ACR Meeting Abstracts

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Abstracts tagged "immunology"

  • Abstract Number: L20 • ACR Convergence 2021

    Efficacy of Emapalumab, an Anti-IFNγ Antibody in Patients with Macrophage Activation Syndrome (MAS) Complicating Systemic Juvenile Idiopathic Arthritis (sJIA) Who Had Failed High-Dose Glucocorticoids (GCs)

    Fabrizio De Benedetti1, Alexei Grom2, Paul Brogan3, Claudia Bracaglia1, Manuela Pardeo1, Giulia Marucci1, Despina Eleftheriou3, Charalampia Papadopoulou3, Pierre Quartier4, Jordi Antón5, Rikke Frederiksen6, Veronica Asnaghi6 and Cristina De Min6, 1Bambino Gesù Children's Hospital IRCCS, Rome, Italy, 2Cincinnati Children’s Hospital, Division of Rheumatology, Cincinnati, OH, 3UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 4Université de Paris, IMAGINE Institute, RAISE reference centre, Pediatric Immuno-Hematology and Rheumatology Unit, Necker Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France, 5Hospital Sant Joan de Déu, Division of Pediatric Rheumatology, University of Barcelona, Barcelona, Spain, 6Swedish Orphan Biovitrum AG (Sobi), Basel, Switzerland

    Background/Purpose: MAS is a life-threatening complication of rheumatic diseases, occurring most frequently in sJIA. The mainstay of MAS treatment is high dose GCs; however, GCs…
  • Abstract Number: L02 • ACR Convergence 2021

    COVID-19 Vaccine in Immunosuppressed Adults with Autoimmune Diseases

    Ines Colmegna1, Mariana Useche1, Emmanouil Rampakakis2, Nathalie Amiable3, Emmanuelle Rollet-Labelle3, Louis Bessette4, Jo-Anne Costa4, Marc Dionne4, Mary-Ann Fitzcharles2, Elizabeth Hazel2, Deirdre McCormack2, Laetitia Michou4, Pantelis Panopalis2, Marc-Andre Langlois5, Sasha Bernatsky6 and Paul R. Fortin7, 1The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2McGill University Health Centre, Montreal, QC, Canada, 3Centre de Recherche du CHU de Quebec, Quebec, Canada, 4Universite Laval, Quebec, QC, Canada, 5University of Ottawa, Ottawa, ON, Canada, 6McGill University, Montreal, QC, Canada, 7CHU de Quebec - Universite Laval, Quebec, Canada

    Background/Purpose: Immunocompromised conditions and/or a history of autoimmune disease were exclusion criteria of the initial SARS-CoV-2 vaccines clinical trials. We assessed the safety and immunogenicity…
  • Abstract Number: 0471 • ACR Convergence 2021

    Therapeutic Efficacy of BT-104, an Oral LANCL2 Agonist, for the Treatment of Systemic Lupus Erythematosus

    Andrew Leber, Raquel Hontecillas, Nuria Tubau-Juni, Sarah Fitch, Jyoti Chauhan and Josep Bassaganya-Riera, Landos Biopharma, Blacksburg, VA

    Background/Purpose: Systemic lupus erythematosus is a complex disease in which the immune system is dysfunctional at multiple levels including impaired regulatory responses, altered self-antigen processing…
  • Abstract Number: 1503 • ACR Convergence 2021

    Putting the Pieces on the Board: Mapping SLE Nephritis Biopsies from the Accelerating Medicines Project Using High-Density Immunofluorescence Imaging

    Craig Smuda1, Anna Eichinger2, Robert Clancy2, Jill Buyon3 and Boris Reizis4, 1NYU Grossman School of Medic ine, New York, NY, 2NYU Grossman School of Medicine, New York, NY, 3NYU School of Medicine, New York, NY, 4New York University Grossman School of Medicine, New York, NY

    Background/Purpose: The Accelerating Medicines Project (AMP) has enabled significant increases in understanding of SLE nephritis pathology, providing a profile of dozens of leukocyte subsets within…
  • Abstract Number: 0534 • ACR Convergence 2021

