ACR Meeting Abstracts

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Abstracts tagged "innate immunity"

  • Abstract Number: 0924 • ACR Convergence 2024

    The Cytosolic DNA Sensor AIM2 Regulates Bone Homeostasis Through Bone Progenitor Cell Differentiation

    Jia (Sijia) Chen1, Yukiko Maeda2, Catherine Manning3, Victor Le4, Jae-Hyuck Shim5, Katherine A. Fitzgerald6 and Ellen Gravallese7, 1Brigham and Women's Hospital, Boston, MA, 2Sanofi, worcester, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Digital Biology, Boston, MA, 5University of Massachusetts, Worcester, MA, 6UMass Chan Medical School, Worchester, MA, 7Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Innate sensing pathways and inflammasomes play an important role in autoimmunity and aging. AIM2 is a DNA sensor that triggers inflammasome assembly in myeloid…
  • Abstract Number: 2327 • ACR Convergence 2024

    Differential Quantitative Profile of Myeloid Derived Suppressor Cells and Monocyte Subsets Relate to Clinical Phenotype and Disease Activity in Psoriatic Arthritis Patients

    Jennifer Balderas Miranda1, Jiram Torres Ruiz2, Guillermo Guaracha Basañez3, Virginia Pascual Ramos4, Beatriz Alcalá-Carmona5, Yatzil Reyna-Juárez5, María José Ostos-prado5, Nancy R Mejía-Domínguez5, Guillermo Juarez-Vega6 and Diana Gomez-martin7, 1Universidad Nacional Autónoma de México, Ciudad de México, Mexico, 2INCMNSZ, Mexico, Federal District, Mexico, 3Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirón", Mexico City, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Federal District, Mexico, 5Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico, 6Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico, 7INCMNSZ, Mexico City, Federal District, Mexico

    Background/Purpose: The innate immune system not only participates in PsA pathogenesis but may also counteract with immunomodulatory elements. Proinflammatory and repairing roles according to monocyte…
  • Abstract Number: 0932 • ACR Convergence 2024

    IRAK4 Degrader GS-6791 Inhibits TLR and IL-1R-Driven Inflammatory Signaling, and Ameliorates Disease in a Preclinical Arthritis Model

    Grace Teng1, Thomas Fung2, Annamaria Mocciaro2, Ceyda Llapashtica1, Angie Hammond3, Jesse Gurgel4, zhiyu Huang1, Maria Mouchess1, Vanessa Gorney5, Wesley Minto1, Sunish Mohanan1, Adam Schrier1, Wylie Palmer2, Alexandra Borodovsky2 and Gundula Min-oo1, 1Gilead Sciences, Foster City, CA, 2Nurix Therapeutics, San Francisco, CA, 3Gilead Sciences, Inc., Seattle, WA, 4Gilead Sciences, Seattle, CA, 5Alterome Therapeutics, San Diego, CA

    Background/Purpose: Despite advances in treatment, chronic inflammatory diseases such as rheumatoid arthritis (RA) represent areas of high unmet medical need. IRAK4 is a proximal mediator…
  • Abstract Number: 2505 • ACR Convergence 2024

    C5 Signaling Pathway Genes as Key Drivers of the Pathogenesis of IgA Vasculitis?

    Joao Carlos Batista-Liz1, Vanesa Calvo-Rio2, María Sebastián Mora-Gil3, Ligia Gabrie-Rodriguez4, Rafael Gálvez Sánchez4, Belén Sevilla-Pérez5, José Luis Callejas6, María Teresa Leonardo7, Ana Peñalba7, Javier Narvaez-García8, Luis Martín-Penagos9, Luis Caminal-Montero10, PAZ COLLADO11, Patricia Quiroga Colina12, Esther Vicente-rabaneda13, Esteban Rubio14, Manuel León Luque15, Juan María Blanco-Madrigal16, Eva Galindez-Agirregoikoa17, Santos Castañeda13, Ricardo Blanco-Alonso18, Veronica Pulito-Cueto1 and Raquel Lopez-mejias1, 1IDIVAL, Santander, Spain, 2Valdecilla Hospital, Santander, Cantabria, Spain, 3Immunopathology Group, IDIVAL, Santander, Spain, 4Immunopathology Group, IDIVAL. Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 5Division of Pediatrics, Hospital Universitario San Cecilio, Granada, Spain, 6Systemic Autoimmune Diseases Unit, Hospital Clinico San Cecilio, Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, Granada, Spain, 7Division of Pediatrics, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 8Hospital Universitario de Bellvitge, Barcelona, Spain, 9Immunopathology Group, IDIVAL. Division of Nephrology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 10Internal Medicine Department, Hospital Universitario Central de Asturias, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain, 11Hospital Universitario Severo Ochoa, MADRID, Spain, 12Division of Rheumatology, Hospital Universitario de La Princesa, Madrid, Spain, 13Hospital Universitario de La Princesa, Madrid, Spain, 14Division of Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain, Sevilla, Spain, 15Division of Rheumatology, Hospital Universitario Virgen del Rocío, Sevilla, Spain., Sevilla, Spain, 16Division of Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain., Bilbao, Spain, 17BASURTO UNIVERSITY HOSPITAL, BILBAO, Spain, 18Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Immunoglobulin A Vasculitis (IgAV) is an inflammatory disease caused by the accumulation of immune complexes of IgA in the walls of small blood vessels…
  • Abstract Number: 0938 • ACR Convergence 2024

