ACR Meeting Abstracts

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Abstracts tagged "Knee"

  • Abstract Number: 416 • 2019 ACR/ARP Annual Meeting

    Global Management of Patients with Knee Osteoarthritis Begins with Quality of Life Assessment: A Systematic Review

    Josep Verges1, Marianna Vitaloni 1, Rosa Sciortino 2, Maritza Quintero 2, Marco Bibas 1, Jordi Monfort 3, Francisco de Abajo 4, Marco Matucci-Cerinic 5, Patrick du Souich 6, Ingrid Möller 7, Guy Eakin 8 and Angie Botto-van Bemden 8, 1Osteoarthritis International Foundation, Barcelona, Spain, 2De los Andes University, Merida, Venezuela, 3Hospital del Mar, Barcelona, Spain, 4Universidad de Alcalá, Madrid, Spain, 5University of Florence, Department of Medicine, Florence, Italy, Florence, Italy, 6University of Montreal, Montreal, Canada, 7Poal Institute, Barcelona, Spain, 8Arthritis Foundation, Atlanta

    Background/Purpose: Knee OA (KOA) associates with remarkable functional restrictions due to pain that seriously affect social and emotional well-being, reducing the quality of life (QoL).…
  • Abstract Number: 1180 • 2019 ACR/ARP Annual Meeting

    Confirmation of Manual Cartilage Segmentation Findings by Automated Segmentation: Retrospective Analysis of MRI Images from a Sprifermin Phase II Study

    Alan Brett1, Michael A Bowes 1, Philip G Conaghan 2, Christoph Ladel 3, Jeffrey Kraines 4, Hans Guehring 3, Flavie Moreau 4 and Felix Eckstein 5, 1Imorphics, Manchester, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 3Merck KGaA, Darmstadt, Germany, 4EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 5Paracelsus Medical University, Salzburg, Austria

    Background/Purpose: Sprifermin is under investigation as a potential disease-modifying osteoarthritis drug (DMOAD). 2-yr results from the FORWARD study showed significant dose-dependent modification of cartilage thickness…
  • Abstract Number: 1301 • 2019 ACR/ARP Annual Meeting

    Rates of Incident Radiographic Knee Osteoarthritis and Knee Replacement by Sex and Race, Across Three Large, Diverse Cohorts

    C. Kent Kwoh1, Amanda Nelson 2, Yvonne Golightly 3, Erin Ashbeck 4, Liubov Arbeeva 5, Na Wang 6, Jeffrey Duryea 7 and Tuhina Neogi 6, 1University of Arizona, Tucson, AZ, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, 3University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, 4The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, 5University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, 6Boston University School of Medicine, Boston, MA, 7Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Previous studies have suggested differences in the development of incident radiographic knee osteoarthritis (RKOA) and the receipt of knee replacement (KR) by sex and…
  • Abstract Number: 1304 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety of Hylan G-F 20 versus Intra-Articular Corticosteroids in Patients with Knee Osteoarthritis: A Systematic Literature Review, Meta-Analysis, and Network Meta-analysis

    Xavier Chevalier 1, Brendan Sheehan 2, Craig Whittington 3, Chunyi Ho 4, Wilson Ngai5 and Gustavo Campos 6, 1Department of Rheumatology, Hospital henri Mondor, Paris University XII, Creteil, France, 2Department of Medicine, Dalhousie University, Saint John, NB, Canada, 3Doctor Evidence, Santa Monica, CA, 4Doctor Evidence, Santa Monica, 5Sanofi, U.S. Medical Affairs, Bridgewater, 6Universidade Estadual de Campinas, Campinas, Brazil

    Background/Purpose: Knee OA is a progressive joint disease which affects more than 250 million people worldwide. Meta-analysis (MA) has demonstrated that IA CS were more…
  • Abstract Number: 1305 • 2019 ACR/ARP Annual Meeting

    Quality Improvement in Diagnostic and Therapeutic Arthrocentesis in the Flexed Knee Using Pneumatic Compression of the Suprapatellar Bursa

    Fatemeh Jafari Farshami1, Jaren Trost 2, Wilmer Sibbitt 2, Maheswari Muruganandam 2, Philip Band 3, Monthida Fangtham 1, Nicole Emil 1, William Hayward 4, Luke Haseler 5 and Arthur Bankhurst 1, 1Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 2Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, 3Department of Orthopaedic Surgery, Biochemistry & Molecular Pharmacology NYU School of Medicine, New York City, New York City, NY, 4The Department of Exercise and Sport Sciences, New Mexico Highlands University, Las Vegas, NM, 5Faculty of Health Sciences, School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia

    Background/Purpose: Arthrocentesis is an essential procedure in diagnosing inflammatory and septic arthritis and is a basic procedure for intra-articular therapy, including therapeutic arthrocentesis and intra-articular…
  • Abstract Number: 1307 • 2019 ACR/ARP Annual Meeting

