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Abstracts tagged "Knee"

  • Abstract Number: 2198 • 2019 ACR/ARP Annual Meeting

    Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis

    Kevin Ong1, Maria Runa 1, Wilson Ngai 2, Zhimin Xiao 3, Edmund Lau 4 and Roy Altman 5, 1Exponent, Inc., Philadelphia, 2Sanofi, U.S. Medical Affairs, Bridgewater, 3Sanofi US, Cambridge, 4Exponent, Inc., Menlo Park, 5University of California, Los Angeles

    Background/Purpose: Some concerns have been raised about subsequent severe acute localized reactions (SALR) (flares, pseudoseptic reactions, etc.) following hyaluronic acid (HA) injections for pain relief…
  • Abstract Number: 2760 • 2019 ACR/ARP Annual Meeting

    A Phase 2 Double-Blind Clinical Trial to Examine the Comparative Effects on Osteoarthritic Knee Pain of CGS-200-1 (1% Capsaicin Topical Liquid), CGS-200-5 (5% Capsaicin Topical Liquid), and CGS-200-0 (Vehicle, No Capsaicin)

    Michael Billard 1, John Todhunter 1, Margaret Fleming 1, Tim Warneke1, Yuhui Qiu 2, Nhu Ly 2, William Aronstein 2 and William Moore 1, 1Vizuri Health Sciences, LLC, Columbia, MD, 2CTI Clinical Trial & Consulting, Covington, KY

    Background/Purpose: There is considerable unmet medical need for an osteoarthritic knee pain (OAKP) treatment that does not require regular daily use, does not carry gastrointestinal…
  • Abstract Number: 2761 • 2019 ACR/ARP Annual Meeting

    Cartilage Thickness Modification with Sprifermin in Knee Osteoarthritis Patients Translates into Symptomatic Improvement over Placebo in Patients at Risk of Further Structural and Symptomatic Progression: Post-Hoc Analysis of a Phase II Trial

    Hans Guehring1, Jeffrey Kraines 2, Flavie Moreau 2, Benjamin Daelken 1, Christoph Ladel 1, Wolfgang Wirth 3, Philip G Conaghan 4, Felix Eckstein 5 and Marc C. Hochberg 6, 1Merck KGaA, Darmstadt, Germany, 2EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 3Paracelsus Medical University, Salzbury, Austria, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 5Paracelsus Medical University, Salzburg, Austria, 6University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Results from the 5-year Phase II FORWARD study showed significant dose-dependent modification of total femorotibial joint (TFTJ) cartilage thickness change with sprifermin at 2…
  • Abstract Number: 281 • 2019 ACR/ARP Annual Meeting

    Frequency of Ultrasound Features of Knee Osteoarthritis and Their Association with Radiographic Features and Symptoms in a Community-Based Cohort

    Nadiya Yerich1, Carolina Alvarez 2, Todd Schwartz 3, Sue Savage-Guin 2, Catherine Bakewell 4, Minna Kohler 5, Janice Lin 6, Jonathan Samuels 7 and Amanda Nelson 2, 1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, 3University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, 4Intermountain Medical Center, Salt Lake City, UT, 5MGH, Boston, 6Stanford University, Palo Alto, CA, 7NYU Langone Medical Center, New Yort, NY

    Background/Purpose: To evaluate the frequency and associations of osteoarthritis (KOA) features on knee ultrasound (KUS) in a community-based cohort study with radiographic and symptomatic data…
  • Abstract Number: 416 • 2019 ACR/ARP Annual Meeting

    Global Management of Patients with Knee Osteoarthritis Begins with Quality of Life Assessment: A Systematic Review

    Josep Verges1, Marianna Vitaloni 1, Rosa Sciortino 2, Maritza Quintero 2, Marco Bibas 1, Jordi Monfort 3, Francisco de Abajo 4, Marco Matucci-Cerinic 5, Patrick du Souich 6, Ingrid Möller 7, Guy Eakin 8 and Angie Botto-van Bemden 8, 1Osteoarthritis International Foundation, Barcelona, Spain, 2De los Andes University, Merida, Venezuela, 3Hospital del Mar, Barcelona, Spain, 4Universidad de Alcalá, Madrid, Spain, 5University of Florence, Department of Medicine, Florence, Italy, Florence, Italy, 6University of Montreal, Montreal, Canada, 7Poal Institute, Barcelona, Spain, 8Arthritis Foundation, Atlanta

    Background/Purpose: Knee OA (KOA) associates with remarkable functional restrictions due to pain that seriously affect social and emotional well-being, reducing the quality of life (QoL).…
  • Abstract Number: 1180 • 2019 ACR/ARP Annual Meeting

    Confirmation of Manual Cartilage Segmentation Findings by Automated Segmentation: Retrospective Analysis of MRI Images from a Sprifermin Phase II Study

