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Abstracts tagged "immunology"

  • Abstract Number: 1670 • ACR Convergence 2020

    Low Copy Number of Long C4 Genes Is a Genetic Risk Factor for Childhood Onset SLE (cSLE) but Is Associated with Higher Age of Disease Onset

    Fatima Barbar-Smiley1, Danlei Zhou2, Joanne Drew2, Bi Zhou2, Cagri Yildirim-Toruner2, Vidya Sivaraman3, Wael Jarjour4, Stacy Ardoin2 and Chack-Yung Yu5, 1Nationwide Children's Hospital/The Ohio State University, Columbus, OH, 2Nationwide Children's Hospital, Columbus, OH, 3Nationwide Children's Hospital, Bexley, OH, 4The Ohio State University, Columbus, OH, 5Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH

    Background/Purpose: Hypocomplementemia is a marked feature of systemic lupus erythematosus (SLE), which may be a result of consumption initiated by immune complexes between self-nuclear antigens…
  • Abstract Number: 0090 • ACR Convergence 2020

    110 Patients with Monoclonal Gammopathy of Undetermined Significance (MGUS) in a Rheumatology Disease Unit: Fracture, Neuropathy, and Pernicious Anemia Are Clues to Recognition

    Michael Lovy1 and Andrew Dulalia1, 1Desert Oasis Healthcare, Palm Springs, CA

    Background/Purpose: Monoclonal gammopathy of undetermined significance (MGUS) has been associated with osteoporosis, neuropathy, pernicious anemia, and low vitamin B12, and may precede multiple myeloma and…
  • Abstract Number: 0511 • ACR Convergence 2020

    ERAP1-mediated Immunogenicity and Immune-phenotypes in HLA-B51+ Behçet’s Disease Point to Pathogenic CD8 T Cell Effector Responses

    Ann Cavers1, Yesim Ozguler2, Olivier Manches3, Arshed Al-Obeidi1, Hua Zhong1, Beatrix Ueberheide1, Gülen Hatemi4, Matthias Kugler1 and Johannes Nowatzky5, 1NYU School of Medicine, New York, 2Istanbul University Cerrahpaşa Medical School, Istanbul, Turkey, 3Inserm, U 1209, Grenoble, France, 4Istanbul University‒Cerrahpaşa, Cerrahpaşa Medical School and Behçet’s Disease Research Center, Istanbul, Turkey, 5New York University School of Medicine, New York, NY

    Background/Purpose: HLA-B51 is a definite risk factor for Behçet’s disease (BD). A coding variant of ERAP1, Hap10 – with low peptide-trimming activity – vastly potentiates…
  • Abstract Number: 1402 • ACR Convergence 2020

    Galectin-3 Decreases the Activity of 4-1BB by Facilitating Its Decoy Surface Binding in Rheumatoid Arthritis

    Morten Aagaard Nielsen1, Kristian Juul-Madsen2, John Stegmayr3, Chao Gao4, Tue Wenzel Kragstrup1, Malene Hvid1, Thomas Vorup-Jensen1, Richard Cummings5, Hakon Leffler3 and Bent Deleuran1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University, Aarhus, Midtjylland, Denmark, 3Lund University, Lund, Sweden, 4Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, 5Beth Israel Deaconess Medical Center Harvard Medical School, Boston

    Background/Purpose: Orchestration of immune checkpoints is central for the outcome of immune activation, especially in patients with rheumatoid arthritis (RA). We have previously shown that…
  • Abstract Number: 1747 • ACR Convergence 2020

    Brain fMRI Predicts Responses to Certolizumab Pegol in RA. an International, Multi-center, Randomized, Double-blind, Placebo-controlled Trial (PreCePRA)

    Juergen Rech1, Hannah Schenker2, Koray Tascilar1, Melanie Hagen2, Arnd Kleyer1, David Simon1, Larissa Valor Mendez2, Verena Schoenau3, Jutta Prade4, Marina Sergeeva4, Mageshvar Sulvakumar5, Sandra Strobelt4, Laura Konerth4, Frank Behrens6, Christoph Baerwald7, Stephanie Finzel8, Reinhard Voll9, Axel Hueber10, Julie Roesch11, Eugen Feist12, José A. P. da Silva13, Arnd Doerfler11, Nemanja Damjanov14, Andreas Hess15 and Georg Schett16, 1Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, 2Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany, Erlangen, Germany, 3Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany, Erlangen, 4Institute for Experimental Pharmacology, Erlangen, Germany, 5Insitute for Experimental Pharmacology , Fau Erlangen-Nürnberg, Erlangen, Germany, 6CIRI/Rheumatology & Fraunhofer TMP, Goethe University, Frankfurt, Germany, 7Uniklinik Leipzig, Medizinische Klinik III - Bereich Rheumatologie, Leipzig, Germany, 8Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freiburg, Germany, 9Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freibrug, 10Section Rheumatology, Sozialstiftung Bamberg, Bamberg, Germany, 11Abteilung für Neuroradiologie, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany, Erlangen, Germany, 12Department of Rheumatology, Helios Vogelsang-Gommern, Vogelsang-Gommern, Germany, 139.Centro Hospitalar e Universitário Coimbra (Rheumatology Department), Coimbra, Portugal, Coimbra, Portugal, 14University of Belgrade Medical School, Belgrade, Serbia, 15Institute for Experimental Pharmacology, Erlangen, 16Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany

