Abstracts tagged "Juvenile idiopathic arthritis"

Abstract Number: 2675 • ACR Convergence 2025
RANTES and CXCL10 as Potential Tear-Based Biomarkers Associated with Ocular Damage in Pediatric Chronic Anterior Uveitis
Ilaria Maccora¹, Mariia Pavlenko², Mekibib Altaye³, Hermine Brunner⁴, Alexandra Duell⁴, Megan Quinlan-Waters⁵, Alyssa Sproles⁶, Sherry Thornton⁴, Grant Schulert⁴, Virginia Miraldi Utz⁴ and Sheila Angeles-Han⁶, ¹Rheumatology Unit, ERN ReCoNNET Center, Meyer Children's Hospital IRCCS, Florence, Italy, Firenze, Florence, Italy, ²Rheumatology Division, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA, Cincinnati, OH, ³Cincinnati Children's Hospital, Cincinnati, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Cincinnati Children's Hospital Medical Center, CCHMC, ⁶Cincinnati Children's Hospital, Cincinnati, OH
Background/Purpose: Pediatric chronic anterior uveitis (CAU) leads to sight-threatening complications in approximately 50% of affected children. Among complications, cataract and glaucoma are among the most…
Abstract Number: 1828 • ACR Convergence 2025
CD14+CXCL10+Monocytes Remodel the Peripheral Immune Network in sJIA via UBE2D1-Driven Inflammatory Programming
Xuemei Tang¹, Qiang Luo², Jun Yang³, Haiguo Yu⁴, Xinglin Wu¹, Xiwen Luo⁵, Xi Yang⁵, Zhiyong Zhang⁵, Yunfei An⁵, Xiaodong Zhao¹ and Hongmei Song⁶, ¹Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China, Chongqing, China (People's Republic), ²Department of Rheumatology and Immunology, Children’s Hospital of Chongqing Medical University, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China (People's Republic), ³Rheumatology and Immunology Department of Shenzhen Children's Hospital, Shenzhen, ⁵¹⁸¹⁰⁰, China., Shenzhen, China (People's Republic), ⁴Department of Rheumatology and Immunology, Nanjing Children's Hospital, Nanjing, ²¹⁰⁰⁰⁰, China., Nanjing, China (People's Republic), ⁵Department of Rheumatology & Immunology, Children’s Hospital of Chongqing Medical University, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Chongqing, China., Chongqing, China (People's Republic), ⁶Pediatric Department of Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, ¹⁰⁰⁰⁰⁰, China., Beijing, China (People's Republic)
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disorder characterized by systemic immune dysregulation. However, reliable biomarkers to predict its unpredictable disease course are…
Abstract Number: 1066 • ACR Convergence 2025
Assessing Disparities in Outcomes and Processes of Care for Patients with Juvenile Idiopathic Arthritis in the Pediatric Rheumatology Care and Outcomes Improvement Network
Julia Harris¹, Catherine Bingham², Sheetal Vora³, Jon Burnham⁴, Cagri Yildirim-Toruner⁵, Tzielan Lee⁶, Kerry Ferraro⁷, Erik Friedrichsen⁸, Katelyn Banschbach⁹, Michelle Batthish¹⁰, Danielle Fair¹¹, Mileka Gilbert¹², Beth Gottlieb¹³, Melissa Mannion¹⁴, Edward Oberle¹⁵, Nancy Pan¹⁶, Natalie Rosenwasser¹⁷, Mary Toth¹⁸, Jennifer Weiss¹⁹ and Esi Morgan¹⁷, ¹Children's Mercy Kansas City, Overland Park, KS, ²Penn State Children's Hospital, Hershey, PA, ³Atrium Health Levine Children's Hospital, Charlotte, NC, ⁴Children's Hospital of Philadelphia, Bryn Mawr, PA, ⁵Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁶Stanford University School of Medicine, Palo Alto, CA, ⁷Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, ⁸Seattle