ACR Meeting Abstracts

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Abstracts tagged "immunology"

  • Abstract Number: 0815 • ACR Convergence 2024

    Interferon-stimulated Gene Expression in Non-lesional Skin Is Similarly Elevated in Incomplete SLE and SLE

    Svenja Henning1, Lam Tsoi2, Benjamin Klein2, Celine Berthier2, Joseph Kirma2, Rachael Wasikowski3, Gilles Diercks4, Barbara Horvath1, Hendrika Bootsma5, Johann Gudjonsson2, Johanna Westra4, Karina de Leeuw6 and J. Michelle Kahlenberg2, 1University of Groningen, Groningen, Netherlands, 2University of Michigan, Ann Arbor, MI, 3Michigan, Dept. of Dermatology, Ann Arbor, MI, 4University Medical Center Groningen, University of Groningen, Groningen, Groningen, Netherlands, 5Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, 6University Medical Center Groningen, Groningen, Groningen, Netherlands

    Background/Purpose: Patients with features of systemic lupus erythematosus (SLE) who do not fulfill classification criteria are referred to as incomplete SLE (ILE). These patients are…
  • Abstract Number: 1636 • ACR Convergence 2024

    Age-associated B Cells Contribute to Inflammation of Takayasu’s Arteritis in an Antibody-secreting Cell Differentiation Independent Manner

    Chenglong Fang1, Xiaochuan Sun2, Shangyi Jin2, Lihong du2, Jing Li2, Xiaofeng Zeng3, Yuexin Chen4, Mengtao Li5 and Xinping Tian3, 1Department of Rheumatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China (People's Republic), 2Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, 3Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 4Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing, China, 5Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China

    Background/Purpose: Although Takayasu’s arteritis (TAK) is not a prototypical autoantibody-mediated autoimmune disease, several lines of evidence suggested the pathogenic potential of B cells. However, limited…
  • Abstract Number: 1855 • ACR Convergence 2024

    ­Identification of Autoreactive Cytotoxic T Cells in ANCA-Associated Vasculitis

    Laura van Dam1, Shady Younis2, Jae-Seung Moon3, Mengrui Zhang4, Shima Parfasar4, Audra Horomanski3, orr Sharpe3, Jolijn van Leeuwen5, Tobias Lanz4, Cees van Kooten6, Onno Teng7 and William Robinson8, 1Stanford, Palo Alto, CA, 2Stanford University, Stanford, CA, 3Department of Immunology and Rheumatology, Stanford University, Stanford, CA, 4Department of Immunology and Rheumatology, Stanford University, Stanford, 5Department of Nephrology, Leiden University Medical Center, Leiden, Netherlands, 6Department of Nephrology, Leiden University Medical Center, Leiden, 7Leiden University Medical Center, Leiderdorp, Netherlands, 8Division of Immunology and Rheumatology, Stanford University, and VA Palo Alto Health Care System, Stanford, CA

    Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare and severe autoimmune disease, characterized by a pauci-immune necrotizing vasculitis leading to inflammation and damage…
  • Abstract Number: 2201 • ACR Convergence 2024

    Immunodeficiency-Related Monogenic Autoinflammatory Diseases; Expanding Spectrum of Immunodysregulation Disorders

    Alhanouf Alsaleem1, Lujain Akbar2 and Sulaiman Al-Mayouf3, 1KFSH&RC, Riyadh, Saudi Arabia, 2RIYADH, RIYADH, Saudi Arabia, 3KFSHRRC, Riyadh, Saudi Arabia

    Background/Purpose: Human inborn errors of immunity are caused by monogenic germline mutations characterized by Immunodeficiency like features with increase susceptibility to infection as well as…
  • Abstract Number: 2678 • ACR Convergence 2024

    History of Cutaneous Lupus Promotes Blood and Skin Interferon Signatures in SLE Patients

    Svenja Henning1, Lam Tsoi2, Craig Dobry2, Celine Berthier2, Benjamin Klein2, Amy Hurst2, Rachael Wasikowski3, Johann Gudjonsson2 and J. Michelle Kahlenberg2, 1University of Groningen, Groningen, Netherlands, 2University of Michigan, Ann Arbor, MI, 3Michigan, Dept. of Dermatology, Ann Arbor, MI

    Background/Purpose: Cutaneous lupus (CLE) can present in isolation or as one of the most common manifestations of systemic lupus erythematosus (SLE). Interferon (IFN) stimulated genes…
  • Abstract Number: 0053 • ACR Convergence 2024

    Fasting Reduces an IL-17+/IFNg+ T Helper Cell-inducing Gut Pathobiont in Patients with Rheumatoid Arthritis

