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Abstracts tagged "interleukins (IL)"

  • Abstract Number: 1440 • 2013 ACR/ARHP Annual Meeting

    Effects Of Tocilizumab On Serum Cytokines In Rheumatoid Arthritis With An Inadequate Response To Disease-Modifying Antirheumatic Drugs

    Sang Jin Lee1,2, Kyung Rok Kim3, Sang Hyun Joo3, Jae Myung Lee3, In Ah Choi3, Joo Youn Lee2, Hyun Jung Yoo2, Eun Young Lee4, Eun Bong Lee1, Won Park5, Sung Hwan Park6, Seung-Cheol Shim7, Dae-Hyun Yoo8, Han Joo Baek9, Hyun Ah Kim10, Soo Kon Lee11, Yun Jong Lee1, Young Eun Park12, Hoon-Suk Cha13 and Yeong Wook Song2,3, 1Division of Rheumatology, Department of Internal Medicine, Rheumatology, Seoul National University, Seoul, South Korea, 2Department of molecular medicine and biophamaceutical sciences,Seoul National University, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, 4Internal medicine, Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, 6Division of Rheumatology, Department of Internal Medicine, Rheumatology, The Catholic University, Seoul, South Korea, 7Medicine, Rheumatology, Eulji University, Daejeon, South Korea, 8Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 9Rheumatology, Rheumatology, Gachon University, Incheon, South Korea, 10Division of Rheumatology, Department of Internal Medicine, Hallym university, Kyunggi, South Korea, 11Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, 12Rheumatology, Rheumatology, Pusan Nationl University, Pusan, South Korea, 13Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Background/Purpose: The objective of this study was to investigate the effects of tocilizumab on serum cytokines in rheumatoid arthritis (RA) patients with an inadequate response…
  • Abstract Number: 1375 • 2013 ACR/ARHP Annual Meeting

    Synergistic Enhancement Of Aggregated IgG-Induced Tumor Necrosis Factor α In Human Synovial Mast Cells By Interleukin 33

    Hyunho Lee1,2, Jun-ichi Kashiwakura3, Masahiko Yanagisawa1,2, Yuki Okamura1,2, Takao Ishii2, Masayuki Seki2, Shu Saito2, Yasuaki Tokuhashi2, Chisei Ra1 and Yoshimichi Okayama1, 1Allergy and Immunology Group, Nihon University School of Medicine, Tokyo, Japan, 2Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan, 3Laboratory for Allergic Disease, RIKEN Center for Integrateive Medical Sciences, Kanagawa, Japan

    Background/Purpose: Recent studies suggest that human synovial mast cells (MCs) are involved in the pathogenesis of rheumatoid arthritis (RA). Circulating IgG isotype autoantibodies and synovial…
  • Abstract Number: 152 • 2012 ACR/ARHP Annual Meeting

    Rilonacept for Gout Flare Reduction: Estimation of Number Needed to Treat to Benefit (NNTB)

    Robert R. Evans1, Steven P. Weinstein2, George D. Yancopoulos3 and Yuhwen Soo4, 1Clinical Sciences, Regeneron Pharmaceuticals Inc, Tarrytown, NY, 2Clinical Development, Regeneron Pharmaceuticals Inc, Tarrytown, NY, 3Research Labs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 4BioStatistics, Regeneron Pharmaceuticals, Inc., Tarrytown, NY

    Background/Purpose: Two similarly designed phase 3 randomized clinical trials (PRESURGE-1 and PRESURGE-2) in gout patients initiating urate-lowering therapy (ULT) showed that subcutaneous treatment with the…
  • Abstract Number: 1178 • 2012 ACR/ARHP Annual Meeting

    IL-6 and IL-21 in Rheumatoid Arthritis

    Gustavo Carbone1, Augusta Wilson1, Sean Diehl2, Janice Bunn3, Sheldon Cooper4 and Mercedes Rincon5, 1Rheum & Clinical Imm Unit, University of Vermont College of Medicine, Burlington, VT, 2Immunobiology, University of Vermont College of Medicine, 3Mathematics and Statistics, University of Vermont, Burlington, VT, 4Rheum & Clinical Imm Unit, Univ Vermont College of Med, Burlington, VT, 5Immunobiology, University of Vermont College of Medicine, Burlington, VT

    Background/Purpose: Interleukin-6 (IL-6) levels are known to be increased in patients with rheumatoid arthritis (RA). Tocilizumab, a monoclonal antibody to the IL-6 receptor (IL-6R), reduces…
  • Abstract Number: 2119 • 2012 ACR/ARHP Annual Meeting

    Interleukin-6 As a Biomarker for the Clinical and Radiological Effectiveness of Methotrexate in Rheumatoid Arthritis