Children's Hospital, Burien, WA, ⁹cincinnati Children's hospital, Villa Hills, KY, ¹⁰McMaster Children's Hospital, Hamilton, ON, Canada, ¹¹Medical College of Wisconsin/Children's Wisconsin, Wauwatosa, WI, ¹²Medical University of South Carolina, Charleston, SC, ¹³Cohen Children's Medical Center, Northwell Health, Lake Success, NY, ¹⁴University of Alabama at Birmingham, Birmingham, AL, ¹⁵Nationwide Children's Hospital, Columbus, OH, ¹⁶Hospital for Special Surgery, New York, NY, ¹⁷Seattle Children's Hospital, seattle, WA, ¹⁸Nemours Foundation, Orlando, FL, ¹⁹Joseph M. Sanzari Children's Hospital and Hackensack Meridian School of Medicine, Hackensack, NJ
Background/Purpose: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) has a mission to deliver exceptional and equitable health care to children with rheumatic diseases…
Abstract Number: 0413 • ACR Convergence 2025
Improving Access to Timely Joint Injections for Pediatric Rheumatology Patients – A Quality Improvement Initiative
Kendra Lauer¹, Vidya Sivaraman², Melissa Argraves³, Ysabella Esteban⁴, Laura Pratt⁵, Alysha Taxter⁶, Shoghik Akoghlanian³, Kelly Wise⁷, Kathryn Anliker³, Jonnie Hughes³, James Booker³, Ashlee Leone³ and Edward Oberle³, ¹Nationwide Children's Hospital, Dublin, OH, ²Nationwide Children's Hospital/ The Ohio State University, Columbus, OH, ³Nationwide Children's Hospital, Columbus, OH, ⁴Nationwide Children's Hospital, Plain City, OH, ⁵Nationwide Children's Hospital/The Ohio State University College of Medicine, Columbus, OH, ⁶Nationwide Children's, Columbus, OH, ⁷Nationwide Children's Hospital, Hilliard, OH
Background/Purpose: Timely treatment for juvenile idiopathic arthritis (JIA) is essential for disease remission and decreasing risk of long-term morbidity. Intra-articular corticosteroid joint injections can treat…
Abstract Number: 0393 • ACR Convergence 2025
Effects of Self-Reported Medication Barriers on Medication Adherence and Disease Activity in a Cohort of Patients with Juvenile Idiopathic Arthritis
Aditi Shaily¹, Allison R. Eckard², Paul Nietert³, Emily Vara¹, Natasha Ruth⁴ and Mileka Gilbert³, ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Departments of InternDivision of Infectious Diseases, Medical University of South Carolina, Charleston, SC, ³Medical University of South Carolina, Charleston, SC, ⁴Medical University South Carolina, Charleston, SC
Background/Purpose: Medications used to manage juvenile idiopathic arthritis (JIA) are highly effective in preventing joint damage and provide a favorable prognosis. Many patients, however, struggle…
Abstract Number: 2242 • ACR Convergence 2025
Analysis of Bronchoalveolar Fluid Cytokine Profile as a Way to Understand the Lung Disease Associated with Systemic Juvenile Idiopathic Arthritis
Ivanna Romankevych¹, Donna Do¹, Alyssa Sproles², Lexi Auld¹, Taskin Sabit¹, Richard Chhaing¹, Joy Baker¹, John Brewington³, Christopher Towe⁴, Alexiei GROM⁵ and Grant Schulert⁶, ¹Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, ²Cincinnati Children's Hospital, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, Division of Pulmonary Medicine; University of Cincinnati, Cincinnati, OH, ⁴Cincinnati Children’s Hospital Medical Center, Division of Pulmonary medicine; University of Cincinnati, Cincinnati, OH, ⁵Cincinnati Children’s Hospital Medical Center, Division of Rheumatology, Cincinnati, OH, ⁶Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: The lung disease associated with systemic JIA (SJIA-LD) remains poorly understood. Measurement of cytokine levels in bronchoalveolar lavage fluid (BALF) may offer insights into…
