ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "human leukocyte antigens (HLA)"

  • Abstract Number: 82 • 2014 ACR/ARHP Annual Meeting

    HLA-DPB1*04:01 Confers Risk for PR3-ANCA Positive ANCA-Associated Vasculitis (AAV), but Protects Against MPO-ANCA Positive AAV, in a Japanese Population

    Aya Kawasaki1, Misaki Hidaka2, Narumi Hasebe2, Ken-ei Sada3, Shigeto Kobayashi4, Hidehiro Yamada5, Hiroshi Furukawa6, Kunihiro Yamagata7, Takayuki Sumida8, Nobuyuki Miyasaka9, Shigeto Tohma6, Shoichi Ozaki10, Seiichi Matsuo11, Hiroshi Hashimoto12, Hirofumi Makino3, Masayoshi Harigai13 and Naoyuki Tsuchiya1, 1Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 3Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 4Department of Internal Medicine, Juntendo University Koshigaya Hospital, Tokyo, Japan, 5Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 6Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, 7Department of Internal Medicine (Nephrology), Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 8Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 9Department of Medicine and Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, 10Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 11Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 12Juntendo University School of Medicine, Tokyo, Japan, 13Department of Pharmacovigilance, Tokyo Medical and Dental University, Tokyo, Japan

    Background/Purpose Epidemiologic difference between European and Asian populations is observed in antineutrophil cytoplasmic antibody (ANCA) – associated vasculitis (AAV). Granulomatosis with polyangiitis (GPA) is prevalent…
  • Abstract Number: 2918 • 2014 ACR/ARHP Annual Meeting

    Fine-Mapping Major Histocompatibility Complex Associations in ACPA-Positive Rheumatoid Arthritis Identified Shared HLA Amino Acid Polymorphisms in Asian and European Populations

    Yukinori Okada1, Kwangwoo Kim2, Buhm Han3, Nisha E. Pillai4, Rick T-H. Ong4, Woei-Yuh Saw4, Ma Luo5, Lei Jiang6, Jian Yin6, So-Young Bang7, Hye-Soon Lee7, Matthew A. Brown8, Sang-Cheol Bae2, Huji Xu9, Yik-Ying Teo4, Paul IW. de Bakker10 and Soumya Raychaudhuri3, 1Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 2Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 3Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 4National University of Singapore, Singapore, Singapore, 5University of Manitoba, Winnipeg, MB, Canada, 6The Second Military Medical University, Shanghai, China, 7Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, 8University of Queensland Diamantina Institute, Brisbane, Australia, 9Shanghai Changzheng Hospital, Shanghai, China, 10Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) risk is strongly associated with variations within the major histocompatibility complex (MHC) region, and in particular to HLA-DRB1 alleles. We aimed…
  • Abstract Number: 2457 • 2014 ACR/ARHP Annual Meeting

    Anti-Major Histocompatibility Complex Class I-Related Chain a (MICA) Antibodies in Rheumatoid Arthritis Patients with Interstitial Lung Disease

    Hiroshi Furukawa1, Shomi Oka1, Kota Shimada2, Akiko Komiya1, Naoshi Fukui1, Naoyuki Tsuchiya3 and Shigeto Tohma1, 1Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, 2Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, 3Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

    Background/Purpose: Interstitial lung disease (ILD) is frequently associated with rheumatoid arthritis (RA), and is designated RA-associated ILD (RA-ILD) that influences the prognosis of the disease.…
  • Abstract Number: 2466 • 2014 ACR/ARHP Annual Meeting

    Increased Risk of Rheumatoid Arthritis (RA) Among Shared Epitope-Negative (SE-) Mothers with Shared Epitope-Positive (SE+) Children

    Giovanna Cruz1, Lindsey A. Criswell2, Xiaorong Shao3, Hong L. Quach1, Janelle Noble4, Nikolaos Patsopoulos5, Michael Busch6 and Lisa F. Barcellos1, 1Epidemiology, University of California, Berkeley, Berkeley, CA, 2Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 3Genetic Epidemiology and Genomics Lab, Division of Epidemiology, University of California, Berkeley, Berkeley, CA, 4Children's Hospital Oakland Research Institute (CHORI), Oakland, CA, 5Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 6Blood Systems Research Institute, San Francisco, CA

