Abstracts tagged "Juvenile idiopathic arthritis"

Abstract Number: 0401 • ACR Convergence 2025
Longitudinal Effectiveness of Abatacept in JIA: Results From an Ongoing JIA Registry
Daniel Lovell¹, Nicolino Ruperto², Jennifer Huggins³, Ekaterina Alexeeva⁴, Colleen Correll⁵, John Bohnsack⁶, Stacey Tarvin⁷, Gabriele Simonini⁸, Thomas Griffin⁹, Andrew Zeft¹⁰, Gerd Horneff¹¹, Pierre Quartier¹², Iionka Orban¹³, Heather Walters¹⁴, Valda Stanevica¹⁵, Julisa Patel¹⁶, Adam M Huber¹⁷, Margalit Rosenkranz¹⁸, Daniel Kingsbury¹⁹, Rosie Scuccimarri²⁰, Gabriel Vega Cornejo²¹, Joost Swart²², Robert Carroll²³, Hermine Brunner¹, Tina Sherrard²⁴, Chiara Pallotti²⁵, Clara Malattia²⁶ and Alberto Martini²⁶, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Università degli Studi Milano-Bicocca, Milan, Italy, ³Cincinnati Children's Medical Center, Cincinnati, OH, ⁴National Medical Research Center for Children’s Health Federal State Autonomous Institution of the Russian Federation Ministry of Health and I.M. Sechenov First Moscow State Medical University (Sechenovskiy University), Moscow, Russia, ⁵University of Minnesota, Minneapolis, MN, ⁶University of Utah, Salt Lake City, UT, ⁷Riley Hospital for Children at Indiana University, Indianapolis, IN, ⁸Rheumatology Unit, ERN-ReCONNET center, Meyer Children's Hospital IRCCS, Firenze, Firenze, Italy, ⁹Atrium Health Levine Children’s Hospital, Charlotte, NC, ¹⁰Cleveland Clinic, Cleveland, OH, ¹¹Asklepios Klinik, Hamburg, Germany, ¹²Hôpital Necker-Enfants Malades, Paris, France, ¹³Department of Rheumatology and Clinical Immunology of Semmelweis University, Budapest, Hungary, ¹⁴Northwell, New Hyde Park, NY, ¹⁵Riga Stradiņš University, Riga, Latvia, ¹⁶Children’s Hospital of Georgia, Augusta University, Augusta, GA, ¹⁷IWK Grace Health Centre, Halifax, NS, Canada, ¹⁸University of Pittsburgh, Pittsburgh, PA, ¹⁹Randall Children’s Hospital at Legacy Emanuel, Portland, OR, ²⁰McGill University Health Centre, Montreal, QC, Canada, ²¹Clinica de reumatología Guadalajara, Guadalajara, Jalisco, Mexico, ²²Wilhelmina Children's Hospital / UMC Utrecht, Utrecht, Utrecht, Netherlands, ²³Bristol Myers Squibb, London, United Kingdom, ²⁴Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²⁵Istituto G. Gaslini, Servizio di Sperimentazioni Cliniche Pediatriche, Genova, Italy, ²⁶Istituto G. Gaslini Pediatria II Reumatologia and University of Genova, Genova, Italy
Background/Purpose: Abatacept is a selective T-cell co-stimulation modulator approved for use in JIA. Efficacy and safety of abatacept in patients (pts) with JIA have been…
Abstract Number: 2029 • ACR Convergence 2025
Characteristics of a Historical Cohort of Adult Patients with Juvenile Idiopathic Arthritis
Francina salabert-Carreras¹, Raquel Ugena-García², Cristina Rocamora-Gisbert³, Cristina Calomarde-Gómez², Clara Churtichaga Domenech¹, Judith Vidal ripoll¹, LOURDES MATEO SORIA⁴, Laia Gifre-Sala¹, Maria Aparicio³, Susana Holgado⁵, Águeda Prior Español¹, Anne Riveros frutos³, Ivette Casafont-Solé², Eva Forcadell Pirretas¹, Anna Pujol Manresa¹, Judit Font-Urgelles², Melania Martínez-Morillo¹ and Annika Nack³, ¹Hospital Germans Trias i Pujol, Barcelona, ²Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³Hospital Germans Trias i Pujol, Barcelona, Spain, ⁴HOSPITAL GERMANS TRIAS I PUJOL, BADALONA, Spain, ⁵Hospital Germans Trias i Pujol, Barcelona, Catalonia, Spain
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. Up to one-third of patients experience disease flares in adulthood, with…
Abstract Number: 1654 • ACR Convergence 2025
A Dual Inhibitor of TAK1 and MAP4K2, NG25, Suppresses Cytokine-Driven Inflammation in Juvenile Idiopathic Arthritis Synovial Fibroblasts
Meena Afroze Shanta¹ and Salahuddin Ahmed², ¹College of Pharmacy and Pharmaceutical Science, Washington State University, Spokane, WA, ²Washington State University, Spokane, WA
Background/Purpose: Chronic synovitis is a hallmark of juvenile idiopathic arthritis (JIA), and synovial fibroblasts are major perpetrators of inflammation and tissue destruction. Thus, we tested…