Abstract Number: 1824 • ACR Convergence 2025
Tissue-Resident Natural Killer Cells May Drive Monocyte Differentiation And Macrophage Accumulation In The Inflamed Joints Of Pediatric Juvenile Idiopathic Arthritis Patients
Roselyn Fierkens¹, Jun Inamo², Clara Lin³, Nathan Rogers⁴, Kari Hayes¹, Heather Leach³ and Kentaro Yomogida¹, ¹University of Colorado, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO, ³Children's Hospital Colorado, Aurora, ⁴Children’s Hospital Colorado, Aurora, CO
Background/Purpose: Natural Killer (NK) cells are the most abundant innate lymphoid cells, accounting for 10–40% of total lymphocytes in peripheral blood. They adapt to diverse…
Abstract Number: 1064 • ACR Convergence 2025
Characterization of Juvenile Idiopathic Arthritis in Indigenous North American Children enrolled in a North American registry
Hayley M Lynch¹, Jordan E. Roberts¹ and James N. Jarvis², ¹Seattle Children's Hospital/UW, Seattle, WA, ²University of Washington Center for Indigenous Health, Seattle, WA
Background/Purpose: Several studies detail a higher prevalence and severity of juvenile idiopathic arthritis (JIA) in Indigenous North American (INA) children compared to the general population.…
Abstract Number: 0412 • ACR Convergence 2025
The Association of Obesity with Juvenile Spondyloarthritis
Katelyn Baggett¹, Timothy Brandon² and Pamela Weiss³, ¹Johns Hopkins University, Newtown Square, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA, ³Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Childhood obesity is a global public health concern that impacts the health and wellbeing of all children and particularly negatively affects children living with…
Abstract Number: 0392 • ACR Convergence 2025
Clinical Indicators of Methotrexate Response in Juvenile Idiopathic Arthritis (JIA) and JIA with Uveitis (JIA-U)
Abigale Jagger¹, Mara Becker², Susan Thompson³, Mekibib Altaye⁴, John Bohnsack⁵, Hermine Brunner⁶, Margaret Chang⁷, Ashley Cooper⁸, Stefanie Davidson⁹, Alexandra Duell⁶, Bharti Gangwani⁷, Carl Langefeld¹⁰, Melissa Lerman¹¹, Mindy Lo⁷, Serena Pastore¹², Mariia Pavlenko¹³, Sampath Prahalad¹⁴, Megan Quinlan-Waters¹⁵, Laura Ramsey¹⁶, Grant Schulert⁶, Gabriele Simonini¹⁷, Erin Stahl⁸, Gabriele Stocco¹⁸, Marc Sudman¹⁹, Andrea Taddio¹⁸, Virginia Miraldi Utz⁶, Rae Yeung²⁰ and Sheila Angeles-Han¹, ¹Cincinnati Children's Hospital, Cincinnati, OH, ²Duke University Medical Center/Duke Clinical Research Institute, Chapel Hill, NC, ³Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, BLUE ASH, OH, ⁴Cincinnati Children's Hospital, Cincinnati, ⁵University of Utah, Salt Lake City, UT, ⁶Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Boston Children's Hospital, Boston, MA, ⁸Children's Mercy Kansas City, Kansas City, MO, ⁹University of Pennsylvania/CHOP, Philadelphia, PA, ¹⁰Wake Forest University School of Medicine, Winston Salem, NC, ¹¹Children's Hospital of Philadelphia, Philadelphia, PA, ¹²Institute of Child and Maternal Health - IRCCS "Burlo Garofolo", Trieste, Italy, ¹³Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ¹⁴Emory + Children's Pediatric Institute, Atlanta, GA, ¹⁵Cincinnati Children's Hospital Medical Center, CCHMC, ¹⁶Children's Mercy, Kansas City, MO, ¹⁷Rheumatology Unit, ERN-ReCONNET center, Meyer Children's Hospital IRCCS, Firenze, Firenze, Italy, ¹⁸Insitute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, Italy, ¹⁹Cincinnati Children's Hospital Medical Center, Cincinnati, ²⁰The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Background/Purpose: Patients with JIA are at high risk for development of chronic anterior uveitis (CAU), impacting 10-20% of this population. Although methotrexate (MTX) is the…
Abstract Number: 2150 • ACR Convergence 2025
Rheum to Grow:An Approach Towards Human Centered Design through a Qualitative Analysis on the Transition from Pediatric to Adult Rheumatology
Lillian Chang¹, Rhea Sharma², Elyse Guziewicz¹, Jordan Jackson³, Katrina Romagnoli¹, Gemme Campbell¹, Saritha Korukonda¹, Priyanka Pawar¹, Jonida Cote⁴, Thomas Davis¹ and Emily Brunner¹, ¹Geisinger, Danville, PA, ²Geisinger Medical Center Internal Medicine Residency, Danville, PA, ³Geisinger Medical Center Medicine-Pediatrics Residency, Danville, PA, ⁴Geisinger Health System, Wilkes-Barre, PA
Background/Purpose: Up to half of patients who transition to adult care are lost to follow up within 2 years of transfer from pediatric to adult…
Abstract Number: 1822 • ACR Convergence 2025
The Circulating Immune Profile of Systemic JIA Patients with HLA-DRB1*15 alleles, Eosinophilia, and Lung Disease
Jennifer Cheng¹, Alexandra Pommier², Ki Pui Lam³, Evan Hsu⁴, Courtney Leson⁵, Kyle McBrearty¹, Itohan Aigbekaen¹, Maryam Ashoor⁶, Ahmad Bakhsh¹, Carrie Bryant¹, Siobhan Case⁷, Mia Chandler¹, Margaret Chang¹, Ezra Cohen⁸, Fatma Dedeoglu¹, Olha Halyabar⁹, Jonathan Hausmann¹⁰, Melissa Hazen¹, Sonia Iosim¹, Liyoung Kim⁶, Jeffrey Lo¹, Mindy Lo¹, Emma Materne¹, Esra Meidan¹¹, Megan Perron¹², Helene Powers¹³, Mary Beth Son¹, Holly Wobma¹, Peter Nigrovic⁶, Alicia Casey¹, Joyce Chang¹, Pui Lee⁴ and Lauren Henderson¹⁴, ¹Boston Children's Hospital, Boston, MA, ²Harvard Medical School, Boston, MA, ³Division of Immunology, Boston Childrens Hospital, Harvard Medical School, Boston, MA, ⁴Boston Children's Hospital, Newton, MA, ⁵Boston Children's Hospital, Boston, ⁶Boston Children's Hospital, Brookline, MA, ⁷UpToDate, Brigham and Women's Hospital, Boston Children's Hospital, Boston, MA, ⁸Bmc, NEEDHAM, MA, ⁹Children's Hospital/Boston Medical Center, Newton, MA, ¹⁰Boston Children's Hospital / Massachusetts General Hospital, Cambridge, MA, ¹¹Boston Children's Hospital, Somerville, MA, ¹²Boston Children's Hospital, Natick, MA, ¹³Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, ¹⁴Boston Children's Hospital, Watertown, MA
Background/Purpose: We aimed to explore the association between HLA-DRB1*15 alleles, eosinophilia, and lung disease (LD) in patients with systemic juvenile idiopathic arthritis (sJIA) through proteomic…
Abstract Number: 0824 • ACR Convergence 2025
Characterizing Immune Responses in Abatacept-treated Patients with Limited Juvenile Idiopathic Arthritis
