ACR Meeting Abstracts

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Abstracts tagged "Lung Disease"

  • Abstract Number: 854 • 2017 ACR/ARHP Annual Meeting

    Predictive Modeling of Mortality in Polymyositis/Dermatomyositis Patients with Interstitial Lung Disease Based on Combination of Serum Myositis-Specific Autoantibodies and Conventional Biomarkers

    Takahisa Gono1, Kenichi Masui2, Yasushi Kawaguchi3, Kei Ikeda4, Atsushi Kawakami5, Maasa Tamura6, Yoshinori Tanino7, Takahiro Nunokawa8, Yuko Kaneko9, Shinji Sato10, Katsuaki Asakawa11, Naoshi Nishina9 and Masataka Kuwana1, 1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 2Department of Anesthesiology, National Defense Medical College School of Medicine, Tokorozawa, Japan, 3Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 4Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, 5Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan, 6Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 7Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan, 8Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, 9Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 10Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, 11Division of Respiratory Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan

    Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of mortality in patients with polymyositis or dermatomyositis (PM/DM). Since clinical courses and outcomes…
  • Abstract Number: 939 • 2017 ACR/ARHP Annual Meeting

    Stimulator of Interferon Genes (STING)-Induced Endothelial-Mesenchymal Transition (EndMT) Contributes to Interstitial Lung Disease in Sting-Associated Vasculopathy with Onset in Infancy (SAVI) Patients

    Louise Malle1, Dan Yang2, Adriana Almeida de Jesus1, Guibin Chen2, Bernadette Marrero1, Gina A. Montealegre Sanchez1, Yin Liu3, Gregor Dueckers4, Suzanne Ramsey5, Joseph Fontana6, Rachel VanTries1, Yan Huang1, Laisa Santiago7, Benito Gonzalez8, Paul Brogan9, Juergen Brunner10, Ebun Omoyinmi11, Athimalaipet V. Ramanan12, Amy Paller13, Olcay Y. Jones14, Seza Ozen15, Stephen R. Brooks16, Manfred Boehm17 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, 2Center for Molecular Medicine, NHLBI/NIH, Bethesda, MD, 3Scientific Review Branch, NIAMS/NIH, Bethesda, MD, 4Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, 5Pediatric Rheumatology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada, 6Cardiovascular and Pulmonary Branch, NHLBI/NIH, Bethesda, MD, 7Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, 8Luis Calvo Mackenna Hospital, Santiago, Chile, 9Infection Inflammation and Rheumatology, UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 10Division of Pediatric Rheumatology, Medical University Innsbruck, Innsbruck, Austria, 11University College London Institute of Child Health, London, United Kingdom, 12Bristol Royal Hospital for Children, Bristol, United Kingdom, 13Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IN, 14Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, 15Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 16Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, 17Center for Molecular Medicine, NHLBI/ NIH, Bethesda, MD

    Background/Purpose: Pulmonary fibrosis, is a life-threatening complication of the monogenic autoinflammatory interferonopathy, STING-Associated Vasculopathy with onset in Infancy (SAVI) that is caused by gain-of-function mutations…
  • Abstract Number: 1486 • 2017 ACR/ARHP Annual Meeting

    Interstitial Lung Disease in Primary Sjögren’s Syndrome : Clinical Presentation, Serological Biomarkers and Long Term Outcome

    Chiara Baldini1, Ilaria Puxeddu2, Martina Orlandi3, Francesco Ferro4, Elena Elefante4, Nicoletta Luciano4, Marco Matucci-Cerinic3, Paola Migliorini2 and Marta Mosca4, 1Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 2Allergology and Clinical Immunology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Unit, University of Florence, Florence, Italy, 4Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Interstitial lung disease (ILD) is a rare but potentially severe manifestation of primary Sjögren’s syndrome (pSS). The aims of this study were to: 1)…
  • Abstract Number: 1488 • 2017 ACR/ARHP Annual Meeting

    Correlation between Lung Ultrasound, HRCT Findings and  Pulmonary Function Tests  in Primary Sjögren’s Syndrome (pSS)-Associated  Interstitial Lung Disease

    Francesco Ferro1, Alessandra Bulleri2, Andrea Delle Sedie1, Simone Barsotti1, Nicoletta Luciano1, Elisa Cioffi3, Elena Elefante1, Gianfranco Puppo4, Marta Mosca1 and Chiara Baldini5, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Radiology Unit, University of Pisa, Pisa, Italy, 3Rheumatology Unit, Rheumatology Unit, University of Pisa, Pisa, Italy, 4Pneumology Unit, University of Pisa, Pisa, Italy, 5Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Recently, pleural irregularity (PI), a new lung ultrasound (US) sign, has been proposed as an emerging tool for the diagnosis of interstitial lung disease…
  • Abstract Number: 2188 • 2016 ACR/ARHP Annual Meeting

