ACR Meeting Abstracts

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Abstracts tagged "innate immunity"

  • Abstract Number: 1455 • ACR Convergence 2020

    Functional Characterization of PLCG2 Mutations Found in Subjects with Autoinflammation and PLCG2-Associated Antibody Deficiency and Immune Dysregulation (APLAID) Reveals Both Hypermorphic and Hypomorphic Mutants

    Kathleen Baysac1, Charles Fisher2, Hiroto Nakano2, Joshua Milner3 and Michael Ombrello4, 1NIAMS, NIH, Bethesda, MD, 2NIAMS, NIH, Bethesda, 3Division of Allergy, Immunology and Rheumatology Columbia University Medical Center, New York, NY, 4Translational Genetics and Genomics Unit, NIAMS, NIH, Bethesda, MD

    Background/Purpose: PLCG2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammatory PLAID (APLAID) are autosomal dominant diseases caused by mutations of PLCG2. APLAID is clinically characterized by episodic…
  • Abstract Number: 0062 • ACR Convergence 2020

    The Role of PGLYRP1 in the Pathogenesis of Lyme Disease

    Akash Gupta1, Gunjan Arora1, Connor Rosen2, Yongguo Cao1, Jiri Cerny3, Carmen Booth4, Noah Palm2, Aaron Ring2 and Erol Fikrig1, 1Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 2Department of Immunobiology, Yale University School of Medicine, New Haven, CT, 3Faculty of Tropical AgriSciences, Czech University of Life Sciences in Prague, Prague, Czech Republic, 4Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT

    Background/Purpose: Lyme Disease is caused by the spirochete Borrelia Burgdorferi (Bb). The infection often begins in the skin, following a tick bite, and spreads to…
  • Abstract Number: 1517 • ACR Convergence 2020

    Metabolic Regulation of Type 3 Innate Lymphoid Cells by Intestinal Bacteria-Derived Indoles in Ankylosing Spondylitis

    Adam Berlinberg1, Adam Lefferts2, Emilie Regner3, Andrew Stahly4 and Kristine Kuhn4, 1University of Colorado, Denver, CO, 2University of Colorado, Anschutz Medical Campus, Denver, CO, 3University of California San Francisco, San Francisco, CA, 4University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Intestinal microbial dysbiosis, intestinal inflammation, and Th17 immunity are all linked to the pathophysiology of ankylosing spondylitis (AS); however, the mechanisms linking them remain…
  • Abstract Number: 0063 • ACR Convergence 2020

    Novel Repurposed Drugs Against Joint Inflammation Reveal Potential Use for Gout Treatment: An In Silico, In Vitro and Clinical Study

    Eloi Franco-Trepat1, Ana Alonso-Pérez1, Maria Guillán-Fresco1, Miriam López-Fagundez1, Andrés Pazos-Pérez1, Ana Lois Iglesias2, Susana Belén Bravo3, Alberto Jorge-Mora1, JJ Gómez-Reino4 and Rodolfo Gómez1, 1IDIS-CHUS - Musculoskeletal Pathology Group, Santiago de Compostela, Spain, 2IDIS-CHUS - Musculoskeletal Pathology Group, A Coruna, Spain, 3IDIS-CHUS - Proteomics Unit, Santiago de Compostela, Galicia, Spain, 4IDIS-CHUS - Rheumatology Group, Santiago de Compostela, Spain

    Background/Purpose: Joint inflammation is a common feature across multiple rheumatic diseases. To deal with the induction of innate immune factors, targeting therapeutic targets such as…
  • Abstract Number: 1531 • ACR Convergence 2020

    Characterization of Cytokine/chemokine Profile in Patient-derived M1/ M2 Macrophages to Identify Biomarkers for Genetically-defined Systemic Autoinflammatory Diseases

    Farzana Bhuyan1, Adriana Almeida de Jesus2, Kim Johnson3, Jacob Mitchell4, Yan Huang5 and Raphaela Goldbach-Mansky5, 1NIH, bhetesda, MD, 2Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 3NIH, NIAID, Bethesda, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 5NIH, Bethesda

    Background/Purpose: Genetic mutations in key regulatory molecules of the innate immune system cause autoinflammatory diseases through propagation of hyperinflammatory responses. Monocytes/ macrophages regulate inflammatory processes…
  • Abstract Number: 0064 • ACR Convergence 2020

    Neutrophil Extracellular Traps Are Sufficient to Activate the Alternative Pathway of Complement

    Rebecca Schriefer1, Michelle Elvington2, Priyan Weerappuli3 and Alfred Kim4, 1Washington University School of Medicine, Saint Louis, MO, 2Kypha, Inc., Saint Louis, MO, 3University of Michigan, Ann Arbor, MI, 4Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Systemic lupus erythematosus (SLE) replies on complement activation to drive many of the pathophysiologic features of disease. We and others have noted that SLE…
  • Abstract Number: 1636 • ACR Convergence 2020

    8 Years Follow-Up of a Novel Autoinflammatory Disease: CD59 Malfunction Causes Hemolytic Anemia, Recurrent Guillain-Barre Syndrome, and Strokes in Pediatric Populations and Respond Well to Eculizumab and Pozelimab