Lwiza AitDowd¹, Ekaterina Murzin², Alexandra Pommier³, Ki Pui Lam⁴, Claudia Harris⁵, Melanie Kohlheim⁶, Grant Schulert⁷, Marc Sudman⁸, Eveline Wu⁹, Laura Schanberg¹⁰, Peter Nigrovic¹¹, James Lederer¹² and Lauren Henderson¹³, ¹Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA, ⁴Division of Immunology, Boston Childrens Hospital, Harvard Medical School, Boston, MA, ⁵Division of Immunology, Boston Childrens Hospital, Boston, MA, ⁶CARRA, Granville, OH, ⁷Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Cincinnati Children's Hospital Medical Center, Cincinnati, ⁹UNC Chapel Hill, Chapel Hill, NC, ¹⁰Duke University Medical Center, DURHAM, NC, ¹¹Boston Children's Hospital, Brookline, MA, ¹²Brigham and Women's Hospital, Millis, MA, ¹³Boston Children's Hospital, Watertown, MA
Background/Purpose: Our ability to tailor treatments to individual patients with JIA remains limited. To identify candidate biomarkers that may be associated with treatment response, we…
Abstract Number: 0411 • ACR Convergence 2025
Outcomes in Juvenile Idiopathic Arthritis Based on Geographic Region in the Pediatric Rheumatology Care and Outcomes Improvement Network Registry
Julia Harris¹, Sheetal Vora², Catherine Bingham³, Cagri Yildirim-Toruner⁴, Kerry Ferraro⁵, Erik Friedrichsen⁶, Katelyn Banschbach⁷, Jon Burnham⁸, Danielle Fair⁹, Mileka Gilbert¹⁰, Beth Gottlieb¹¹, Tzielan Lee¹², Melissa Mannion¹³, Edward Oberle¹⁴, Nancy Pan¹⁵, Natalie Rosenwasser¹⁶, Mary Toth¹⁷, Jennifer Weiss¹⁸ and Esi Morgan¹⁶, ¹Children's Mercy Kansas City, Overland Park, KS, ²Atrium Health Levine Children's Hospital, Charlotte, NC, ³Penn State Children's Hospital, Hershey, PA, ⁴Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, ⁵Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, ⁶Seattle Children's Hospital, Burien, WA, ⁷cincinnati Children's hospital, Villa Hills, KY, ⁸Children's Hospital of Philadelphia, Bryn Mawr, PA, ⁹Medical College of Wisconsin/Children's Wisconsin, Wauwatosa, WI, ¹⁰Medical University of South Carolina, Charleston, SC, ¹¹Cohen Children's Medical Center, Northwell Health, Lake Success, NY, ¹²Stanford University School of Medicine, Palo Alto, CA, ¹³University of Alabama at Birmingham, Birmingham, AL, ¹⁴Nationwide Children's Hospital, Columbus, OH, ¹⁵Hospital for Special Surgery, New York, NY, ¹⁶Seattle Children's Hospital, seattle, WA, ¹⁷Nemours Foundation, Orlando, FL, ¹⁸Joseph M. Sanzari Children's Hospital and Hackensack Meridian School of Medicine, Hackensack, NJ
Background/Purpose: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a learning health network focused on improving healthcare delivery and outcomes in patients with…
Abstract Number: 0391 • ACR Convergence 2025
Which score fits best? Correlation of clinical indices of Disease Activity and Ultrasound findings in Juvenile Idiopathic Arthritis during Transitional Care
Andrea Pilato¹, Giusyda Tarantino², Maria Isabella Petrone², Angela Aquilani², Emiliano Marasco², Rebecca Nicolai², Fabrizio De Benedetti³, Roberto Giacomelli⁴, Luca Navarini¹ and Silvia Magni-Manzoni², ¹University of Rome Campus Bio-Medico, Rome, Italy, ²Bambino Gesù IRCCS Children's Hospital, Rome, Italy, ³Bambino Gesu Children's Hospital, Rome, Rome, Italy, ⁴i) Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Biomedico; ii) Rheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy
Background/Purpose: Monitoring disease activity is a crucial aspect of the treat to target paradigm in the management of rheumatic diseases. There are no standardized protocols…

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