Abstracts tagged "innate immunity"

Abstract Number: 1196 • 2014 ACR/ARHP Annual Meeting
Inflammation Develops in a Toll-like Receptor 9-Independent Manner in Experimental Arthritis and Rheumatoid Arthritis
Julie Mussard¹, Matthieu Ribon¹, Gaelle Clavel², Marie-Christophe Boissier³ and Patrice Decker¹, ¹INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ²Fondation Ophtalmologique A. De Rothschild, Paris cedex 19, France, ³INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology. Toll-like receptor (TLR) 9 recognizes pathogen-derived DNA and even self DNA under certain circumstances.…
Abstract Number: 1199 • 2014 ACR/ARHP Annual Meeting
Alarmins S100A8/S100A9 Aggravate Osteophyte Formation in Experimental Osteoarthritis and Predict Osteophyte Progression in EARLY Human Osteoarthritis in the Dutch Check Cohort
Rik Schelbergen¹, Wouter de Munter², Martijn van den Bosch³, Floris Lafeber⁴, Annet Sloetjes³, Thomas Vogl⁵, Johannes Roth⁵, Peter M. van der Kraan⁶, Arjen B. Blom³, Wim B van den Berg³ and Peter L. van Lent³, ¹Radboud university medical center, Nijmegen, Netherlands, ²Experimental rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁵Immunology, Institute of Immunology University of Muenster, Muenster, Germany, ⁶Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose The main pathological feature of osteoarthritis (OA) is degradation of the articular cartilage. Other important hallmarks include subclinical inflammation of the synovium and ectopic…
Abstract Number: 1044 • 2014 ACR/ARHP Annual Meeting
Novel Compound Cytokine Release Inhibitory Drug 3 (CRID3) Inhibits the NLRP3 Inflammasome in Rheumatoid Arthritis
Trudy McGarry¹, Mary Connolly¹, Rebecca C. Coll², Avril A. B. Robertson³, Matthew A. Cooper³, Luke A. O'Neill², Douglas J. Veale¹ and Ursula Fearon¹, ¹Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, ²Inflammation Research, School of Biochemistry and Immunology, Dublin, Ireland, ³The University of Queensland, Brisbane, Australia
Background/Purpose: The NLRP3 inflammasome is a multi-protein complex activated in response to environmental pathogens. This results in caspase-1-dependant cleavage of pro-IL-1β and IL-18 to their…
Abstract Number: 965 • 2014 ACR/ARHP Annual Meeting
Blockade of TLR4 Signaling By TAK242 Ameliorates Experimental Organ Fibrosis
Swati Bhattacharyya¹, Wenxia Wang¹, Zenshiro Tamaki², Yasuhiro Tsukimi³, Masashi Yamasaki³ and John Varga⁴, ¹Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Takeda Pharmaceutical Company Limited, Kanagawa, Japan, ⁴Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose Our recent studies implicate innate immune signaling through Toll like receptor 4 (TLR4) in scleroderma pathogenesis. Aberrant production and accumulation of the endogenous TLR4…
Abstract Number: 752 • 2014 ACR/ARHP Annual Meeting
Potential Roles of Toll-like Receptor 4 in the Murine Models of Systemic Sclerosis
Takehiro Takahashi, Yoshihide Asano, Yohei Ichimura, Tetsuo Toyama, Takashi Taniguchi, Shinji Noda, Kaname Akamata and Shinichi Sato, Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Bleomycin (BLM)-induced fibrosis model and tight skin mice (TSK/+) model are well-established experimental murine models of human systemic sclerosis (SSc). Growing evidence has demonstrated…
Abstract Number: 1149 • 2013 ACR/ARHP Annual Meeting
Phenotypic and Molecular Profile Of Innate Lymphoid Cells In Chronic Synovial Inflammation
Hulda S. Hreggvidsdottir^1,2, Maureen C. Turina¹, Troy Noordenbos^1,3, Marius Munneke⁴, Charlotte Peters², Jochem Bernink², Jenny Mjosberg⁵, Dominique L. Baeten⁶ and Hergen Spits², ¹Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Tytgat Institute for Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Department of Hematology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Innate lymphoid cells (ILCs) represent a novel family of effector and regulatory cells in innate immunity and tissue remodelling. The family comprises several phenotypically…
Abstract Number: 2500 • 2013 ACR/ARHP Annual Meeting
Mast Cells Are a Major Source Of IL-17 In Synovium and Extra-Articular Tissues In Spondyloarthritis Related Diseases
T. Noordenbos¹, I. Gofita¹, M. Alsina², E.W.M. Vogels³, A. A. te Velde³, J. D. Cañete⁴, Dominique L. Baeten⁵ and N. Yeremenko¹, ¹Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ²Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain, ³Tytgat Institute for Liver and Intestinal Research, Academic Medical Centre/University of Amsterdam, the Netherlands, Amsterdam, Netherlands, ⁴Rheumatology, Hospital Clinic, Barcelona, Spain, ⁵Department of Clinical Immunology and Rheumatology Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: IL-17 plays a key role in the pathogenesis of spondyloarthritis (SpA) as demonstrated by a recent proof-of-concept trial with the anti-IL17A mAb secukinumab. The…
Abstract Number: 1778 • 2013 ACR/ARHP Annual Meeting
Physical Interactions Between Histidyl-tRNA Synthetase and Endogenous/Exogenous Alarmins Enhance Immunogenicity In a Model Of Antigen-Induced Myositis
Irina Fernandez¹, Lisa Harlow², William Ridgway³ and Dana P. Ascherman⁴, ¹Rheumatology, University of Miami, Miami, FL, ²Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ³Immunology, Allergy and Rheumatology, University of Cincinnati, Cincinnati, OH, ⁴Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Objective: To assess the biological interplay between histidyl-tRNA synthetase (HRS) and different endogenous/exogenous ligands capable of generating signals through MyD88-dependent receptor systems in idiopathic inflammatory…
Abstract Number: 1156 • 2013 ACR/ARHP Annual Meeting
Suppression Of Immune Responses and Joint Inflammation By Myeloid-Derived Suppressor Cells In a T Cell-Dependent Mouse Model Of Rheumatoid Arthritis
Katalin Mikecz¹, Julia Kurko¹, Timea Ocsko¹, Andras Vida¹, Beata Tryniszewska¹, Tibor A. Rauch¹, Joel A. Block², Robert S. Katz³, Anjali Nair², Carla R. Scanzello⁴ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Section of Rheumatology, Rush University Medical Center, Chicago, IL, ³Rush Medical College, Chicago, IL, ⁴Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of innate immune cells with immunosuppressive properties. We previously identified MDSCs in the synovial fluid (SF)…
Abstract Number: 1168 • 2013 ACR/ARHP Annual Meeting
Innate Immune Cell Production Of Interleukin-12 Drives CpG-Induced Macrophage Activation Syndrome
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatrics/Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Hemophagocytic syndromes are caused by an uncontrolled systemic inflammatory response resulting in cytopenias, multisystem organ failure, and rapid death, often despite aggressive therapy. Macrophage…

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