ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "innate immunity"

  • Abstract Number: 2427 • ACR Convergence 2023

    Degranulating PR3+ Myeloid Cells Characterize Proliferative Lupus Nephritis

    Alessandra Ida Celia1, Xiaoping Yang2, Hana Minsky2, Silvia Malvica2, Michelle Petri3, the Accelerating Medicines Partnership in RA/SLE4, Avi Rosenberg5 and Andrea Fava2, 1John Hopkins University of Medicine, Rome, Italy, 2Johns Hopkins University, Baltimore, MD, 3Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 4Multiple, Multiple, 5Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: As part of the Accelerating Medicines Partnership (AMP), we discovered that urinary PR3, a neutrophil degranulation product, is associated with histological activity, indicating the…
  • Abstract Number: 0894 • ACR Convergence 2023

    The Cellular and Spatial Type I Interferon Response Following Skin Exposure to Ultraviolet Light

    Jie An1, Xizhang Sun1, Rayan Najjar1, Connie Zhao1, Paul Kong2, Stephanie Weaver2, Amanda Koehne2, Matt Fitzgibbon2 and Keith Elkon1, 1University of Washington, Seattle, WA, 2Fred Hutchinson Cancer Center, Seattle, WA

    Background/Purpose: SLE patients characteristically have a prominent type I interferon (IFN-I) signature in lesional and non-lesional skin. We recently demonstrated that, following a single exposure…
  • Abstract Number: 2440 • ACR Convergence 2023

    Synovial Shaping of Skin-derived Migrating Immune Cells Determines Initiation of Inflammation in Psoriatic Arthritis

    Maria Gabriella Raimondo1, Simon Rauber2, Hashem Mohammadian3, Mario Angeli1, Cong Xu1, Aleix Rius Rigau4, Markus Luber1, Hannah Labinsky5, Alina Ramming1, Stefano Alivernini6, Jörg Distler1, Ursula Fearon7, Douglas Veale8, Michael Sticherling9, Juan D Canete10, Georg Schett11 and Andreas Ramming1, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany; Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 23 Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. 4 Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany. Deutsches Zentrum für Immuntherapie, Friedrich Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3, Rheumatology and Clinical Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), FAU Erlangen-Nürnberg and University Hospital Erlangen, Erlangen, Germany, 5Medical Department II, Rheumatology, University Hospital Würzburg, Würzburg, Germany, 6Immunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy, 7Trinity College Dublin, Dublin, Ireland, 8St.Vincent's University Hosp, Dublin, Ireland, 9Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg & Universitätsklinikum Erlangen, Department of Dermatology, Erlangen, Germany, 10Hospital Clinic an IDIBAPS, Barcelona, Spain, 11Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Background/Purpose: Around 30% of the patients with psoriasis (PsO) develop psoriatic arthritis (PsA) overtime, suggesting the existence of a disease mediated skin-joint crosstalk. To date,…
  • Abstract Number: 0905 • ACR Convergence 2023

    Low-Density Granulocytes and Neutrophil Extracellular Traps in Incomplete Systemic Lupus Erythematosus

    Svenja Henning1, Tobias Reimers2, Berber Doornbos-van der Meer2, Barbara Horvath3, Hendrika Bootsma4, Karina de Leeuw2 and Johanna Westra2, 1University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, Groningen, Netherlands, 2University Medical Center Groningen, Groningen, Netherlands, 3University Medical Center Groningen / Department of Dermatology, Groningen, Netherlands, 4Department of Rheumatology, University Medical Centre Groningen, Groningen, Netherlands

    Background/Purpose: Incomplete SLE (iSLE) defines a group of patients with symptoms typical of SLE but not meeting sufficient criteria required for the classification of SLE.…
  • Abstract Number: 2442 • ACR Convergence 2023

    Neutrophils Induce Contact-Dependent Expansion of Arthritogenic Th17 Cells and Are Necessary for Disease in Experimental Ankylosing Spondylitis

    Hillary Struthers1, Emily Vance1, Kofi Asare-Konadu1, Holly Rosenzweig2 and Ruth Napier1, 1Oregon Health & Science University, Portland, OR, 2VA Portland Healthcare System, Portland, OR

