Abstracts tagged "inflammatory arthritis"

Abstract Number: 1363 • 2019 ACR/ARP Annual Meeting
Longitudinal Work Transitions in Early Inflammatory Arthritis Patients: Are There Targets for Intervention to Improve Employment?
Lily SH Lim¹, Doris Cheung ¹, Kaviul Mohamed ², Diane Lacaille ³, Eleanor M. Pullenayegum ⁴ and Carol Hitchon ¹, ¹University of Manitoba, Winnipeg, MB, Canada, ²University of Toronto, Toronto, ON, Canada, ³Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada, ⁴Child Health Evaluative Sciences, The Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Background/Purpose: Historically, increasing proportions of patients with rheumatoid arthritis stop working on long-term follow-up, often due to arthritis. The trajectory of work transitions in early…
Abstract Number: 2823 • 2019 ACR/ARP Annual Meeting
Progression to Inflammatory Arthritis After Screening Autoantibody Positive in a Non-Clinical Setting
Jill Norris¹, Elizabeth Bemis ², Marie Feser ³, M. Kristen Demoruelle ⁴, Jennifer Seifert ⁵, Michael Weisman ⁶, Jane Buckner ⁷, Peter Gregersen ⁸, Ted Mikuls ⁹, James O'Dell ⁹, Richard M. Keating ¹⁰, Kevin Deane ³ and V. Michael Holers ⁵, ¹Colorado School of Public Health, Aurora, ²University of Colorado Denver, School of Public Health, Aurora, CO USA, Aurora, ³University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ⁴University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, ⁵University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ⁶David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁷Benaroya Research Institute, Seattle, WA, ⁸Feinstein Institutes for Medical Research, Manhasset, NY, ⁹VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ¹⁰Scrippshealth, La Jolla
Background/Purpose: Rheumatoid arthritis (RA)-related autoantibodies are typically elevated prior to the onset of seropositive RA. Screening for autoantibody (aAb) positive individuals is a means to…
Abstract Number: 1806 • 2019 ACR/ARP Annual Meeting
Inflammatory Arthritis Induced by Immune Checkpoint Inhibitor Therapy: A Distinct Clinical Entity and Immunologic Phenotype
Uma Thanarajasingam¹, Xingxing Zhu ¹, Xian Zhou ¹, Jane Jaquith ¹, Yanfeng Li ¹ and Hu Zeng ¹, ¹Mayo Clinic, Rochester, MN
Background/Purpose: Immune checkpoint inhibitors (ICIs) are being used in the treatment of a variety of malignancies. ICIs target cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell-death…
Abstract Number: 1006 • 2018 ACR/ARHP Annual Meeting
Physical Activity at Lower Intensities Reduces Localized IL-1b in a Murine Model of Gout By Systemically Down-Regulating TLR2 Expression on Circulating Neutrophils and Suppressing CXCL1 Expression
Kyle Jablonski¹, Nicholas A. Young², Bianca Sandoval³, Ifeoma Okafor⁴, Emily Schwarz³, Caitlin Henry³, Peter Harb³, Anuradha Kalyanasundaram⁵, Wael Jarjour⁶ and Naomi Schlesinger⁷, ¹The Ohio State University Wexner Medical Center, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, Columbus, OH, ⁴Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Physiology and Cell Biology, The Ohio State University, Columbus, OH, ⁶Department of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁷Department of Medicine/Rheumatology Division, Rutgers- Robert Wood Johnson Medical School, New Brunswick, New Brunswick, NY
Background/Purpose: Exercise was originally believed to exacerbate inflammation in rheumatic disease, however, recent studies have shown that regular physical activity is anti-inflammatory. In gout, there…
Abstract Number: 1176 • 2018 ACR/ARHP Annual Meeting
Experiences of Urban First Nations and Métis Patients Accessing and Navigating the Health System for Inflammatory Arthritis Care
Cheryl Barnabe¹, Jean Miller², Sylvia Teare², Casey Eaglespeaker³, Brenda Roland⁴, Scott Calling Last⁴, Nicole Eshkakogan⁴, Lynden Crowshoe⁵, Elena Lopatina⁶ and Deborah A. Marshall⁶, ¹Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²O'Brien Institute for Public Health, Calgary, AB, Canada, ³Wisdom Council, Alberta Health Services, Calgary, AB, Canada, ⁴Indigenous Health Program, Alberta Health Services, Calgary, AB, Canada, ⁵Family Medicine, University of Calgary, Calgary, AB, Canada, ⁶Community Health Sciences, University of Calgary, Calgary, AB, Canada