Abstract Number: 0419 • ACR Convergence 2025
Ultrasound-Guided Synovial Biopsy in Children and Adolescents with Juvenile Arthritis: Initial Results
Patricia Vega-Fernandez¹, Kelly Rogers², Megan Quinlan-Waters³, Sheila Angeles-Han², Alexei Grom¹, Daniel Lovell¹, Jennifer Huggins⁴, Ekemini Ogbu¹, Amy Cassedy⁵, Sara Szabo¹, Tracy Ting¹, Grant Schulert¹, McKenzie Vater⁶, Hermine Brunner¹, Jackeline Rodriguez-Smith¹ and Katelyn Banschbach⁷, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Cincinnati Children's Hospital, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, CCHMC, ⁴Cincinnati Children's Medical Center, Cincinnati, OH, ⁵Cincinnati Children's hospital medical center, cincinnati, OH, ⁶Cincinnati Children's Hospital Medical Center, Fort Thomas, KY, ⁷cincinnati Children's hospital, Villa Hills, KY
Background/Purpose: Ultrasound-guided synovial biopsy (USGSB) has been recently implemented for clinical and research purposes in adults with inflammatory arthritis. The current use of USGSB in…
Abstract Number: 0400 • ACR Convergence 2025
Recent Antibiotic Exposure and Response to Treatment of Juvenile Idiopathic Arthritis
Daniel Horton¹, Charu Verma², Sanika Rege², Alicia Iizuka², Matthew Iozzio³, Dawn Koffman³, Stephen Crystal⁴, Amy Davidow⁵, Tobias Gerhard², Lauren Parlett⁶, Carlos Rose⁷ and Brian Strom⁸, ¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Rutgers Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA, New Brunswick, NJ, ³Rutgers Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA, New Brunswick, ⁴Rutgers Center for Health Services Research, Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, ⁵New Jersey Medical School, Newark, NJ, ⁶Carelon Research, Inc, Wilmington, DE, ⁷Thomas Jefferson University, Wilmington, DE, ⁸Rutgers Biomedical and Health Sciences, New Brunswick
Background/Purpose: Juvenile idiopathic arthritis (JIA), the most common pediatric rheumatic disease, has been tied to microbiome disruption (dysbiosis). Dysbiosis in adults with arthritis affects response…
Abstract Number: 1989 • ACR Convergence 2025
Moving Out of the Kid’s Rheum: Transitioning Young Adult Patients from Pediatric to Adult Rheumatology Practices
Victoria Koenigsberger¹, Madeleine Ward², Meghan Geary³ and Ali Yalcindag⁴, ¹The Warren Alpert Medical School of Brown University, Providence, RI, ²The Warren Alpert Medical School of Brown University, Division of Medicine-Pediatrics, Providence, ³The Warren Alpert Medical School of Brown University, Division of General Internal Medicine, Providence, ⁴The Warren Alpert Medical School of Brown University, Division of Rheumatology, Department of Pediatrics, Milton, MA
Background/Purpose: Young adults with childhood-onset rheumatic conditions encounter challenges and barriers to care when transitioning to an adult rheumatologist. At this Pediatric Rheumatology Clinic, patients…
Abstract Number: 1304 • ACR Convergence 2025
The role of PET/CT in evaluating rheumatologic conditions in children with fever of unknown origin – a multicenter study
Neta Berlak¹, Lydia Christodoulou², Gil Amarilyo³, Oded Scheuerman⁴, Irit Tirosh⁵, Eyal Kristal⁶, Ester Forer⁷, Amit Carmi⁸, Alon Kalter⁹ and Yoel Levinsky¹⁰, ¹Schneider children's medical center of Israel, Tel Aviv, Israel, ²Tel Hashomer, Periatric rheumatology unit, Tel Aviv, Israel, ³Schneider Children's Medical Center of Israel, Kibbutz Maggal, Israel, ⁴schneider children's meidcal center of Israel, Petah tikva, Israel, ⁵Tel Aviv universty, Ramat Gan, Israel, ⁶Soroka medical center Beer Sheva, Beer Sheva, Israel, ⁷Soroka medical center, Beer Sheva, Israel, ⁸Schneider children's meidcal center of Israel, Tel Aviv, Israel, ⁹Schneider children's medical center of ISrael, Petah Tikva, Israel, ¹⁰Schneider Children's Medical Cenetr of Israel, Tel Aviv University, JERUSALEM, Israel
Background/Purpose: Fever of Unknown Origin (FUO) is a relatively common clinical challenge that is frequently referred for evaluation by pediatric rheumatologists. In many cases, it…
Abstract Number: 0418 • ACR Convergence 2025
