Abstracts tagged "human leukocyte antigens (HLA)"

Abstract Number: 2430 • 2017 ACR/ARHP Annual Meeting
For Each HLA-DRB1 Genotype, the Likelihood to Develop RA Correlates with the Probability of Binding at Least a Peptide from PAD4
Isabelle Auger¹, Nathalie Balandraud² and Jean Roudier³, ¹INSERM UMRs 1097, Marseille, France, ²Rheumatology, APHM, Marseilles, France, ³Arthrites auto-immunes, INSERM UMRs 1097, Marseille, France
HLA-DRB1 genotypic risk to develop ACPA positive RA correlates with capability of encoded HLA-DRB1 chains to bind Peptidyl Arginyl Deiminase (PAD4) peptides, not citrullinated Fibrinogen…
Abstract Number: 271 • 2017 ACR/ARHP Annual Meeting
The Trend of Incidence Rate, Frequency and HLA Phenotype of Reactive Arthritis and Uveitis in Japanese Patients with Bladder Cancer Following Intravesical BCG Therapy: A 20-Year, Two-Center Retrospective Study
Yoshinori Taniguchi¹, Satoshi Inotani², Hirofumi Nishikawa², Kosuke Inoue³, Taro Horino², Takashi Karashima⁴, Yasuhiko Yoshinaga⁵ and Yoshio Terada³, ¹Endocrinology, Metabolism,Nephrology and Rheumatology, Kochi University, Kochi, Japan, ²Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School, Nankoku, Japan, ³Kochi University, Nankoku, Japan, ⁴Urology, Kochi University, Nankoku, Japan, ⁵Kurashiki Medical Center, Kurashiki, Japan
Background/Purpose: Intravesical instillation of Bacillus Calmette-Guerin (iBCG) is used as an effective immunotherapy of bladder cancer. However it may have, as adverse event, a reactive…
Abstract Number: 1102 • 2017 ACR/ARHP Annual Meeting
Choosing Unwisely: HLA-B27 Testing and Adherence to Choosing Wisely Practices in a Large Integrated Academic Healthcare System
Marc W. Nolan^1,2, Morgan M. Brown³ and Elie Gertner^1,2, ¹Section of Rheumatology, Regions Hospital, St. Paul, MN, ²Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ³HealthPartners Institute, St. Paul, MN
Background/Purpose: The ACR in 2013 and the Canadian Rheumatology Association (CRA) in 2015 published their respective Choosing Wisely recommendations to promote evidence-based care and reduce…
Abstract Number: 1297 • 2016 ACR/ARHP Annual Meeting
Positive Sacroiliac Joint MRI in Asymptomatic Patients with Recurrent Acute Anterior Uveitis: A Proof of Concept
Thauana Oliveira¹, Walter Maksymowych², Robert G Lambert³, Cristina Muccioli¹ and Marcelo Pinheiro¹, ¹Federal University of São Paulo, São Paulo, Brazil, ²Medicine, University of Alberta,, Edmonton, AB, Canada, ³Radiology, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Recurrent acute anterior uveitis (rAAU) is associated with spondyloarthritis (SpA). However, it is not known if patients with rAAU, but no back symptoms could…
Abstract Number: 1332 • 2016 ACR/ARHP Annual Meeting
Severe Complications and Immunosuppressive Treatments in 33 Patients with Relapsing Polychondritis
Toshiki Nakajima¹, Hajime Yoshifuji¹, Chikashi Terao², Kosaku Murakami¹, Nobuo Kuramoto¹, Ran Nakashima¹, Yoshitaka Imura³, Masao Tanaka¹, Koichiro Ohmura¹ and Tsuneyo Mimori¹, ¹Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ²Genomic Center, Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, ³Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Background/Purpose: Since relapsing polychondritis (RP) is a rare disease as the prevalence rate is 0.0004% in Japan, its severe complications, prognosis and immunosuppressive therapies have…
Abstract Number: 2035 • 2016 ACR/ARHP Annual Meeting
Dosage Contribution of a Non-Classical HLA Gene, HLA-Doa, to the Risk of Rheumatoid Arthritis
Yukinori Okada¹, Akari Suzuki², Katsunori Ikari³, Chikashi Terao⁴, Yuta Kochi², Koichiro Ohmura⁵, Koichiro Higasa⁵, Masato Akiyama², Kyoto Ashikawa², Masahiro Kanai², Jun Hirata¹, Naomasa Suita¹, Yik-Ying Teo⁶, Huji Xu⁷, Sang-Cheol Bae⁸, Yukihide Momozawa², koichi Matsuda⁹, Shigeki Momohara¹⁰, Atsuo Taniguchi¹⁰, Ryo Yamada⁵, Tsuneyo Mimori⁵, Michiaki Kubo², Matthew A. Brown¹¹, Soumya Raychaudhuri¹², Fumihiko Matsuda⁵, Hisashi Yamanaka¹⁰, Yoichiro Kamatani² and Kazuhiko Yamamoto⁹, ¹Osaka University, Osaka, Japan, ²Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ³Inst of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁴Departments of Genetics and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁶Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, ⁷The Second Military Medical University, Shanghai, Japan, ⁸Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, ⁹The University of Tokyo, Tokyo, Japan, ¹⁰Tokyo Women's Medical University, Tokyo, Japan, ¹¹The University of Queensland Diamantina Institute, Brisbane, Australia, ¹²Brigham and Women's Hospital, Boston, MA
