Abstracts tagged "inflammatory arthritis"

Abstract Number: 0045 • ACR Convergence 2021
Endothelial Cells from Patients with DMARD Naïve, Active Inflammatory Arthritis Demonstrate Pro-inflammatory Sensitisation That Is Reversed by Therapy Initiation
Robert Maughan¹, Marie Lang¹, Anton Olsson¹, Andrew Porter¹, Antonia Greeves², Taryn Youngstein³, Charis Pericleous¹ and Justin Mason¹, ¹Imperial College London, London, United Kingdom, ²Hammersmith Hospital, London, United Kingdom, ³Hammersmith Hospital & Imperial College London, London, United Kingdom
Background/Purpose: Inflammatory arthritides (IA) including rheumatoid arthritis are associated with increased cardiovascular disease (CVD) mortality. Although inflammation-driven endothelial dysfunction is considered a major factor, the…
Abstract Number: 0577 • ACR Convergence 2021
Comorbidity Burden as Scored Using the Rheumatic Disease Comorbidity Index (RDCI) Is Associated with Varying Treatment Patterns in Patients with Inflammatory Arthritis – a Study Using the EHR-Derived Rheumatic and Arthritis Disease Information Registry (RADIR)
Diviya Rajesh, Deanna Jannat-Khah, Huong Do, Jonah Levine, Medha Barbhaiya, Lisa Mandl and Vivian Bykerk, Hospital for Special Surgery, New York, NY
Background/Purpose: Higher comorbidity burden (CB) has been associated with treatment choices in RA, but not assessed in populations including multiple forms of inflammatory arthritis (IA)…
Abstract Number: 0786 • ACR Convergence 2021
Diagnostic Utility of FibroScan in Screening for Liver Injury in Patients with Inflammatory Arthritis on Treatment with Methotrexate (MTX)
Saman Darabian¹, john Wade², Stefanie Wade³, Jason Kur² and Maziar Badii², ¹University of British Columbia, North Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Methotrexate (MTX) is often the primary medication to treat various rheumatic diseases, including rheumatoid arthritis, psoriasic arthritis and many other inflammatory diseases. MTX is…
Abstract Number: 1131 • ACR Convergence 2021
Interleukin 6 Concentration in Synovial Fluid and Its Clinical Significance
Ivars Veckalns and Anna Mihailova, Riga Stradins University, Riga, Latvia
Background/Purpose: Inflammatory arthritis (IA) treated with disease modifying antirheumatic drugs lead to secondary osteoarthritis (OA) due to inflammation, aging, and other factors. Inflammatory arthritis can…
Abstract Number: 1510 • ACR Convergence 2021
Joint CD8+ Tissue Resident Memory Cell Activation Produces Local Inflammatory Arthritis
Sahar Lotfi-Emran and David Masopust, University of Minnesota, Minneapolis, MN
Background/Purpose: Following infection, resident memory CD8+ T cells (TRM) populate tissues as long lived sentinel cells. Their aberrant activation can trigger relapsing inflammation in autoimmune…
Abstract Number: 997 • 2019 ACR/ARP Annual Meeting
Stromal Cell-derived DCSTAMP Coordinates Cell Migration and Osteoclast Activation in TNF-driven Murine Arthritis
Maria de la luz Garcia-Hernandez¹, Javier Rangel-Moreno ², Benjamin Korman ², Ananta Paine ¹, Nelson Huertas ³ and Christopher T. Ritchlin ³, ¹Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, ²University of Rochester Medical center, Rochester, NY, ³University of Rochester, Rochester, NY
Background/Purpose: DC-STAMP is a transmembrane protein involved in the fusion of mononuclear osteoclasts and essential for the formation of fully functional multinucleated osteoclasts (OCs). Recently…
Abstract Number: 1360 • 2019 ACR/ARP Annual Meeting
Ultrasound Guided Synovial Biopsies Safely Aid in the Assessment of Inflammatory Arthritis
Khin Lim¹, Ami Ben-artzi ¹, Lindsy Forbess ¹, Swamy Venuturupalli ², John Jalas ³ and Mariko Ishimori ¹, ¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Cedars Sinai Medical Center, Los Angeles, CA, ³Saint John Health Center, Los Angeles, CA
Background/Purpose: Synovial biopsies have an important role in the diagnostic evaluation of patients with undifferentiated inflammatory arthritis (UIA) whose clinical examination and blood and synovial…
Abstract Number: 1363 • 2019 ACR/ARP Annual Meeting
Longitudinal Work Transitions in Early Inflammatory Arthritis Patients: Are There Targets for Intervention to Improve Employment?