    Group 2 Innate Lymphoid Cells Promote T Cell Activation and Development of Autoimmune Arthritis

    Agnieszka Lastowska1, Anders Nguyen2, Miriam Bollmann2 and Mattias Svensson3, 1University of Gothenburg, Goteborg, Sweden, 2University of Gothenburg, Göteborg, Sweden, 3University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Innate Lymphoid Cells (ILCs) are the innate counterparts to T cells and can be divided into three functionally distinct subpopulations: Group 1 (ILC1), Group…
  • Abstract Number: 2506 • ACR Convergence 2024

    THP1-derived Macrophage Polarization in Takayasu Arteritis – Impact of Disease Status and Therapy

    João Paulo dos Santos1, Cristina Orikaza1, Mariana Aguiar2, Gerson Keppeke3 and Alexandre de Souza4, 1Universidade Federal de Sao Paulo, São Paulo, SP, Brazil, 2Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil, 3Universidad Catolica del Norte, São Paulo, Coquimbo, Brazil, 4UNIFESP-EPM, São Paulo, SP, Brazil

    Background/Purpose: Macrophages play an important role in the pathophysiology of Takayasu arteritis (TAK) as granulomatous inflammation is typically found in affected arteries. The expression of…
  • Abstract Number: 0951 • ACR Convergence 2024

    A Feedback Loop Involving mtDNA, Platelets and Neutrophil Extracellular Traps Amplifies Inflammation in Systemic Sclerosis

    Stavros Giaglis1, Diego Kyburz2 and Ulrich Walker3, 1Experimental Rheumatology Laboratory, University of Basel, Basel, Switzerland, 2University Hospital Basel, Basel, Switzerland, 3Basel University Hospital, Basel, Switzerland

    Background/Purpose: Mitochondria are essential eucaryotic cell organelles with several bacterial features, such as a double-stranded circular genome with hypomethylated CpG areas (1). A fundamental role of…
  • Abstract Number: 2518 • ACR Convergence 2024

    Behçet’s Disease Immune Landscape Exhibits a Universal NF-kB-mediated Hyperactivation Pattern with Cell-specific TNFAIP3 Responses and a Superimposed IFN-regulated Endotype

    Yesim Ozguler1, Olivier Manches2, Didar Ucar3, Ziyan Lin2, Alireza Khodadadi-Jamayran2, Aristotelis Tsirigos2, Gulen Hatemi1 and Johannes Nowatzky4, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 2NYU Grossman School of Medicine, New York, NY, 3Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul, Turkey, 4New York University Grossman School of Medicine, New York, NY

    Background/Purpose: The immune landscape of Behçet’s disease (BD) remains ill-defined, lacking a unifying picture, precise disease phenotype-endotype correlations, and an understanding of immunity at target…
  • Abstract Number: 0952 • ACR Convergence 2024

    Single Cell RNA-seq of Scleroderma-associated Interstitial Lung Disease Lung Explants Reveals an Active, Cytotoxic Natural Killer Cell Population

    Cristina Padilla, Eleanor Valenzi, Tracy Tabib, Banafsheh Nazari, Patrizia Fuschiotti and Robert Lafyatis, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Scleroderma-associated interstitial lung disease (SSc-ILD) is the leading cause of death among SSc patients. Loss of alveolar epithelial cells (AEC) and bronchial cell hyperplasia,…
  • Abstract Number: 2540 • ACR Convergence 2024

    Characterizing the Functional Role of Type I Interferons in Inflammatory Arthritis

    Mary Huang, Richard Bell, Toolika Singh and Lionel Ivashkiv, Hospital for Special Surgery, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation due to cellular infiltration and inflammatory mediators. Type I interferons (IFN) have…
  • Abstract Number: 0964 • ACR Convergence 2024

