ACR Meeting Abstracts

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Abstracts tagged "innate immunity"

  • Abstract Number: 1327 • ACR Convergence 2022

    Immune Cell Subsets and Risk of Incident Hip Fracture in Older Adults: The Cardiovascular Health Study

    Rachel Elam1, Petra Buzkova2, Joseph Delaney3, Howard Fink4, Joshua Barzilay5, Laura Carbone1, Rick Saha1, John Robbins6, Kenneth Mukamal7, Rodrigo Valderrabano8, Bruce Psaty2, Russell Tracy9, Nels Olson9, Sally Huber10, Margaret Doyle9, Alan Landay11 and Jane Cauley12, 1Augusta University, Augusta, GA, 2University of Washington, Seattle, WA, 3University of Manitoba, Winnipeg, MB, Canada, 4University of Minnesota, Minneapolis, MN, 5Kaiser Permanente, Atlanta, GA, 6UC Davis, Davis, CA, 7Beth Israel Deaconess Medical Center, Boston, MA, 8Brigham and Women's Hospital, Boston, MA, 9University of Vermont, Burlington, VT, 10University of Vermont, Burlingon, VT, 11Rush University Medical Center, Chicago, IL, 12University of Pittsburgh, PIttsburgh, PA

    Background/Purpose: Cell-mediated immunity may play a role in osteoporosis development. Fracture is the major consequence of osteoporosis. Thus, cell-mediated immunity may impact fracture risk. We…
  • Abstract Number: 2051 • ACR Convergence 2022

    Targeting Janus Kinase Pathway in Sjogren’s Disease Corrects IFN-Driven Inflammation and Epithelial Dysfunction

    Sarthak Gupta1, Eiko Yamada2, Hiroyuki Nakamura2, Zohreh Khavandgar3, Daniel Martin2, Mayank Tandon4, Ilias Alevizos5, Shyh-Ing Jang2, Paola Perez2, Kalie Dominick2, Thomas Pranzatelli2, Alan Baer6, john chiorini4 and Blake Warner3, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 2NIDCR, Bethesda, MD, 3National Institutes of Health, Bethesda, MD, 4NIH, Bethesda, MD, 5Horizon Therapeutics, Gaithersburg, MD, 6Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Many of the inflammatory cytokines implicated in Sjogren's Disease (SjD) pathogenesis, in particular Type I and II interferons (IFNs), signal through Janus kinases (JAK)…
  • Abstract Number: 1565 • ACR Convergence 2022

    Dissection of Ocular and Peripheral Blood Immune Phenotypes Suggests Preferential Transmigration of CD16+ Monocytes to Effector Sites in Behçet’s Disease

    Yesim Ozguler1, Ziyan Lin2, Ann Cavers3, gulen Hatemi4, Olivier Manches5 and Johannes Nowatzky3, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, New York, NY, 2NYU Grossman School of Medicine, NYU Langone Applied Informatics Laboratories, New York, NY, 3NYU Grossman School of Medicine, New York, NY, 4Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 5Recherche et Développement, Immunobiology and Immunotherapy in Chronic Diseases, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes Etablissement Français du Sang Auvergne-Rhône-Alpes, Grenoble, France

    Background/Purpose: Cellular immunity of Behçet's Disease (BD) remains poorly understood. Previous work has provided clues pointing to most innate and adaptive immune cell types in…
  • Abstract Number: 1663 • ACR Convergence 2022

    Age-Dependent Expansion and Activation of Disease-Associated Microglia in Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Hadijat Makinde1, Caroline Shah1, Miranda Gurra1, Yidan Wang1, Deborah Winter2 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Skokie, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multipe end organs, including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 0025 • ACR Convergence 2022