    Márcia Pereira1, Katja Stuhlträger2, Natalie Scherff3, Anika Rajput Khokhar4, Sylvio Redanz1, Hebah Ebid5, Bérénice Hansen5, Cédric C. Lacny5, Ulrike Löschberger2, Stefan Bletz6, Jochen G. Schneider7, Paul Wilmes7, Christian S. Kessler4, Andreas Michalsen4, Alexander Mellmann3 and Martin Kriegel1, 1Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Münster, Germany, 2Institute of Musculoskeletal Medicine, University of Münster, Department of Translational Rheumatology and Immunology, Münster, Germany, Muenster, Germany, 3Institute of Hygiene, University Hospital Münster, Münster, Germany, Muenster, Germany, 4Institute of Social Medicine, Epidemiology and Health Economics, Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, Berlin, Germany, 54University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg, 6Institute of Hygiene, University Hospital Münster, Germany, Muenster, Germany, 7University of Luxembourg, Department of Life Sciences and Medicine (DLSM), 6, Avenue du Swing, L-4367 Belvaux, Luxembourg, Luxemburg, Luxembourg

    Background/Purpose: The mucosal origins hypothesis suggests rheumatoid arthritis (RA) is triggered at mucosal sites in genetically predisposed hosts1. Animal models support that microbiota‐induced Th17 cells are…
  • Abstract Number: 0837 • ACR Convergence 2024

    Bispecific Autoantigen-T Cell Engagers (BaiTE) to Selectively Target Autoreactive B Cells in Antiphospholipid Syndrome

    Yuanxuan Xia1, Jin Liu1, Alexander Pearlman1, Brian Mog1, Elana Shaw1, Kyle J. Kaeo1, Colin Gliech1, Brock Moritz1, Tolulope Awosika1, Sarah DiNapoli1, Stephanie Glavaris1, Jiaxin Ge1, Tushar Nichakawade1, Nikita Marcou1, Suman Paul1, Drew Pardoll1, Chetan Bettegowda1, Daniel Goldman2, Michelle Petri2, Antony Rosen1, Kenneth W. Kinzler1, Shibin Zhou1, Bert Vogelstein1 and Maximilian F. Konig1, 1The Johns Hopkins University School of Medicine, Baltimore, MD, 2Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Available drugs to treat autoimmune diseases are indiscriminate, suppressing self-reactive and protective immune responses alike. This lack of therapeutic precision results in infection and…
  • Abstract Number: 1657 • ACR Convergence 2024

    Immunological Profiling of Pain in Knee Osteoarthritis: Treg Cells as Potential New Key Players in Symptomatic Knee Osteoarthritis

    Marie Binvignat1, Maria Marco-Salvador1, Johanna Dubois1, Paul Stys1, Alice Courties2, Fabien Pitoiset1, Alexandra Roux3, Michele Barbier4, Roberta Lorenzon2, Signe Hassler3, Claire Ribet1, helene Vantomme1, Leslie Adda1, Vanessa Mhanna1, Nicolas Coatnoan2, Gwladys Fourcade1, Vimala Didelot1, PIerre Barennes1, Lise Minssen2, Caroline Aheng1, Sanchita Bhattacharya5, Yannick Marie6, Atul J. butte5, Adrien Six1, Nicolas Tchitcheck1, Michelle Rosenzwajg1, Francis Berenbaum1, David Klatzmann1, Encarnita Mariotti-Ferrandiz1 and Jérémie Sellam7, 1Sorbonne University, Paris, France, 2AP-HP, Paris, France, 3Sorbonne University, Paris, 4AP-HP, Paris, 5UCSF, San Francisco, 6ICM, Paris, France, 7Saint-Antoine Hospital - AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Pain is the main osteoarthritis (OA) symptom and remains poorly understood. While significant attention has been given to the potential role of innate immunity,…
  • Abstract Number: 1857 • ACR Convergence 2024

    Thymic Mimetic Cells in Humans, Mice and Fish Are Evolutionarily Ancient with Species-specific Adaptations

    Brooke Huisman1, Daniel Michelson1, Sara Rubin1, Katherine Kohlsaat2, Wilson Gomarga2, Yuan Fang1, Ji Myung Lee2, Pedro del Nido2, Meena Nathan2, Christophe Benoist1, Leonard Zon2 and Diane Mathis1, 1Harvard Medical School, Boston, MA, 2Boston Children's Hospital, Boston, MA

    Background/Purpose: Thymic mimetic cells are molecular hybrids between medullary thymic epithelial cells (mTECs) and diverse peripheral cell types. They are involved in eliminating autoreactive T…
  • Abstract Number: 2217 • ACR Convergence 2024

    A Significant Alteration in Circulating Endocannabinoid Levels in Rheumatoid Arthritis and Fibromyalgia Syndrome Patients and Its Correlation with Diseases Severity

    Gilad Halpert1, Eri Govrin2, Boris Gilburd3, Shlomo Segev3, Omer Gendelman4, Abdulla Watad5, Yehuda Shoenfeld6, David Meiri7 and Howard Amital8, 1CAHIM SHEBA MEDICAL CENTER, Tel Hashomer, Israel, 2Sheba Medical Center, Sdot Micha, Israel, 3Sheba Medical Center, Ramat-Gan, Israel, 4Sheba Medical Center, Ramat Gan, Israel, 5Tel Hashomer Medical Center, Ramat Gan, Israel, 6sheba medical center , Israel, Ramat Gan, Israel, 7Technion-Israel Institute of Technology, Haifa, Israel, 8Sheba Medical Center, Tel-Hashomer, Israel, Ramat Gan, Israel