    Lymphatic Dysfunction in Murine Lupus Photosensitivity

    William Ambler1, Noa Schwartz2, Jin Yeon Shin3, Rahgu Kataru4, Camila Carballo5, Scott Rodeo6, Babak Mehrara4 and Theresa Lu7, 1Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery. HSS Research Institute, Hospital for Special Surgery, New York, NY, 2Department of Medicine, Division of Rheumatology, Albert Einstein College of Medicine, New York, NY, 3Department of Surgery, Division of Plastic and Reconstructive Surgery Memorial Sloan Kettering, New York, NY, 4Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering, New York, NY, 5HSS Research Institute, Hospital for Special Surgery, New York, NY, 6HSS Research Institute, Hospital for Special Surgery; Department of Orthopedics, Hospital for Special Surgery, New York, NY, 7Hospital for Special Surgery, New York, NY

    Background/Purpose: The lymphatic system is composed of vessels which carry fluid, soluble molecules, and cells from peripheral tissue to draining lymph nodes. Photosensitivity, an exaggerated…
  • Abstract Number: 1507 • ACR Convergence 2021

    Role of CD4+ T Cells in the Pathogenesis of RA: Immunization with Citrullinated T Cell Epitopes Is Sufficient to Induce Immunological and Clinical Manifestations of Arthritis in DR4-Transgenic Mice

    Elena Tonti1, Bhargavi Duvvuri2, Sudeshna Dhar1, Derek Haaland3, Maggie Larche1 and Mark Larché1, 1McMaster University, Hamilton, ON, Canada, 2University of Washington, Seattle, WA, 3McMaster University, Hamilton, Ontario and The Waterside Clinic, Oro Medonte, ON, Canada

    Background/Purpose: Although the etiology of rheumatoid arthritis (RA) remains unclear, existing research suggests a complex interplay of both genetic and environmental factors. Citrullinated proteins/peptides, and…
  • Abstract Number: 0010 • ACR Convergence 2021

    Relaxed Peripheral Tolerance Drives Broad de Novo Autoreactivity in Severe COVID-19

    Matthew Woodruff1, Richard Ramonell2, Ankur Singh Saini2, Mark Rudolph3, F. Eun-Hyung Lee2 and Iñaki Sanz4, 1Emory University, Decatur, GA, 2Emory University, Atlanta, GA, 3Exagen Inc., Vista, CA, 4Emory University School of Medicine, Atlanta, GA

    Background/Purpose: An emerging feature of COVID-19 is the identification of autoreactivity in patients with severe disease that may contribute to disease pathology, however the origins…
  • Abstract Number: 0539 • ACR Convergence 2021

    Vgll3-transgenic Autoimmune Mice Display Features of Cutaneous Fibrosis

    Mehrnaz Gharaee-Kermani1, Allison Billi2, Marisa Hildebrandt2, Jacob Martens3, Rachael Wasikowski2, Joanne (Michelle) Kahlenberg1 and Johann Gudjonsson2, 1Internal Medicine - Division of Rheumatology and Department of Dermatology, University of Michigan, Ann Arbor, MI, 2Department of Dermatology, University of Michigan, Ann Arbor, MI, 3Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, MI

    Background/Purpose: Fibrosis is characterized by collagen deposition, fibro/myofibroblast accumulation, and extracellular matrix remodeling and can lead to disfiguring skin changes. In cutaneous lupus, scar formation…
  • Abstract Number: 1509 • ACR Convergence 2021

    Pharmacological Inhibition of MALT1 Reverses Activation-Induced Metabolic Reprogramming and Ameliorates Autoimmune Pathogenesis in Multiple Animal Models of Chronic Inflammation

    Subhabrata Biswas, Mya Steadman, Ynes Helou, Katherine Sellers, Keng Soh, Aditi Chalishazar, Mehmet Badur, Joanna DiSpirito, Brian DeChristopher, John Monroe, Dania Rabah, Barbara Fox and Andy Long, Rheos Medicines, Inc, Cambridge, MA

    Background/Purpose: Current therapies for autoimmune and inflammatory diseases generally target select disease nodes, often failing to produce durable clinical remission. Chronic inflammation is associated with…
  • Abstract Number: 0015 • ACR Convergence 2021

    Rheumatoid Factor Recognizes Specific Domains of IgG Heavy Chain Complexed with HLA Class II Molecules

