Abstracts tagged "Inflammation"

Abstract Number: 757 • 2018 ACR/ARHP Annual Meeting
Urinary Galectin-3 Binding Protein As a Novel Biomarker of Renal Disease Activity in Lupus Nephritis
Huihua Ding¹, Cheng Ling², Roberto Bassi³, Shinji L Okitsu⁴, Julie A. DeMartino⁴ and Nan Shen¹, ¹Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, ²Department of Rheumatology, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁴TIP Immunology, EMD Serono Research and Development Institute, Inc., Billerica, MA
Background/Purpose: Lupus nephritis (LN) is one of the most common and severe manifestations of systemic lupus erythematosus (SLE). This study investigates urinary galecting-3 binding protein…
Abstract Number: 2005 • 2018 ACR/ARHP Annual Meeting
Identification of a Human Cartilage Microbial DNA Signature and Characterization of Distinct Microbiome Profiles Associated with Osteoarthritis
Chris Dunn^1,2, Cassandra Velasco^1,3, Alexander Rivas⁴, Madison Andrews^3,5, Paul Jacob⁶ and Matlock A. Jeffries^2,7, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴University of Arkansas for Medical Sciences, Little Rock, AR, ⁵Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Oklahoma Sport Science and Orthopedics, Oklahoma City, OK, ⁷Department of Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is both the most common form of arthritis and a leading cause of chronic disability. Bacterial products, including lipopolysaccharide (LPS), have been…
Abstract Number: 796 • 2018 ACR/ARHP Annual Meeting
Demographic and Clinical Features of Systemic Sclerosis Patients with Anti-U1RNP Antibodies: A European Scleroderma Trials and Research (EUSTAR) Analysis
Wanlong Wu^1,2, Petra Hoederath¹, Eric Hachulla³, Paolo Airò⁴, Gabriele Valentini⁵, Marco Matucci Cerinic⁶, Franco Cozzi⁷, Gabriela Riemekasten⁸, Yannick Allanore⁹, Patricia Carreira¹⁰, Suzana Jordan¹¹ and Oliver Distler¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, South Campus, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Department of Internal Medicine and Clinical Immunology, Hôpital Claude Huriez, University of Lille, Lille, France, ⁴Rheumatology and Clinical immunology Unit, Spedali Civili of Brescia, Brescia, Italy, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ⁶Division of Rheumatology, Division of Rheumatology, University of Florence, Florence, Italy, ⁷Division of Rheumatology, Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ⁸Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, ⁹Cochin Hospital, Paris Descartes University, Paris, France, Paris, France, ¹⁰Servicio de Reumatologia, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹¹Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Anti-U1RNP antibodies can be detected in patients with systemic sclerosis (SSc). However, their prevalence and clinical correlation with organ-specific complications have not been well…
Abstract Number: 2006 • 2018 ACR/ARHP Annual Meeting
Murine Ear Wound Cartilage Superhealer Trait Is Associated with Gut Microbiota Changes and Is Transferable to Non-Healer Mice By Gut Microbiome Transplant
Chris Dunn^1,2, Cassandra Velasco^1,3, Madison Andrews^3,4, Alexander Rivas⁵ and Matlock A. Jeffries^2,6, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵University of Arkansas for Medical Sciences, Little Rock, AR, ⁶Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. Previous studies…
Abstract Number: 86 • 2017 ACR/ARHP Annual Meeting
Regulation of Interleukin-1β Signaling By Inhibition of O-Glc-Nacase in Rheumatoid Arthritis Synovial Fibroblasts
Mahamudul Haque¹, Anil Singh², Kelly Kopczynski¹ and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, ²Washington State University, College of Pharmacy, Spokane, WA
Background/Purpose: O-GlcNAcylation is an important post-translational modification of nuclear and cytosolic proteins involved in the cytokine signaling networks. Studies show both pro- and anti-inflammatory roles…