Background/Purpose: Outcome inequities exist for Indigenous patients in Canada with inflammatory arthritis conditions. Primary health services innovations that better support urban Indigenous patients exist, but…
Abstract Number: 1229 • 2018 ACR/ARHP Annual Meeting
Diagnosing Prosthetic Joint Infections in Patients with Inflammatory Arthritis
Serene Z. Mirza¹, Shawn Richardson², Cynthia Kahlenberg², Jason Blevins², Michelle Demetres³, Lily Martin³, Jackie Szymonifka², Peter K. Sculco⁴, Mark P. Figgie⁵ and Susan M. Goodman², ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Weill Cornell Medicine, New York, NY, ⁴Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: Patients with inflammatory arthritis (IA) are at increased risk of prosthetic joint infections, yet differentiating between septic and aseptic failure is a challenge in…
Abstract Number: 1380 • 2018 ACR/ARHP Annual Meeting
Complications Following Total Hip Arthroplasty in Inflammatory Versus Osteoarthritis
Shawn Richardson¹, William Schairer², Cynthia Kahlenberg¹, Thomas P. Sculco³, Peter K. Sculco³, Linda A. Russell⁴, Susan M. Goodman¹ and Mark P. Figgie⁵, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, new york, NY, ³Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁴Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: THA is commonly performed in patients with a history of inflammatory arthritis. These patients are likely at higher risk of complications, from both the…
Abstract Number: 1932 • 2018 ACR/ARHP Annual Meeting
Complications Following Total Knee Arthroplasty in Inflammatory Versus Osteoarthritis
Shawn Richardson¹, William Schairer¹, Cynthia Kahlenberg², Thomas P. Sculco³, Peter K. Sculco³, Linda A. Russell⁴, Susan M. Goodman² and Mark P. Figgie⁵, ¹Hospital for Special Surgery, new york, NY, ²Hospital for Special Surgery, New York, NY, ³Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁴Rheumatology, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: TKA is commonly performed in patients with a history of inflammatory arthritis. These patients are likely at higher risk of complications, from both the…
Abstract Number: 1972 • 2018 ACR/ARHP Annual Meeting
Resolving the Synovial Fluid Proteome and Peptidome for Disease-Specific Mediators of Inflammatory Arthritis
Shalini Mahendran¹, Eleftherios Diamandis² and Vinod Chandran³, ¹Laboratory Medicine and Pathobiology, University of Toronto, Mount Sinai Hospital, Toronto, ON, Canada, ²Pathology and Laboratory Medicine, University of Toronto, Mount Sinai Hospital, University Health Network, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Idiopathic inflammatory arthritis (IA) is a T-cell driven chronic condition characterized an imbalance in cell proliferation and apoptosis leading to significant synovial hyperplasia and…
Abstract Number: 2076 • 2018 ACR/ARHP Annual Meeting
Transmembrane TNF (tmTNF) Transgenic Mice Exhibit Enlarged Lymph Nodes and Elevated Numbers of High Endothelial Cells Associated with Increased Lymphocyte Recruitment
Kim Jeucken¹, Jan Piet van Hamburg², Merlijn Kaaij³, Leonie van Duivenvoorde³, Dominique Baeten³ and Sander W. Tas², ¹2Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: The NF-κB family of transcription factors plays a crucial role in chronic inflammatory diseases and can be activated via two distinct pathways. Non-canonical NF-κB…
Abstract Number: 2432 • 2018 ACR/ARHP Annual Meeting
Peripartum Issues in the Inflammatory Arthritis (IA) Patient: A Survey of the Rapport (Rheumatoid Arthritis Pharmacovigilence Program and Outcomes Research in New Therapies) Registry
Tharindri Dissanayake¹, Stephanie Keeling² and Walter P. Maksymowych³, ¹Department of Medicine, University of Alberta, Division of Rheumatology, Edmonton, AB, Canada, ²Department of Medicine, University of Alberta, University of Alberta, Edmonton, AB, Canada, ³CaRE Arthritis, Edmonton, AB, Canada
Background/Purpose: Multiple issues surround the peripartum period for IA patients including medication use, risk of disease flare and potential impact on neonatal outcomes. We aimed…
