Abstracts tagged "juvenile SLE"

Abstract Number: 1725 • 2019 ACR/ARP Annual Meeting
Disease Activity in Childhood-Onset Systemic Lupus Erythematosus: Initial Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry
Emily Smitherman¹, Mary Beth Son ², Andrea Knight ³, Timothy Beukelman ⁴, Jeffrey Curtis ¹ and Aimee Hersh ⁵, ¹University of Alabama at Birmingham, Birmingham, AL, ²Boston Children's Hospital, Boston, MA, ³Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of Utah, Salt Lake City, UT
Background/Purpose: Substantial risk of early morbidity and mortality exists for patients with childhood-onset systemic lupus erythematosus (cSLE) despite widespread use of immunosuppressive therapy. There are…
Abstract Number: 1734 • 2019 ACR/ARP Annual Meeting
Low Bone Mineral Density Was Associated with Lupus Nephritis Irrespective of Duration on Steroid Treatment in a Large Observational Study of Juvenile Systemic Lupus Erythematosus Patients
Anastasia-vasiliki Madenidou¹, Yasmin Mahfouz ², Oliver Cheng ², Farah El-Sharnouby ², Charlene Foley ² and Coziana Ciurtin ³, ¹Centre for Adolescent Rheumatology, University College London London, UK, LOndon, ²Centre for Adolescent Rheumatology, University College London London, UK, London, United Kingdom, ³Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom
Background/Purpose: An estimated 10-20% of all patients with systemic lupus erythematosus (SLE) develop clinical disease before the age of 18 years and are therefore classified…
Abstract Number: 1736 • 2019 ACR/ARP Annual Meeting
Cognitive Impairment in Childhood-Onset Systemic Lupus Erythematosus: Early Detection with MRI Spectroscopy and Its Association with MOG Antibodies
Huseyin Kilic ¹, Sezgin Sahin ², Mekiya Filiz Toprak ³, Gokce Hale Atay ⁴, Kubra Yilmaz ¹, Amra Adrovic ⁵, Kenan Barut ⁶, Esin Ozturk Isik ⁴, Erdem Tuzun ⁷, Osman Kizilkilic ⁸, Sema Saltik ¹ and Ozgur Kasapcopur⁹, ¹Department of Pediatric Neurology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, ²Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Istanbul, Turkey, ³Department of Pediatric Neurology, Bezmialem Vakif University, School of Medicine, Istanbul, Turkey, Istanbul, Turkey, ⁴Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey, Istanbul, Turkey, ⁵Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, ⁶Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, İstanbul, Istanbul, Turkey, ⁷Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, Istanbul, Turkey, ⁸Department of Neuroradiology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, ⁹Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the presence of various autoantibodies. Unnoticed and progressive cognitive impairment may develop in…
Abstract Number: 1741 • 2019 ACR/ARP Annual Meeting
Depression and Anxiety Symptoms in Childhood-Onset Systemic Lupus Erythematosus
Kate Neufeld¹, Frank Silverio ², Lawrence Ng ³, Ashley Danguecan ⁴, Daniela Dominguez ³, Reva Schachter ², Michelle Quilter ⁵, Julie Couture ⁶, Daphne Korczak ⁷, Deborah Levy ⁸, Linda Hiraki ⁹, Earl D. Silverman ¹⁰ and Andrea Knight ¹¹, ¹Division of Rheumatology, The Hospital For Sick Children, University of Toronto, Toronto, Canada, ²The Hospital for Sick Children, Toronto, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, ⁴Division of Rheumatology and Dept of Psychology, The Hospital For Sick Children, Toronto, Canada, ⁵Department of Psychiatry,The Hospital For Sick Children, Toronto, Canada, ⁶The Hospital for Sick Children, Montreal, Canada, ⁷Dept of Psychiatry, SickKids and Dept of Psychiatry, University of Toronto, Toronto, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁹Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada, ¹⁰Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ¹¹Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Background/Purpose: Depression and anxiety disorders are common in patients with childhood-onset systemic lupus erythematosus (cSLE). It is unclear if they are due to central nervous…