Abstract Number: 1203 • 2017 ACR/ARHP Annual Meeting
Differences in Serum Protein Biomarkers between Combined Glucosamine and Chondroitin Versus Celecoxib Treatment in a Randomized, Double-Blind Trial in Osteoarthritis Patients
Sandi L Navarro¹, Marta Herrero², Helena Martinez², Jon Ladd¹, Yuzheng Zhang¹, Edward Lo¹, David Shelley¹, Timothy W Randolph¹, Yvonne Schwarz¹, Johanna W Lampe¹ and Paul D Lampe¹, ¹Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, ²Clinical R&D Area, Bioiberica, SAU, Barcelona, Spain
Background/Purpose: Non-steroidal anti-inflammatory drugs, e.g., celecoxib, are commonly used for inflammatory conditions, including osteoarthritis (OA), but are associated with adverse effects. Combined glucosamine hydrochloride plus…
Abstract Number: 1949 • 2017 ACR/ARHP Annual Meeting
Anti-Inflammatory Effects of Standardized Platelet-Rich Plasma Releasates in Knee and Hip OA Chondrocytes
Lucia Gato-Calvo¹, Ángela Vela-Anero², Elena F. Burguera¹ and Francisco J Blanco³, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade de A Coruña (UDC), A Coruña, Spain, ²Cell Therapy and Regenerative Medicine Group, Department of Medicine, University of A Coruña, A Coruña, Spain, ³Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña,15006 A Coruña-Spain, A Coruña, Spain
Background/Purpose : There is a need to standardize platelet-rich plasma (PRP)-derived products and their dosage to evaluate efficacy for each intended indication. Our purpose here…
Abstract Number: 165 • 2017 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Risk Polymorphisms in CCR6, SNP and Estrogen-Dependent Response to Immune Mediator Gene Expression, and NF-κb Transcriptional Activity: Crosstalk between the Immune and Endocrine Systems
Ming-Fen Ho¹, Tim Bongartz², James N. Ingle³, Liewei Wang¹ and Richard M. Weinshilboum¹, ¹Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, ²Emergency Medicine, Vanderbilt University, Nashville, TN, ³Department of Medical Oncology, Mayo Clinic, Rochester, MN
Background/Purpose: The rheumatoid arthritis (RA) risk locus CCR6 rs3093024 SNP is associated with increased risk of RA in a sex-specific pattern in Asian populations. Specifically,…
Abstract Number: 1205 • 2017 ACR/ARHP Annual Meeting
Effectiveness of Low-Dose Radiation Therapy on Symptoms in Knee Osteoarthritis: First Results of a Triple Blinded, Randomized Controlled Trial
E.A.M. Mahler¹, M.J.M Minten¹, M.M. Leseman-Hoogenboom², P.M.P. Poortmans², S.S. Boks³, J.W.J. Bijlsma⁴, F.H.J. van den Hoogen^1,5, A.A. Den Broeder^1,5 and C.H.M. van den Ende^1,5, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Radiation Therapy, Radboud university medical centre, Nijmegen, Netherlands, ³Radiology, Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁵Rheumatology, Radboud university medical centre, Nijmegen, Netherlands
Background/Purpose: Previous research in animal osteoarthritis (OA) has shown that low-dose radiation therapy (LD-RT) exerts anti-inflammatory effects, but a systematic review concluded that the evidence…
Abstract Number: 2016 • 2017 ACR/ARHP Annual Meeting
Favourable Changes in Power Doppler Scores in the Feet over 1-Year in an Early Rheumatoid Arthritis Cohort: The Role of Rheumatoid Factor and Anti–Citrullinated Protein Antibody
Karen A. Beattie¹, Hanyan Zou², George Ioannidis³ and Maggie Larche¹, ¹Medicine, McMaster University, Hamilton, ON, Canada, ²McMaster University, Hamilton, ON, Canada, ³St Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Background/Purpose : MTP joints are seldom examined in routine clinical visits. As such, it is important to understand how the standard treatment of patients with…
Abstract Number: 298 • 2017 ACR/ARHP Annual Meeting
Anabasum (JBT-101) Enhances Resolution of Inflammation in Humans