Abstract Number: 2457 • 2018 ACR/ARHP Annual Meeting
Association between Biologic Dmards and Weight Change in Patients with Inflammatory Arthritis
Britney Jones¹, Imran Hassan², Walter P. Maksymowych³ and Elaine Yacyshyn⁴, ¹University of Alberta, Edmonton, AB, Canada, ²EPICORE Centre, University of Alberta, Edmonton, AB, Canada, ³CaRE Arthritis, Edmonton, AB, Canada, ⁴Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Inflammatory arthritis (IA) is a chronic disorder that encompasses rheumatoid and psoriatic arthritis. Rheumatoid cachexia is defined as elevated HDL, increased adiposity, and loss…
Abstract Number: 2908 • 2018 ACR/ARHP Annual Meeting
Agreement between Ultrasound and Whole Body Magnetic Resonance Imaging Assessment of Joint Inflammation and Enthesitis in Rheumatoid Arthritis Patients
Sin Ngai Ng¹, Mette Bjørndal Axelsen², Mikkel Østergaard³, Iris Eshed⁴, Merete Lund Hetland², Jakob M. Møller⁵, Susanne J Pedersen^6,7 and Lene Terslev⁸, ¹Medicine, Queen Elizabeth Hospital , Hong Kong, Hong Kong, Hong Kong, ²Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ³Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ⁴Department of Radiology, Sheba Medical Center, Israel, Tel Hashomer, Israel, ⁵Dept. of Radiology, Copenhagen University Hospitals, Herlev and Gentofte, Copenhagen, Denmark, ⁶Depart of Rheumatology VRR, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, ⁷Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ⁸Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark
Background/Purpose: To evaluate the agreement between ultrasound (US), whole body magnetic resonance imaging (WBMRI) and clinical assessment of joint inflammation and enthesitis in rheumatoid arthritis…
Abstract Number: 2957 • 2018 ACR/ARHP Annual Meeting
Socioeconomic Differences in Opioid Use By People with Inflammatory Arthritis
Ashley Fletcher^1,2, Marissa Lassere³, Rachel Black^4,5, Claire Barrett⁶, Graeme Carroll⁷, Susan Lester^8,9, Bethan Richards³, Lyn March¹⁰, Rachelle Buchbinder^11,12 and Catherine Hill^5,13,14, ¹Monash Department of Clinical Epidemiology, Cabrini Institute, Melbourne, Australia, ²Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ³University of New South Wales, Sydney, Australia, ⁴Rheumatology, Royal Adelaide Hospital, Adelaide, Australia, ⁵Medicine, The University of Adelaide, Adelaide, Australia, ⁶Redcliffe Hospital, University of Queensland, Redcliffe, Australia, ⁷Adult Rheumatology and Osteoarthritis, University of Notre Dame, Mount Lawley WA, Australia, ⁸Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia, ⁹Discipline of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia, ¹⁰Department of Rheumatology, Northern Clinical School, Institute of Bone and Joint Research, Kolling Institute, University of Sydney & Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, Australia, ¹¹Cabrini Institute, Victoria, Australia, ¹²Monash University, Melbourne, Australia, ¹³The Queen Elizabeth Hospital, Adelaide, Australia, ¹⁴Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia
Background/Purpose: Internationally, prescription opioid use is often higher among patients of lower socioeconomic status (SES). In addition, despite improved treatments for inflammatory arthritis, opioid use…
Abstract Number: 51 • 2018 ACR/ARHP Annual Meeting
Genetic Ablation of Inducible Nitric Oxide Synthase in TNF Transgenic Mice with Inflammatory-Erosive Arthritis Prevents Lymph Node Expansion and Decreases Synovial Infiltrates
Richard Bell¹, Emily Wu², Lianping Xing³, Christopher T. Ritchlin⁴ and Edward Schwarz⁵, ¹Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ²Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ³University of Rochester Medical Center, Rochester, NY, ⁴Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ⁵Orthopedeatrics, University of Rochester, Rochester, NY
Background/Purpose: Recent studies in the TNF-Tg mouse model of rheumatoid arthritis (RA) demonstrated a critical role of lymphatic vessel (LV) function in joint homeostasis and…

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