ACR Meeting Abstracts

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Abstracts tagged "macrophages"

  • Abstract Number: 0096 • ACR Convergence 2024

    Simultaneous Contribution of Brain-Intrinsic and Peripheral Disease Mechanisms to Neuropsychiatric Symptoms of Systemic Lupus Erythematosus (NPSLE)

    Hadijat Makinde1, Mohammad Khan1, Cecilia Stumpf2, Yidan Wang3, Tyler Therron2, Margaret Goldman2, Deborah Winter4 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University, Hanover Park, IL, 4Northwestern University, Skokie, IL

    Background/Purpose: While NPSLE are among the least understood complications, increasing evidence points to microglia, a brain-resident innate immune cell population, as a driver of disease.…
  • Abstract Number: 1643 • ACR Convergence 2024

    Single Nuclei Multiome and Spatial Transcriptomic Analysis of Early, Untreated SSc Skin Identifies Signaling Interactions Between Macrophages and Fibroblasts

    Helen Jarnagin1, Dillon Popovich2, Rezvan Parvizi3, Rosemary Gedert4, Lam C. Tsoi5, Rachael Wasikowski5, Zhiyun Gong1, Madeline Morrisson6, Laurent Perreard7, Fred Kolling IV7, Dinesh Khanna4, Johann Gudjonsson4 and Michael Whitfield3, 1Dartmouth College, Lebanon, NH, 2Dartmouth College, West Lebanon, NH, 3Geisel School of Medicine at Dartmouth, Hanover, NH, 4University of Michigan, Ann Arbor, MI, 5Michigan, Dept. of Dermatology, Ann Arbor, MI, 6Geisel School of Medicine at Dartmouth College, Hanover, NH, 7Geisel School of Medicine, Dartmouth College, Lebanon

    Background/Purpose: We generated a vertically integrated dataset on treatment naïve patients with dcSSc (diffuse Systemic Sclerosis) skin that includes bulk RNA-seq, single nuclei multiome, and…
  • Abstract Number: 2645 • ACR Convergence 2024

    Human NCF1-p.R90H Variant Promotes Pulmonary Fibrosis in the Bleomycin-induced Mouse Model and Systemic Sclerosis Patients via Expansion of SPP1+Monocytes-derived Macrophages

    Xinran Yuan1, Xiaodong Qin2, Kenji Takemoto1, Jian Zhao1, Matthew Sanderson1, Xue Xu1, Kristi L Helke3, Bethany Wolf4, Joel Guthridge5, Judith A James6, Xiaodong Zhou7, Shervin Assassi8, Carol Feghali-Bostwick4, Dandan Wang9, Lingyun Sun10 and Betty P Tsao1, 1Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 2Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China (People's Republic), 3Department of Comparative Medicine, Medical University of South Carolina, Charleston, SC, 4Medical University of South Carolina, Charleston, SC, 5Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Division of Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 8UTHealth Houston Division of Rheumatology, Houston, TX, 9Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical Schoo, Nanjing, Jiangsu, China (People's Republic), 10Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China (People's Republic)

    Background/Purpose: We previously identified a systemic lupus erythematosus (SLE) causal risk variant, p.Arg90His (p.R90H, rs201802880) substitution encoded in neutrophil cytosolic factor 1 (NCF1), an essential component…
  • Abstract Number: 0263 • ACR Convergence 2024

    Characteristics and Coinfections of Diffuse Alveolar Hemorrhage in Rheumatic Patients

    Eduardo Briones-García1, Shaul Navarro-Lara2, Marco A Ortiz-Bustamante2, Iris Paola García Herrera3, Carla M Roman-Montes2 and Guillermo A Guaracha-Basañez4, 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department., Ciudad de México, Distrito Federal, Mexico, 2Departamento de Infectología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador-Zubirán., México city, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion “Salvador Zubirán”, Mexico City, Distrito Federal, Mexico

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a severe respiratory complication observed in certain rheumatic diseases, such as systemic lupus erythematosus (SLE), ANCA-associated vasculitides (AAV), and…
  • Abstract Number: 1686 • ACR Convergence 2024

    Urine Proteomics in Class II Lupus Nephritis Reveals Immune Activation and Pro-Fibrotic Signatures

    Jasmine Shwetar1, Jill Buyon2, Michelle Petri3, Kelly Ruggles4 and Andrea Fava5, 1New York School of Medicine, Ann Arbor, MI, 2NYU Grossman School of Medicine, New York, NY, 3Johns Hopkins University School of Medicine, Timonium, MD, 4NYU Grossman School of Medicine, Brooklyn, NY, 5Johns Hopkins University, Baltimore, MD

