ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "inflammatory arthritis"

  • Abstract Number: 0045 • ACR Convergence 2021

    Endothelial Cells from Patients with DMARD Naïve, Active Inflammatory Arthritis Demonstrate Pro-inflammatory Sensitisation That Is Reversed by Therapy Initiation

    Robert Maughan1, Marie Lang1, Anton Olsson1, Andrew Porter1, Antonia Greeves2, Taryn Youngstein3, Charis Pericleous1 and Justin Mason1, 1Imperial College London, London, United Kingdom, 2Hammersmith Hospital, London, United Kingdom, 3Hammersmith Hospital & Imperial College London, London, United Kingdom

    Background/Purpose: Inflammatory arthritides (IA) including rheumatoid arthritis are associated with increased cardiovascular disease (CVD) mortality. Although inflammation-driven endothelial dysfunction is considered a major factor, the…
  • Abstract Number: 0577 • ACR Convergence 2021

    Comorbidity Burden as Scored Using the Rheumatic Disease Comorbidity Index (RDCI) Is Associated with Varying Treatment Patterns in Patients with Inflammatory Arthritis – a Study Using the EHR-Derived Rheumatic and Arthritis Disease Information Registry (RADIR)

    Diviya Rajesh, Deanna Jannat-Khah, Huong Do, Jonah Levine, Medha Barbhaiya, Lisa Mandl and Vivian Bykerk, Hospital for Special Surgery, New York, NY

    Background/Purpose: Higher comorbidity burden (CB) has been associated with treatment choices in RA, but not assessed in populations including multiple forms of inflammatory arthritis (IA)…
  • Abstract Number: 0786 • ACR Convergence 2021

    Diagnostic Utility of FibroScan in Screening for Liver Injury in Patients with Inflammatory Arthritis on Treatment with Methotrexate (MTX)

    Saman Darabian1, john Wade2, Stefanie Wade3, Jason Kur2 and Maziar Badii2, 1University of British Columbia, North Vancouver, BC, Canada, 2University of British Columbia, Vancouver, BC, Canada, 3Beth Israel Deaconess Medical Center, Boston, MA

    Background/Purpose: Methotrexate (MTX) is often the primary medication to treat various rheumatic diseases, including rheumatoid arthritis, psoriasic arthritis and many other inflammatory diseases. MTX is…
  • Abstract Number: 1131 • ACR Convergence 2021

    Interleukin 6 Concentration in Synovial Fluid and Its Clinical Significance

    Ivars Veckalns and Anna Mihailova, Riga Stradins University, Riga, Latvia

    Background/Purpose: Inflammatory arthritis (IA) treated with disease modifying antirheumatic drugs lead to secondary osteoarthritis (OA) due to inflammation, aging, and other factors. Inflammatory arthritis can…
  • Abstract Number: 1510 • ACR Convergence 2021

    Joint CD8+ Tissue Resident Memory Cell Activation Produces Local Inflammatory Arthritis

    Sahar Lotfi-Emran and David Masopust, University of Minnesota, Minneapolis, MN

    Background/Purpose: Following infection, resident memory CD8+ T cells (TRM) populate tissues as long lived sentinel cells. Their aberrant activation can trigger relapsing inflammation in autoimmune…
  • Abstract Number: 2480 • 2019 ACR/ARP Annual Meeting

    Opioid Use Surrounding Diagnosis of Inflammatory Arthritis

    Anna Sheahan1, Victor Sloan 1, Jeffrey Stark 2 and Robert Suruki 1, 1UCB Pharma, Raleigh, NC, 2UCB Pharma, Smyrna, GA

    Background/Purpose: Although treatment of inflammatory arthritis (IA) has improved, opioid use among patients remains common. A study from Finland showed increases in opioid use leading…
  • Abstract Number: 2823 • 2019 ACR/ARP Annual Meeting

    Progression to Inflammatory Arthritis After Screening Autoantibody Positive in a Non-Clinical Setting

    Jill Norris1, Elizabeth Bemis 2, Marie Feser 3, M. Kristen Demoruelle 4, Jennifer Seifert 5, Michael Weisman 6, Jane Buckner 7, Peter Gregersen 8, Ted Mikuls 9, James O'Dell 9, Richard M. Keating 10, Kevin Deane 3 and V. Michael Holers 5, 1Colorado School of Public Health, Aurora, 2University of Colorado Denver, School of Public Health, Aurora, CO USA, Aurora, 3University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, 4University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, 5University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, 6David Geffen School of Medicine at UCLA, Los Angeles, CA, 7Benaroya Research Institute, Seattle, WA, 8Feinstein Institutes for Medical Research, Manhasset, NY, 9VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, 10Scrippshealth, La Jolla

    Background/Purpose: Rheumatoid arthritis (RA)-related autoantibodies are typically elevated prior to the onset of seropositive RA.  Screening for autoantibody (aAb) positive individuals is a means to…
  • Abstract Number: 2857 • 2019 ACR/ARP Annual Meeting

    Decision Tree Analysis to Identify Inflammatory Arthritis Patient Subgroups with Different Levels of Treatment Persistence with First-Line Subcutaneous TNF-alpha Inhibitors

    Emma Hernlund 1, Johan Klint 1, Axel Svedbom 1, Johan Dalén 1, Christopher Black 2 and Amy Puenpatom2, 1ICON plc, Stockholm, Sweden, Stockholm, Sweden, 2Merck & Co., Inc., Kenilworth, NJ, United States, Kenilworth, NJ