    Dror Mevorach1 and Netanel Karbian1, 1Hadassah-University Hospital, Jerusalem, Yerushalayim, Israel

    Background/Purpose: In 2013 we have described the first patients with a novel autoinflammatory disease manifested in 4 children with recurrent Guillain-Barre syndrome and hemolytic anemia…
  • Abstract Number: 159 • 2020 Pediatric Rheumatology Symposium

    Interleukin-18 as a Key Cytokine to Understand Pathology and to Decide Appropriate Therapeutic Strategy in Chronic Arthritic Systemic Juvenile Idiopathic Arthritis

    Takako Miyamae1, Yumi Tani 1, Manabu Kawamoto 2, Takayuki Kishi 3 and Masayoshi Harigai 2, 1Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Institute of Rheumatology, Tokyo Women's Medical University, TOKYO, Japan, 3Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Long-term outcomes of systemic JIA are highly variable. approximately half of the patients have chronic persistent arthritis requiring extended anti-inflammatory therapy, sometimes into adulthood.…
  • Abstract Number: 75 • 2019 ACR/ARP Annual Meeting

    Microglia-Specific Transcriptional Signatures Correlate with Behavioral Deficits in ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’

    Hadijat Makinde1, Elise Mike 2, Chaim Putterman 3, Deborah Winter 4 and Carla Cuda 5, 1Northwestern University, Chicago, IL, 2Albert Einstein College of Medicine, Bronx, NY, 3Albert Einstein College of Medicine, New York, NY, 4Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, 5Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune syndrome affecting multiple organs, including the brain. More than 50% of patients experience neuropsychiatric symptoms of…
  • Abstract Number: 76 • 2019 ACR/ARP Annual Meeting

    Effect of Ifnα and Costimulatory Blockade on Brain Infiltration in a Model of ‘Neuropsychiatric Symptoms of Systemic Lupus Erythematosus’

    Hadijat Makinde1, Chirag Raparia 2, Anne Davidson 2 and Carla Cuda 3, 1Northwestern University, Chicago, IL, 2Feinstein Institutes for Medical Research, Manhasset, 3Northwestern University Feinberg School of Medicine, Division of Rheumatology, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 79 • 2019 ACR/ARP Annual Meeting

    Unique Primed Status of Microglia Under the Systemic Autoimmune Condition of Lupus-Prone Mice

    Atsushi Nomura1, Daisuke Noto 2, Goh Murayama 3, Asako Chiba 1 and Sachiko Miyake 1, 1Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, 2Juntendo University School of Medicine, Tokyo, Japan, 3Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the…
  • Abstract Number: 800 • 2019 ACR/ARP Annual Meeting

    Cryopyrin-Associated Periodic Syndrome in Korea: 19 Years of Experience

    Young Ho Kim1, Bongjik Kim 2, Byung Yoon Choi 2, Haeng Jin Lee 3, Dae-Chul Jeong 4, Jinhee Han 2, Hye-Rim Park 2, Jayoung Oh 2, Seungmin Lee 2, Dooyi Oh 5 and Soyoung Lee 1, 1Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Seoul-t'ukpyolsi, Republic of Korea, 2Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Kyonggi-do, Republic of Korea, 3Department of Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea, 4Department of Pediatrics, The Catholic University of Korea, Seoul, Seoul-t'ukpyolsi, Republic of Korea, 5Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul, Kyonggi-do, Republic of Korea

    Background/Purpose: Cryopyrin-associated periodic syndrome (CAPS) is rare auto-inflammatory disorder characterized by recurrent episodes fever with variable manifestation of systemic inflammation such as urticarial skin rash,…
  • Abstract Number: 1020 • 2019 ACR/ARP Annual Meeting

    NLRP12 Regulates Interferon-α Expression and Is a Biomarker for Disease Activity of Systemic Lupus Erythematosus

    Ming-Han Chen1, Yen-Po Tsao 1 and Szu-Ting Chen 2, 1Division of Allergy, Immunology & Rheumatology/Taipei Veterans General Hospital, Taipei, Taiwan (Republic of China), 2Institutes of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (Republic of China)

    Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune disease with diverse etiological factors. It was well recognized that interferon (IFN) signature did the perpetration…
  • Abstract Number: 2736 • 2019 ACR/ARP Annual Meeting

    Mucosal-associated Invariant T Cells Can Be Therapeutically Targeted in Lupus

    Goh Murayama1, Asako Chiba 2, Tomohiro Mizuno 3, Atsushi Nomura 2, Taiga Kuga 4, HIrofumi Amano 4, Ken Yamaji 4, Naoto Tamura 4 and Sachiko Miyake 2, 1Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan, 2Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Immunlogy, Juntendo University School of Medicine, Tokyo, Japan, 4Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate T cells that are restricted by the nonpolymorphic MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain:…
  • Abstract Number: 2807 • 2019 ACR/ARP Annual Meeting

    Activation of the STING Pathway Is a Shared Feature of Salivary Gland and Lung Inflammation in Sjogren’s Syndrome

    Joanna Papinska 1, Grzegorz Gmyrek 2, Umesh Deshmukh1 and Harini Bagavant 1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City

    Background/Purpose: Sjögren’s syndrome is a chronic autoimmune disorder characterized by an increased type 1 interferon gene signature. The engagement of stimulator of interferon genes (STING)…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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