    Association Between Extent of Symptomatic Joint Involvement in Osteoarthritis and Comorbid Lung Disease in Patients Scheduled for Joint-Replacement Surgery

    Anthony V. Perruccio1,2,3, Rajiv Gandhi4, J. Denise Power5,6 and Elizabeth M. Badley7, 1The Arthritis Program, University Health Network, Toronto, ON, Canada, 2Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, 3Health Care & Outcomes Research, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4University Health Network, Arthritis Program, Toronto, ON, Canada, 5Arthritis Program, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 6Dalla Lana School of Public Health, Toronto, ON, Canada, 7Toronto Western Research Institute, Toronto, ON, Canada

    Background/Purpose: Comorbidity is highly prevalent in osteoarthritis (OA), although the origin of this is not well understood. The presence of multi-joint symptoms in OA, and…
  • Abstract Number: 2189 • 2016 ACR/ARHP Annual Meeting

    The Association of Arthritis and Lung Diseases: A Population-Based Study

    Elizabeth M. Badley1,2, Marcia Maguire1 and Anthony V. Perruccio1,3, 1Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, 2Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 3Arthritis Program, Toronto Western Hospital, University Health Network, Toronto, ON, Canada

    Background/Purpose:  While rheumatoid arthritis is associated with a number of different lung conditions, the relationship with osteoarthritis, overwhelmingly the most frequent type of arthritis in…
  • Abstract Number: 2326 • 2016 ACR/ARHP Annual Meeting

    Intravenous Cyclophosphamide Followed By Oral Immunosuppressive Treatment Versus Rituximab in Inflammatory Myopathy-Related Interstitial Lung Disease

    Vincent Langlois1, Kuberaka Mariampillai2, Nicolas Champtiaux3, Marie-Laure Chabi4, Yurdagul Uzunhan5, Eric Hachulla6, Olivier Benveniste7 and Baptiste Hervier3, 1Internal Medicine, University Hospital, Rouen, France, 2Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Department of Internal Medicine and Clinical Immunology, Hospital University Department: inflammation, immunopathology and biotherapy (DHU i2B), Paris, France, Paris, France, 3Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, 4Radiology department, APHP, Hôpital Pitié Salpêtrière, Paris, France, 5Pulmonary diseases department, Avicenne Hospital (AP-HP), Bobigny, France, 6Internal Medicine, Lille University Hospital, Lille, France, 7Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose: Interstitial lung disease (ILD) associated with inflammatory myopathy (IM) has a poor prognosis and requires specific treatments. Intravenous Cyclophosphamide (CYC) is one of the…
  • Abstract Number: 2429 • 2016 ACR/ARHP Annual Meeting

    Mechanisms for the Development of Lung Fibrosis in Sting-Associated Vasculopathy with Onset in Infancy (SAVI)

    Adriana Almeida de Jesus1, Louise Malle1, Dan Yang2, Bernadette Marrero1, Yin Liu3, Gina A. Montealegre Sanchez1, Dawn C. Chapelle4, Hanna Kim4, Michelle O'Brien4, Gregor Dueckers5, Suzanne Ramsey6, Joseph R. Fontana7, Steven M. Holland8, Yan Huang1, Suvimol Hill9, Laisa Santiago10, Benito Gonzalez11, Paul Brogan12, Juergen Brunner13, Ebun Omoyinmi14, Athimalaipet V Ramanan15, Amy Paller16, Olcay Y. Jones17, Seza Ozen18, Stephen Brooks4, Zuoming Deng4, Manfred Boehm19, Raphaela Goldbach-Mansky20 and Helmut Wittkowski21, 1National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, 2National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 3Scientific Review Branch, NIAMS, NIH, Bethesda, MD, 4NIAMS/NIH, Bethesda, MD, 5Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, 6Pediatric Rheumatology, IWK Health Centre, Halifax, NS, Canada, 7Cardiovascular and Pulmonary Branch, NHLBI, NIH, Bethesda, MD, 8Laboratory of Clinical Infectious Disease, NIAID, NIH, Bethesda, MD, 9Radiology Department, Clinical Center, NIH, Bethesda, MD, 10Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, 11Luis Calvo Mackenna Hospital, Santiago, Chile, 12UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 13Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria, 14University College London Institute of Child Health, London, United Kingdom, 15University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom, 16Departments of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;, Chicago, IL, 17Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, 18Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, ANKARA, Turkey, 19Laboratory of Cardiovascular Regenerative Medicine, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, 20Translational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, 21Department of Pediatric Rheumatology and Immunology, University Hospital of Muenster, Münster, Germany