    Background/Purpose: The advent of biologic medications, such as subcutaneous TNF-alpha inhibitors (SC-TNFi), has transformed the management of inflammatory arthritis (IA) during the last decades. However,…
  • Abstract Number: 483 • 2019 ACR/ARP Annual Meeting

    Can a Single Question on Functional Impairments Facilitate the Diagnosis of Early Inflammatory Arthritis? A Cross-Sectional Derivation and Validation Study in Two Early Arthritis Recognition Clinics

    Bastiaan van Dijk1, Hanna van Steenbergen 1, Ellis Niemantsverdriet 1 and Annette van der Helm-van Mil 2, 1Leiden University Medical Center, Leiden, Netherlands, 2LUMC, Leiden, Zuid-Holland, Netherlands

    Background/Purpose: Early treatment initiation in RA is associated with improved outcomes but requires early identification of synovitis. Joint swelling in early inflammatory arthritis (IA) may…
  • Abstract Number: 997 • 2019 ACR/ARP Annual Meeting

    Stromal Cell-derived DCSTAMP Coordinates Cell Migration and Osteoclast Activation in TNF-driven Murine Arthritis

    Maria de la luz Garcia-Hernandez1, Javier Rangel-Moreno 2, Benjamin Korman 2, Ananta Paine 1, Nelson Huertas 3 and Christopher T. Ritchlin 3, 1Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, 2University of Rochester Medical center, Rochester, NY, 3University of Rochester, Rochester, NY

    Background/Purpose: DC-STAMP is a transmembrane protein involved in the fusion of mononuclear osteoclasts and essential for the formation of fully functional multinucleated osteoclasts (OCs). Recently…
  • Abstract Number: 1360 • 2019 ACR/ARP Annual Meeting

    Ultrasound Guided Synovial Biopsies Safely Aid in the Assessment of Inflammatory Arthritis

    Khin Lim1, Ami Ben-artzi 1, Lindsy Forbess 1, Swamy Venuturupalli 2, John Jalas 3 and Mariko Ishimori 1, 1Cedars-Sinai Medical Center, Los Angeles, CA, 2Cedars Sinai Medical Center, Los Angeles, CA, 3Saint John Health Center, Los Angeles, CA

    Background/Purpose: Synovial biopsies have an important role in the diagnostic evaluation of patients with undifferentiated inflammatory arthritis (UIA) whose clinical examination and blood and synovial…
  • Abstract Number: 1363 • 2019 ACR/ARP Annual Meeting

    Longitudinal Work Transitions in Early Inflammatory Arthritis Patients: Are There Targets for Intervention to Improve Employment?

    Lily SH Lim1, Doris Cheung 1, Kaviul Mohamed 2, Diane Lacaille 3, Eleanor M. Pullenayegum 4 and Carol Hitchon 1, 1University of Manitoba, Winnipeg, MB, Canada, 2University of Toronto, Toronto, ON, Canada, 3Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada, 4Child Health Evaluative Sciences, The Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada

    Background/Purpose: Historically, increasing proportions of patients with rheumatoid arthritis stop working on long-term follow-up, often due to arthritis. The trajectory of work transitions in early…
  • Abstract Number: 1806 • 2019 ACR/ARP Annual Meeting

    Inflammatory Arthritis Induced by Immune Checkpoint Inhibitor Therapy: A Distinct Clinical Entity and Immunologic Phenotype

    Uma Thanarajasingam1, Xingxing Zhu 1, Xian Zhou 1, Jane Jaquith 1, Yanfeng Li 1 and Hu Zeng 1, 1Mayo Clinic, Rochester, MN

    Background/Purpose: Immune checkpoint inhibitors (ICIs) are being used in the treatment of a variety of malignancies. ICIs target cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell-death…
  • Abstract Number: 1842 • 2019 ACR/ARP Annual Meeting

    Patients and Relatives Coping with Inflammatory Arthritis: Impact of Communication, Social Support and Relatives Burden on Patients Perceived Health

    Morgane Brignon 1, Catherine Beauvais 2, Martine Beranger 3, Jean-David Cohen 4, Isabelle Griffoul 5, Janine Sophie Le Quintrec 6, Didier Poivret 7, Corinne Thevenot 8, Sonia Trope 9 and Anne-Christine Rat10, 1Université de Lorraine, EA 4360 APEMAC, Nancy, France, 2Saint-Antoine Hospital, Hôpitaux universitaires Est Parisien, AP–HP, Paris, France, 3Orléans Hospital, Orléans, France, 4Montpellier University hospital, Montpellier, France, 5Tours University Hospital, Tours, France, 6Cochin University Hospital, Paris, France, 7Metz Hospital, Metz, France, 8Laon Hospital, Laon, France, 9Andar, Montpellier, France, 10CHU Caen, rheumatology department, Caen Normandie University, Université de Lorraine, EA 4360 APEMAC, Caen, France

    Background/Purpose: Relatives’ and patients’ adjustment to a chronic disease is complex, and there is room for improvement in the support provided to the dyad. So…
  • Abstract Number: 1901 • 2019 ACR/ARP Annual Meeting

    Serious Infections in Offspring Exposed in Utero to Non-TNFi Biologics and Tofacitinib

    Evelyne Vinet1, Yvan St-Pierre 1, Cristiano S. Moura 1, Jeffrey Curtis 2 and Sasha Bernatsky 3, 1McGill University Health Centre, Montreal, QC, Canada, 2University of Alabama at Birmingham, Birmingham, AL, 3Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: During pregnancy, maternal circulating immunoglobulins G (IgG) are actively transported across the placenta through their Fc portion. Thus, TNFi and other biologics harbouring an Fc…
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