Abstracts tagged "Knee"

Abstract Number: 1322 • 2019 ACR/ARP Annual Meeting
Evaluation of Intra-articular CNTX-4975 in Subjects with Painful Bilateral Knee Osteoarthritis: Effects on Pain with Walking and Patient Impression of Change in Pain
Randall Stevens ¹, Kimberly Guedes ¹, Nilam Mistry ¹, Paul Tiseo ², Duncan Lascelles ³, Mario Mendoza¹ and David Ball ⁴, ¹Centrexion Therapeutics Corp, Boston, MA, ²Centrexion Therapeutics Corp, Boston, ³Translational Research in Pain, North Carolina State University, Raleigh, NC, ⁴MAC Clinical Research, Manchester, United Kingdom
Background/Purpose: A double-blind, randomized, placebo-controlled trial (TRIUMPH; NCT02558439) with a single 1 mg intra-articular (IA) injection of CNTX-4975 (highly purified trans-capsaicin) into one knee for…
Abstract Number: 1961 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Sub-haplogroup H1 Influences the Risk of Rapidly Progressive Osteoarthritis of the Knee: Data from the Osteoarthritis Initiative
Alejandro Duran-Sotuela¹, Mercedes Fernandez-Moreno ², María E. Vázquez-Mosquera ³, Paula Ramos-Louro ¹, Andrea Dalmao-Fernández ³, Sara Relaño ¹, Natividad Oreiro ¹, Francisco J. Blanco ¹ and Ignacio Rego-Pérez ¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain
Background/Purpose: There is a need to identify the rapid progressive phenotype of Osteoarthritis (OA). Our aim is to analyze the effect of mitochondrial haplogroups in…
Abstract Number: 2176 • 2019 ACR/ARP Annual Meeting
A Novel Composite Score Reflecting Disease Activity Predicts Future Knee Replacements: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Matthew Harkey ², Lori Lyn Price ³, Grace Lo ⁴, Jincheng Pang ⁵, Ming Zhang ⁶ and Timothy McAlindon ¹, ¹Tufts Medical Center, Boston, MA, ²Tufts Medical Center, University of Massachusetts Medical School, Boston, MA, ³Tufts Medical Center, Tufts University, Boston, MA, ⁴Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, ⁵Pfizer, Inc., Cambridge, MA, ⁶Tufts Medical Center, Wentworth Institute of Technology, Boston, MA
Background/Purpose: While knee osteoarthritis (KOA) leads to cumulative damage to a diarthrodial joint there are also more dynamic processes that fluctuate throughout the disease process…
Abstract Number: 2188 • 2019 ACR/ARP Annual Meeting
The Association of Plasma Fatty Acids Levels with Hand and Knee Osteoarthritis
Marieke Loef¹, Andreea Ioan-Facsinay ¹, Dennis O Mook-Kanamori ², Ko Willems van Dijk ¹, Renée de Mutsert ¹, Margreet Kloppenburg ¹ and Frits R Rosendaal ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Obesity is one of the most important risk factors for osteoarthritis, and is strongly associated with increased levels of circulating fatty acids, which may…
Abstract Number: 2198 • 2019 ACR/ARP Annual Meeting
Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis
Kevin Ong¹, Maria Runa ¹, Wilson Ngai ², Zhimin Xiao ³, Edmund Lau ⁴ and Roy Altman ⁵, ¹Exponent, Inc., Philadelphia, ²Sanofi, U.S. Medical Affairs, Bridgewater, ³Sanofi US, Cambridge, ⁴Exponent, Inc., Menlo Park, ⁵University of California, Los Angeles
Background/Purpose: Some concerns have been raised about subsequent severe acute localized reactions (SALR) (flares, pseudoseptic reactions, etc.) following hyaluronic acid (HA) injections for pain relief…
Abstract Number: 2760 • 2019 ACR/ARP Annual Meeting
A Phase 2 Double-Blind Clinical Trial to Examine the Comparative Effects on Osteoarthritic Knee Pain of CGS-200-1 (1% Capsaicin Topical Liquid), CGS-200-5 (5% Capsaicin Topical Liquid), and CGS-200-0 (Vehicle, No Capsaicin)