    A Prospective, Multi-center, Randomized, Clinical Trial Comparing the Effectiveness and Safety of Cooled Radiofrequency Ablation versus a Single Injection of Hyaluronic Acid in the Management of OA Knee Pain

    Antonia Chen1, Fred Khalouf 2, Michael DePalma 3, Keith Zora 4, Lynn Kohan 5, Maged Guirguis 6, Douglas Beall 7, Eric Loudermilk 8, Matthew Pingree 9, Ignacio Badiola 10 and Jeffrey Lyman 11, 1Brigham and Women’s Hospital, Boston, MA, 2University Orthopedics Center, Altoona, PA, 3Virginia iSpine Physicians, Richmond, VA, 4University Orthopedics Center, State College, PA, 5University of Virginia School of Medicine, Charlottesville, VA, 6Ochsner Clinic Foundation, New Orleans, LA, 7Clinical Investigations, Edmond, OK, 8PCPMG Clinical Research Unit LLC, Anderson, SC, 9Mayo Clinic, Rochester, MN, 10University of Pennsylvania, Philadelphia, PA, 11Institute for Orthopedic Research and Innovation, Coeur d'Alene, IN

    Background/Purpose: This prospective, randomized, multi-center study was conducted to compare pain relief, functional improvement, and the safety of cooled radiofrequency ablation (CRFA) to hyaluronic acid…
  • Abstract Number: 1315 • 2019 ACR/ARP Annual Meeting

    Relation of MRI-detected Structural Damage in the Patellofemoral Joint to Pain and Performance Based Function: The MOST Study

    Jessica Maxwell1, Tuhina Neogi 2, Kay Crossley 3, Erin Macri 4, Daniel White 5, Ali Guermazi 6, Frank Roemer 7, Michael Nevitt 8, Beth Lewis 9, James Torner 10 and Joshua Stefanik 11, 1Northeastern University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3La Trobe University, Victoria, Australia, 4Erasmus MC, Rotterdam, Netherlands, 5University of Delaware, Newark, DE, 6Boston Medical Center, Boston, 7University of Erlangen-Nuremberg, Erlangen, Germany, 8University of California at San Francisco, San Francisco, CA, 9University of Alabama at Birmingham, Birmingham, AL, 10University of Iowa at Iowa City, Iowa City, 11Northeastern University, Boston

    Background/Purpose: Osteoarthritis (OA) of the knee is one of the most common causes of disability in the U.S. Often overlooked, OA specific to the patellofemoral…
  • Abstract Number: 1321 • 2019 ACR/ARP Annual Meeting

    What Is the Relationship Between the 3 Knee Bones in Osteoarthritis? Baseline and Longitudinal Associations Using a Latent Growth Modelling Approach on 37,583 MR Images from the Osteoarthritis Initiative

    Bright Dube1, Michael Bowes 2, Elizabeth Hensor 1, Sarah Kingsbury 3 and Philip G Conaghan 4, 1University of Leeds, LEEDS, England, United Kingdom, 2Imorphics, Manchester, England, United Kingdom, 3University of Leeds, Leeds, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom

    Background/Purpose: 3D femur bone shape measured by statistical shape modelling (SSM) provides a responsive biomarker of knee OA. However it is unclear how the 3…
  • Abstract Number: 1322 • 2019 ACR/ARP Annual Meeting

    Evaluation of Intra-articular CNTX-4975 in Subjects with Painful Bilateral Knee Osteoarthritis: Effects on Pain with Walking and Patient Impression of Change in Pain

    Randall Stevens 1, Kimberly Guedes 1, Nilam Mistry 1, Paul Tiseo 2, Duncan Lascelles 3, Mario Mendoza1 and David Ball 4, 1Centrexion Therapeutics Corp, Boston, MA, 2Centrexion Therapeutics Corp, Boston, 3Translational Research in Pain, North Carolina State University, Raleigh, NC, 4MAC Clinical Research, Manchester, United Kingdom

    Background/Purpose: A double-blind, randomized, placebo-controlled trial (TRIUMPH; NCT02558439) with a single 1 mg intra-articular (IA) injection of CNTX-4975 (highly purified trans-capsaicin) into one knee for…
  • Abstract Number: 1961 • 2019 ACR/ARP Annual Meeting

    Mitochondrial DNA Sub-haplogroup H1 Influences the Risk of Rapidly Progressive Osteoarthritis of the Knee: Data from the Osteoarthritis Initiative

    Alejandro Duran-Sotuela1, Mercedes Fernandez-Moreno 2, María E. Vázquez-Mosquera 3, Paula Ramos-Louro 1, Andrea Dalmao-Fernández 3, Sara Relaño 1, Natividad Oreiro 1, Francisco J. Blanco 1 and Ignacio Rego-Pérez 1, 1Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, 2Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, 3Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain

    Background/Purpose: There is a need to identify the rapid progressive phenotype of Osteoarthritis (OA). Our aim is to analyze the effect of mitochondrial haplogroups in…
  • Abstract Number: 2176 • 2019 ACR/ARP Annual Meeting