    Naoshi Nishina, Hideto Kameda, Yuko Kaneko, Masataka Kuwana and Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Methotrexate (MTX) is now an anchor drug in the treatment strategy of rheumatoid arthritis (RA) and its effectiveness has been established. However it is…
  • Abstract Number: 21 • 2012 ACR/ARHP Annual Meeting

    IL-32 and IL-17 Interact and Aggravate Osteoclastogenesis in Rheumatoid Arthritis

    Bo Young Yoon1, Young-Mee Moon2, Yang-Mi Her2, Hye Jwa Oh2, Jae-Seon Lee2, Kyoung-Woon Kim3, Seon-Yeong Lee2, Yun-Ju Woo2, Kyung-Su Park2, Sung-Hwan Park4, Ho-Youn Kim2 and Mi-La Cho2, 1Inje University Ilsan Paik Hospital, Goyang, South Korea, 2Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, 3Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, 4Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea

    Background/Purpose: Interleukin (IL)-32 and IL-17 play critical roles in pro-inflammatory responses and are highly expressed in the synovium of patients with rheumatoid arthritis (RA). We…
  • Abstract Number: 1209 • 2012 ACR/ARHP Annual Meeting

    Functional Role of Chondrogenic Progenitor Cells in Rheumatoid Arthritis

    Sabine Blaschke1, Sandra Trautmann1, Alexander W. Beham2, Burkhard Mai3, Sebastian Koelling1, Caroline Breysach4, Gabriele Wolf1, Gerhard A. Mueller1 and Nicolai Miosge5, 1Nephrology & Rheumatology, University Medical Center Goettingen, Goettingen, Germany, 2Department of Surgery, Germany, 3Vitos Orthopaedic Clinic Kassel, Kassel, Germany, 4Department of Surgery, Goettingen, Germany, 5Dept. of Prosthodontics, Goettingen, Germany

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease of still unknown etiology leading to progressive cartilage and bone destruction. Proinflammatory cytokines, immunoregulatory cells…
  • Abstract Number: 2293 • 2012 ACR/ARHP Annual Meeting

    Interleukin-17A Positive Cells Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated to Skin Thickness

    Marie-Elise Truchetet1, Nicolò Costantino Brembilla1, Elisa Montanari1, Paola Lonati2, Pier Luigi Meroni3 and Carlo Chizzolini1, 1University hospital of Geneva, Geneva, Switzerland, 2Division of Rheumatology, Istituto G. Pini, University of Milan, Milan, Italy, 3Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy

    Background/Purpose: T cell producing IL-17A are increased in the peripheral blood of individuals affected by systemic sclerosis (SSc). We asked the question whether IL-17A-producing cells…
  • Abstract Number: 316 • 2012 ACR/ARHP Annual Meeting

    The Interleukin-10 (IL-10) Producing Regulatory B Cell (“B10 cell”) Compartment Expands with Disease Activity in Juvenile Dermatomyositis (JDM) and Pediatric-Onset Systemic Lupus Erythematosus (pSLE)

    Ioannis Kalampokis1, Jeffrey A. Dvergsten2 and Thomas Tedder3, 1Immunology and Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 2Pediatrics Division of Pediatric Rheumatology, Duke University Medical Center, Durham, NC, 3Department of Immunology, Duke University Medical Center, Durham, NC

    Background/Purpose: pSLE and JDM are multisystem inflammatory diseases, whereas juvenile idiopathic arthritis (JIA) is typically an organ-limited disease. “B10 cells”, a rare subset of human…
  • Abstract Number: 1279 • 2012 ACR/ARHP Annual Meeting

    First in Human Study with Recombinant Anti-IL-21 Monoclonal Antibody in Healthy Subjects and Patients with Rheumatoid Arthritis

    Stanislav Ignatenko1, Birte K. Skrumsager2, Adam Steensberg3 and Ulrik Mouritzen3, 1Charité Research Organization GmbH, Berlin, Germany, 2Clinical Pharmacology Biopharm, Novo Nordisk A/S, Copenhagen, Denmark, 3Medical & Science, Inflammation, Novo Nordisk A/S, Copenhagen, Denmark

    Background/Purpose: Interleukin-21 (IL-21), a cytokine produced by activated T cells (especially T17 and TFH cells), has a proinflammatory and pleiotropic nature, and drives mainly activation…
  • Abstract Number: 2329 • 2012 ACR/ARHP Annual Meeting

    Increase of CD4+CD25+FoxP3+ T Cell in Patients with Systemic Sclerosis Could Secret IL-17 with Dysfunction of Immunosuppression