    Background/Purpose: Lupus nephritis (LN) is a pathologically diverse autoimmune disease that can lead to end-stage kidney disease and mortality. Although Class II LN is considered…
  • Abstract Number: 0279 • ACR Convergence 2024

    Macrophage Intracellular Fates of Monosodium Urate and Calcium Pyrophosphate Crystals: Phagocytosis, Exchanged/expulsion and Dissolution of Crystals

    Charles Leroy1, Nghia Pham2, François Brial3, Brenda Kischkel4, gwénaêlle Jayat5, Elena Ishow6, Christèle Combes7, Leo Joosten4, Augustin Latourte8, Pascal Richette9 and Hang-Korng Ea10, 1Inserm 1132 / Université Paris Cité, levallois-perret, France, 2INSERM 1132, BIOSCAR, Lariboisière hospital, Paris, France, 3Inserm 1132/ Université Paris Cité, Paris, France, 4Radboudumc, Nijmegen, Netherlands, 5Université Paris cité / Inserm 1132, paris, France, 6Université de Nantes / Ceisam, Nantes, France, 7INP-ENSIACET, Toulouse, France, 8AP-HP, Paris, France, 9Lariboisière Hospital, Paris, France, 10Université Paris Cité, INSERM UMR 1132 BIOSCAR, Paris, France

    Background/Purpose: Gout, due to the presence of monosodium urate crystals (MSU) and calcium pyrophosphate (CPP) crystal deposition disease are both responsible for recurrent inflammation flares.…
  • Abstract Number: 1702 • ACR Convergence 2024

    Placental Developmental Defects in a Humanized-TLR8 Mouse Model of Spontaneous Anti-Phospholipid Antibody Induced Pregnancy Loss

    Yunwei Xia1, Naomi I. Maria2, Zhengzi Yi3, Chirag Raparia4, Gayathri Konanur Gopikrishna1, Weijia Zhang3 and Anne Davidson2, 1Feinstein Institutes for Medical Research, Manhasset, 2Feinstein Institutes for Medical Research, Manhasset, NY, 3Mt. Sinai School of Medicine, New York, NY, 4Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Shoreham, NY

    Background/Purpose: Antiphospholipid antibodies (aPL) confer a high risk for adverse pregnancy outcomes, especially in women with SLE. aPLs can induce pro-inflammatory signaling via TLR8 receptors,…
  • Abstract Number: 0746 • ACR Convergence 2024

    Single-cell RNA-Seq Analysis Reveals Distinct Compositional Characterizations and Transcriptomic Profiles of Macrophages in Takayasu’s Arteritis

    Lihong du1, Chenglong Fang2, shang Gao3, zuoguan Chen3 and Yongjun Li3, 1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, 2Department of Rheumatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China (People's Republic), 3Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology, Beijing, China

    Background/Purpose: Macrophages play key roles in the pathogenesis of various inflammatory vascular diseases, such as Takayasu’s arteritis (TAK) and atherosclerosis. However, limited data on the…
  • Abstract Number: 1793 • ACR Convergence 2024

    SLE Patient Serum and SLE-associated Danger Signals Impair Efferocytosis in Human Macrophages

    Jessica Shannon and Rafael de Queiroz Prado, AstraZeneca, Gaithersburg, MD

    Background/Purpose: Efficient clearance of apoptotic cells, known as efferocytosis, plays a pivotal role in maintaining self-tolerance. Dysfunction in efferocytosis is implicated in the pathogenesis of…
  • Abstract Number: 0757 • ACR Convergence 2024

    Regulation of Macrophage Differentiation by Serum Adiponectin: A Novel Mechanism to Increase Alternatively Activated Macrophages During the Remission Phase of Giant Cell Arteritis

    Anna Kernder1, Lena Noack1, Adina Morar1, Lara Burg2, Torsten Lowin1, Dennis Bleck1, matthias schneider1, Jörg Distler3, Georg Pongratz4 and Valentin S. Schäfer5, 1Clinic for Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine-University, Düsseldorf, Germany., Düsseldorf, Germany, 2Department of Rheumatology and Clinical Immunology, Clinic of Internal Medicine III, University Hospital of Bonn, Germany, Bonn, Germany, 3Universitätsklinikum Düsseldorf and Heinrich-Heine-Universität Düsseldorf, Duesseldorf, Germany, 4Clinic for Rheumatology, University Hospital Düsseldorf, Medical Faculty of Heinrich-Heine-University, Düsseldorf, Germany., Regensburg, Germany, 5University Hospital Bonn, Bonn, Germany

    Background/Purpose: The immunopathogenesis of giant cell arteritis (GCA) remains unclear. It is known that monocytes are recruited from peripheral blood, infiltrate the vessel wall, and…
  • Abstract Number: 1814 • ACR Convergence 2024