Evaluation of Disease Activity in the Knee Joint Through Clinical, Radiologic, Synovial Fluid and Histopathologic Measurements of Inflammation in Children with Juvenile Idiopathic Arthritis
Patricia Vega-Fernandez¹, Kelly Rogers², Alyssa Sproles², Sherry Thornton¹, Lexi Auld³, Jackeline Rodriguez-Smith¹, Ekemini Ogbu¹, Kara Murphy Schmidt⁴, McKenzie Vater⁵, Katelyn Banschbach⁶, Grant Schulert¹, Alexei Grom¹, Sheila Angeles-Han², Hermine Brunner¹, Jennifer Huggins⁷, Daniel Lovell¹, Amy Cassedy⁸, Yuriy Baglaenko², Tracy Ting¹ and Sara Szabo¹, ¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Cincinnati Children's Hospital, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, ⁴Cincinnati Children’s Hospital Medical Center, Louisville, KY, ⁵Cincinnati Children's Hospital Medical Center, Fort Thomas, KY, ⁶cincinnati Children's hospital, Villa Hills, KY, ⁷Cincinnati Children's Medical Center, Cincinnati, OH, ⁸Cincinnati Children's hospital medical center, cincinnati, OH
Background/Purpose: Clinical, radiologic and biomarker data are measurements used in the assessment of juvenile idiopathic arthritis (JIA) disease activity. The development of ultrasound-guided synovial biopsy…
Abstract Number: 0399 • ACR Convergence 2025
External Validation of Claims-based Algorithms for Newly Diagnosed Juvenile Idiopathic Arthritis
Daniel Horton¹, Lauren Parlett², Yuyang Zhu³, Sanika Rege⁴, Patricia Hoffman⁵, Daniel Reiff⁶, Sarah McGuire⁷, Sonia Pothraj⁸, Cynthia Salvant⁹, Lakshmi Moorthy¹, Cecilia Huang⁴, Dawn Koffman⁴, Matthew Iozzio³, Alicia Iizuka⁴, Kevin Schott², Stephen Crystal¹⁰, Amy Davidow¹¹, Tobias Gerhard⁴, Kevin Haynes¹², Brian Strom¹³, Daniel Beachler² and Carlos Rose¹⁴, ¹Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Carelon Research, Inc, Wilmington, DE, ³Rutgers Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA, New Brunswick, ⁴Rutgers Center for Pharmacoepidemiology and Treatment Science, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, NJ, USA, New Brunswick, NJ, ⁵Hospital for Special Surgery, New York, NY, ⁶Boys Town National Research Hospital, Boys Town, ⁷Department of Obstetrics and Gynecology, Cooper Medical School, Camden, Camden, NJ, ⁸Washingtonville Pediatrics, Washingtonville, NY, ⁹Albany Medical Center, Albany, NY, ¹⁰Rutgers Center for Health Services Research, Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, ¹¹New Jersey Medical School, Newark, NJ, ¹²Janssen Research & Development, Titusville, NJ, ¹³Rutgers Biomedical and Health Sciences, New Brunswick, ¹⁴Thomas Jefferson University, Wilmington, DE
Background/Purpose: Administrative claims databases enable research in large populations with JIA. We previously showed that machine learning (ML)-based algorithms accurately identify new JIA diagnoses within…
Abstract Number: 2680 • ACR Convergence 2025
High Health Care Utilization Preceding Diagnosis of Juvenile Idiopathic Arthritis
Anna Costello¹, Rui Xiao¹, Jahan Jazayeri¹, Timothy Brandon¹, Xuemei Zhang¹, Irit Rasooly¹ and Pamela Weiss², ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Timely diagnosis of Juvenile Idiopathic Arthritis (JIA) enables early initiation of therapy and improves outcomes, yet JIA patients often experience circuitous pathways to diagnosis.…
Abstract Number: 1978 • ACR Convergence 2025
Utilizing a Gap to Target Function in the Pediatric Rheumatology Care and Outcomes Improvement Network Registry Dashboard of Quality Measures
Julia Harris¹, Catherine Bingham², Sheetal Vora³, Kerry Ferraro⁴, Erik Friedrichsen⁵, Cagri Yildirim-Toruner⁶, Ted Wimmel⁷, Delores Mincarelli⁸, Magen Phillips⁹ and Esi Morgan¹⁰, ¹Children's Mercy Kansas City, Overland Park, KS, ²Penn State Children's Hospital, Hershey, PA, ³Atrium Health Levine Children's Hospital, Charlotte, NC, ⁴Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, ⁵Seattle Children's Hospital, Burien, WA, ⁶Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁷Hive Solutions, LLC, Cincinnati, OH, ⁸Hive Solutions, LLC, Newport, KY, ⁹Hive Solutions, LLC, Blue Ash, OH, ¹⁰Seattle Children's Hospital, Seattle, WA