    Engaging the PD-1 Pathway Attenuates Inflammation Associated Fibrosis in Systemic Sclerosis Fibroblasts and a Preclinical Mouse Model

    Maithri Aspari1, Voon Ong2, Klaus Soendergaard3, Esben Naeser4, Malene Hvid4, Angela Tam5, Shiwen Xu5, Christopher Denton6, David Abraham7, Bent Deleuran1 and Stinne Greisen8, 1Aarhus University, Aarhus, Denmark, 2University College London, London, England, United Kingdom, 3Aarhus University Hospital, Aarhus, Denmark, 4AARHUS UNIVERSITET, AARHUS C, Denmark, 5University College London, London, United Kingdom, 6University College London, Northwood, United Kingdom, 7UCL, London, United Kingdom, 8Aarhus University/Aarhus University Hospital, Aarhus, Denmark

    Background/Purpose: The precise molecular mechanisms driving fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) remain to be elucidated. The immune regulatory programmed cell death protein 1…
  • Abstract Number: 2542 • ACR Convergence 2024

    Group 2 Innate Lymphoid Cells Aggravates Development of Inflammatory Arthritis

    Anders Nguyen1, Miriam Bollmann1, Agnieszka Lastowska2, Anna-Karin Hultgård Ekwall1, Dietmar Zaiss3, Gary Firestein4 and Mattias Svensson5, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Goteborg, Sweden, 3University Hospital Regensburg, Regensburg, Germany, 4University of California, San Diego, San Diego, CA, 5University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Activation of fibroblast-like synoviocytes (FLS) by immune cells drives inflammation and joint damage in rheumatoid arthritis (RA). Hence, understanding factors that induce destructive behaviors…
  • Abstract Number: L02 • ACR Convergence 2023

    Mutational Analysis of UNC93B1 Identifies Regulatory Regions Mutated in Human SLE

    John Huizar1, Victoria Rael2, Julian Yano2, Leianna Slayden3, Madeleine Weiss4, Robert Saxton4, Bo Liu5, Olivia Majer6 and Gregory Barton7, 1UCSF, San Francisco, CA, 2Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA, 3HHMI at UC Berkeley, Berkeley, CA, 4UC Berkeley, Berkeley, CA, 5Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shangai, China, 6Max Planck Institute for Infection Biology, Berlin, Germany, 7UC Berkeley / HHMI, Berkeley, CA

    Background/Purpose: Endosomal nucleic acid-sensing toll-like receptors 3, 7 and 9 are key innate immune sensors of dsRNA, ssRNA and ssDNA, respectively, whose activities must be…
  • Abstract Number: L08 • ACR Convergence 2023

    Early Clinical Development of CIT-013, a First in Class NETosis Inhibitor, in a Randomized Phase I Dose Escalation Study in Healthy Volunteers Demonstrating Potent Inhibition of LPS Induced Neutrophil Extracellular Trap Formation

    Leonie Middelink1, Renato Chirivi2, Helmuth van Es2, Eric Meldrum2, Peter van Zandvoort2, Tirza Bruurmijn2, Matthijs Moerland3 and Patrick Round2, 1Middelinc., Utrecht, Netherlands, 2Citryll BV, Oss, Netherlands, 3CHDR, Leiden, Netherlands

    Background/Purpose: Aberrant Neutrophil Extracellular Traps (NETs) production contributes to the pathophysiology of multiple inflammatory and autoimmune diseases such as Rheumatoid arthritis (RA) Hidradenitis suppurativa (HS),…
  • Abstract Number: 0892 • ACR Convergence 2023

    Single-Cell RNA Sequencing Reveals Keratinocytes and Fibroblasts Drive Hippo and TGFb Dysregulation and Fibrosis in Epidermal Overexpression of VGLL3 in Cutaneous Lupus

    Mehrnaz Gharaee-Kermani1, Allison Billi1, Jacob Martens1, Marisa Hildebrandt1, Amanda Victory1, Mitra Maz2, Shannon Loftus1, J. Michelle Kahlenberg1 and Johann E. Gudjonsson1, 1University of Michigan, Ann Arbor, MI, 2University of Michigan Medical School, Ann Arbor, MI

    Background/Purpose: Fibrosis is characterized by collagen deposition, fibro/myofibroblast (MYOFB) accumulation, and extracellular matrix remodeling. In some subtypes of cutaneous lupus erythematosus (CLE), particularly discoid lupus…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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