    Background/Purpose: Ankylosing spondylitis (AS) patients have irregular neutrophil responses, as indicated clinically by neutrophilia and increased neutrophil to lymphocyte ratios that positively associate with disease…
  • Abstract Number: 0911 • ACR Convergence 2023

    Spatial Transcriptomics Reveals Normal-density and Low-density Neutrophils Are More Prevalent Than Macrophages in Lupus Nephritis Glomeruli, and Urine DNA Methylation Analyses Capture Both Myeloid Populations

    Sladjana Skopelja-Gardner1, Joshua Skydel2, Alecia Roy3, Brenna Kerin3, James Whitley3, Fred Kolling4, Noelle Kosarek4, Michelle Petri5, Andrea Fava6, Lucas Salas7 and Christopher Burns3, 1Department of Medicine, Dartmouth Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, 2Dartmouth-Hitchcock Medical Center, Lebanon, NH, 3Dartmouth Hitchcock Medical Center, Lebanon, NH, 4Geisel School of Medicine at Dartmouth, Hanover, NH, 5Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Timonium, MD, 6Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 7Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH

    Background/Purpose: Despite compelling evidence that normal-density (NDN) and low-density neutrophils (LDN) are activated in the blood of lupus patients, their role in lupus nephritis (LN)…
  • Abstract Number: 2600 • ACR Convergence 2023

    Clonal Hematopoiesis Is Associated with Giant Cell Arteritis

    Background/Purpose: Giant cell arteritis (GCA) is an age-related vasculitis of large and medium vessels. Prior population studies have identified an association between GCA and hematologic…
  • Abstract Number: 0920 • ACR Convergence 2023

    Proinflammatory Neutrophils and NETs Mediate Skin and Kidney Inflammation During Lupus Flare in Asymptomatic Lupus-prone Mice Triggered by UVB

    Xing Lyu1, minghui li1, ping zhang2, Wei Wei3, victoria werth4 and Ming-Lin Liu5, 1Tianjin Medical University, Tianjin, China, 2Beaumont Hospital Royal Oak, Royal Oak, MI, 3Tianjin Medical University General Hospital, Tianjin, China, 4University of Pennsylvania, Wynnewood, PA, 5University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Ultraviolet B (UVB) exposure triggers lupus flare by worsening both skin lesions and systemic symptoms, i.e. lupus nephritis. We recently reported that UVB exposure…
  • Abstract Number: 0040 • ACR Convergence 2023

    Non-canonical NF-κB Signalling Is Required for Extrathymic AIRE Expression and Immunoregulatory Molecules in Cells of the Dendritic Lineage

    Guus van Laar1, Leonie Huitema1, Boy helder1, Joanna Fergusson1, Hergen Spits1, Jan Piet van Hamburg1 and Sander Tas2, 1Amsterdam University Medical Centers, Amsterdam, Netherlands, 2Amsterdam UMC, locatie AMC, Utrecht, Netherlands

    Background/Purpose: The transcription factor Autoimmune Regulator (AIRE) is crucial for the establishment of central tolerance in the thymus. Recently, peripheral CD45+ extrathymic AIRE-expressing cells (eTACs)…
  • Abstract Number: 0940 • ACR Convergence 2023

    A Novel Therapeutic Opportunity in Systemic Sclerosis: The Fibrolytic Activities of a Specialized Macrophage Secretome

    Françis Bonnefoy1, Susanne Behlke2 and Sylvain Perruche1, 1Univ. Bourgogne Franche-Comté, INSERM, EFS BFC, UMR1098, RIGHT Institute/MedINNPharma, Besançon, France, 2MedINNPharma, Besançon, France

    Background/Purpose: Systemic sclerosis (SSc) a complex and rare immune-mediated connective tissue disorder characterized by microvascular damage, inflammatory cell infiltration, and excessive deposition of extracellular matrix…
  • Abstract Number: 0041 • ACR Convergence 2023

    Interactions Between Synovial Fibroblasts and Macrophages: Implications for Tissue Remodeling in Chronic Inflammatory Diseases and Macrophage Differentiation in Response to the Immune Microenvironment