    Alan Brett1, Michael A Bowes 1, Philip G Conaghan 2, Christoph Ladel 3, Jeffrey Kraines 4, Hans Guehring 3, Flavie Moreau 4 and Felix Eckstein 5, 1Imorphics, Manchester, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, 3Merck KGaA, Darmstadt, Germany, 4EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, 5Paracelsus Medical University, Salzburg, Austria

    Background/Purpose: Sprifermin is under investigation as a potential disease-modifying osteoarthritis drug (DMOAD). 2-yr results from the FORWARD study showed significant dose-dependent modification of cartilage thickness…
  • Abstract Number: 1301 • 2019 ACR/ARP Annual Meeting

    Rates of Incident Radiographic Knee Osteoarthritis and Knee Replacement by Sex and Race, Across Three Large, Diverse Cohorts

    C. Kent Kwoh1, Amanda Nelson 2, Yvonne Golightly 3, Erin Ashbeck 4, Liubov Arbeeva 5, Na Wang 6, Jeffrey Duryea 7 and Tuhina Neogi 6, 1University of Arizona, Tucson, AZ, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, 3University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, 4The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, 5University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, 6Boston University School of Medicine, Boston, MA, 7Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Previous studies have suggested differences in the development of incident radiographic knee osteoarthritis (RKOA) and the receipt of knee replacement (KR) by sex and…
  • Abstract Number: 1304 • 2019 ACR/ARP Annual Meeting

    Efficacy and Safety of Hylan G-F 20 versus Intra-Articular Corticosteroids in Patients with Knee Osteoarthritis: A Systematic Literature Review, Meta-Analysis, and Network Meta-analysis

    Xavier Chevalier 1, Brendan Sheehan 2, Craig Whittington 3, Chunyi Ho 4, Wilson Ngai5 and Gustavo Campos 6, 1Department of Rheumatology, Hospital henri Mondor, Paris University XII, Creteil, France, 2Department of Medicine, Dalhousie University, Saint John, NB, Canada, 3Doctor Evidence, Santa Monica, CA, 4Doctor Evidence, Santa Monica, 5Sanofi, U.S. Medical Affairs, Bridgewater, 6Universidade Estadual de Campinas, Campinas, Brazil

    Background/Purpose: Knee OA is a progressive joint disease which affects more than 250 million people worldwide. Meta-analysis (MA) has demonstrated that IA CS were more…
  • Abstract Number: 1305 • 2019 ACR/ARP Annual Meeting

    Quality Improvement in Diagnostic and Therapeutic Arthrocentesis in the Flexed Knee Using Pneumatic Compression of the Suprapatellar Bursa

    Fatemeh Jafari Farshami1, Jaren Trost 2, Wilmer Sibbitt 2, Maheswari Muruganandam 2, Philip Band 3, Monthida Fangtham 1, Nicole Emil 1, William Hayward 4, Luke Haseler 5 and Arthur Bankhurst 1, 1Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 2Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, 3Department of Orthopaedic Surgery, Biochemistry & Molecular Pharmacology NYU School of Medicine, New York City, New York City, NY, 4The Department of Exercise and Sport Sciences, New Mexico Highlands University, Las Vegas, NM, 5Faculty of Health Sciences, School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia

    Background/Purpose: Arthrocentesis is an essential procedure in diagnosing inflammatory and septic arthritis and is a basic procedure for intra-articular therapy, including therapeutic arthrocentesis and intra-articular…
  • Abstract Number: 1307 • 2019 ACR/ARP Annual Meeting

    A Prospective, Multi-center, Randomized, Clinical Trial Comparing the Effectiveness and Safety of Cooled Radiofrequency Ablation versus a Single Injection of Hyaluronic Acid in the Management of OA Knee Pain

    Antonia Chen1, Fred Khalouf 2, Michael DePalma 3, Keith Zora 4, Lynn Kohan 5, Maged Guirguis 6, Douglas Beall 7, Eric Loudermilk 8, Matthew Pingree 9, Ignacio Badiola 10 and Jeffrey Lyman 11, 1Brigham and Women’s Hospital, Boston, MA, 2University Orthopedics Center, Altoona, PA, 3Virginia iSpine Physicians, Richmond, VA, 4University Orthopedics Center, State College, PA, 5University of Virginia School of Medicine, Charlottesville, VA, 6Ochsner Clinic Foundation, New Orleans, LA, 7Clinical Investigations, Edmond, OK, 8PCPMG Clinical Research Unit LLC, Anderson, SC, 9Mayo Clinic, Rochester, MN, 10University of Pennsylvania, Philadelphia, PA, 11Institute for Orthopedic Research and Innovation, Coeur d'Alene, IN

    Background/Purpose: This prospective, randomized, multi-center study was conducted to compare pain relief, functional improvement, and the safety of cooled radiofrequency ablation (CRFA) to hyaluronic acid…
  • Abstract Number: 1315 • 2019 ACR/ARP Annual Meeting

    Relation of MRI-detected Structural Damage in the Patellofemoral Joint to Pain and Performance Based Function: The MOST Study

    Jessica Maxwell1, Tuhina Neogi 2, Kay Crossley 3, Erin Macri 4, Daniel White 5, Ali Guermazi 6, Frank Roemer 7, Michael Nevitt 8, Beth Lewis 9, James Torner 10 and Joshua Stefanik 11, 1Northeastern University, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3La Trobe University, Victoria, Australia, 4Erasmus MC, Rotterdam, Netherlands, 5University of Delaware, Newark, DE, 6Boston Medical Center, Boston, 7University of Erlangen-Nuremberg, Erlangen, Germany, 8University of California at San Francisco, San Francisco, CA, 9University of Alabama at Birmingham, Birmingham, AL, 10University of Iowa at Iowa City, Iowa City, 11Northeastern University, Boston

    Background/Purpose: Osteoarthritis (OA) of the knee is one of the most common causes of disability in the U.S. Often overlooked, OA specific to the patellofemoral…
  • Abstract Number: L03 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety from a Phase 2b Trial of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor for the Treatment of Osteoarthritis of the Knee

    Yusuf Yazici1, Timothy E. McAlindon2, Allan Gibofsky3, Nancy Lane4, Christian Lattermann5, Nebojsa Skrepnik6, Christopher Swearingen1, Anita DiFrancesco1, Jeymi Tambiah1 and Marc Hochberg7, 1Samumed, LLC, San Diego, CA, 2Division of Rheumatology, Tufts Medical Center, Boston, MA, 3Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, 4Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Tucson Orthopaedic Institute, Tucson, AZ, 7University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: A previous Phase 2a study of SM04690, a small molecule, intra-articular (IA), Wnt pathway inhibitor, demonstrated positive effects on knee OA pain, physical function,…
  • Abstract Number: 420 • 2018 ACR/ARHP Annual Meeting

    Accelerated Knee Osteoarthritis Is Characterized By Destabilizing Meniscal Tears and Pre-Radiographic Structural Disease Burden

    Jeffrey B. Driban1, Julie Davis2, Bing Lu3, Lori Lyn Price4,5, Robert J. Ward6, James MacKay7, Charles B. Eaton8, Grace H. Lo9, Mary Barbe10, Ming Zhang11, Jincheng Pang12, Alina Stout13, Matthew Harkey13 and Timothy E. McAlindon14, 1Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, 2Rheumatology, Tufts Medical Center, BOSTON, MA, 3Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 4Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, 5Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, 6Radiology, Tufts Medical Center, Boston, MA, 7Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, 8Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, 9Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, 10Temple University School of Medicine, Philadelphia, PA, 11Tufts Medical Center, Boston, MA, 12Electrical Engineering, Tufts University, Medford, MA, 13Rheumatology, Tufts Medical Center, Boston, MA, 14Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: A subset of adults who develop knee osteoarthritis (KOA) quickly progress from no radiographic disease to advanced-stage disease often in ≤12 months. Adults with…
  • Abstract Number: 956 • 2018 ACR/ARHP Annual Meeting

    Bone Mineral Density Is a Causal Risk Factor for Knee and Hip Osteoarthritis: A Population-Based and Mendelian Randomization Study in the UK Biobank

    Thomas Funck-Brentano1, Maria Nethander2, Sofia Moverare Skrtic1, Pascal Richette3 and Claes Ohlsson1, 1Center for Bone and Arthritis Research, Department of Internal Medicine, Sahlgrensaka Academy, Gothenburg University, Gothenburg, Sweden, 2Bioinformatics Core Facility, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden, 3Lariboisière Hospital, Lariboisière, University of Paris 7, Paris, France

    Background/Purpose: Osteoarthritis (OA) involves the whole joint, with alterations of cartilage, synovium and bone. Whether bone changes are a cause or consequence of the disease…
  • Abstract Number: 1947 • 2018 ACR/ARHP Annual Meeting

    Do Changes in Pain Sensitization and Depressive Symptoms Mediate the Effect of Extreme Weight Loss on Knee Pain Improvement?

    S. Reza Jafarzadeh1, Tuhina Neogi1, Joshua J. Stefanik2, Margaret M. Clancy1, Jing-Sheng Li3 and David T. Felson1, 1Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 2Department of Physical Therapy, University of Delaware, Newark, DE, 3College of Health and Rehabilitation Sciences: Sargent College, Boston University, Boston, MA

    Background/Purpose: We previously showed that the one-year effects of weight loss on knee pain reduction were not mediated by changes in structural features of osteoarthritis…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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