Abstracts tagged "juvenile idiopathic arthritis (JIA)"

Abstract Number: 014 • 2020 Pediatric Rheumatology Symposium
Successful Validation of a Rapid Point-of-care Test for Serum Calprotectin (MRP8/14) as Biomarker in Juvenile Idiopathic Arthritis
Dirk Foell¹, Carolin Park ², Linda Ziegler ², Dirk Holziner ³, Kirsten Minden ⁴, Renato Cotti ⁵ and Jakob Weber ⁵, ¹University Hospital Muenster, Muenster, Nordrhein-Westfalen, Germany, ²University of Muenster, Muenster, Germany, ³University of Essen, Essen, Germany, ⁴Berlin, Germany, ⁵Buehlmann Laboratories, Schoenenbuch, Switzerland
Background/Purpose: Treat-to-target strategies are established for the therapeutic approach to patients suffering from juvenile idiopathic arthritis (JIA). Another proposed therapeutic concept in pediatric rheumatology involves…
Abstract Number: 086 • 2020 Pediatric Rheumatology Symposium
Advanced Multidisciplinary Care: A New Approach to Childhood Arthritis
Julia Brooks¹, Dorothy Adams ², Robin Hellweg ¹, Maggie Mercer ¹, Joni Shair ², Dwaraka Veeramreddy ³, Aynsley Wennberg ¹ and Heinrike Schmeling ⁴, ¹Alberta Children's Hospital, Calgary, Alberta, Canada, ²Alberta Children's Hospital, Calgary, Canada, ³Alberta Children's Hospital/University of Calgary, Calgary, Canada, ⁴Alberta Children's Hospital/University of Calgary, Calgary, Alberta, Canada
Background/Purpose: Many patients are overwhelmed with the diagnosis of chronic childhood arthritis and require long-term treatments. Our objective was to develop a new, child and…
Abstract Number: 165 • 2020 Pediatric Rheumatology Symposium
A Massively Parallel Reporter Assay Screen of Genetic Variants on JIA Haplotypes Reveals Variants Associated with Altered Function of an Intergenic Enhancer in the HLA Class II Locus
Kaiyu Jiang ¹, tao liu ², Ryan Tewhey ³ and James Jarvis⁴, ¹University at Buffalo, Buffalo, ²Roswell Park Cancer Institute, Buffalo, ³Jackson Laboratories, Bar Harbor, ⁴University at Buffalo Jacobs School of Medicine, Buffalo
Background/Purpose: While genome-wide association studies have provided valuable information about genetic risk for juvenile idiopathic arthritis (JIA), we are still unable to determine the actual…
Abstract Number: 017 • 2020 Pediatric Rheumatology Symposium
MyD88 S209R-Mediated Immune Dysregulation in Mouse Models of Arthritis
Sufia Bakshi¹, Malika Waschmann ², Anders Lindstedt ², Emily Rominger ², Robert Colbert ³ and Keith Sikora ⁴, ¹National Institutes of Health, Bethesda, Maryland, ²National Institutes of Health, Bethesda, ³NIH/NIAMS, Bethesda, Maryland, ⁴National Institutes of Health Clinical Center, Bethesda, Maryland
Background/Purpose: MYD88 is a critical adaptor protein that connects Toll-like and IL-1 receptor signaling to activation of NF-kB. We previously reported a heterozygous de novo mutation in MYD88 (S222R)…
Abstract Number: 097 • 2020 Pediatric Rheumatology Symposium
A Pilot Randomized Controlled Trial of the iCanCope Pain Self-management Application for Adolescents with Juvenile Idiopathic Arthritis
Chitra Lalloo ¹, Lauren Harris ², Amos Hundert ², Roberta Berard ³, Joseph Cafazzo ⁴, Mark Connelly ⁵, Brian Feldman ², Kristin Houghton ⁶, Adam Huber ⁷, Ronald Laxer ⁸, Nadia Luca ⁹, Heinrike Schmeling ¹⁰, Lynn Spiegel ¹¹, Lori Tucker ¹², Quynh Pham ⁴, Cleo Davies-Chalmers ¹³ and Jennifer Stinson¹⁴, ¹The Hospital for Sick Children, Toronto, Ontario, Canada, ²The Hospital for Sick Children, Toronto, Canada, ³Children's Hospital London Health Sciences Centre, London, Canada, ⁴University of Toronto, Toronto, Canada, ⁵Kansas City, ⁶University of British Columbia - Vancouver, Vancouver, Canada, ⁷IWK Health Centre & Dalhousie University, Halifax, Nova Scotia, Canada, ⁸The Hospital for Sick Children and University of Toronto, Toronto, Canada, ⁹University of Calgary, Calgary, Alberta, Canada, ¹⁰Alberta Children's Hospital/University of Calgary, Calgary, Alberta, Canada, ¹¹University of Toronto/Hospital for Sick Children, Thornhill, Canada, ¹²BC Children's Hospital, Vancouver, British Columbia, Canada, ¹³The Hospital for Sick Children, Toonto, Canada, ¹⁴University of Toronto & The Hospital for Sick Children, Toronto, Ontario, Canada