    Jia Li, Yanrong Cai, Xin Guan, Meike Ewald, Lars-Oliver Tykocinski, Hanns-Martin Lorenz and Theresa Tretter, Department of Internal Medicine V, Div. of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

    Background/Purpose: Activated macrophages (Mph) can be subdivided in at least 2 major subgroups according to their polarization into classical pro-(M1-Mph) or anti-inflammatory (M2-Mph) subtypes. Together…
  • Abstract Number: 0947 • ACR Convergence 2023

    Fcγ Receptors Define Pro-Phagocytic Macrophages and Trigger Pro-Inflammatory Responses in Patients with Systemic Sclerosis

    Amela Hukara1, Gino Andrea Bonazza1, Tracy Tabib2, Raphael Micheroli1, Suzana Jordan3, Kristina Bürki1, Sylvie Schlitz Schönbächler1, Adrian Ciurea4, Oliver Distler3, Robert Lafyatis5, Przemyslaw Blyszczuk1 and Gabriela Kania1, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 2Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 3Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, 4University Hospital Zurich, Zürich, Switzerland, 5University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Fcy receptors (FcγR) are opsonic phagocytic receptors, requiring tight regulations to prevent uncontrolled activation of pro-inflammatory phagocytosis. SSc macrophages display an alternatively-activated profibrotic phenotype.…
  • Abstract Number: 0049 • ACR Convergence 2023

    Soluble Uric Acid Is an Endogenous Inhibitor of CD38

    Shijie Wen1, Hiroshi Arakawa1, Shigeru Yokoyama2, Yoshiyuki Shirasaka1, Haruhiro Higashida3 and Ikumi Tamai1, 1Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan, 2Research Center for Child Mental Development, Kanazawa University; Division of Socio-Cognitive-Neuroscience, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Kanazawa University, Kanazawa, Japan, 3Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan

    Background/Purpose: CD38 is the main NAD+-degrading enzyme that plays a key role in innate immunity, aging, cancer, and metabolic disorders. Pharmacological inhibition of CD38 has…
  • Abstract Number: 1329 • ACR Convergence 2023

    R851, a Potent Second Generation IRAK1 and IRAK4 Inhibitor Suppresses IL-6 in Vitro and in Vivo for the Treatment of Rheumatoid Arthritis

    Yan Chen1, Sothy Yi1, Vadim Markovtsov1, Bhushan Samant1, Andrew Chow1, Esteban Masuda1 and Simon Shaw2, 1Rigel Pharmaceuticals, Inc, South San Francisco, CA, 2Rigel Pharmaceuticals, Inc., South San Francisco, CA

    Background/Purpose: The Toll-Like Receptor family (except TLR3) signal through IRAK4 and IRAK1 to produce an array of cytokines (including IL-6, IL-23 and TNFα in response…
  • Abstract Number: 0050 • ACR Convergence 2023

    Anti-Citrullinated Histone Antibody CIT-013, a Dual Action Therapeutic for Neutrophil Extracellular Trap Associated Autoimmune Disease

    Maarten van der Linden1, Sangeeta Kumari1, Daphne Montizaan1, Stephanie van Dalen1, Annemarie Kip1, Martyn FOSTER2, Inge Reinieren1, Elsa Neubert3, Luise Erpenbeck4, Tirza Bruurmijn1, Peter van Zandvoort1, Paul Vink1, Eric Meldrum5, Helmuth van Es1 and Renato Chirivi1, 1Citryll BV, Oss, Netherlands, 2Experimental Pathology Consultancy, Benfleet, United Kingdom, 3Leiden Academic Centre for Drug Research, Leiden, Netherlands, 4University Medical Center Münster, General Dermatology and Venereology, Münster, Germany, 5Citryll BV, Basel, Switzerland

    Background/Purpose: Neutrophil extracellular traps (NETs) contribute to the pathophysiology of multiple inflammatory and autoimmune diseases (Chirivi et al., 2021; DOI: 10.1038/s41423-020-0381-3). Targeting the NETosis pathway…
  • « Previous Page
  • 1
  • 2
  • 3
  • 4
  • 5
  • …
  • 14
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

Copyright Policy

View ACR Policies.

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology