ACR Meeting Abstracts

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Abstracts tagged "interleukins (IL)"

  • Abstract Number: 310 • 2012 ACR/ARHP Annual Meeting

    STAT3 Plays a Central Role in NLRP3 Inflammasome-Mediated IL-1β Production and Pyronecrosis

    Jehad H. Edwan1, Tri M. Tran2, Mones Abu-Asab3, Raphaela T. Goldbach-Mansky4 and Robert A. Colbert1, 1NIAMS NIH, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD, 3NEI NIH, Bethesda, MD, 4Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD

    Background/Purpose: Gain of function mutations in NLRP3 cause cryopyrin-associated periodic fever syndromes (CAPS), the most severe form of which is neonatal-onset multisystem inflammatory disease (NOMID),…
  • Abstract Number: 2329 • 2012 ACR/ARHP Annual Meeting

    Increase of CD4+CD25+FoxP3+ T Cell in Patients with Systemic Sclerosis Could Secret IL-17 with Dysfunction of Immunosuppression

    Xinjuan Liu1, Na Gao1, Mengtao Li1, Dong Xu1, Yong Hou1, Qian Wang1, Guohua Zhang1, Qiuning Sun2, Henghui Zhang3 and Xiaofeng Zeng4, 1Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 2Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 3Hepatology Institute, Peking University, People's Hospital, Beijing, China, 4Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Background/Purpose:  Immune unbalance between Th17 and regulatory T cells (Treg) is a characteristic of systemic sclerosis (SSc). The functional heterogeneity and differentiation dynamics can be…
  • Abstract Number: 1279 • 2012 ACR/ARHP Annual Meeting

    First in Human Study with Recombinant Anti-IL-21 Monoclonal Antibody in Healthy Subjects and Patients with Rheumatoid Arthritis

    Stanislav Ignatenko1, Birte K. Skrumsager2, Adam Steensberg3 and Ulrik Mouritzen3, 1Charité Research Organization GmbH, Berlin, Germany, 2Clinical Pharmacology Biopharm, Novo Nordisk A/S, Copenhagen, Denmark, 3Medical & Science, Inflammation, Novo Nordisk A/S, Copenhagen, Denmark

    Background/Purpose: Interleukin-21 (IL-21), a cytokine produced by activated T cells (especially T17 and TFH cells), has a proinflammatory and pleiotropic nature, and drives mainly activation…
  • Abstract Number: 316 • 2012 ACR/ARHP Annual Meeting

    The Interleukin-10 (IL-10) Producing Regulatory B Cell (“B10 cell”) Compartment Expands with Disease Activity in Juvenile Dermatomyositis (JDM) and Pediatric-Onset Systemic Lupus Erythematosus (pSLE)

    Ioannis Kalampokis1, Jeffrey A. Dvergsten2 and Thomas Tedder3, 1Immunology and Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 2Pediatrics Division of Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 3Department of Immunology, Duke University Medical Center, Durham, NC

    Background/Purpose: pSLE and JDM are multisystem inflammatory diseases, whereas juvenile idiopathic arthritis (JIA) is typically an organ-limited disease. “B10 cells”, a rare subset of human…
  • Abstract Number: 2293 • 2012 ACR/ARHP Annual Meeting

    Interleukin-17A Positive Cells Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated to Skin Thickness

    Marie-Elise Truchetet1, Nicolò Costantino Brembilla1, Elisa Montanari1, Paola Lonati2, Pier Luigi Meroni3 and Carlo Chizzolini1, 1University hospital of Geneva, Geneva, Switzerland, 2Division of Rheumatology, Istituto G. Pini, University of Milan, Milan, Italy, 3Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy

    Background/Purpose: T cell producing IL-17A are increased in the peripheral blood of individuals affected by systemic sclerosis (SSc). We asked the question whether IL-17A-producing cells…
  • Abstract Number: 1209 • 2012 ACR/ARHP Annual Meeting