Background/Purpose: Pain is the most common symptom of Juvenile Idiopathic Arthritis (JIA), a chronic childhood illness that has potentially debilitating effects on health-related quality of…
Abstract Number: 167 • 2020 Pediatric Rheumatology Symposium
Lipidomic Profiles of Synovial Fluid from Patients with Oligoarticular Juvenile Idiopathic Arthritis Naïve to Treatment
Melissa Elder ¹, Luciana Paim marques², Akaluck Thatayatikom ¹, John Bowden ², Bianca da SIlva ² and Juan Aristizabal ², ¹University of Florida, Gainesville, ²University of Florida, Gainesville, Florida
Background/Purpose: Metabolomic and lipidomic pathways serve as key sensors and effectors of genetic, epigenetic, and environmental factors that shape the development and function of the…
Abstract Number: 022 • 2020 Pediatric Rheumatology Symposium
Association of Plasma Metabolomic Profiles with Methotrexate Response in Juvenile Idiopathic Arthritis
Ryan Funk¹ and Mara Becker ², ¹University of Kansas, Leawood, Kansas, ²Duke University Medical Center/Duke Clinical Research Institute, Chapel Hill
Background/Purpose: Despite efforts to identify biomarkers to guide therapy in the treatment of juvenile idiopathic arthritis (JIA), drug therapy remains a trial-and-error process. In the…
Abstract Number: 101 • 2020 Pediatric Rheumatology Symposium
Uveitis Treatment in the CARRA II Registry: Tumor Necrosis Factor-inhibitors and Beyond
Mona Riskalla¹, Fatima Barbar-Smiley ², Michael Shyne ¹ and Melissa Lerman ³, ¹University of Minnesota, Minneapolis, Minnesota, ²Nationwide Children's Hospital, Columbus, Ohio, ³Philadelphia, Pennsylvania
Background/Purpose: Uveitis associated with JIA (JIA-U) is the most common extra-articular complication of JIA. As JIA-U is associated with significant risk of visual loss and…
Abstract Number: 171 • 2020 Pediatric Rheumatology Symposium
Development and Acceptability of an Adolescent Self-management Program for Juvenile Idiopathic Arthritis
Kelsey Chomistek¹, Cheryl Barnabe ², Katie Birnie ³, Julia Brooks ⁴, Tracey Clancy ⁵, Syeda Farwa Naqvi ⁵, Nadia Luca ⁵, Maggie Mercer ⁴, Maria Santana ⁵, Jennifer Stinson ⁶, Aynsley Wennberg ⁴ and Heinrike Schmeling ⁷, ¹Calgary, Alberta, Canada, ²University of Calgary, Calgary, Alberta, Canada, ³Alberta Children's Hospital, Calgary, Canada, ⁴Alberta Children's Hospital, Calgary, Alberta, Canada, ⁵University of Calgary, Calgary, Canada, ⁶University of Toronto & The Hospital for Sick Children, Toronto, Ontario, Canada, ⁷Alberta Children's Hospital/University of Calgary, Calgary, Alberta, Canada
Background/Purpose: Needs assessments have revealed an urgent need for disease information, self-management skills, and peer support for patients with juvenile idiopathic arthritis (JIA). Our aim…
Abstract Number: 029 • 2020 Pediatric Rheumatology Symposium
Comparison of Efficacy Between Triamcinolone Acetonide and Hexacetonide Intra-articular Treatment for Clinical Remission in Juvenile Idiopathic Arthritis
Angela Chun¹, Lutfiyya Muhammad ² and Deirdre De Ranieri ³, ¹Lurie Children's Hospital, Chicago, Iowa, ²Northwestern University Feinberg School of Medicine, Chicago, ³Lurie Children's Hospital, Chicago, Illinois
Background/Purpose: The use of intra-articular corticosteroid (IAC) injections for Juvenile Idiopathic Arthritis (JIA) was extrapolated from its use in adult inflammatory joint diseases to achieve…
Abstract Number: 107 • 2020 Pediatric Rheumatology Symposium
Defining the Prevalence of Depression and Anxiety Symptoms in Adolescents with Juvenile Idiopathic Arthritis
Lydia Li¹, Mehveen Merchant ², Shelina Gordon ³, David Lovas ⁴, Joanne Gillespie ⁴, Adam Huber ⁵, Bianca Lang ⁶, Suzanne Ramsey ⁴ and Elizabeth Stringer ⁴, ¹Dalhousie University, Halifax, Canada, ²Calgary, Canada, ³IWK Health Centre, Halifax, ⁴IWK Health Centre, Halifax, Canada, ⁵IWK Health Centre & Dalhousie University, Halifax, Nova Scotia, Canada, ⁶Dalhousie University - Halifax, Halifax, Canada
Background/Purpose: We aimed to evaluate the prevalence of depressive and/or anxiety symptoms in adolescents with juvenile idiopathic arthritis (JIA) and explore the association with demographic…
Abstract Number: 175 • 2020 Pediatric Rheumatology Symposium
Application of Juvenile Idiopathic Arthritis Treatment Guidelines and Factors Associated with Increased Likelihood of Intra-articular Corticosteroid Administration