Background/Purpose: Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is…
Abstract Number: 2699 • 2016 ACR/ARHP Annual Meeting
Spa-Associated HLA-B*27 Subtypes Accumulate More in Endoplasmic Reticulum (ER) Compartment and in Association with β2-Microglobulin (β2m) Than Non-Associated HLA-B Alleles
Nadège Jah¹, Gilles Chiocchia², Maxime A. Breban³ and Claudine Andre¹, ¹Infection and inflammation, INSERM UMR1173, Montigny-le-Bretonneux, France, ²Infection and Inflammation, INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ³Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France
Background/Purpose: Mechanisms underlying the striking association of SpA with the MHC class I molecule HLA-B27 remain poorly understood. SpA-like disease develops spontaneously in B*2705 transgenic…
Abstract Number: 93 • 2015 ACR/ARHP Annual Meeting
An HLA-C Amino Acid Variant in Addition to HLA-B*27 Confers Risk for Ankylosing Spondylitis in the Korean Population
Kwangwoo Kim¹, So-Young Bang², Seunghun Lee³, Hye-Soon Lee², Seung-Cheol Shim⁴, Young Mo Kang⁵, Chang-Hee Suh⁶, Celi Sun⁷, Swapan Nath⁷, Sang-Cheol Bae² and Tae-Hwan Kim², ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Department of Radiology, Hanyang University College of Medicine, Seoul Hospital, Seoul, South Korea, ⁴Division of Rheumatology, Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University, Daejeon, South Korea, ⁵Dept of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ⁶Allergy-Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ⁷Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Ankylosing spondylitis (AS) is a highly heritable rheumatic disease causing chronic inflammation of axial spine, joints and various organs. The presence of HLA-B*27 is…
Abstract Number: 979 • 2015 ACR/ARHP Annual Meeting
HLA Class I Genes As Susceptibility Markers of Psoriatic Arthritis in Patients with Psoriasis – a Meta-Analysis
Lihi Eder¹, Fatima Abji², Cheryl Rosen³, Muhammad Haroon⁴, Vinod Chandran¹, Rubén Queiro⁵, Shelley Bull⁶, Richard J. Cook⁷, Proton Rahman⁸, Robert Winchester⁹, Oliver FitzGerald¹⁰ and Dafna D. Gladman¹, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Kerry General Hospital, Tralee, Ireland, ⁵Rheumatology Service, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁶School of Public Health, Mount Sinai Hospital, Toronto, ON, Canada, ⁷Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁸Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada, ⁹Columbia University, New York, NY, ¹⁰Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland
Background/Purpose: Genes that differentiate patients with psoriatic arthritis (PsA) from those with psoriasis alone may serve as markers for the development of PsA in psoriasis…
Abstract Number: 1471 • 2015 ACR/ARHP Annual Meeting
Phenotypic Differences Between HLA-B27 Positive and Negative Children with Enthesitis-Related Arthritis
Sabrina Gmuca¹, Timothy Brandon², Rui Xiao³, Ilaria Pagnini⁴, Tracey B. Wright⁵, Timothy Beukelman⁶, Esi Morgan-DeWitt⁷ and Pamela F. Weiss⁸, ¹Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ³Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, ⁴Department of Paediatrics, University of Florence and Anna Meyer Children's Hospital, Florence, Italy, Florence, Italy, ⁵Pediatrics/Rheumatology, UT Southwestern Medical Center, Dallas, TX, ⁶Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁷Pediatric rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁸Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: The association of HLA-B27 with spondyloarthritis is well-established. Under the International League of Associations for Rheumatology (ILAR) criteria most children with spondyloarthritis are classified…
Abstract Number: 1618 • 2015 ACR/ARHP Annual Meeting
The Protective Effect of HLA-DRB1*13 Alleles during Specific Phases in the Development of ACPA-Positive RA
J. van Heemst¹, A.H. Hensvold², X. Jiang², H. van Steenbergen¹, L. Klareskog², T. W. J. Huizinga¹, A.H.M. van der Helm- van Mil¹, A.I. Catrina², René E. M. Toes¹, K. Lundberg² and Diane van der Woude¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Karolinska Institute, Stockholm, Sweden