    Functional Role of Chondrogenic Progenitor Cells in Rheumatoid Arthritis

    Sabine Blaschke1, Sandra Trautmann1, Alexander W. Beham2, Burkhard Mai3, Sebastian Koelling1, Caroline Breysach4, Gabriele Wolf1, Gerhard A. Mueller1 and Nicolai Miosge5, 1Nephrology & Rheumatology, University Medical Center Goettingen, Goettingen, Germany, 2Department of Surgery, Germany, 3Vitos Orthopaedic Clinic Kassel, Kassel, Germany, 4Department of Surgery, Goettingen, Germany, 5Dept. of Prosthodontics, Goettingen, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease of still unknown etiology leading to progressive cartilage and bone destruction. Proinflammatory cytokines, immunoregulatory cells…
  • Abstract Number: 152 • 2012 ACR/ARHP Annual Meeting

    Rilonacept for Gout Flare Reduction: Estimation of Number Needed to Treat to Benefit (NNTB)

    Robert R. Evans1, Steven P. Weinstein2, George D. Yancopoulos3 and Yuhwen Soo4, 1Clinical Sciences, Regeneron Pharmaceuticals Inc, Tarrytown, NY, 2Clinical Development, Regeneron Pharmaceuticals Inc, Tarrytown, NY, 3Research Labs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 4BioStatistics, Regeneron Pharmaceuticals, Inc., Tarrytown, NY

    Background/Purpose: Two similarly designed phase 3 randomized clinical trials (PRESURGE-1 and PRESURGE-2) in gout patients initiating urate-lowering therapy (ULT) showed that subcutaneous treatment with the…
  • Abstract Number: 2119 • 2012 ACR/ARHP Annual Meeting

    Interleukin-6 As a Biomarker for the Clinical and Radiological Effectiveness of Methotrexate in Rheumatoid Arthritis

    Naoshi Nishina, Hideto Kameda, Yuko Kaneko, Masataka Kuwana and Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Methotrexate (MTX) is now an anchor drug in the treatment strategy of rheumatoid arthritis (RA) and its effectiveness has been established. However it is…
  • Abstract Number: 1178 • 2012 ACR/ARHP Annual Meeting

    IL-6 and IL-21 in Rheumatoid Arthritis

    Gustavo Carbone1, Augusta Wilson1, Sean Diehl2, Janice Bunn3, Sheldon Cooper4 and Mercedes Rincon5, 1Rheum & Clinical Imm Unit, University of Vermont College of Medicine, Burlington, VT, 2Immunobiology, University of Vermont College of Medicine, 3Mathematics and Statistics, University of Vermont, Burlington, VT, 4Rheum & Clinical Imm Unit, Univ Vermont College of Med, Burlington, VT, 5Immunobiology, University of Vermont College of Medicine, Burlington, VT

    Background/Purpose: Interleukin-6 (IL-6) levels are known to be increased in patients with rheumatoid arthritis (RA). Tocilizumab, a monoclonal antibody to the IL-6 receptor (IL-6R), reduces…
  • Abstract Number: 21 • 2012 ACR/ARHP Annual Meeting

    IL-32 and IL-17 Interact and Aggravate Osteoclastogenesis in Rheumatoid Arthritis

    Bo Young Yoon1, Young-Mee Moon2, Yang-Mi Her2, Hye Jwa Oh2, Jae-Seon Lee2, Kyoung-Woon Kim3, Seon-Yeong Lee2, Yun-Ju Woo2, Kyung-Su Park2, Sung-Hwan Park4, Ho-Youn Kim2 and Mi-La Cho2, 1Inje University Ilsan Paik Hospital, Goyang, South Korea, 2Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, 3Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, 4Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea

    Background/Purpose: Interleukin (IL)-32 and IL-17 play critical roles in pro-inflammatory responses and are highly expressed in the synovium of patients with rheumatoid arthritis (RA). We…
  • Abstract Number: 2084 • 2012 ACR/ARHP Annual Meeting

    ASP015K: A Novel JAK Inhibitor Demonstrated Potent Efficacy in Adjuvant-Induced Arthritis Model in Rats