Abstract Number: 1744 • 2019 ACR/ARP Annual Meeting
Serum Sickness Following Rituximab Treatment of Childhood-Onset SLE: A Single Center Experience
Ugo Awa¹, Marietta De Guzman ² and Eyal Muscal ³, ¹Baylor College of Medicine/Texas Children's Hospital, Houston, ²Baylor College of Medicine/Texas Children's Hospital, Houston, TX, ³Baylor College of Medicine, Houston, TX
Background/Purpose: Childhood-onset SLE (cSLE) is an autoimmune disease characterized by multiorgan involvement often necessitating a variety of immunolytic and immunomodulatory therapies to achieve adequate disease…
Abstract Number: 1748 • 2019 ACR/ARP Annual Meeting
Incidence of Retinopathy in Individuals Who Initiated Hydroxychloroquine Therapy During Childhood
Sara Patrizi¹, Douglas Stram ², Miranda Weintraub ³ and Alexandra Aminoff ¹, ¹Kaiser Permanente, Department of Pediatrics, Oakland, ²Kaiser Permanente Northern California, Division of Research, Oakland, ³Kaiser Permanente, Department of Graduate Medical Education, Oakland
Background/Purpose: Hydroxychloroquine (HCQ), a medication used to treat Systemic Lupus Erythematosus (SLE), Discoid Lupus Erythematosus (DLE) and Sjogren’s Syndrome (SS), reduces disease flare-ups, organ damage,…
Abstract Number: 2867 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety of Intravenous Belimumab in Children with Systemic Lupus Erythematosus
Hermine I. Brunner¹, Carlos Abud-Mendoza², Diego I. Viola³, Inmaculada Calvo⁴, Deborah M. Levy⁵, Julia Calderon Gallegos⁶, Manuel Ferrandiz⁷, Vyacheslav Chasnyk⁸, Vladmir Keltsev⁹, Jordi Anton¹⁰, Maria Paz¹¹, Michael Shishov¹², Alina Lucica Boteanu¹³, Michael Henrickson¹⁴, Damon Bass¹⁵, Kenneth Clark¹⁶, Anne Hammer¹⁵, Beulah Ji¹⁶, David Roth¹⁵, Herbert Struemper¹⁷, Mei-Lun Wang¹⁸, Alberto Martini¹⁹, Daniel J Lovell²⁰ and Nicola Ruperto¹⁹, ¹Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosy, Mexico, ³CAICI Institute, Rosario City, Santa Fe State, Argentina, ⁴Hospital Universitario La Fe, Valencia, Spain, ⁵Rheumatology, Hospital for Sick Children, Toronto, ON, Canada, ⁶Instituto de Ginecologia y Reproduccion, Santiago De Surco, Peru, ⁷Instituto Nacional de Salud del Nino, Lima, Peru, ⁸St Petersburg State Pediatric Medical Academy, St Petersburg, Russian Federation, ⁹City Clinical Hospital No.5, Tolyatti, Russian Federation, ¹⁰SJD Barcelona Children’s Hospital, Barcelona, Spain, ¹¹Clinica Anglo Americana, Lima, Peru, ¹²Phoenix Children's Hospital, Phoenix, AZ, ¹³University Hospital Ramón y Cajal, Madrid, Spain, ¹⁴Cincinnati Children’s Medical Center, Cincinnati, OH, ¹⁵GlaxoSmithKline, Philadelphia, PA, ¹⁶GlaxoSmithKline, Stevenage, United Kingdom, ¹⁷GlaxoSmithKline, Research Triangle Park, NC, ¹⁸GlaxoSmithKline, Collegeville, PA, ¹⁹Universita di Genova Pediatria II, Genova, Italy, ²⁰Cincinnati Children's Medical Center, Cincinnati, OH
Background/Purpose: Belimumab (BEL) is approved in adults with active systemic lupus erythematosus (SLE). There are no approved biologic therapies for pediatric patients with childhood-onset SLE…