Lily SH Lim¹, Doris Cheung ¹, Kaviul Mohamed ², Diane Lacaille ³, Eleanor M. Pullenayegum ⁴ and Carol Hitchon ¹, ¹University of Manitoba, Winnipeg, MB, Canada, ²University of Toronto, Toronto, ON, Canada, ³Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada, ⁴Child Health Evaluative Sciences, The Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Background/Purpose: Historically, increasing proportions of patients with rheumatoid arthritis stop working on long-term follow-up, often due to arthritis. The trajectory of work transitions in early…
Abstract Number: 2823 • 2019 ACR/ARP Annual Meeting
Progression to Inflammatory Arthritis After Screening Autoantibody Positive in a Non-Clinical Setting
Jill Norris¹, Elizabeth Bemis ², Marie Feser ³, M. Kristen Demoruelle ⁴, Jennifer Seifert ⁵, Michael Weisman ⁶, Jane Buckner ⁷, Peter Gregersen ⁸, Ted Mikuls ⁹, James O'Dell ⁹, Richard M. Keating ¹⁰, Kevin Deane ³ and V. Michael Holers ⁵, ¹Colorado School of Public Health, Aurora, ²University of Colorado Denver, School of Public Health, Aurora, CO USA, Aurora, ³University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, CO, ⁴University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Aurora, ⁵University of Colorado Denver, Division of Rheumatology, Aurora, CO, USA, Denver, ⁶David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁷Benaroya Research Institute, Seattle, WA, ⁸Feinstein Institutes for Medical Research, Manhasset, NY, ⁹VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ¹⁰Scrippshealth, La Jolla
Background/Purpose: Rheumatoid arthritis (RA)-related autoantibodies are typically elevated prior to the onset of seropositive RA. Screening for autoantibody (aAb) positive individuals is a means to…
Abstract Number: 1806 • 2019 ACR/ARP Annual Meeting
Inflammatory Arthritis Induced by Immune Checkpoint Inhibitor Therapy: A Distinct Clinical Entity and Immunologic Phenotype
Uma Thanarajasingam¹, Xingxing Zhu ¹, Xian Zhou ¹, Jane Jaquith ¹, Yanfeng Li ¹ and Hu Zeng ¹, ¹Mayo Clinic, Rochester, MN
Background/Purpose: Immune checkpoint inhibitors (ICIs) are being used in the treatment of a variety of malignancies. ICIs target cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), programmed cell-death…
Abstract Number: 1842 • 2019 ACR/ARP Annual Meeting
Patients and Relatives Coping with Inflammatory Arthritis: Impact of Communication, Social Support and Relatives Burden on Patients Perceived Health
Morgane Brignon ¹, Catherine Beauvais ², Martine Beranger ³, Jean-David Cohen ⁴, Isabelle Griffoul ⁵, Janine Sophie Le Quintrec ⁶, Didier Poivret ⁷, Corinne Thevenot ⁸, Sonia Trope ⁹ and Anne-Christine Rat¹⁰, ¹Université de Lorraine, EA 4360 APEMAC, Nancy, France, ²Saint-Antoine Hospital, Hôpitaux universitaires Est Parisien, AP–HP, Paris, France, ³Orléans Hospital, Orléans, France, ⁴Montpellier University hospital, Montpellier, France, ⁵Tours University Hospital, Tours, France, ⁶Cochin University Hospital, Paris, France, ⁷Metz Hospital, Metz, France, ⁸Laon Hospital, Laon, France, ⁹Andar, Montpellier, France, ¹⁰CHU Caen, rheumatology department, Caen Normandie University, Université de Lorraine, EA 4360 APEMAC, Caen, France