    A Novel Composite Score Reflecting Disease Activity Predicts Future Knee Replacements: Data from the Osteoarthritis Initiative

    Jeffrey Driban1, Matthew Harkey 2, Lori Lyn Price 3, Grace Lo 4, Jincheng Pang 5, Ming Zhang 6 and Timothy McAlindon 1, 1Tufts Medical Center, Boston, MA, 2Tufts Medical Center, University of Massachusetts Medical School, Boston, MA, 3Tufts Medical Center, Tufts University, Boston, MA, 4Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, 5Pfizer, Inc., Cambridge, MA, 6Tufts Medical Center, Wentworth Institute of Technology, Boston, MA

    Background/Purpose: While knee osteoarthritis (KOA) leads to cumulative damage to a diarthrodial joint there are also more dynamic processes that fluctuate throughout the disease process…
  • Abstract Number: L03 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety from a Phase 2b Trial of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor for the Treatment of Osteoarthritis of the Knee

    Yusuf Yazici1, Timothy E. McAlindon2, Allan Gibofsky3, Nancy Lane4, Christian Lattermann5, Nebojsa Skrepnik6, Christopher Swearingen1, Anita DiFrancesco1, Jeymi Tambiah1 and Marc Hochberg7, 1Samumed, LLC, San Diego, CA, 2Division of Rheumatology, Tufts Medical Center, Boston, MA, 3Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, 4Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Tucson Orthopaedic Institute, Tucson, AZ, 7University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: A previous Phase 2a study of SM04690, a small molecule, intra-articular (IA), Wnt pathway inhibitor, demonstrated positive effects on knee OA pain, physical function,…
  • Abstract Number: 428 • 2018 ACR/ARHP Annual Meeting

    Significant Pain Reduction with Oral Methotrexate in Knee Osteoarthritis; Results from a Randomised Controlled Phase III Trial of Treatment Effectiveness

    Sarah R. Kingsbury1, Puvan Tharmanathan2, Ada Keding2, Belen Corbacho2, Fiona E Watt3, David L Scott4, Edward Roddy5, Fraser Birrell6, Nigel K Arden7, Catherine Arundel2, Sarah Ronaldson2, Lema Vernon8, Catherine Hewitt2, Michael Doherty9, David Torgerson2 and Philip G. Conaghan1, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom, 2York Trials Unit, University of York, York, United Kingdom, 3Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 4Department of Rheumatology, King's College London, London, United Kingdom, 5Staffordshire and Stoke on Trent Partnership NHS Foundation Trust, Newcastle Under Lyme, United Kingdom, 6Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom, 7Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, University of Oxford, Oxford, United Kingdom, 8Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 9The University of Nottingham, Nottingham, United Kingdom

    Background/Purpose: Current treatments for osteoarthritis (OA) are severely limited. Synovitis is prevalent in OA and is associated with pain. The slow-acting anti-rheumatic drug methotrexate (MTX)…
  • Abstract Number: 1138 • 2018 ACR/ARHP Annual Meeting

    Public Health Impact of Physical Inactivity in the Knee OA Population in the US

    Elena Losina1, Genevieve S. Silva2, Karen C. Smith2, Jamie E. Collins3, David J. Hunter4, Swastina Shrestha2, Stephen P. Messier5, Edward H. Yelin6, Lisa Gale Suter7, A. David Paltiel8 and Jeffrey N. Katz9, 1Orthopedics, Brigham and Women's Hospital, BU School of Public Health and Harvard Medical School, Boston, MA, 2Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, 3Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, 4Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 5Department of Health and Exerc, Wake Forest University, Winston-Salem, NC, 6Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, 7Rheumatology, Rheumatology, Yale University School of Medicine, New Haven, CT, New Haven, CT, 8Yale University, New Haven, CT, 9Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: The benefits of physical activity (PA) in persons with OA are well-documented: PA reduces OA pain, improves mental health, and reduces the risk of…
  • Abstract Number: 2191 • 2018 ACR/ARHP Annual Meeting

    Safety of Ultrasound-Guided Injections Using Local Puncture Site Sterility

    Suzan Jaradat1, Maheswari Muruganandam2, Noelle Rolle2, Wilmer Sibbitt Jr.3, William Hayward4, N. Suzanne Emil3, Monthida Fangtham3, Roderick Fields3 and Arthur Bankhurst3, 1Internal Medicine, University of New Mexico Health Sciences Center, ALBUQUERQUE, NM, 2University of New Mexico Health Sciences Center, ALBUQUERQUE, NM, 3Rheumatology, University of New Mexico Health Sciences Center, Albuquerque, NM, 4The Department of Exercise and Sport Sciences, New Mexico Highlands University, Las Vegas, NM

    Background/Purpose:  Ultrasound (US)-guided injections in musculoskeletal medicine typically utilize either local puncture site sterility or conventional surgical sterility. We report on the safety and complications…
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