Michael Billard ¹, John Todhunter ¹, Margaret Fleming ¹, Tim Warneke¹, Yuhui Qiu ², Nhu Ly ², William Aronstein ² and William Moore ¹, ¹Vizuri Health Sciences, LLC, Columbia, MD, ²CTI Clinical Trial & Consulting, Covington, KY
Background/Purpose: There is considerable unmet medical need for an osteoarthritic knee pain (OAKP) treatment that does not require regular daily use, does not carry gastrointestinal…
Abstract Number: 2761 • 2019 ACR/ARP Annual Meeting
Cartilage Thickness Modification with Sprifermin in Knee Osteoarthritis Patients Translates into Symptomatic Improvement over Placebo in Patients at Risk of Further Structural and Symptomatic Progression: Post-Hoc Analysis of a Phase II Trial
Hans Guehring¹, Jeffrey Kraines ², Flavie Moreau ², Benjamin Daelken ¹, Christoph Ladel ¹, Wolfgang Wirth ³, Philip G Conaghan ⁴, Felix Eckstein ⁵ and Marc C. Hochberg ⁶, ¹Merck KGaA, Darmstadt, Germany, ²EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³Paracelsus Medical University, Salzbury, Austria, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ⁵Paracelsus Medical University, Salzburg, Austria, ⁶University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Results from the 5-year Phase II FORWARD study showed significant dose-dependent modification of total femorotibial joint (TFTJ) cartilage thickness change with sprifermin at 2…
Abstract Number: 281 • 2019 ACR/ARP Annual Meeting
Frequency of Ultrasound Features of Knee Osteoarthritis and Their Association with Radiographic Features and Symptoms in a Community-Based Cohort
Nadiya Yerich¹, Carolina Alvarez ², Todd Schwartz ³, Sue Savage-Guin ², Catherine Bakewell ⁴, Minna Kohler ⁵, Janice Lin ⁶, Jonathan Samuels ⁷ and Amanda Nelson ², ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁴Intermountain Medical Center, Salt Lake City, UT, ⁵MGH, Boston, ⁶Stanford University, Palo Alto, CA, ⁷NYU Langone Medical Center, New Yort, NY
Background/Purpose: To evaluate the frequency and associations of osteoarthritis (KOA) features on knee ultrasound (KUS) in a community-based cohort study with radiographic and symptomatic data…
Abstract Number: 416 • 2019 ACR/ARP Annual Meeting
Global Management of Patients with Knee Osteoarthritis Begins with Quality of Life Assessment: A Systematic Review
Josep Verges¹, Marianna Vitaloni ¹, Rosa Sciortino ², Maritza Quintero ², Marco Bibas ¹, Jordi Monfort ³, Francisco de Abajo ⁴, Marco Matucci-Cerinic ⁵, Patrick du Souich ⁶, Ingrid Möller ⁷, Guy Eakin ⁸ and Angie Botto-van Bemden ⁸, ¹Osteoarthritis International Foundation, Barcelona, Spain, ²De los Andes University, Merida, Venezuela, ³Hospital del Mar, Barcelona, Spain, ⁴Universidad de Alcalá, Madrid, Spain, ⁵University of Florence, Department of Medicine, Florence, Italy, Florence, Italy, ⁶University of Montreal, Montreal, Canada, ⁷Poal Institute, Barcelona, Spain, ⁸Arthritis Foundation, Atlanta
Background/Purpose: Knee OA (KOA) associates with remarkable functional restrictions due to pain that seriously affect social and emotional well-being, reducing the quality of life (QoL).…
Abstract Number: 1180 • 2019 ACR/ARP Annual Meeting
Confirmation of Manual Cartilage Segmentation Findings by Automated Segmentation: Retrospective Analysis of MRI Images from a Sprifermin Phase II Study
Alan Brett¹, Michael A Bowes ¹, Philip G Conaghan ², Christoph Ladel ³, Jeffrey Kraines ⁴, Hans Guehring ³, Flavie Moreau ⁴ and Felix Eckstein ⁵, ¹Imorphics, Manchester, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵Paracelsus Medical University, Salzburg, Austria
Background/Purpose: Sprifermin is under investigation as a potential disease-modifying osteoarthritis drug (DMOAD). 2-yr results from the FORWARD study showed significant dose-dependent modification of cartilage thickness…