    Background/Purpose:  STING-Associated Vasculopathy with Onset in Infancy (SAVI) is a monogenic autoinflammatory interferonopathy caused by gain-of-function mutations in TMEM173/STING, a nucleic acid sensor adaptor linked…
  • Abstract Number: 2583 • 2016 ACR/ARHP Annual Meeting

    Abatacept in Rheumatoid Arthritis with Interstitial Lung Disease: A Multicenter Study of  55  Patients

    Carlos Fernández-Díaz1, Javier Loricera1, Santos Castañeda2, Clara Ojeda-Garcia3, Alejandro Olivé4, Patricia E. Carreira5, Trinidad Perez Sandoval6, Miriam Retuerto7, Evelin Cecilia Cervantes Pérez8, Samantha Rodriguez-Muguruza4, Bryan Josue Robles Flores9, Blanca Hernández-Cruz10, Ana Urruticoechea11, O. Maiz Alonso12, Desiree Palma13, Luis Arboleya14, Gema Bonilla15, Íñigo Hernández-Rodríguez16, Concepción Delgado17, Rosa Expósito Molinero18, Ana Ruibal Escribano19, Juan Blanco Madrigal20, José Antonio Bernal21, Manuel Rodríguez-Gómez22, Paloma Vela Casasempere23, Belen Alvarez-Rodriguez24, María Concepción Fito Manteca25, Francisco Ortiz Sanjuan26, Javier Narváez27, Manuel Jose Moreno28, Mireia Lopez-corbeto29, Natalia Mena-Vazquez30, Lucia C. Domínguez-Casas1, Clara Aguilera-Cros31, Victor Mora-Cuesta32, Natalia Palmou-Fontana1, Miguel Angel Gonzalez-Gay33, José Luis Hernandez34 and Ricardo Blanco1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Rheumatology, Hospital de la Princesa, IIS-IP, Madrid, Spain, 3Rheumatology, Hospital Virgen de la Macarena, Sevilla, Spain, 4Rheumatology, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain, 5Multidisciplinary Pulmonary Hypertension Unit. Hospital Universitario 12 de Octubre, Madrid, Spain, 6Rheumatology, Hospital de León, LEÓN, Spain, 7Rheumatology, Hospital de Leon, Leon, Spain, 8Rheumatology, Hospital Santiago de Compostela, Santiago de Compostela, Spain, 9Rheumatology, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain, 10Rheumatology, Hospital Universitario Virgen Macarena, Sevilla, Spain, 11Hospital Can Misses, Ibiza, Spain, 12Rheumatology, Hospital Donostia, San Sebastian, Spain, 13Rheumatology, Rafael Mendez Hospital, Spain., Lorca (Murcia), Spain, 14Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain, 15Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, 16Rheumatology, CHUVI Vigo, Vigo, Spain, 17Rheumatology, Hospital Clinico Universitario Lozano Blesa, zaragoza, Spain, 18Rheumatology, Hospital Comarcal de Laredo. Spain, Laredo, Spain, 19Rheumatology, Hospital Universitario de Araba, Vittoria, Spain, 20Rheumatology, Hospital de Basurto, BIlbao, Spain, 21Sección de Reumatología, Hospital General de Alicante, Alicante, Spain, 22Complejo Hospitalario Universitario de Ourense, Ourense, Spain, 23Rheumatology, Hospital General de Alicante, Alicante, Spain, 24Hospital Txagorritxu, Vittoria, Spain, 25Reumatología, Hospital de Navarra, Pamplona, Spain, 26Rheumatology, Hospital La Fe, Valencia, Spain, 27Rheumatology Department, Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Spain, 28Rheumatology, Hospital Virgen de la Arrixaca, MURCIA, Spain, 29Hospital Universitario Vall d'Hebron, Barcelona, Spain, 30Rheumatology, Hospital Universitario de Malaga, Malaga, Spain, 31Rheumatology, Hospital Virgen del Rocio, Sevilla, Spain, 32Neumology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 33Department of RheumaRheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 34Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose: Interstitial Lung Disease (ILD) is a severe extra-articular manifestation of rheumatoid arthritis (RA). A potential association of anti-TNFα drugs and conventional disease-modifying anti-rheumatic drugs…
  • Abstract Number: 2677 • 2016 ACR/ARHP Annual Meeting

    Clinical Features of Primary Sjogren’s Syndrome Associated Lung Involvement with Extro-Glandular Manifestations at Onset