    Wnt Pathway/Innate Immunity Equilibrium in OA Articular Cells

    Eloi Franco-Trepat1, Ana Alonso Pérez1, María Guillán-Fresco2, Miriam López Fagúndez1, Andrés Pazos-Pérez3, Antia Crespo Golmar4, María Piñeiro-Ramil5, Ana Lois Iglesias6, Alberto Jorge-Mora1 and Rodolfo Gomez1, 1MSP Group - Institute IDIS - CHUS - SERGAS, Santiago de Compostela, Spain, 2MSP Group - Institute IDIS - CHUS - SERGAS, Catoira, Spain, 3MSP Group - Institute IDIS - CHUS - SERGAS, Pontevedra, Spain, 4MSP Group - Institute IDIS - CHUS - SERGAS, León, Spain, 5MSP Group - Institute IDIS - CHUAC - SERGA, A Coruña, Spain, 6MSP Group - Institute IDIS - CHUAC - SERGAS, A Coruña, Spain

    Background/Purpose: The progressive degradation of osteoarthritis (OA) cartilage has been associated with articular innate immune responses (IIR) mediated by the Toll-like receptor 4 (TLR4). Additionally,…
  • Abstract Number: 1690 • ACR Convergence 2022

    Butyric Acid Suppresses Migration of Human Monocyte Derived Dendritc Cell by Inhibiting Actin Polymerization via mDia1 Inhibition

    Takumi Nagamoto1, takaichi okano2, Yoshikazu Fujikawa3, Yuzuru Yamamoto2, Hirotaka Yamada2, Yo Ueda2, Sho Sendo4 and Jun saegusa2, 1Kobe University, Kobe, Japan, 2Kobe University, Rheumatology, Kobe, Japan, 3Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Japan, 4University California, San Diego (UCSD), La Jolla, CA

    Background/Purpose: Butyric acid is known to improve chronic inflammation such as inflammatory bowel disease and arthritis. Dendritic cells activate in inflammatory condition, migrate to regional…
  • Abstract Number: 0049 • ACR Convergence 2022

    IL-18 Receptor-α Signaling Pathway Contributes to Autoantibody-induced Arthritis via Neutrophil Recruitment

    Shinjiro Kaieda and Tomoaki Hoshino, Kurume University School of Medicine, Kurume, Japan

    Background/Purpose: We have previously reported that IL-18 levels in the lungs, serum and bronchoalveolar lavage fluid (BALF) were increased in patients with idiopathic pulmonary lung…
  • Abstract Number: 1693 • ACR Convergence 2022

    Skin Pigmentation Association with Regulation of Cyclic-GMP-AMP Following Skin Exposure to UV Light

    Jie An1, Sladjana Skopelja-Gardner2, Xizhang Sun1, Lena Tanaka1 and Keith Elkon1, 1University of Washington, Seattle, WA, 2Dartmouth Hitchcock Medical Center, Lebanon, NH

    Background/Purpose: Amongst the most important cytosolic DNA sensors is Cyclic GMP-AMP synthase (cGAS). Binding of DNA to cGAS results in the synthesis of the cyclic…
  • Abstract Number: 0148 • ACR Convergence 2022

    Dysferlin Associated Autoinflammatory Disease Causing Systemic Inflammation and Sterile Lung Abcesses Through Impaired Efferocytosis

    Farzana Bhuyan1, Adriana Almeida de Jesus2, Clinton Bradfield3, Mohammad Arif Rahman4, Andre Rastegar3, sundar ganesan3, Sachin Gaurav3, Sara Alehashemi3, Ronit Herzog5, Steven Holland3, Deborah Consilini6, Iain Fraser3 and Raphaela Goldbach-Mansky7, 1National Institutes of Health, Bethesda, MD, 2NIAID, NIH, Silver Spring, MD, 3NIAID, Bethesda, MD, 4NCI, Bethesda, MD, 5Langone Medical Center, New York, NY, 6Nemours Children's Hospital-Delaware, Wilmington, DE, 7NIAID, NIH, Rockville

    Background/Purpose: Using whole exome sequencing (WES), we identified a de novo mutation in DYSF encoding dysferlin in 2 unrelated patients with systemic inflammation and sterile…
  • Abstract Number: 1695 • ACR Convergence 2022

    Dermatomyositis (DM) Macrophages Upregulate Genes Involved in the Remodeling of the Extracellular Matrix and Activate Keratinocytes in a Novel 3D Tissue Model of DM Skin Disease