Abstract Number: 369 • 2017 ACR/ARHP Annual Meeting
Hepatitis A Virus Vaccination in Juvenile-Onset Systemic Lupus Erythematosus
Sevinc Mertoglu¹, Sezgin Sahin¹, Omer Faruk Beser², Amra Adrovic¹, Kenan Barut¹, Pelin Yuksel³, Soner Sazak⁴, Bekir Kocazeybek⁵ and Ozgur Kasapcopur¹, ¹Pediatric Rheumatology, Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul, Turkey, ²Pediatric Gastroenterology, Department of Pediatrics, Okmeydani Education and Training Hospital, Istanbul, Turkey, ³Microbiology, Istanbul University, Cerrahpasa Medical School, Department of Microbiology, Istanbul, Turkey, ⁴Pediatrics, Department of Pediatrics, Okmeydani Education and Training Hospital, Istanbul, Turkey, ⁵Istanbul University, Cerrahpasa Medical School, Department of Microbiology, Istanbul, Turkey
Background/Purpose: Various infections play significant roles in flares of systemic lupus erythematosus (SLE). Hepatitis A virus is one of these infectious agents that has high…
Abstract Number: 2027 • 2017 ACR/ARHP Annual Meeting
Pre-Visit Planning Improves Pneumococcal Vaccination in Patients with Childhood-Onset Systemic Lupus Erythematosus
Kelly Wise¹, Fatima Barbar-Smiley², Stephanie Lemle², Darby MacDonald², Ohoud AlAhmed³, Evan Mulvihill⁴, William Cotton², Monica Ardura², Cagri Yildirim-Toruner⁵ and Vidya Sivaraman^6,7, ¹Pharmacy/Rheumatology, Nationwide Children's Hospital, Columbus, OH, ²Nationwide Children's Hospital, Columbus, OH, ³Pediatrics, Nationwide Children's Hospital, Columbus, OH, ⁴Pediatrics and Rheumatology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, ⁵Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁶Pediatric Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁷Pediatrics, The Ohio State University, COLUMBUS, OH
Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) lupus are up to 13 times more likely to develop invasive pneumococcal infections, resulting in increased morbidity and…
Abstract Number: 2975 • 2017 ACR/ARHP Annual Meeting
Using Immune and Metabolic Phenotyping to Understand the Immunopathogenesis of Juvenile-Onset SLE and Stratify Patient Groups
George Robinson¹, Marsilio Adriani¹, Ines Pineda Torra², Yiannis Ioannou³ and Elizabeth Jury⁴, ¹Centre for Rheumatoloy Research, University College London, London, United Kingdom, ²Centre for Clinical Pharmacology, University College London, London, United Kingdom, ³Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ⁴Division of Medicine, Centre for Rheumatology Research, University College London, London, United Kingdom
Background/Purpose: Juvenile-onset systemic lupus erythematosus (JSLE) is an autoimmune disorder characterized by immune cell dysregulation, chronic inflammation and increased cardiovascular risk. Disease onset dominates mid-puberty…
Abstract Number: 1430 • 2016 ACR/ARHP Annual Meeting
Adherence to the International Consensus Quality Indicators for Longitudinal Health Maintenance and Preventative Care in a Pediatric Rheumatology Clinic
Abigail Bosk, Barbara Edelheit, Lawrence Zemel and Heather Tory, Rheumatology, Connecticut Children's Medical Center, Hartford, CT
Background/Purpose: Juvenile systemic lupus erythematosus (jSLE) is a chronic disease associated with significant morbidity. Variability in the health maintenance-related management of these patients can contribute…
Abstract Number: 389 • 2015 ACR/ARHP Annual Meeting
Clinical and Serological Differences Between Juvenile-Onset and Adult-Onset Systemic LUPUS Erythematosus Patients from a National Registry of Patients