    Background/Purpose: Accumulating evidence suggests that medical cannabis therapy might have beneficial therapeutic effects in the fibromyalgia syndrome (FMS) and in difficult-to-treat rheumatoid arthritis (RA) patients.…
  • Abstract Number: 2686 • ACR Convergence 2024

    Dose Escalation Safety Study of Brentuximab Vedotin for Diffuse Cutaneous Systemic Sclerosis:Clinical Results and Mechanistic Analysis of Skin and Peripheral Blood Mononuclear Cells

    David Fox1, Laura Cooney2, Lia Stelzig3, Robert Lafyatis4, Johann Gudjonsson5, Lam Tsoi6, Maureen Mayes7, Ankoor Shah8, Suzanne Kafaja9, William Barry3, Ellen Goldmuntz10, Dawn Smilek11 and Dinesh Khanna6, 1University of Michigan, Dexter, MI, 2University of Michigan and Immune Tolerance Network, Ann Arbor, MI, 3Rho, Durham, NC, 4Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 5Department of Dermatology, University of Michigan, Ann Arbor, MI, 6University of Michigan, Ann Arbor, MI, 7UTHealth Houston Division of Rheumatology, Houston, TX, 8Duke University, Durham, NC, 9Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, 10Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, Rockville, MD, 11Immune Tolerance Network, UCSF, San Francisco, CA

    Background/Purpose: Brentuximab vedotin (ADCETRIS®) is a drug antibody conjugate targeting CD30 approved for treatment of Hodgkin’s lymphoma (HL) and other hematologic malignancies. Association of CD30…
  • Abstract Number: 0060 • ACR Convergence 2024

    Spectral Cytometry Shows Increased CD56hi NK Cells and New HLA-DR+CD56+ Phenotypes in RA

    Estelle Khairallah1, Haani Qudsi2, Jihad Ben Gabr1, Andras Perl3 and Christian Geier1, 1SUNY Upstate Medical University, Syracuse, NY, 2Norton College of Medicine, Syracuse, NY, 3SUNY, Syracuse, NY

    Background/Purpose: Previous studies of RA patients have shown changes in NK cell populations (as defined by CD56 expression). The nature of these cellular changes remains…
  • Abstract Number: 0875 • ACR Convergence 2024

    Targeted IL-15 Muteins Provide Selective Expansion of KIR+ CD8 Regulatory T Cells, with the Potential to Ameliorate Disease in Autoimmune Patients with Deficient CD8 Treg Populations

    Daniel Patton, Alex Chen, Justin Bowser, Kaelen Encarnacion, Jennifer Gardell, Emily Gilbertson, Susan Julien, Meghan Maurer, Brent Meengs, Nadine Morgan, Allison O'Rourke, Cong Tan, Jon Therriault, Kristine Swiderek and Courtney Crane, Mozart Therapeutics, Seattle, WA

    Background/Purpose: CD8 Treg, characterized in human peripheral blood mononuclear cells (PBMC) by expression of inhibitory killer immunoglobulin receptors (KIRs), regulate immune balance by eliminating self-reactive…
  • Abstract Number: 1725 • ACR Convergence 2024

    Exploring Risks of Polymyalgia Rheumatica (PMR), Giant Cell Arteritis (GCA) and Complications While Receiving Immune Checkpoint Inhibitors: Comparative Analysis

    Irakli Tskhakaia and Arthur Lau, Jefferson Einstein Hospital, Philadelphia, PA

    Background/Purpose: Immune checkpoint inhibitors (ICIs) have transformed cancer treatment, offering significant benefits in various malignancies. However, these therapies can induce immune-related adverse events (irAEs), including…
  • Abstract Number: 1862 • ACR Convergence 2024

    Folate Receptor β CAR-Tregs Induce Monocyte Apoptosis and Immune Polarization: Potential for Therapeutic Application in Rheumatoid Arthritis

    Xiangni Wu1, Pin-I Chen2, Magdiel Pérez Cruz3, Kent Jensen3 and Everett Meyer3, 1UMKC, KANSAS CITY, MO, 2Department of Medicine, Division of Blood and Bone Marrow Transplantation and Cell Therapy, Stanford University School of Medicine, Stanford, CA, USA., Sunnyvale, CA, 3Department of Medicine, Division of Blood and Bone Marrow Transplantation and Cell Therapy, Stanford University School of Medicine, Stanford, CA, USA., Stanford

    Background/Purpose: Rheumatoid arthritis (RA) affects approximately 1.3 million adults in the United States, causing significant morbidity and economic burden. Current treatments reduce inflammation and slow…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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