ACR Meeting Abstracts

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Abstracts tagged "Inflammation"

  • Abstract Number: 0943 • ACR Convergence 2021

    Metabolomic Profiling of Synovial Tissue of Patients with Osteoarthritis

    Jessica Murillo Saich1, Roxana Coras2, Robert Meyer3 and Monica Guma4, 1University of California San Diego, La Jolla, CA, 2University of California San Diego/Department of Medicine, Autonomous University of Barcelona, San Diego, CA, 3San Diego VA Healthcare Service, La Jolla, CA, 4University of California San Diego/San Diego VA Healthcare Service/Department of Medicine, Autonomous University of Barcelona, La Jolla, CA

    Background/Purpose: Increasing evidence indicates that osteoarthritis (OA) progression is mediated not simply by progressive degeneration of cartilage, but also by low-grade synovial inflammation (synovitis) that…
  • Abstract Number: 1341 • ACR Convergence 2021

    Ixekizumab Shows a Pattern of Pain Improvement in Patients with and Without Measurable Inflammation in Psoriatic Arthritis

    Kurt de Vlam1, Gaia Gallo2, Philip Mease3, Proton Rahman4, Venkatesh Krishnan2, David Sandoval2, Chen Yen Lin2, Danting Zhu2, Rebecca Bolce2 and Philip Conaghan5, 1University Hospitals Leuven, Leuven, Belgium, 2Eli Lilly and Company, Indianapolis, IN, 3Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 4Department of Medicine, Eastern Health and Memorial University of Newfoundland, St John's, NL, Canada, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: The efficacy of ixekizumab (IXE) and adalimumab (ADA) in patients with psoriatic arthritis (PsA) has been previously reported using ACR 50 and Psoriasis Area…
  • Abstract Number: 1767 • ACR Convergence 2021

    CXCL5 Dampens Inflammation in Murine Lupus by Orchestral Suppression of Effector Cell Proliferation and Leukocyte Extravasation

    Xiubo Fan1, Chin Teck Ng1, Dianyang Guo1, Frances Lim1, Annie Law2, Julian Thumboo1, William Hwang3 and Andrea Low1, 1Singapore General Hospital, Singapore, Singapore, 2Singhealth, Singapore, Singapore, 3National Cancer Centre Singapore, Singapore, Singapore

    Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease characterized by dysregulation of both innate and adaptive immunity. Current therapeutic options are limited,…
  • Abstract Number: L03 • ACR Convergence 2020

    Efficacy and Safety of Deucravacitinib (BMS-986165), an Oral, Selective Tyrosine Kinase 2 Inhibitor, in Patients with Active Psoriatic Arthritis: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial

    Philip Mease1, Atul Deodhar2, Désirée van der Heijde3, Frank Behrens4, Alan Kivitz5, Jonghyeon Kim6, Shalabh Singhal6, Miroslawa Nowak6 and Subhashis Banerjee6, 1Swedish Medical Center/Providence St. Joseph Health and University of Washington, Seattle, WA, 2Oregon Health & Science University, Portland, OR, 3Leiden University Medical Center, Leiden, Netherlands, 4CIRI/Rheumatology and Fraunhofer Institute IME, Translational Medicine and Pharmacology, Goethe University, Frankfurt, Germany, 5Department of Rheumatology, Altoona Center for Clinical Research, Duncansville, PA, 6Bristol Myers Squibb, Princeton, NJ

    Background/Purpose: Tyrosine kinase 2 (TYK2) is an intracellular kinase that mediates signaling by key cytokines involved in psoriatic arthritis (PsA) pathophysiology. Deucravacitinib (BMS-986165) is a…
  • Abstract Number: L06 • ACR Convergence 2020

    Mavrilimumab (anti GM-CSF Receptor α Monoclonal Antibody) Reduces Time to Flare and Increases Sustained Remission in a Phase 2 Trial of Patients with Giant Cell Arteritis

    Maria C. Cid1, Sebastian Unizony2, Lara Pupim3, Fang Fang4, Joseph Pirrello3, Ai Ren4, Manoj Samant4, Teresa Zhou4 and John F Paolini4, 1Hospital Clinic Barcelona, Barcelona, Spain, 2Massachusetts General Hospital, Boston, MA, 3Kiniksa Pharmaceuticals, Lexington, MA, 4Kiniksa Pharmaceuticals, Lexington

    Background/Purpose: T helper (Th)1 and Th17 lymphocytes play a role in the pathogenesis of giant cell arteritis (GCA). Current treatments (e.g., corticosteroids and tocilizumab) target…
  • Abstract Number: 0096 • ACR Convergence 2020