Background/Purpose: HLA-DRB1*13 alleles are associated with protection from anti-citrullinated protein antibody (ACPA-)positive rheumatoid arthritis (RA). It is however unknown at which phase of disease development…
Abstract Number: 3039 • 2015 ACR/ARHP Annual Meeting
Possible Contribution of HLA-A0207, B5201 and IL-23 Receptor Polymorphism in Ocular Behçet Disease
Toshikatsu Kaburaki¹, Shinji Harihara², Rie Tanaka³, Hiromasa Sawamura⁴, Ai Nishi⁴, Atsushi Hatamochi⁵, Jun Shimizu⁶, Masumi Takeuchi⁷, Shoji Kuwata⁸, Hidetoshi Kawashima⁹ and Fujio Takeuchi¹⁰, ¹Ophthalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Division of Anthropology, Department of Biological Science, The University of Tokyo Graduate School of Science, Tokyo, Japan, ³Department of Ophtalmology, The University of Tokyo Graduate School of Medicine,, Tokyo, Japan, ⁴Department of Ophtalmology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁵Department of Dermatology, Dokkyo Medical University, Tochigi, Japan, ⁶Department of Neurology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁷Teikyo University Support Center for Women Physicians and Researchers, Teikyo University School of Medicine, Tokyo, Japan, ⁸Third Department of Internal Medicine, Teikyo University Chiba Medical Center, Teikyo University School of Medicine, Chiba, Japan, ⁹Department of Ophthalmology, Jichi Medical University, Tochigi, Japan, ¹⁰Department of Allergy and Rheumatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
Background/Purpose: Behçet's disease (BD) is known to be associated with HLA-B*51:01 and HLA- A*26:01 in many different ethnic groups. Recently, HLA-A*02:07, IL-10 and IL23R-IL12RB polymorphisms…
Abstract Number: 626 • 2014 ACR/ARHP Annual Meeting
The Impact of the Interaction Between Human Leukocyte Antigen Alleles and Obesity on Psoriatic Arthritis Risk
Lihi Eder¹, Fatima Abji¹, Cheryl Rosen², Proton Rahman³, Vinod Chandran¹ and Dafna D. Gladman¹, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Human Leukocyte Antigen (HLA) class I alleles and obesity are risk factors for psoriatic arthritis (PsA). We aimed to assess whether there is an…
Abstract Number: 625 • 2014 ACR/ARHP Annual Meeting
Fine-Mapping Major Histocompatibility Complex Associations Identified Contribution of Multiple Class I and II HLA Genes on Risk of Psoriasis and Its Clinical Subtypes
Yukinori Okada¹, Buhm Han², Lam C. Tsoi³, Philip E. Stuart⁴, Eva Ellinghaus⁵, Trilokraj Tejasvi⁶, Vinod Chandran⁷, Fawnda Pellett⁸, Remy Pollock⁹, Anne M. Bowcock¹⁰, Gerald G. Krueger¹¹, Michael Weichenthal⁵, John J. Voorhees⁶, Proton Rahman¹², Peter K. Gregersen¹³, Andre Franke¹⁴, Rajan P. Nair⁶, Gonçalo R. Abecasis¹⁵, Dafna D. Gladman⁷, James T. Elder⁶, Paul IW. de Bakker¹⁶ and Soumya Raychaudhuri¹⁷, ¹Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ²Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, ³Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, ⁴Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Christian-Albrechts-University of Kiel, Kiel, Germany, ⁶University of Michigan Medical School, Ann Arbor, MI, ⁷University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁸University of Toronto, Toronto, ON, Canada, ⁹Rheumatology, University of Toronto, Toronto, ON, Canada, ¹⁰Imperial College, London, United Kingdom, ¹¹Dermatology, University of Utah, Salt Lake City, UT, ¹²Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ¹³The Feinstein Institute for Medical Research, Manhasset, NY, ¹⁴Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany, ¹⁵University of Michigan, Ann Arbor, MI, ¹⁶University Medical Center, Utrecht, Netherlands, ¹⁷Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Psoriasis vulgaris (PsV) risk is strongly associated with genetic variation within the major histocompatibility complex (MHC) region, although its fine genetic architecture has not…
Abstract Number: 597 • 2014 ACR/ARHP Annual Meeting
Inflammatory Burden in Recent-Onset Axial Spondyloarthritis
Juan Jose Aznar Sánchez¹, Raul Veroz Gonzalez¹, Adela Gallego Flores¹, Tamara Libertad Rodriguez Araya¹, Piter José Cossio Jimenez² and Eugenio Chamizo Carmona¹, ¹Rheumatology, Hospital de Mérida, Mérida, Spain, ²Hospital de Mérida, Mérida, Spain
Background/Purpose Patients with Non-Radiographic Axial Spondylarthritis (non-Rx AxSpA) don't presnt with different clinical manifestations than patients with Ankilosing Spondylitis (AS), although the inflammatory burden measured…

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