    Hui Gao1, Xuewu Zhang1,2 and Zhan-Guo Li1,3, 1Peking University International Hospital, Beijing, China, 2Rheumatology, Peking University People's Hospital, Beijing, China, 3Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China

    Background/Purpose:  To investigate the common initial clinical presentations of primary Sjogren’s syndrome with pulmonary complications, and to explore the differences between patients with extro-glandular manifestations…
  • Abstract Number: 2894 • 2016 ACR/ARHP Annual Meeting

    Efficacy of Rituximab in Systemic Sclerosis with Interstitial Lung Disease

    Ahmet Mesut Onat1, Orhan Zengin1, Savas Aksoy1, Mustafa Erkut Onder1, Koray Gorkem Sacıntı2 and Bunyamin Kisacik1, 1Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, 2Gaziantep University, School of Medicine, Gaziantep, Turkey

    Background/Purpose: Systemic sclerosis (SSc) is a progressive fibrotic and autoimmune disease, which results to severe systemic complications. Rituximab (Rtx), an anti CD-20 antibody, has recently…
  • Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting

    CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice

    Sho Sendo1, Jun Saegusa1, Takaichi Okano2, Soshi Takahashi3 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…
  • Abstract Number: 971 • 2016 ACR/ARHP Annual Meeting

    Reliability and Minimal Clinically Important Differences (MCID) of Forced Vital Capacity: Post-Hoc Analyses from the Scleroderma Lung Studies (SLS-I and II)

    Suzanne Kafaja1, Philip J. Clements2, Holly Wilhalme3, Daniel E. Furst4, Chi-hong Tseng2, Kim Hyun5, Jonathan Goldin3, Elizabeth R. Volkmann3, Michael Roth2, Donald P. Tashkin6 and Dinesh Khanna7, 1Medicine/Rheumatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 2Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 3University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 4David Geffen School of Medicine at UCLA, Los Angeles, CA, 5Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 6David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 7University of Michigan, Ann Arbor, MI

    Background/Purpose: Forced vital capacity (FVC) is used as a primary outcome measure in clinical trials of systemic sclerosis-related interstitial lung disease (SSc-ILD). Minimally Clinically Important…
  • Abstract Number: 1016 • 2016 ACR/ARHP Annual Meeting

    Soluble BAT-3: A New Biomarker for Antisynthetase Syndrome

    Baptiste Hervier1,2, Samra Ouaras2, Laurent Gilardin3, Hanane Ouakrim4, Damien Amelin5, Fleur Cohen6, Yurdagul Uzunhan7, Yves Allenbach1, Anne Bourgarit-Durand8, Olivier Benveniste9 and Vincent Vieillard10, 1Internal Medicine, Pitié-Salpêtrière University Hospital, Paris, France, 2CIMI Paris, UMR-S 1135, INSERM & UPMC, Paris, France, 3Internal Medicine, APHP, Hôpital Pitié Salpêtrière, Paris, France, 4INSERM UMR-S 1138, Centre des cordeliers & APHP, Cochin Hospital, Laboratory of Pathology, Paris, France, 5Sorbonne Universités UPMC Univ Paris 06, Myology research center, INSERM UMRS974, CNRS FRE3617, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, 6Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, 7Pulmonary diseases department, Avicenne Hospital (AP-HP), Bobigny, France, 8CHU Bondy, Bondy, France, 9Pitié-Salpêtrière University Hospital, Paris, France, 10P&M Curie university, INSERM 543, Paris, France

    Background/Purpose: Antisynthetase syndrome (ARS) is an inflammatory myopathy (IM) commonly associated to interstitial lung disease (ILD) and different anti-tRNA-synthetase autoantibodies. The immune mechanisms leading to…
  • Abstract Number: 1457 • 2016 ACR/ARHP Annual Meeting

    Early Onset Morbidity and Mortality in Female Tumor Necrosis Factor Transgenic Mice with Inflammatory-Erosive Arthritis and Interstitial Lung Disease

    Richard Bell1, Emily Wu2, Ronald Wood3, Joe Chakkalakal2, Javier Rangel-Moreno4, Maria de la Luz Garcia-Hernandez2, Christopher T. Ritchlin5, Edward Schwarz6 and Homaira Rahimi7, 1Center for Musculoskelatal Research, University of Rochester, Rochester, NY, 2University of Rochaester, Rochester, NY, 3University of Rochester, Rochester, NY, 4Allergy, Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, 5Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY, 6Orthopedeatrics, University of Rochester, Rochester, NY, 7Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY

    Background/Purpose: Although exacerbated morbidity and mortality in rheumatoid arthritis (RA) is frequently seen in women, the etiology of this sexual dimorphism remains unclear. Previously, we…
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