    Shunji Yamazaki1, Masamichi Inami1, Misato Ito1, Yasutomo Fujii1, Kaori Hanaoka1, Kaoru Yamagami1, Kenji Okuma1, Yoshiaki Morita1, Shohei Shirakami2, Takayuki Inoue2, Susumu Miyata3 and Yasuyuki Higashi1, 1Pharmacology Research Labs, Astellas Pharma Inc., Tsukuba, Japan, 2Chemistry Research Labs, Astellas Pharma Inc., Tsukuba, Japan, 3Research Planning & Administration, Astellas Pharma Inc., Tsukuba, Japan

    Background/Purpose: The Janus kinase (JAK) family of enzymes plays a key role in cytokine signaling, which is involved in the pathogenic events of immune-mediated disorders…
  • Abstract Number: 1062 • 2012 ACR/ARHP Annual Meeting

    Identification of Highly Potent and Selective Interleukin-1 Receptor-Associated Kinase 4 Inhibitors for the Treatment of Rheumatic Diseases

    Divya Chaudhary1, Shaughnessy Robinson2, Craig E. Masse1, Matthew D. Wessel2, Shawn Watts2, Jeremy Greenwood2, Mee Shelley2, Mark Brewer2, Geraldine Harriman1, Leah L. Frye2, Ronald T. Wester1, Rosana Kapeller1 and Donna Romero1, 125 First Street Suite 404, Nimbus Discovery, Inc., Cambridge, MA, 2Schrödinger, Inc., New York, NY

    Background/Purpose:   Interleukin-1 receptor-associated kinase 4 (IRAK4) is a key mediator of the innate immune response orchestrated by interleukin-1 receptor (IL-1R), interleukin-18 receptor (IL-18R), IL-33…
  • Abstract Number: 2677 • 2012 ACR/ARHP Annual Meeting

    IL-23 Controls Autoimmunity by Facilitating Clearance of Apoptotic Bodies in the Marginal Zone in Lupus-Prone BXD2 Mice

    Hao Li1, Hui-Chen Hsu2, Qi Wu3, PingAr Yang3, Jun Li4, Daniel Cua5, Mohamed Oukka6 and John D. Mountz7, 1Microbiology, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Med - Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5Discovery Research, Merck Research Laboratory, Palo Alto, CA, 6Pediatrics, Seattle, WA, 7Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Failure to clear apoptotic bodies is a central pathogenic mechanism for SLE. We have observed that spontaneous systemic autoimmunity and lupus in BXD2 mice…
  • Abstract Number: 2077 • 2012 ACR/ARHP Annual Meeting

    IL-6 Blockade Augments the Anti-Inflammatory Effect without Increasing the Side Effects of Steroids in Collagen-Induced Arthritis

    Miho Suzuki1, Hiroto Yoshida2, Misato Hashizume1, Masashi Shiina2, Keisuke Tanaka1 and Yoshihiro Matsumoto1, 1Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, 2Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan

    Background/Purpose: Steroids are the main therapy for chronic inflammatory diseases. They are very effective, but induce many side effects, such as osteoporosis, making it important…
  • Abstract Number: 894 • 2012 ACR/ARHP Annual Meeting

    Genetic Variants in the IL-4 and IL-4 Receptor Genes in Association with the Severity of Joint Damage in Rheumatoid Arthritis: A Study in Seven Cohorts

    A. Krabben1, A. G. Wilson2, R. Knevel1, A. Zhernakova3, E. Brouwer3, E. Lindqvist4, T. Saxne4, G. Stoeken-Rijsbergen1, J. A. B. van Nies1, D. P. C. de Rooy1, T.W.J. Huizinga1, B. P. C. Koeleman5, R. E. M. Toes1, P. K. Gregersen6 and A. H. M. van der Helm-van Mil1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Infection & Immunity, University of Sheffield, Sheffield, United Kingdom, 3Rheumatology and Clinical Immunology, University of Groningen, University Medical Center, Groningen, Netherlands, 4Rheumatology, Lund University, Lund, Sweden, 5Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 6Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY

    Background/Purpose: The severity of RA is reflected by the severity of radiological joint destruction. It is highly variable between patients and up to 58% of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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