ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0916 • ACR Convergence 2021

    Disease Activity and Inflammation in Axial Spondyloarthritis Patients Who Did Not Experience Flares Following Certolizumab Pegol Withdrawal, Dose Reduction or Dose Continuation

    Lianne Gensler1, Xenofon Baraliakos2, Lars Bauer3, Bengt Hoepken3, Thomas Kumke3, Mindy Kim4 and Robert Landewé5, 1Department of Rheumatology, University of California San Francisco, San Francisco, CA, 2Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 3UCB Pharma, Monheim am Rhein, Germany, 4UCB Pharma, Smyrna, GA, 5Amsterdam Rheumatology & Clinical Immunology Center, Amsterdam, Netherlands; Zuyderland MC, Heerlen, Netherlands

    Background/Purpose: C-OPTIMISE was a phase 3b study investigating certolizumab pegol (CZP) maintenance dose continuation, reduction or withdrawal following achievement of sustained remission in patients with…
  • Abstract Number: 1196 • ACR Convergence 2021

    Morning Stiffness Already Associates with Systemic Inflammation and Subclinical Joint Inflammation in the Pre-RA Phase of Arthralgia

    Doortje Krijbolder1, Fenne Wouters1, Elise van Mulligen2 and Annette H.M van der Helm-van Mil1, 1Leiden University Medical Center, Leiden, Netherlands, 2Erasmus Medical Center, Rotterdam, Netherlands

    Background/Purpose: Morning stiffness (MS) is characteristic for Rheumatoid Arthritis (RA) and associates with markers of systemic and local inflammation in RA-patients. In patients with arthralgia,…
  • Abstract Number: 1625 • ACR Convergence 2021

    Clinical Characteristics of Multisystem Inflammatory Syndrome in Children: A Provincial Cohort

    Herman Tam1, Alison Lopez2, Mona Patel2, Jonathan Rayment3, Lori Tucker4 and Catherine Biggs5, 1Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada, 2British Columbia Children's Hospital, University of British Columbia, Vancouver, BC, Canada, 3British Columbia Children’s Hospital, University of British Columbia, Vancouver, BC, Canada, 4BC Children's Hospital, Vancouver, BC, Canada, 5[email protected], Vancouver, BC, Canada

    Background/Purpose: Multisystem Inflammatory Syndrome in Children (MIS-C) is a post-infectious complication of COVID-19 infection with overlapping features of Kawasaki Disease (KD) and Toxic Shock Syndrome…
  • Abstract Number: L03 • ACR Convergence 2020

    Efficacy and Safety of Deucravacitinib (BMS-986165), an Oral, Selective Tyrosine Kinase 2 Inhibitor, in Patients with Active Psoriatic Arthritis: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial

    Philip Mease1, Atul Deodhar2, Désirée van der Heijde3, Frank Behrens4, Alan Kivitz5, Jonghyeon Kim6, Shalabh Singhal6, Miroslawa Nowak6 and Subhashis Banerjee6, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Oregon Health & Science University, Portland, OR, 3Leiden University Medical Center, Leiden, Netherlands, 4CIRI/Rheumatology and Fraunhofer Institute IME, Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany, 5Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 6Bristol Myers Squibb, Princeton, NJ

    Background/Purpose: Tyrosine kinase 2 (TYK2) is an intracellular kinase that mediates signaling by key cytokines involved in psoriatic arthritis (PsA) pathophysiology. Deucravacitinib (BMS-986165) is a…
  • Abstract Number: L06 • ACR Convergence 2020

    Mavrilimumab (anti GM-CSF Receptor α Monoclonal Antibody) Reduces Time to Flare and Increases Sustained Remission in a Phase 2 Trial of Patients with Giant Cell Arteritis

    Maria C. Cid1, Sebastian Unizony2, Lara Pupim3, Fang Fang4, Joseph Pirrello3, Ai Ren4, Manoj Samant4, Teresa Zhou4 and John F Paolini4, 1Hospital Clinic Barcelona, Barcelona, Spain, 2Massachusetts General Hospital, Boston, MA, 3Kiniksa Pharmaceuticals, Lexington, MA, 4Kiniksa Pharmaceuticals, Lexington

    Background/Purpose: T helper (Th)1 and Th17 lymphocytes play a role in the pathogenesis of giant cell arteritis (GCA). Current treatments (e.g., corticosteroids and tocilizumab) target…
  • Abstract Number: 0073 • ACR Convergence 2020