    Understanding Monocyte Derived Macrophages in the Skin of SSc Patients Through Single Cell Analysis of Blister Fluid Immune Cell Populations

    Sandra Lopez Garces1, Tamara Searle2, Siyu Zhang1, Henry Lopez3, Isra Elhussin4, Clayton Yates4, David Abraham5, Christopher Denton6, Bahja Ahmed Abdi1 and Richard Stratton7, 1University College London, London, United Kingdom, 2Imperial College London, London, United Kingdom, 3Riptide Bioscience Inc, Bethesda, MD, 4Johns Hopkins University, Baltimore, MD, 5UCL, London, United Kingdom, 6University College London, Northwood, United Kingdom, 7UCL, London, England, United Kingdom

    Background/Purpose: Cells of the monocyte-macrophages (Mφ) are key players in the pathogenesis of systemic sclerosis (SSc), contributing to inflammation and fibrosis. To advance beyond the…
  • Abstract Number: 0759 • ACR Convergence 2024

    Macrophage-Lineage Cells in Giant Cell Arteritis Express MMP12, Phagocytosis and Osteoclast-associated Molecules That May Contribute to Destruction of the Tunica Media

    Makoto Sugihara1, Nobumasa Watanabe2, Yuichiro Hara2, Yasumasa Nishito3, Mai Kounoe4, Kazunari Sekiyama4, Eisuke Takamasu5, Naofumi Chinen6, Kota Shimada5 and Hideya Kawaji2, 1Department of Rheumatic Diseases, Tokyo Metropolitan Tama-Hokubu Medical Center, Tokyo, Japan, Higashimurayama-shi, Tokyo, Japan, 2Research Center for Genome & Medical Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 3Center for Basic Technology Research, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 4Center for Medical Research Cooperation, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, Setagaya-ku, Tokyo, Japan, 5Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, Fuchu-shi, Tokyo, Japan, 6Department of Rheumatic Diseases, Tokyo Metropolitan Tama-Nambu Chiiki Hospital, Tokyo, Japan, Tama-shi, Tokyo, Japan

    Background/Purpose: Giant cell arteritis (GCA) is a large vessel vasculitis characterized by inflammatory cell infiltration and destruction of the tunica media. In this study, we…
  • Abstract Number: 1816 • ACR Convergence 2024

    Paracrine WNT Signaling Drives Pro-fibrotic Metabolic Activation of Systemic Sclerosis Macrophages

    Emily Morris1, Helen Jarnagin2, Heetaek Yang3, Alexandra Turnquist2, Michael Whitfield4 and Patricia Pioli5, 1Dartmouth College, Enfield, NH, 2Dartmouth College, Lebanon, NH, 3Dartmouth College, West Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: While we have shown that systemic sclerosis (SSc) dermal fibroblasts and macrophages (MØs) engage in reciprocal activation mediated by exosomes via paracrine signaling, the…
  • Abstract Number: 0760 • ACR Convergence 2024

    A Macrophage-smooth Muscle Cell Axis Influences Vascular Remodeling Through Activation of the EGFR Pathway in Giant Cell Arteritis

    Kevin Chevalier1, Léa Dionet1, Paul Breillat1, Margot Poux1, Julien Dang1, Benoit Terris2, Patrick Bruneval3, Luc Mouthon4, Olivia Lenoir1, Tharaux Pierre-Louis1 and Benjamin Terrier5, 1Paris Cardiovascular Research Center, INSERM U970, Paris, France, 2Department of pathology, Hôpital Cochin, GHU Paris Centre, AP-HP, Université Paris Cité,, Paris, France, 3Department of Pathology, Hôpital Européen Georges Pompidou, GHU Paris Centre, AP-HP, Université Paris Cité, Paris, France, 4Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, 5Service de Médecine interne, Hôpital Cochin, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Giant cell arteritis (GCA) is a granulomatous vasculitis affecting large vessels. The role of macrophages and vascular smooth muscle cells (VSMC) appears to be…
  • Abstract Number: 1817 • ACR Convergence 2024

    Activated Macrophages Mediate Loss of Dermal White Adipose Tissue in Fibrotic Skin

    Chanhyuk Park1, Helen Jarnagin2, Asmaa Mohamed3, Yina Huang3, Michael Whitfield4 and Patricia Pioli1, 1Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Dartmouth College, Lebanon, NH, 3Dartmouth, Lebanon, 4Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: Autoimmune systemic sclerosis (SSc) is characterized by inflammation, vasculopathy, and dermal and internal organ fibrosis. A widely-reported but poorly understood aspect of SSc skin…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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