Abstracts tagged "Knee"

Abstract Number: 1206 • 2017 ACR/ARHP Annual Meeting
Chondroitin Sulfate Reduces Pain and Improves Function in Knee Osteoarthritis Significantly Better Than Placebo, Independently of the Definition of Responders
J-Y Reginster, Bone Cartilage Unit, University of Liege, Liege, Belgium
Background/Purpose: In addition to the assessment of the two co-primary endpoints – pain and function – regulatory agencies recommend the use of responder rates in…
Abstract Number: 2217 • 2017 ACR/ARHP Annual Meeting
Combined Impacts of Lifestyle Factors on Knee Osteoarthritis in the Osteoarthritis Initiative
Zhaoli (Joy) Dai¹, Carrie Brown², Yuqing Zhang³ and David T. Felson⁴, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Body mass index (BMI), healthy diet or components, physical activity, and tobacco smoking have been examined independently with risk of knee osteoarthritis (OA). Sleep…
Abstract Number: 936 • 2017 ACR/ARHP Annual Meeting
Knee Confidence Trajectories over 8 Years and Factors Associated with Poor Trajectories: Data from the Osteoarthritis Initiative
Alison H. Chang, Julia (Jungwha) Lee, Orit Almagor, Joan S. Chmiel, Kirsten C. Moisio, Karen W. Hayes, Julie Szymaszek and Leena Sharma, Northwestern University, Chicago, IL
Background/Purpose: Lack of knee confidence, a frequent complaint, has been associated with function decline in knee OA. Given its key role in weight-bearing activities, a…
Abstract Number: 1207 • 2017 ACR/ARHP Annual Meeting
Clinical Relevance of Structural Measures in Knee Osteoarthritis: Baseline Values and Change from Baseline Discriminate Patients Subsequently Receiving Knee Replacement
C. Kent Kwoh¹, Hans Guehring², Michael J Hannon³ and Aida Aydemir⁴, ¹University of Arizona Arthritis Center, Tuscan, AZ, ²Merck KGaA, Darmstadt, Germany, ³Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Structural measures of knee OA (KOA) progression include assessment of radiographic joint space width (JSW) and quantitative MRI (qMRI) measurement of cartilage thickness, both…
Abstract Number: 2251 • 2017 ACR/ARHP Annual Meeting
Preferences for Physical Activity: A Discrete Choice Experiment in People with Chronic Knee Pain
Daniel Pinto¹, Ulf Bockenholt², Rowland W. Chang^3,4, Julia (Jungwha) Lee⁵, Jane Holl⁶, Daniel Finn⁶, Leena Sharma⁷, Allen Heinemann⁸ and Paul Hansen⁹, ¹Department of Physical Therapy & Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Marketing, Kellogg School of Management, Northwestern University, Evanston, IL, ³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Medicine, and Physical Medicine & Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Center for Rehabilitation Outcomes Research, Shirley Ryan Ability Lab, Chicago, IL, ⁹Economics, University of Otago, Dundin, New Zealand
Preferences For Physical Activity: A Discrete Choice Experiment In People With Chronic Knee Pain Background/Purpose: Understanding preferences for physical activity (PA) can help guide patient…
Abstract Number: 977 • 2017 ACR/ARHP Annual Meeting
Association of Leisure-Time Physical Activity with Late-Life Mobility Limitation Among Women with Total Joint Replacement for Hip or Knee Osteoarthritis
Aladdin Shadyab¹, Wenjun Li², Charles Eaton³ and Andrea LaCroix⁴, ¹Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ⁴Family Medicine and Public Health, University of California, San Diego School of Medicine, La Jolla, CA
Background/Purpose: Maintaining mobility in old age is an important public health goal for patients with hip or knee osteoarthritis (OA), who are vulnerable to functional…
Abstract Number: 1208 • 2017 ACR/ARHP Annual Meeting
Levels of Serum Biomarkers from a Two-Year Multicentre Trial Are Associated with Treatment Response on Knee Osteoarthritis Cartilage Loss As Assessed By MRI: An Exploratory Study
Johanne Martel-Pelletier¹, Jean-Pierre Raynauld¹, François Mineau¹, François Abram², Patrice Paiement³, Philippe Delorme³ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³ArthroLab Inc., Montreal, QC, Canada
Background/Purpose: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in…
Abstract Number: 2767 • 2017 ACR/ARHP Annual Meeting
Active Yet Sedentary: The Association of Moderate to Vigorous Physical Activity and Sedentary Behavior with Incident Functional Limitation in Knee OA
Hiral Master¹, Louise Thoma¹, Meredith Christiansen¹, Dana Mathews² and Daniel White³, ¹Physical Therapy and Biomechanics and Movement Science, University of Delaware, Newark, DE, ²Physical Therapy, Biomechanics and Movement Science, University of Delaware, Newark, DE, ³Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Engaging in adequate levels of moderate to vigorous physical activity (MVPA) reduces the risk of functional limitation in people with knee osteoarthritis (OA). Sedentary…
Abstract Number: 980 • 2017 ACR/ARHP Annual Meeting
Is Intra-Articular Injection of Synvisc Associated with a Delay to Knee Arthroplasty in Knee OA Patients?