Erin Balay¹, Jennifer Weiss ², Y. Ingrid Goh ³, Nathan Rubin ⁴ and Danielle Bullock ⁴, ¹University of Minnesota, saint paul, ²Hackensack University Medical Center, Hackensack, ³The Hospital for Sick Children, Toronto, Canada, ⁴University of Minnesota, Minneapolis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is a chronic childhood disease which can result in debilitating arthritis. The 2011 ACR JIA treatment guidelines recommend intra-articular corticosteroid…
Abstract Number: 030 • 2020 Pediatric Rheumatology Symposium
The Efficacy and Safety of Intraarticular Injection of Triamcinolone Acetonide versus Triamcinolone Hexacetonide in the Treatment of Juvenile Idiopathic Arthritis
Shiri Rubin ¹, Rotem Tal ², Ori Goldberg ³, Yoel Levinsky ⁴, Zohar Habot-Wilner ⁵, Orly Ohana ⁶, Yulia Gendler ⁷, Liora Harel ⁸ and Gil Amarilyo⁹, ¹Schneider Children's hospital of Israel, Tel Aviv university, Petach Tikva, Israel, ²schneider medical center, Ramat Gan, Israel, ³Schneider Children's Medical Center of Israel, Tel Aviv University, Petach Tikva, Israel, ⁴Schneider Children's Medical Cnetr of Israel, Tel Aviv University, Petach Tikva, Israel, ⁵Tel Aviv Sourasky Medical Center, Tel Aviv Univrsity, Tel Aviv, Israel, ⁶Schneider Children's Medical Cener of Israel, Petach Tikva, Israel, ⁷Schneider Children's Medical Center of Israel, Tel Aviv Univesity, Petach Tikva, Israel, ⁸Schneider Hospital, Tel Aviv University, Petah-Tiqva, Israel, ⁹Schneider Hospital, Tel Aviv University, Kibbutz Magal, Israel
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. Intra-articular corticosteroids joint injection (IAJI) with Triamcinolone hexacetonide (TH) or triamcinolone acetonide…
Abstract Number: 109 • 2020 Pediatric Rheumatology Symposium
Incidence, Contributing Factors, and Impact of Diagnostic Delay in Juvenile Idiopathic Arthritis: Analysis of the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry
Mei-Sing Ong¹, Gordon Schiff ² and Marc Natter ³ for the CARRA investigators, ¹Harvard Medical School & Harvard Pilgrim Healthcare Institute, Boston, ²Harvard Medical School, Boston, ³Boston Children's Hospital, Boston
Background/Purpose: While early treatment of patients with newly diagnosed juvenile idiopathic arthritis (JIA) is an area of active study, delayed diagnosis of JIA is poorly…
Abstract Number: 179 • 2020 Pediatric Rheumatology Symposium
New Juvenile Idiopathic Arthritis Quality Measure Set for the Pediatric Rheumatology Care and Outcomes Improvement Network
Julia Harris¹, Esi Morgan ², Sheetal Vora ³, Mileka Gilbert ⁴, Cagri Yildirim-Toruner ⁵, Nancy Griffin ⁶, Kerry Ferraro ⁷, Stephanie Loos ⁶, Tingting Qiu ⁶, Anne Paul ⁸, Jon Burnham ⁹, Erik Meyer ⁷, Michelle Batthish ¹⁰, Beth Gottlieb ¹¹, Danielle Bullock ¹², Melissa Hazen ¹³, Ronald Laxer ¹⁴, Tzielan Lee ¹⁵, Melissa Mannion ¹⁶, Judyann Olson ¹⁷, Michael Shishov ¹⁸, Richard Vehe ¹⁹, Jennifer Weiss ²⁰ and C. April Bingham ²¹, ¹Children's Mercy Kansas City, Overland Park, ²Cincinnati Children's Hospital, Cincinnati, ³Atrium Health Levine Children's Hospital, Charlotte, ⁴Medical University of South Carolina, Charleston, South Carolina, ⁵Nationwide Children's Hospital, Columbus, ⁶Cincinnati Children's Hospital Medical Center, Cincinnati, ⁷Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, ⁸Cincinnati Children's Hospital Medical Centre, Cincinnati, ⁹Children's Hospital of Philadelphia, Philadelphia, ¹⁰McMaster University, Hamilton, Canada, ¹¹Cohen Children's Medical Center, Lake Success, ¹²University of Minnesota, Minneapolis, ¹³Boston, ¹⁴The Hospital for Sick Children and University of Toronto, Toronto, Canada, ¹⁵Stanford Children's, Palo Alto, ¹⁶University of Alabama at Birmingham, Birmingham, ¹⁷Medical College of Wisconsin: Children's Wisconsin, Wauwatosa, Wisconsin, ¹⁸Phoenix Children's Hospital, Phoenix, ¹⁹University of Minnesota, Roseville, ²⁰Hackensack University Medical Center, Hackensack, ²¹Penn State Children's Hospital, Allentown
Background/Purpose: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a learning network to support pediatric rheumatology centers in improving care delivery and patient…

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