    The Bicipital Stress Test: A Maneuver to More Accurately Diagnose Bicipital Tendinitis and Its Referred Pain Patterns

    Meredith Thomley1, David Spalding2, Ana Preda-Naumescu1 and Raymond Waldrop1, 1University of Alabama at Birmingham, Birmingham, 2University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Inflammation of the bicipital tendon contributes heavily to shoulder joint morbidity. To date, diagnosis of bicipital tendinitis has relied on physical exam findings, particularly…
  • Abstract Number: 0626 • ACR Convergence 2020

    Early Rise in CRP Is Associated with Progression to Respiratory Failure and Intubation in COVID-19 Patients

    Alisa Mueller1, Tomoyoshi Tamura2, Julia Jezmir3, Erin Penn1, Gregory Keras4, Anthony Massaro5 and Edy Kim5, 1Brigham and Women's Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 2Brigham and Women's Hospital, Division of Pulmonary and Critical Care Medicine, Boston, MA, 3Brigham and Women’s Hospital, Department of Medicine, Boston, MA, 4Brigham and Women’s Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 5Brigham and Women’s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, MA

    Background/Purpose: During the course of hospitalization, it is often unclear which COVID-19 patients will progress from non-critical to critical illness. Timely identification of these patients…
  • Abstract Number: 0789 • ACR Convergence 2020

    Matrix Gla Protein (MGP) Modified with Malondialdehyde/Acetaldehyde Is Increased in Rheumatoid Arthritis and Cardiovascular Patients

    Xiarepati Tieliwaerdi1, Nozima Aripova1, Michael Duryee1, Xiaoting Jiang1, Lynell Klassen2, James O'Dell1, Bryant England1, Daniel Anderson1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Univerisity of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased cardiovascular disease (CVD) burden, dramatically increasing the risk of mortality. Circulating antibodies to Malondialdehyde-Acetaldehyde (MAA) modified…
  • Abstract Number: 1118 • ACR Convergence 2020

    Bone Marrow Lesion Scores in Patients with Knee Osteoarthritis Undergoing Tibial Osteotomy: Reliability and Concurrent Validity of the Knee Inflammation MRI Scoring System (KIMRISS)

    Jenna Schulz1, Trevor Birmingham1, Walter Maksymowych2, Robert G Lambert3, Stephany Pritchett4, Frank Beier1, J. Robert Giffin5 and Tom Appleton6, 1Western University, London, Canada, 2University of Alberta, Edmonton, AB, Canada, 3University of Alberta and CARE Arthritis, Edmonton, AB, Canada, 4London Health Sciences Centre, London, Canada, 5Western University and London Health Sciences Centre, London, Canada, 6The University of Western Ontario, LONDON, ON, Canada

    Background/Purpose: Bone marrow lesions (BMLs) commonly occur in knee osteoarthritis (OA) and are associated with increased risk of cartilage damage and pain. The Knee Inflammation…
  • Abstract Number: 1519 • ACR Convergence 2020

    Interleukin-17D, a Cytokine Derived from Stromal Cells, Attenuates Joint Inflammation

    Sijia Chen1, Catherine Manning2, Melissa van Tok3, Yukiko Maeda4, Daniel Montoro5, Jung-Min Kim6, Jeroen den Dunnen3, Nataliya Yeremenko3, Jae-Hyuck Shim4, Dominique Baeten7 and Ellen Gravallese8, 1Brigham and Women's Hospital, Boston, 2Brigham and Women’s Hospital, Boston, 3Amsterdam University Medical Centers, Amsterdam, Netherlands, 4University of Massachusetts Medical School, worcester, MA, 5Broad Institute of Massachusetts Institute of Technology and Harvard, Boston, 6University of Massachusetts Medical School, Worcester, 7UCB Pharma / Amsterdam University Medical Centers, Amsterdam, Netherlands, 8Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Interleukin(IL)-17D is a little recognized member of the IL-17 family of cytokines. While the activities of IL-17A and IL-17F in the pathogenesis of spondyloarthritis…
  • Abstract Number: 1855 • ACR Convergence 2020

    Elevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum Using Digital Chromo-endoscopy and Magnification Colonoscopy in Patients with Spondyloarthritis Without Inflammatory Bowel Disease