Kevin Ong¹, Maria Runa¹, Edmund Lau² and Roy Altman³, ¹Exponent, Inc., Philadelphia, PA, ²Exponent, Inc., Menlo Park, CA, ³UCLA Medical Center, Los Angeles, CA
Background/Purpose: Knee OA patients may undergo intra-articular (IA) hyaluronic acid (HA) injection treatment, but there is debate about its effectiveness. We asked: (1) What is…
Abstract Number: 1788 • 2017 ACR/ARHP Annual Meeting
Dose Intra-Articular Injection of Corticosteroids Increase the Risk of Knee Osteoarthritis Progression? Data from the Osteoarthritis Initiative
Guang-hua Lei¹, Chao Zeng¹, Jie Wei^2,3, Yi-lun Wang¹ and Dong-xing Xie¹, ¹Department of orthopaedics, Xiangya Hospital, Central South University, Changsha, China, ²Health Management Center, Xiangya Hospital, Central South University, Changsha, China, ³Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, China
Background/Purpose: Although intra-articular injection of corticosteroids (IAIC) has been one of the modalities of treatment for symptomatic knee OA, the recommendations for its use are…
Abstract Number: 2793 • 2017 ACR/ARHP Annual Meeting
Joint Location-Specific JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Deepa Hammaker¹, Gyrid Nygaard¹, David L. Boyle², Rizi Ai³, Wei Wang⁴ and Gary S. Firestein⁵, ¹Medicine, UC San Diego, La Jolla, CA, ²University of California San Diego, La Jolla, CA, ³UC San Diego, La Jolla, CA, ⁴Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ⁵Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Aberrant epigenetic marks in RA FLS contribute to disease pathogenesis and aggressive FLS behavior. Computational data also suggest that RA FLS isolated from different…
Abstract Number: 1006 • 2017 ACR/ARHP Annual Meeting
Sex Differences in Depressive Symptom Subtypes in Knee Osteoarthritis
Alan Rathbun¹, Megan Schuler², Elizabeth Stuart³, Michelle Shardell⁴, Michelle S. Yau⁵ and Marc Hochberg⁶, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Rand Coportation, Boston, MA, ³Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁴Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ⁵Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁶Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by structural changes in subchondral bone and degradation of articular cartilage, but the pathology does not necessarily lead to…
Abstract Number: 1853 • 2017 ACR/ARHP Annual Meeting
Exercise and Adherence over Two Years: Beliefs of Adults with Knee Osteoarthritis
Aileen Ledingham¹, Ellen Cohn², Kristin Baker³ and Julie Keysor¹, ¹Physical Therapy, Boston University, Boston, MA, ²Occupational Therapy, Boston University, Boston, MA, ³Physical Therapy, Boston University Sargent College, Boston, MA
Background/Purpose: Exercise is an established treatment to improve pain and physical function in adults with knee osteoarthritis (KOA), which is a leading cause of disability…
Abstract Number: 2823 • 2017 ACR/ARHP Annual Meeting
Preliminary Comparison of Patient-Centered Weight Loss Programs Starting before Versus after Knee Replacement
Christine Pellegrini^1,2, Rowland W. Chang³, Dorothy D. Dunlop⁴, David Conroy^1,5, Julia (Jungwha) Lee⁶, Linda VanHorn⁶, Bonnie Spring¹ and Kenzie Cameron⁷, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Exercise Science, University of South Carolina's Arnold School of Public Health, Columbia, SC, ³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Kinesiology, The Pennsylvania State University, University Park, PA, ⁶Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷General Internal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Most patients risk gaining weight in the years after knee replacement, adding further concern to a population that is mostly overweight/obese prior to surgery.…
Abstract Number: 1029 • 2017 ACR/ARHP Annual Meeting
What to Measure after Arthroplasty? Confirmation of a Core Domain Set
Anh Hoang¹, Susan M. Goodman², Mark P. Figgie³, Mathias Bostrom⁴, Douglas Padgett⁴, Lisa A. Mandl^5,6,7, Peter Sculco⁸, Alexander McLawhorn⁹ and Jasvinder A. Singh¹⁰, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Medicine, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ³Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁴Orthopaedic Surgery, Hospital for Special Surgery, New York, NY, ⁵Department of Medicine, Hospital for Special Surgery, New York, NY, ⁶Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁷Department of Rheumatology, Hospital for Special Surgery, New York, NY, ⁸Orthopaedic Surgery, Hospital for Special Surgey, New York, NY, ⁹Hospital for Special Surgey, New York, NY, ¹⁰Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: The Outcomes Measures in Rheumatology Trials (OMERACT) TJR Working Group has proposed six core domains that would constitute a standardized measurement set that can…

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