui Fan², Jijun Yuan², James Broderick¹ and Li Peng¹, ¹Palleon Pharmaceuticals, Waltham, MA, ²Shanghai Henlius Biotech, Shanghai, China (People's Republic)
Background/Purpose: Abnormal cell surface glycosylation has been observed in various autoimmune diseases, including systemic lupus erythematosus (SLE) and membranous nephropathy. Among these glycan modifications, sialoglycans…

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