    Consuelo Romero-Sanchez1, Cristian Florez-Sarmiento2, Valerie Khoury-Rosas3, Wilson Bautista-Molano4, Magaly Chamorro-Melo5, Diego Alejandro Jaimes6, Adriana Beltran-Ostos7, Juliette De Avila8, Alejandro Ramos-Casallas8, Juan Manuel Bello-Gualtero9, Jaiber Gutierrez5, Cesar Pacheco Tena10, Philipe Chalem Choueka11 and Viviana Parra-Izquierdo12, 1Hospital Militar Central, Rheumatology and Immunology Department, Universidad Militar Nueva Granada / Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada /Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo-, School of Dentistry, Bogotá D.C., Colombia, 2Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo- / Grastroadvanced SAS, Bogotá D.C., Colombia, 3Universidad EL Bosque / School of Medicine, Bogotá D.C., Colombia, 4University Hospital Fundación Santa Fé de Bogotá and Universidad El Bosque, Bogotá, Colombia, 5Hospital Militar Central, Rheumatology and Immunology Department, School of Medicine, Bogotá D.C., Colombia, 6Clínicos IPS- Universidad de la Sabana, Bogotá D.C., Colombia, 7Hospital Militar Central, Subdirección de docencia e Investigación, Bogotá D.C., Colombia, 8Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo-, School of Dentistry, Bogotá D.C., Colombia, 9Hospital Militar Central, Rheumatology and Immunology Department, Universidad Militar Nueva Granada/ Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada, Bogotá D.C., Colombia, 10Universidad Autonoma de Chihuahua, Chihuahua, Chihuahua, Mexico, 11Fundacion Instituto de Reumatología Fernando Chalem, Universidad El Rosario, Bogotá D.C., Colombia, 12.Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo- / Grastroadvanced SAS, Bogotá D.C., Colombia

    Background/Purpose: Fecal calprotectin (FC) is a well bio-marker related to mucosal inflammation. Digital chromo-endoscopy (DCE) with magnification is a technique to identify microscopic inflammation. The…
  • Abstract Number: 0099 • ACR Convergence 2020

    Interleukin 6 Concentration in Synovial Fluid of Patients with Different Types of Arthritis

    Aleksandra Bukina1 and Anna Mihailova1, 1Rigas Stradins university, Riga, Latvia

    Background/Purpose: Persistent synovitis without known markers such as rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) as well as without genetic markers as HLAB27 is not…
  • Abstract Number: 0644 • ACR Convergence 2020

    Characterizations of Cytokine Storm Associated with COVID19

    Ofer Perzon1, Avi Abutbul1, Sigal Sviri1 and Dror Mevorach1, 1Hadassah-University Hospital, Jerusalem, Yerushalayim, Israel

    Background/Purpose: COVID-19, the name given to the clinical syndrome associated with the newly recognized virus SARS-CoV-2 has become pandemic with mortality estimated based on reports…
  • Abstract Number: 0796 • ACR Convergence 2020

    Development of a Tool to Assess Synovial Tissue Infiltrates and Derive Histological Pathotype in Inflammatory Arthritis: Relationship to Clinical and Ultrasound Variables

    Hayley Carr1, Ilfita Sahbudin1, Mark Maybury1, Bernard Dyke2, Jason Turner3, Nicola Gullick4, Karim Raza5, Dagmar Scheel-Toellner1 and Andrew Filer1, 1Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 2Institute of Inflammation and Ageing, University of Birmingham, Birmingham, England, United Kingdom, 3Rheumatology Research Group, Institute for Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Queen Elizabeth Hospital, Birmingham, United Kingdom, 4University Hospitals Coventry & Warwickshire, Coventry, United Kingdom, 5Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom

    Background/Purpose: Evidence suggests that histological pathotypes are linked to pathogenic mechanisms in inflammatory arthritis and may be useful as biomarkers of outcome. The frequently used…
  • Abstract Number: 1133 • ACR Convergence 2020

    Patient Perceptions of Diagnosis, Tests, Treatments, Adherence and the Impact on Their Disease Understanding and Participation in Research Studies

    Viviana Marzaioli1, Mary Canavan1, Siobhan Wade2, Alexander Fraser3, Sinead Harney4, Alex Donnelly5, Arthritis Ireland Charity6, Douglas Veale7 and Ursula Fearon1, 1Molecular Rheumatology, Trinity College Dublin, Dublin, Dublin, Ireland, 2Molecular Rheumatology, Trinity College Dublin, Dublin, Ireland, 3University College Limerick, Limerick, Limerick, Ireland, 4University College Cork, Cork, Ireland, 5Patient Advocate Arthritis Ireland, Dublin, Ireland, 6Arthritis Ireland, Dublin, Ireland, 7EULAR Centre for Arthritis and Rheumatic Diseases, St Vincents University Hospital, UCD, Dublin, Dublin, Ireland

    Background/Purpose: The diagnosis and treatment of inflammatory arthritis has been transformed largely by  the development of drugs that target specific molecules of the immune system.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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