    A Cross-Species Map of Neutrophil Inflammatory Responses

    Felix Radtke1, Frank Huang2, Peter Nigrovic3 and Ricardo Grieshaber-Bouyer4, 1Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Baden-Wurttemberg, Germany, 2Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany, Darmstadt, Baden-Wurttemberg, Germany, 3Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston, 4Department of Medicine V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital, Heidelberg, Germany; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA, Heidelberg, Germany

    Background/Purpose: Neutrophils are important mediators of immune defense as well as key protagonists in immune-mediated disease. How these cells adapt differently to sterile and septic…
  • Abstract Number: 0528 • ACR Convergence 2020

    The Complex Relationship Between C4b Binding Protein, Warfarin and Antiphospholipid Antibodies

    Giorgia Grosso1, Kerstin Sandholm2, Aleksandra Antovic1, Iva Gunnarsson1, Agneta Zickert1, Anna Vikerfors3, Lennart Truedsson4, Maria Bruzelius1, Bo Nilsson5, Kristina Nilsson Ekdahl5 and Elisabet Svenungsson1, 1Karolinska University Hospital, Stockholm, Sweden, 2Linnaeus Center for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden, 3Swedish Medical Products Agency, Uppsala, Sweden, 4Lunds University, Lund, Sweden, 5Uppsala University, Uppsala, Sweden

    Background/Purpose: C4b Binding Protein (C4BP) is the main inhibitor of the classical complement pathway. Both β2glycoprotein-I (β2GPI), the main antigen in the antiphospholipid syndrome (APS),…
  • Abstract Number: 0772 • ACR Convergence 2020

    Modification of THP-1 Cells with Malondialdehyde-Acetaldehyde Increases Cellular Calcium Load Rendering Cells Susceptible to Citrullination of Self-Proteins

    Nozima Aripova1, Michael Duryee1, Xiarepati Tieliwaerdi1, Xiaoting Jiang1, Lynell Klassen2, James O'Dell1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Univerisity of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The post translational modification of self-proteins with malondialdehyde-acetaldehyde (MAA) has been shown to alter protein function and antibodies to MAA are increased in both…
  • Abstract Number: 1041 • ACR Convergence 2020

    Pharmaco-epidemiology of Non-infectious Ocular Inflammatory Disease in a Tertiary Academic Center

    Sanjeev Patil1, Justine Cheng2, Lorraine Provencher3 and Scott Vogelgesang4, 1University of Vermont Medical Center, Essex Junction, VT, 2University of Iowa Hospitals and Clinics, Iowa City, IA, 3Cincinnati Eye Institute, Cincinnati, OH, 4University of Iowa Hospitals and Clinics, Iowa City, IA

    Background/Purpose: Non-Infectious Ocular inflammatory disease (OID) is a group of immune-mediated diseases involving the ocular surface, uveal tract, retina, optic nerve, and peri-orbital tissue. Patients…
  • Abstract Number: 1400 • ACR Convergence 2020

    cAMP Response Element Modulator (CREM)α Promotes PD-1- effector CD4+ T Cells in Psoriasis and Psoriatic Arthritis

    Sigrun Hofmann1, Franz Kapplusch2, Susanne Abraham3, Sarah Northey2, Susanne Russ1, Felix Schulze1, Anna Surace4 and Christian Hedrich5, 1Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany., Dresden, Germany, 2Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom., Liverpool, United Kingdom, 3Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Germany., Dresden, Germany, 4Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, Liverpool, United Kingdom, 5University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Psoriasis is a systemic autoimmune/inflammatory condition that primarily affects the skin, but also other organ systems. Effector CD4+ T lymphocytes have been identified as…
  • Abstract Number: 1796 • ACR Convergence 2020

    A Panel of Urinary Proteins Predicts Active Lupus Nephritis and Response to Rituximab Treatment

    Jennifer Davies1, Emil Carlsson1, Angela Midgley1, Eve Smith1, Ian Bruce2, Michael Beresford1 and Christian Hedrich3, 1Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, Liverpool, England, United Kingdom, 2Centre for Epidemiology Versus Arthritis, The University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 3University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Approximately 30% of patients with adult-onset systemic lupus erythematosus (SLE) develop lupus nephritis (LN). Presence and/or severity of LN are currently assessed by renal…
  • Abstract Number: 0075 • ACR Convergence 2020

    CD209+/CD14+ Dendritic Cells Characterization in Rheumatoid versus Psoriasis Arthritis Patients