Background/Purpose: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a multi-site learning health network organized to improve outcomes of juvenile idiopathic arthritis (JIA).…
Abstract Number: 1280 • ACR Convergence 2025
Investigating the Association Between SARS-CoV-2 Infection, COVID-19 Vaccination, and Autoimmune Diseases in a Pediatric Population: A comprehensive analysis
Yonatan Butbul Aviel¹, Arad Dotan², Dana Arnheim² and Cynthia Freiberg³, ¹Rambam Health Care Campus, Haifa, Israel, ²Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, Tel Aviv, Israel, ³Maccabi Healthcare Services, Tel Aviv, Israel, Tel Aviv
Background/Purpose: During the COVID-19 pandemic there were reports of an increased association between COVID 19 and various autoimmune diseases (AID) in adults. This study aims…
Abstract Number: 0417 • ACR Convergence 2025
Implementation of a Communication Aid in Juvenile Idiopathic Arthritis Patient Visits, a Quality Improvement Study
Nazlican Civilibal Tang¹, Rachel Guess², Ran Hazan³, Amy Monahan⁴ and Maleewan Kitcharoensakkul⁵, ¹WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST.LOUIS, MISSOURI, St.Louis, MO, ²WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST.LOUIS, MISSOURI, st.louis, ³WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST.LOUIS, MISSOURI, Saint Louis, MO, ⁴WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST.LOUIS, MISSOURI, St. Louis, MO, ⁵Washington University/B-JH/SLCH Consortium, St. Louis, MO
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a childhood onset autoimmune disease requiring long-term care and personalized treatment. Through a rigorous series of mixed patient and…
Abstract Number: 0398 • ACR Convergence 2025
Efficacy of Tumor Necrosis Factor Inhibitors in Children Diagnosed With Non-Systemic Juvenile Idiopathic Arthritis ≤ 2 Years Old Using The Childhood Arthritis and Rheumatology Research Alliance Registry
Christina Gulla¹, Tara Lozy² and Ginger Janow³, ¹Hackensack University Medical Center, Hackensack, NJ, ²Joseph M. Sanzari Children's Hospital, Center for Discovery and Innovation, Hackensack Meridian School of Medicine, Nutley, ³Joseph M. Sanzari Children's Hospital at Hackensack Meridian Health, Hackensack, NJ
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is the most common pediatric rheumatic disease. Tumor necrosis factor inhibitors (TNFi) are key treatments in non-systemic JIA (sJIA), but…
Abstract Number: 2679 • ACR Convergence 2025
Early-Life Nutrition and Gene-Environment Interactions Influencing Juvenile Idiopathic Arthritis Risk: Results from a Pregnancy Cohort
Vilde Øverlien Dåstøl¹, Ida Henriette Caspersen², Kristine Løkås Haftorn³, Sigrid Hestetun⁴, Siri Eldevik Håberg⁵, Karen H. Costenbader⁶, Marin Strøm⁷, Sjurdur Frodi Olsen⁸, Anne Lise Brantsæter⁹, Ketil Størdal¹⁰ and Helga Sanner¹, ¹Oslo University Hospital, Oslo, Norway, ²Norwegian Institute of Public Health, Centre for Fertility and Health/Oslo University Hospital, Oslo, Norway, ³Oslo University Hospital, Department of Rheumatology, Oslo, Norway, ⁴Oslo University Hospital, Department of Rheumatology/University of Oslo, Oslo, Norway, ⁵Norwegian Institute of Public Health, Centre for Fertility and Health/University of Bergen, Oslo, Norway, ⁶Harvard Medical School and Brigham and Women's Hospital, Boston, MA, ⁷Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark, ⁸Statens Serum Institut,Biobank, congenital disorders, and vaccines preparedness/Harvard T.H. Chan School of Public Health, Copenhagen, Denmark, ⁹Norwegian Institute of Public Health, Department of Food Safety and Centre for Sustainable Diets, Oslo, Norway, ¹⁰Oslo University Hospital, Department of Pediatric and Adolescent Medicine/University of Oslo, Oslo, Norway
Background/Purpose: Early-life nutrition may influence the risk of immune-mediated diseases like juvenile idiopathic arthritis (JIA). The benefits of breastfeeding are well established, but findings related…

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