    Xinjuan Liu1, Na Gao1, Mengtao Li1, Dong Xu1, Yong Hou1, Qian Wang1, Guohua Zhang1, Qiuning Sun2, Henghui Zhang3 and Xiaofeng Zeng4, 1Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 2Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China, 3Hepatology Institute, Peking University, People's Hospital, Beijing, China, 4Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Background/Purpose:  Immune unbalance between Th17 and regulatory T cells (Treg) is a characteristic of systemic sclerosis (SSc). The functional heterogeneity and differentiation dynamics can be…
  • Abstract Number: 310 • 2012 ACR/ARHP Annual Meeting

    STAT3 Plays a Central Role in NLRP3 Inflammasome-Mediated IL-1β Production and Pyronecrosis

    Jehad H. Edwan1, Tri M. Tran2, Mones Abu-Asab3, Raphaela T. Goldbach-Mansky4 and Robert A. Colbert1, 1NIAMS NIH, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD, 3NEI NIH, Bethesda, MD, 4Translational Autoinflammatory Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD

    Background/Purpose: Gain of function mutations in NLRP3 cause cryopyrin-associated periodic fever syndromes (CAPS), the most severe form of which is neonatal-onset multisystem inflammatory disease (NOMID),…
  • Abstract Number: 1307 • 2012 ACR/ARHP Annual Meeting

    Anti-IL-6 Receptor Nanobody (ALX-0061) Seamless “First-in-Human” Phase I/II POC Study in Patients with Active RA On Stable MTX Treatment

    Steven De Bruyn1, Béla Gachályi2, Bernadette Rojkovich3, Slavomir Bruk4, Petr Sramek5, Mariusz Korkosz6, Krzysztof Krause7, Pieter Schoen8, Laura Sargentini-Maier9, Joke D'Artois10, Katrien Verschueren10, Katelijne De Swert10, Gerhard Arold11 and Josefin-Beate Holz12, 1Clinical Development, Ablynx N.V., Zwijnaarde, Belgium, 2Fázis I-es Klinikai Farmakológiai Vizsgálóhely, Péterfy Sándor Utcai Kórház, Budapest, Hungary, 3II. sz. Reumatológiai Osztály, Budai Irgalmasrendi Kórház Kht., Budapest, Hungary, 4Interni oddeleni, Nemocnice Trinec, Trinec, Czech Republic, 5Pharmaceutical Research Associates CZ, Praha, Czech Republic, 6Malopolskie Centrum Medyczne, Krakow, Poland, 7Specjalistyczny im. J. Gromkowskiego, Wojewodzki Szpital, Wroclaw, Poland, 8Project Management, Ablynx N.V., Zwijnaarde, Belgium, 9Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 10Clinical Development, Ablynx nv, Zwijnaarde, Belgium, 11Medical Affairs, PRA International GmbH, Berlin, Germany, 12Chief Medical Officer, Ablynx N.V., Zwijnaarde, Belgium

    Background/Purpose: ALX-0061 is a 26kD bispecific IL-6R targeting Nanobody® with monovalent binding to IL-6R and serum albumin. It effectively neutralizes IL-6 pathway activity in-vitro and…
  • Abstract Number: 2372 • 2012 ACR/ARHP Annual Meeting

    Efficacy of Quantitative Analysis of Brainstem Atrophy On Magnetic Resonance Imaging for Diagnosis of Chronic Progressive Neuro-Behçet’s Disease

    Hirotoshi Kikuchi1, Maki Takayama2, Yoshitaka Kimura2, Kurumi Asako2, Hajime Kono2, Yasuo Ono1 and Shunsei Hirohata3, 1Department of Microbiology and Immunology, Teikyo University Shool of Medicine, Tokyo, Japan, 2Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 3Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan

    Background/Purpose : CNS involvement in Behçet's disease, usually called neuro-Behçet's disease (NB), can be classified into acute NB (ANB) and chronic progressive NB (CPNB) based…
  • Abstract Number: 336 • 2012 ACR/ARHP Annual Meeting

    Preclinical Development of ALX-0061, an Anti-IL-6R Nanobody® For Therapeutic Use in Rheumatoid Arthritis with a High in Vitro Affinity and Potency and a Competitive in Vivo Pharmacological Profile

    Maarten Van Roy1, Hans Ulrichts2, Stefaan Rossenu2, Sandy Jacobs2, Sofie Poelmans3, Gert Verheyden2, Michel Vierboom4, Bert 't Hart4, Judith Baumeister1 and Josefin-Beate Holz5, 1Department of Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 2Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 3Pharmacology, Ablynx NV, Gent, Belgium, 4Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, Netherlands, 5Chief Medical Officer, Ablynx N.V., Zwijnaarde, Belgium

    Background/Purpose: Interleukin-6 (IL-6) is a pleiotropic cytokine inducing a wide range of biological activities via its receptor IL-6R. IL-6 plays an important role in the…
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