    Background/Purpose: Personalization of RA treatment is not optimal due to lack of predictors. We previously demonstrated in RA patients that central nervous system (CNS) pain…
  • Abstract Number: 0195 • ACR Convergence 2020

    Epidemiology and Characteristics of Incident Rheumatoid Arthritis in Persons with and Without HIV

    Jennifer Hanberg1, Kathleen Akgun2, Liana Fraenkel3, Evelyn Hsieh2 and Amy Justice4, 1Yale University School of Medicine; West Haven VA, Boston, MA, 2Yale University School of Medicine; West Haven VA, New Haven, CT, 3Yale School of Medicine; West Haven VA; Berkshire Medical Center, Lenox, MA, 4Yale University School of Medicine; Yale School of Public Health; West Haven VA, West Haven, CT

    Background/Purpose: Rheumatoid arthritis (RA) is the most common chronic inflammatory arthritis, affecting 1-2% of the population. Estimates of the incidence of RA in patients with…
  • Abstract Number: 0753 • ACR Convergence 2020

    Synovial Tissue Histopathology Findings in Early RA. Is It Useful? Analysis of the Belgian CAP48 Cohort

    Stéphanie de Montjoye1, Tatiana Sokolova1, Emilie Sapart1, Bernard Lauwerys2, Stéphanie Dierckx3, Christine Galant4, Laurent Meric de Bellefon1, Adrien Nzeusseu Toukap5, Clément Triaille6 and Patrick Durez7, 1Rheumatology, Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCL) – Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, 2Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, 3Rheumatology, CHU Mont-Godinne, Mont Godinne, Belgium, 43Pathology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Brussels, Belgium, 51Department of Rheumatology, Cliniques Universitaires Saint Luc, 2Institut de recherche expérimentale et clinique (IREC), Brussels, Belgium, 6Rheumatology, Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, Brussels, Belgium, 7Division of Rheumatology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium

    Background/Purpose: Rheumatoid arthritis is a heterogeneous disease with different clinical presentation and prognostic factors including the immune process in the synovium. The development of ultrasound-guided…
  • Abstract Number: 1409 • ACR Convergence 2020

    Lack of Conventional Acinar Cells in the Salivary Gland Following Anti PD-L1 and anti-PD-1 Immune Checkpoint Inhibitor Therapy

    Sarah Pringle1, Bert van der Vegt1, Xiaoyan Wang1, Nico van Bakelen1, Arjan Vissink1, Frans Kroese2 and Hendrika Bootsma2, 1UMCG, Groningen, 2University Medical Centre Groningen, Groningen, Netherlands

    Background/Purpose: Salivary glands (SGs) can be damaged by immune checkpoint inhibitor (ICI) therapy. In patients with ICI-induced SG dysfunction, 60% progress to fulfill the ACR-EULAR…
  • Abstract Number: 1750 • ACR Convergence 2020

    Longitudinal Change in the Central Nervous System Pain Response After Treatment with Certolizumab or Placebo. a Post-hoc Analysis from the Pre-CEPRA Trial

    Juergen Rech1, Hannah Schenker2, Koray Tascilar1, Melanie Hagen2, Larissa Valor Mendez2, Verena Schoenau3, Marina Sergeeva4, Jutta Prade4, Mageshvar Sulvakumar5, Laura Konert6, Arnd Kleyer1, David Simon1, Sandra Strobelt4, Frank Behrens7, Christoph Baerwald8, Stephanie Finzel9, Reinhard Voll10, Axel Hueber11, Eugen Feist12, Julie Roesch13, José A. P. da Silva14, Arnd Doerfler13, Nemanja Damjanov15, Andreas Hess16 and Georg Schett17, 1Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Bayern, Germany, 2Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany, Erlangen, Germany, 3Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany, Erlangen, 4Institute for Experimental Pharmacology, Erlangen, Germany, 5Insitute for Experimental Pharmacology, FAU Erlangen-Nuremberg, Erlangen, Germany, 6Institute for Experimental Pharmacology, FAU Erlangen-Nürnberg, Erlangen, 7CIRI/Rheumatology & Fraunhofer TMP, Goethe University, Frankfurt, Germany, 8Uniklinik Leipzig, Medizinische Klinik III - Bereich Rheumatologie, Leipzig, Germany, 9Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freiburg, Germany, 10Universitätsklinikum Freiburg, Klinik für Rheumatologie und Klinische Immunologie, Freibrug, 11Section Rheumatology, Sozialstiftung Bamberg, Bamberg, Germany, 12Department of Rheumatology, Helios Vogelsang-Gommern, Vogelsang-Gommern, Germany, 13Abteilung für Neuroradiologie, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054, Erlangen, Germany, Erlangen, Germany, 149.Centro Hospitalar e Universitário Coimbra (Rheumatology Department), Coimbra, Portugal, Coimbra, Portugal, 15Belgrade University School of Medicine, Belgrade, Serbia, 16Institute for Experimental Pharmacology, Erlangen, 17Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany

    Background/Purpose: Biologicals - bring a hope of recovery or amelioration to people suffering from RA, but only half of the patients respond to such treatment.…
  • Abstract Number: 0207 • ACR Convergence 2020

    Upadacitinib Monotherapy in Methotrexate-naïve Patients with Rheumatoid Arthritis: Results at 72 Weeks

    Ronald van Vollenhoven1, Tsutomu Takeuchi2, Maureen Rischmueller3, Ricardo Blanco4, Ricardo Xavier5, Mark Howard6, Alan Friedman6, Yanna Song7 and Vibeke Strand8, 1Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, 2Division of Rheumatology, Department of internal Medicine, School of Medicine, Keio University, Tokyo, Japan, 3The Queen Elizabeth Hospital and Univ of Adelaide, St Peters, South Australia, Australia, 4Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 5Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Rio Grande do Sul, Brazil, 6AbbVie Inc., North Chicago, IL, 7AbbVie Inc., North Chicago,, IL, 8Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA

    Background/Purpose: Upadacitinib (UPA), an oral JAK inhibitor, demonstrated significant improvements in signs, symptoms, and structural inhibition as monotherapy vs methotrexate (MTX) in a randomized, controlled…
  • Abstract Number: 0770 • ACR Convergence 2020

    Effect of Citrullination on the Processing and Presentation of Rheumatoid Arthritis Autoantigens

    Ashley Curran1, Jonathan Crawford1 and Erika Darrah1, 1Division of Rheumatology, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Citrullinated proteins are hallmark targets of the autoimmune response in rheumatoid arthritis (RA), but the mechanism by which immune tolerance is broken to these self-proteins…
  • Abstract Number: 1413 • ACR Convergence 2020

    An Imbalance Between Regulatory and Inflammatory T Cell Subsets Distinguishes Systemic Autoimmune Rheumatic Disease Patients from Asymptomatic ANA+ Individuals

    Emma Vanlieshout1, Rashi Gupta1, Dennisse Bonilla2, Michael Kim3, Sindhu Johnson2, Earl D. Silverman4, Linda Hiraki5, Zareen Ahmad6, Zahi Touma7, Arthur Bookman2 and Joan Wither2, 1Krembil Research Institute, Toronto, ON, Canada, 2University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 3Krembil Research Insitute, Toronto, ON, Canada, 4Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 5Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, 6Mount Sinai Hospital, Toronto, ON, Canada, 7University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network; Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: The anti-nuclear antibody (ANA)-associated systemic autoimmune rheumatic diseases (SARDs) are characterized by a prolonged preclinical phase in which ANAs are produced in the absence…
  • Abstract Number: 1757 • ACR Convergence 2020

    High-Intensity Interval Training Increases Rheumatoid Arthritis Cardiorespiratory Fitness in Association with Improvements in CD4+ T Cell and Skeletal Muscle Mitochondrial Metabolism

    Brian Andonian1, David Bartlett1, Alec Koss1, Deborah Muoio1, Timothy Koves1, Eugene St Clair1, Elizabeth Hauser1, William Kraus1 and Kim Huffman1, 1Duke University, Durham, NC

    Background/Purpose: Persons with rheumatoid arthritis (RA) have poor cardiorespiratory fitness and are at increased risk for cardiometabolic co-morbidities. Endurance exercise training improves cardiorespiratory fitness in…
  • Abstract Number: 0234 • ACR Convergence 2020

    Characterization of Serious Infections with Upadacitinib in Patients with Rheumatoid Arthritis

    Kevin Winthrop1, Leonard Calabrese2, Filip Van den Bosch3, Kunihiro Yamaoka4, Carlo Selmi5, Yanna Song6, Barbara Hendrickson7, Ivan Lagunes-Galindo8 and Iain McInnes9, 1Oregon Health & Science University, Portland, OR, 2Cleveland Clinic, Cleveland, OH, 3Ghent University Hospital, Ghent, Belgium, 4Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan, 5Humanitas Research Hospital and Humanitas University, MIlan, Italy, 6AbbVie Inc., North Chicago,, IL, 7AbbVie, Inc, North Chicago, IL, 8AbbVie Inc., North Chicago, IL, 9Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Upadacitinib (UPA) is a selective and reversible Janus kinase (JAK) inhibitor with an approved dose of 15 mg once daily (QD) for the treatment…
  • Abstract Number: 0772 • ACR Convergence 2020

    Modification of THP-1 Cells with Malondialdehyde-Acetaldehyde Increases Cellular Calcium Load Rendering Cells Susceptible to Citrullination of Self-Proteins

    Nozima Aripova1, Michael Duryee1, Xiarepati Tieliwaerdi1, Xiaoting Jiang1, Lynell Klassen2, James O'Dell1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Univerisity of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The post translational modification of self-proteins with malondialdehyde-acetaldehyde (MAA) has been shown to alter protein function and antibodies to MAA are increased in both…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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