    Shanshan Zhang1, Hideaki Tsuji1, Hui Jin2, Koji Kitagori1, Shuji Akizuki3, Kosaku Murakami1, Ran Nakashima1, Hajime Yoshifuji1, Masao Tanaka1, Hisashi Arase2, Koichiro Ohmura4 and Akio Morinobu1, 1Kyoto University, Kyoto, Japan, 2Osaka University, Osaka, Japan, 3Kyoto Universtiy, Kyoto City, Japan, 4Kobe City Medical Center General Hospital, Kobe, Japan

    Background/Purpose: Rheumatoid factor (RF) is an autoantibody that binds to IgG Fc region (CH2 and CH3 domains) and is detectable in patients with rheumatoid arthritis…
  • Abstract Number: 0648 • ACR Convergence 2021

    Improving Post-Rituximab Hypogammaglobulinemia Risk Assessments: A Fellows’ Quality Improvement Initiative

    Beth Rutstein1, Melissa Argraves2, Atiye Bilgic Dagci2, Sarah Bayefsky2, Julia Rood2, Julie Chase3, Jay Mehta2, Melissa Lerman2, Cory Stingl4 and Jon Burnham2, 1Children's Hospital of Philadelphia, Wynnewood, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3The Children's Hospital of Philadelphia, Philadelphia, PA, 4Children's Hospital of Philadelphia, Durham, NC

    Background/Purpose: Hypogammaglobulinemia following rituximab therapy is a potentially severe complication that can lead to infection-related morbidity and mortality. If recognized, clinicians may prevent infections by…
  • Abstract Number: 1511 • ACR Convergence 2021

    Investigation of Antigen Specific CD4+ T Cells in Patients with Idiopathic Inflammatory Myopathies

    Begum Horuluoglu1, Angeles Shunashy Galindo-Feria2, Karine Chemin3, Genadiy Kozhukh4, Anatoly Dubnovitsky4, Vivianne Malmström5 and Ingrid E Lundberg6, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 3Division of Rheumatology, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, 4Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden, 5Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden, 6Karolinska Institutet, Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, Stockholm, Sweden

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) also known as myositis, are rare chronic autoimmune disorders represented by lesions in muscle, skin and lung. One of the…
  • Abstract Number: 0024 • ACR Convergence 2021

    Heterogeneity of Inflammatory HLA-DR+ Synovial Fibroblasts in Rheumatoid Arthritis Is Driven by Responses to Leukocyte-Derived Cytokines

    Melanie Smith1, Alejandro Kochen1, Vianne Gao2, Michail Schizas2, Edward DiCarlo1, Susan Goodman1, Christina Leslie3, Laura Donlin1 and Alexander Rudensky4, 1Hospital for Special Surgery, New York, NY, 2Memorial Sloan Kettering Cancer Center, New York, NY, 3Computational and Systems Biology Program Memorial Sloan Kettering Cancer Center, New York, NY, 4Memorial Sloan Kettering Cancer Center / Howard Hughes Medical Institute, New York, NY

    Background/Purpose: Treatment-refractory rheumatoid arthritis (RA) represents a major unmet need with substantial societal burden. Targeting RA-associated fibroblast-like synoviocytes (FLS) may provide a less-immunosuppressive therapeutic option.…
  • Abstract Number: 0698 • ACR Convergence 2021

    Flow Cytometry and Sorting of Single Antibody Secreting Cells from Frozen Muscle Tissue

    Andrew Zlobin, Peter Pytel and Vladimir Liarski, University of Chicago, Chicago, IL

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) – dermatomyositis (DM), polymyositis, and inclusion body myositis - are poorly understood autoimmune muscle disorders. Isolation of relevant immune cell…
  • Abstract Number: 1512 • ACR Convergence 2021

    Epigenetic and Transcriptional Programs of CD4+ T Cell Anergy

    Philip Titcombe, Milagros Silva Morales and Daniel Mueller, University of Minnesota, Minneapolis, MN

    Background/Purpose: T cell tolerance is essential for preventing autoimmune diseases and resolving inflammation. To maintain tolerance, CD4+ T cells recognizing self-antigens in the periphery can…
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