Abstract Number: 1301 • 2019 ACR/ARP Annual Meeting
Rates of Incident Radiographic Knee Osteoarthritis and Knee Replacement by Sex and Race, Across Three Large, Diverse Cohorts
C. Kent Kwoh¹, Amanda Nelson ², Yvonne Golightly ³, Erin Ashbeck ⁴, Liubov Arbeeva ⁵, Na Wang ⁶, Jeffrey Duryea ⁷ and Tuhina Neogi ⁶, ¹University of Arizona, Tucson, AZ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁴The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁵University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ⁶Boston University School of Medicine, Boston, MA, ⁷Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies have suggested differences in the development of incident radiographic knee osteoarthritis (RKOA) and the receipt of knee replacement (KR) by sex and…
Abstract Number: L03 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety from a Phase 2b Trial of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor for the Treatment of Osteoarthritis of the Knee
Yusuf Yazici¹, Timothy E. McAlindon², Allan Gibofsky³, Nancy Lane⁴, Christian Lattermann⁵, Nebojsa Skrepnik⁶, Christopher Swearingen¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Marc Hochberg⁷, ¹Samumed, LLC, San Diego, CA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, ⁴Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, ⁵Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Tucson Orthopaedic Institute, Tucson, AZ, ⁷University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: A previous Phase 2a study of SM04690, a small molecule, intra-articular (IA), Wnt pathway inhibitor, demonstrated positive effects on knee OA pain, physical function,…
Abstract Number: 930 • 2018 ACR/ARHP Annual Meeting
Joint Location-Specific IL6 and JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Deepa Hammaker¹, Gyrid Nygaard¹, Amanda Kuhs¹, Rizi Ai², David L. Boyle¹, Wei Wang³ and Gary S. Firestein¹, ¹Medicine, University of California San Diego, La Jolla, CA, ²University of California San Diego, La Jolla, CA, ³Chemistry and Biochemistry, University of California San Diego, La Jolla, CA
Background/Purpose: Recent studies suggest that epigenetic marks distinguish FLS isolated from different joints in RA. Hip and knee joint-derived FLS, in particular, have distinctive DNA…
Abstract Number: 1371 • 2018 ACR/ARHP Annual Meeting
Systemic Exposure of Triamcinolone Acetonide Following Bilateral Injection of Extended-Release Triamcinolone Acetonide and Standard Triamcinolone in Patients with Bilateral Knee Osteoarthritis
Alan J. Kivitz¹, Louis Kwong², Tammi Shlotzhauer³, Joelle Lufkin⁴, Teresa Curto⁵ and Scott Kelley⁴, ¹Altoona Center for Clinical Research, Duncansville, PA, ²Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA, ³Rochester Clinical Research, Inc., Rochester, NY, ⁴Flexion Therapeutics, Inc., Burlington, MA, ⁵Cytel Inc., Waltham, MA
Background/Purpose: Current ACR guidelines recommend the use of IACS for short-term acute pain relief in patients (pts) with knee OA.1 Bilateral knee OA can occur…
Abstract Number: 263 • 2018 ACR/ARHP Annual Meeting
Racial Disparities in Total Knee Replacement Failure Are Not Explained By Poverty
Anne R. Bass¹, Jackie Szymonifka², Lisa A. Mandl¹, Bella Y. Mehta³, Emily Ying Lai², Stephen Lyman¹, Michael L. Parks¹, Serene Z. Mirza², Shirin A. Dey² and Susan M. Goodman², ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery/Weill Cornell Medicine/Mailman School of Public Health, New York, NY
Background/Purpose: U.S. blacks have a higher risk of revision total knee replacement (TKR) than whites, but whether this is mediated by poverty is unknown. The…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].