Background/Purpose: Relatives’ and patients’ adjustment to a chronic disease is complex, and there is room for improvement in the support provided to the dyad. So…
Abstract Number: 1901 • 2019 ACR/ARP Annual Meeting
Serious Infections in Offspring Exposed in Utero to Non-TNFi Biologics and Tofacitinib
Evelyne Vinet¹, Yvan St-Pierre ¹, Cristiano S. Moura ¹, Jeffrey Curtis ² and Sasha Bernatsky ³, ¹McGill University Health Centre, Montreal, QC, Canada, ²University of Alabama at Birmingham, Birmingham, AL, ³Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: During pregnancy, maternal circulating immunoglobulins G (IgG) are actively transported across the placenta through their Fc portion. Thus, TNFi and other biologics harbouring an Fc…
Abstract Number: 2264 • 2019 ACR/ARP Annual Meeting
Prescribing Exercise: Facilitators and Barriers to the Successful Implementation of Physical Activity Guidelines in Inflammatory Arthritis
Lauren Freid¹, Alexis Ogdie ² and Joshua Baker ³, ¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA
Background/Purpose: Physical Activity (PA) is beneficial for people with inflammatory arthritis (IA). In 2018, EULAR published the first recommendations for guiding PA in patients with…
Abstract Number: 2273 • 2019 ACR/ARP Annual Meeting
Risk of Serious Infections in Offspring According to TNFi Subtypes
Evelyne Vinet¹, Yvan St-Pierre ¹, Cristiano S. Moura ¹, Jeffrey Curtis ² and Sasha Bernatsky ³, ¹McGill University Health Centre, Montreal, QC, Canada, ²University of Alabama at Birmingham, Birmingham, AL, ³Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: TNFi subtypes have differential placental transfer, with some reaching higher fetal than maternal blood levels. Thus, certain TNFi subtypes could cause immunosuppression in the offspring.…
Abstract Number: 2369 • 2019 ACR/ARP Annual Meeting
Treatment Patterns with Disease Modifying Anti-rheumatic Drugs in United States Veterans with Newly Diagnosed Rheumatoid Arthritis, Psoriatic Arthritis, or Ankylosing Spondylitis
Rebecca Overbury¹, Shaobo Pei ², Gopi Penmetsa ³, Brian Sauer ², Vikas Patil ², Jodi Walker ⁴, Jerry Clewell ⁴, Kevin Douglas ⁴, Daniel Clegg ⁵, Grant Cannon ⁶, Ahmad Halwani ⁷ and Jessica Walsh ⁸, ¹Assisstant Professor, University of Utah, Salt Lake City, UT, ²Division of Epidemiology, Department of Internal Medicine, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, ³Gopi K. Penmetsa, MD, Division of Rheumatology, Department of Internal Medicine, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, ⁴AbbVie Inc., Salt Lake City, UT, ⁵University of Utah, Salt Lake City, UT, ⁶Salt Lake City VA Medical Center and Univeristy of Utah, Salt Lake City, UT, ⁷Division of Hematology, Department of Internal Medicine, Salt Lake City Veteran Affairs and University of Utah Medical Centers, Salt Lake City, UT, ⁸Division of Rheumatology, University of Utah, Salt Lake City, UT
Background/Purpose: Delays in treatment for inflammatory arthritis (IA) are associated with unfavorable outcomes, including impaired quality of life, irreversible joint damage, and disability. Our objective…

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