Madhur Motwani¹, Fran Bennett¹, Mark Tepper², Barbara White², Paul Norris³, Raymond MacAllister¹, Charles Serhan³ and Derek Gilroy¹, ¹University College London, London, United Kingdom, ²Corbus Pharmaceuticals, Norwood, MA, ³Harvard Medical School, Cambridge, MA
Background/Purpose: Certain rheumatic diseases including systemic sclerosis (SSc) are characterized by chronic activation of innate immune responses, leading to excessive fibrosis. A normal innate…
Abstract Number: 1333 • 2017 ACR/ARHP Annual Meeting
Mortality of Tumor Necrosis Factor Transgenic Arthritic Mice with Interstitial Lung Disease Occurs with Pulmonary Arteriole Thickening and Right Ventricular Hypertrophy but Is Not Associated with Inducible Nitric Oxide Synthase Dependent Inflammatory Cell Infiltration
Richard Bell¹, Emily Wu^1,2, Homaira Rahimi³ and Edward Schwarz^1,4,5, ¹Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ²Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, ³Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY, ⁴University of Rochester, Rochester, NY, ⁵Univ of Rochester Med Ctr, University of Rochester School of Medicine and Dentistry, Rochester, NY
Background/Purpose: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) occurs in up to 15% of RA patients, whose median survival expectancy after diagnosis is only 2.6…
Abstract Number: 2063 • 2017 ACR/ARHP Annual Meeting
Relation of Serum Urate and Gout Duration to Tophi, Urate Deposition, and Inflammation
Ana Beatriz Vargas-Santos¹, S. Reza Jafarzadeh², Geraldo Castelar-Pinheiro¹, Nicola Dalbeth³, William J. Taylor⁴, Jaap Fransen⁵, Tim L. Jansen⁶, H. Ralph Schumacher⁷ and Tuhina Neogi², ¹Internal Medicine - Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³University of Auckland, Auckland, New Zealand, ⁴Department of Medicine, University of Otago, Wellington, New Zealand, ⁵Department of Rheumatolgy, Radboud University Medical Center, Nijmegen, Netherlands, ⁶Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ⁷Medicine, Rheumatology, U Penn & VA Med Ctr, Philadelphia, PA
Background/Purpose: Gout duration and serum urate (SU) levels are thought to influence development of tophi and chronic inflammatory gouty arthropathy, but the extent to which…
Abstract Number: 299 • 2017 ACR/ARHP Annual Meeting
Bik Plays an Important Role of Cell Proliferation Caused By Nitric Oxide in Rheumatoid Arthritis Synovium
Takeshi Ueha¹, Yoshitada Sakai¹, Kohjin Suzuki², Koji Fukuda³, Toshihisa Maeda³, Hanako Nishimoto³, Shinya Hayashi⁴, Yasushi Miura⁴, Ryosuke Kuroda³ and Akira Hashiramoto², ¹Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, ³Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Nitric oxide (NO), a proinflammatory mediator responsible for various physiological processes, plays a central role in the pathogenesis of rheumatoid arthritis (RA). As a…
Abstract Number: 1335 • 2017 ACR/ARHP Annual Meeting
p62/SQSTM1 Modulates Bone Erosions in a Murine Model of Rheumatoid Arthritis
Adelheid Korb-Pap¹, Anja Römer-Hillmann¹, Marianne Heitzmann¹, Masaru Kato², Kerstin Klein², Caroline Ospelt², Steffen Gay³, Susanne Buergis⁴, Thomas Pap¹, Thomas Weide⁵, André Gessner⁴ and Hermann Pavenstädt⁵, ¹Institute of Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ²Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland, ³Center of Experimental Rheumatology, University Hospital Zürich, Zürich, Switzerland, ⁴Department of Immunology, University Erlangen, Erlangen, Germany, ⁵Department of Nephrology and Rheumatology, University Hospital Muenster, Muenster, Germany
Background/Purpose: Rheumatoid arthritis (RA) is characterised by massive bone erosions leading to irreversible joint destructions. In this context, the multi-adapter protein p62/SQSTM1 is of interest…

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