    Viviana Marzaioli1, Achilleas Floudas2, Mary Canavan1, Siobhán Wade3, Kieran Murray4, Ronan Mullan5, Conor Hurson6, Douglas Veale7 and Ursula Fearon1, 1Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 2Molecular Rheumatology Trinity Biomedical Sciences Institute, Dublin, Dublin, Ireland, 3Trinity College Dublin, Dublin, Ireland, 4Saint Vincent's University Hospital, Dublin 4, Dublin, Ireland, 5Adelaide and Meath Hospital, Dublin, Dublin, Ireland, 6St Vincents University Hospital, UCD, Dublin, Dublin, Ireland, 7EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: Dendritic cells (DCs) are a heterogeneous population of professional antigen-presenting cells which are at the interface between innate and adaptive immunity. There are different…
  • Abstract Number: 0558 • ACR Convergence 2020

    Statin Use Pattern in Patients with Inflammatory Joint Disease in a Single Site VA Medical Center

    Lenche Kostadinova1, Sofi Damjanovska2, Angela Gupta3, Ibtissam Gad4, Sameena Syed4, Alyssa Lange5, Corinne Kowal6, Carey Shive7, Christopher Burant4, Brigid Wilson4, David Canaday4, David Zidar8, Donald Anthony9 and Maya Mattar10, 1(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Highland Heights, OH, 2(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH, 3(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, 4(1) Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, ohio, 5Case Western Reserve University, Cleveland, 6Case western reserve university/Cleveland VA Medical Center, ohio, 7(2) Department of Pathology, Case Western Reserve University, ohio, 8Case Western Reserve University/Cleveland VA Medical Center, Cleveland, 9Case Western Reserve University/Cleveland VA Medical Center/MetroHealth Medical Center, Cleveland, OH, 10Department of Medicine, VA Medical Center and VA GRECC, Case Western Reserve University, Cleveland OH, Cleveland, OH

    Background/Purpose: Patients with inflammatory joint disease, including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) carry increased risk of cardiovascular disease (CVD). Mechanisms…
  • Abstract Number: 0776 • ACR Convergence 2020

    The Influence of Adipokine Profile and Periodontal Infection in Early Stages of Rheumatoid Arthritis and First-degree Relatives

    Consuelo Romero-Sanchez1, Juliette De Avila2, Jeimmy Andrea Chaparro-Sanabria3, Philipe Chalem Choueka4, Juan Manuel Bello-Gualtero5, Alejandro Ramos-Casallas2, Lorena Chila-M2 and Wilson Bautista-Molano6, 1Hospital Militar Central, Rheumatology and Immunology Department, Universidad Militar Nueva Granada / Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada /Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo-, School of Dentistry, Bogotá D.C., Colombia, 2Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo-, School of Dentistry, Bogotá D.C., Colombia, 3Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada, Bogotá D.C., Colombia, 4Fundacion Instituto de Reumatología Fernando Chalem, Universidad El Rosario, Bogotá D.C., Colombia, 5Hospital Militar Central, Rheumatology and Immunology Department, Universidad Militar Nueva Granada/ Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada, Bogotá D.C., Colombia, 6University Hospital Fundación Santa Fé de Bogotá and Universidad El Bosque, Bogotá, Colombia

    Background/Purpose: Early RA (eRA) patients have a significant incidence of periodontal inflammation and overweight/obesity. A similar degree of disease activity, functional disability and health-related quality…
  • Abstract Number: 1043 • ACR Convergence 2020

    Ocular Scleral Pathology and Immune-Mediated Inflammatory Diseases. Study of 170 Patients from a Single Universitary Center

    Lara Sanchez-Bilbao1, Inigo Gonzalez-Mazon2, José Luis Martín-Varillas3, David Martinez-Lopez4, Carmen Alvarez-Reguera1, Alba Herrero Morant1, Rosalia Demetrio-Pablo1, Vanesa Calvo-Río1, Miguel Ángel González-Gay5 and Ricardo Blanco1, 1Hospital Universitario Marques de Valdecilla, Santander, Spain, 2Hospital Universitario Marques de Valdecilla, Bezana, Spain, 3Hospital Sierrallana, Torrelavega, Spain, 4Hospital Universitario Marques de Valdecilla, Santander (SPAIN), Spain, 5Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain

    Background/Purpose: Ocular scleral pathology (OSP) includes episcleritis and scleritis. Episcleritis is generally a benign disease with a self-limited course, while scleritis is a more severe…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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