    Zoe Chafouleas1, Angelique Cortez1, James Whitley1, Dorothea Barton1, Lin Brown1, Michael Whitfield2, Patricia pioli3 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Dartmouth Geisel School of Medicine, Department of Biomedical Data Science, Lebanon, NH, 3Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: With an incidence of 10 cases per million and lack of animal or ex vivo disease models, dermatomyositis (DM) remains a debilitating disease without…
  • Abstract Number: 0149 • ACR Convergence 2022

    Autoinflammatory Diseases Associated with NOD2 and Other Concurrent Genetic Mutations

    Hafsa Nomani, Brianne Navetta-Modrov, Mark Yun and QingPing Yao, Stony Brook University, Stony Brook, NY

    Background/Purpose: Systemic autoinflammatoy diseases (SAIDs) are primarily caused by abnormal innate immune response. NOD-like receptors (NLRs) are intracellular sensors to the immune process, including NOD2,…
  • Abstract Number: 1697 • ACR Convergence 2022

    Measurements of Specific Activation Through the Lectin -or Classical Pathway of Complement in Patients with SLE

    Anne Troldborg1, Mads Lamm Larsen1, Erik J.M. Toonen2, Lisa Hurler3, Zoltan Prohaszka3, László Cervenak3, Annette Gudmann Hansen4 and Steffen Thiel4, 1Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 2Hycult Biotech, Arnhem-Nijmegen, Netherlands, 3Semmelweis University, Budapest, Hungary, 4Aarhus University, Aarhus, Denmark

    Background/Purpose: In systemic lupus erythematosus (SLE), the complement system is activated and commonly thought to occur through the classical pathway (CP) [1]. However, our previous…
  • Abstract Number: 0554 • ACR Convergence 2022

    Loss of Synovial Tissue Macrophage Homeostasis Precedes Rheumatoid Arthritis Clinical Onset

    Megan Hanlon1, Mary Canavan2, conor Smith3, Achilleas Floudas4, Nuno Neto5, Qingxuan Song6, Phil Gallagher7, Ronan Mullan8, Conor Hurson9, Barry Moran5, Michael Monaghan5, Sunil Nagpal10, Douglas Veale11 and Ursula Fearon5, 1Molecular Rheumatology, Dublin, Ireland, 2Trinity College, Dublin, Ireland, 3bTrinity College Dublin, Dublin, Ireland, 4Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Ireland, 5Trinity College Dublin, Dublin, Ireland, 6Janssen Research and Development, LLC, Spring House, PA, 7St Vincent's University Hospital, Dublin, Ireland, 8Tallaght University Hospital, Dublin, Ireland, 9St Vincents University Hospital, Dublin, Ireland, 10Janssen Research, Collegeville, PA, 11St. Vincent's University Hospital, Blackrock, Dublin, Ireland

    Background/Purpose: Synovial-tissue macrophages significantly contribute to Rheumatoid Arthritis, yet the precise nature/function of macrophage subsets within the inflamed joint remains unexplored. Here we explore the…
  • Abstract Number: 1700 • ACR Convergence 2022

    IL-21/STAT3 Pathway Mediated Th2-like Vδ2 T Cells Promote Plasmablasts Differentiation in IgG4-Related Disease

    Jieqiong Li1 and Wen Zhang2, 1Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China, 2Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: To explore the phenotype and role of gamma delta (γδ) T cells in the pathogenesis of IgG4-related disease (IgG4-RD), focusing on the effect on…
  • Abstract Number: 0556 • ACR Convergence 2022

    Immune Checkpoint VISTA Regulates Type I Interferon (IFN-I) Production and Controls UV Light Triggered Skin IFN-I Response

    Zachary Peters1, Lindsay Mendyka1, Sicong Shan1, Angelique Cortez1, William Rigby2, Christopher Burns1, Randolph Noelle3 and Sladjana Skopelja-Gardner1, 1Dartmouth Hitchcock Medical Center, Lebanon, NH, 2Dartmouth Hitchcock Medical Center, Lebanon, PA, 3Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Most lupus patients chronically exhibit higher IFN-I scores in the skin, peripheral blood, and kidneys that is exacerbated by ultraviolet (UV) light. In normal…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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