TC Salman-Monte¹, V Torrente-Segarra², I Rúa-Figueroa³, J Calvo-Alen^4,5, FJ Lopez Longo^6,7, M Galindo^8,9 and JM Pego-Reigosa¹⁰, ¹Rheumatology, Hospital del Mar/Parc de Salut Mar, Barcelona, Spain, ²Rheumatology, Hospital General Hospitalet-Moisès Broggi, Hospitalet Llobregat, Spain, ³Rheumatology, Hospital de GC Dr Negrin, Las Palmas GC, Spain, ⁴Rheumatology Division, Sierrallana Hospital, Torrelavega, Spain, ⁵Rheumatology, Hospital Sierrallana. Torrelavega, Torrelavega, Spain, ⁶Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁷Rheumatology, Gregorio Marañón Hospital, Madrid, Spain, ⁸Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ⁹Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ¹⁰Rheumatology, EOXI Vigo, Vigo, Spain
Background/Purpose: To assess clinical and serological differences between patients with juvenile-onset systemic lupus erythematosus (jSLE) and adult-onset (aSLE) from a National database.Methods: Data included in…
Abstract Number: 403 • 2015 ACR/ARHP Annual Meeting
Proteinuria in Childhood Onset Lupus Nephritis: When Does It Go Away ?
Justin Hung Tiong Tan¹, Sook Fun Hoh², Manasita Tanya¹, Lena Das¹, Ma Thin Mar Win³, Yiong Huak Chan³ and Thaschawee Arkachaisri^1,4, ¹Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, ²Nursing, KK Women's and Children's Hospital, Singapore, Singapore, ³Biostatistics Unit, Yong Loo Lin School of Medicine, Singapore, Singapore, ⁴Paediatrics, Duke-NUS Graduate Medical School, Singapore, Singapore
Background/Purpose: The time to recovery from proteinuria in patients with lupus nephritis (LN) receiving standard treatment has been described in adult, but not in children.…
Abstract Number: 2468 • 2015 ACR/ARHP Annual Meeting
Antibodies to Histocompatibility Antigens in Juvenile Systemic Lupus Erythematosus Patients
Ana L Rodríguez-Lozano¹, Anne M. Stevens², Jessica M Foster³, Marisa S. Klein-Gitelman⁴, Hermine I. Brunner⁵, Elizabeth Field⁶, Ann M Reed⁷ and Karen Onel⁸, ¹Immunology, Instituto Nacional de Pediatria, Mexico City, Mexico, ²Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, ³Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ⁴Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Internal Medicine, University of Iowa, Iowa City, IA, ⁷Department of Pediatrics, Duke University, Durham, NC, ⁸Pediatric Rheumatology, Univ of Chicago, Chicago, IL
Background/Purpose: Microchimerism with HLA mismatched maternal cells can be readily demonstrated in normal individuals and is now established as a normal biological phenomenon. Pediatric SLE…
Abstract Number: 2662 • 2014 ACR/ARHP Annual Meeting
Attribution Protocol and Clinical Significance of Neuropsychiatric Manifestations in Childhood-Onset Systemic Lupus Erythematosus
Renata Barbosa¹, Karina Oliveira Peliçari², Aline T. Lapa³, Nailu A. Sinicato³, Mariana Postal³, Roberto Marini⁴, Marcelo Govoni Sr.⁵ and Simone Appenzeller⁶, ¹Medicine, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Germany, ²State University of Campinas, Campinas, Brazil, ³Medicine, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Department of Clinical medicine and Experimental, University of Ferrara, Ferrara, Italy, ⁶Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Systemic lupus erythematosus (SLE) is caused by an imbalance of the immune system and may lead to injury and dysfunction of various systems and…

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