    Background/Purpose RA (RA [MIM 180300]) disproportionately affects women of reproductive age, implicating pregnancy-related factors. Fetal microchimerism (FMC), or the persistence of a small population of…
  • Abstract Number: 1919 • 2014 ACR/ARHP Annual Meeting

    HLA-B27 Expression Shapes the Intestinal Microbiota

    Mark Asquith1, Phoebe Lin2, Tejpal Gill3, Justine Debelius4, Patrick Stauffer5, Sean Davin5, Gail Ackermann4, Robert A. Colbert3, Rob Knight4 and James Rosenbaum1,6, 1Division of Rheumatology, Oregon Health and Science University, Portland, OR, 2Casey Eye Institute, Oregon Health and Science University, Portland, OR, 3NIAMS/NIH, Bethesda, MD, 4University of Colorado Boulder, Boulder, CO, 5Oregon Health and Science University, Portland, OR, 6Dever's Eye Institute, Legacy Hospital, Portland, OR

    Background/Purpose The intestinal microbiota plays a central role in both health and disease. Beyond shaping local immune responses in the gut, it is increasingly clear…
  • Abstract Number: 627 • 2014 ACR/ARHP Annual Meeting

    HLA Markers for Disease Severity Are Associated with a Higher Burden of Atherosclerosis in Patients with Psoriatic Disease

    Lihi Eder1, Fatima Abji1, Cheryl Rosen2, Vinod Chandran1 and Dafna D. Gladman1, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Dermatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose Recent evidence supports the link between the extent of inflammation and cardiovascular risk in patients with psoriatic disease (PsD). We aimed to investigate the…
  • Abstract Number: 2778 • 2013 ACR/ARHP Annual Meeting

    Mortality In United States Veterans With The HLA-B27 Gene

    Jessica Walsh1, Brian C. Sauer2, Daniel O. Clegg1, Grant W. Cannon3, Xi Zhou4 and Chiachen Teng4, 1Division of Rheumatology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT, 2Epdemiology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT, 3Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, 4Epidemiology, George E. Wahlen Veteran Affairs Medical Center, Salt Lake City, UT

    Background/Purpose : HLA-B27 (B27) is carried by in 6-8% of Americans and is strongly associated with spondyloarthritis (SpA).  SpA has been associated with premature mortality.…
  • Abstract Number: 2770 • 2013 ACR/ARHP Annual Meeting

    Complex Functional Effects Within The HLA Contribute To Sjögren’s Syndrome Pathogenesis and May Influence Both Transcriptional Regulation and Peptide Binding

    Christopher J. Lessard1,2, He Li1, Indra Adrianto1, John A. Ice1, Mikhail G. Dozmorov3, Roland Jonsson4, Maureen Rischmueller5, Gunnel Nordmark6, Xavier Mariette7, Corinne Miceli-Richard8, Marie Wahren-Herlenius9, Torsten Witte10, Michael T. Brennan11, Roald Omdal12, Lars Rönnblom13, Patrick M. Gaffney1, Wan-Fai Ng14, Nelson L. Rhodus15, Barbara M. Segal16, Jonathan D. Wren1, R. Hal Scofield1,17,18, Juan-Manuel Anaya19, John B. Harley20,21, Courtney G. Montgomery1 and Kathy L. Sivils1,2, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 5Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, 6Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 7Paris-Sud University, Paris, France, 8Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 9Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 10Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, 11Nidcr NIH, Carolinas Medical Center, Charlotte, NC, 12Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, 13Department of Medical Science, Uppsala University, Uppsala, Sweden, 14Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, 15University of Minnesota, Minneapolis, MN, 16Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 17Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 18US Department of Veterans Affairs Medical Center, Oklahoma City, OK, 19School of Medicine and Health Sciences, Universidad del Rosario. Center for Autoimmune Diseases Research (CREA), Bogotá, Colombia, 20Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 21US Department of Veterans Affairs Medical Center, Cincinnati, OH

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a common, heterogeneous exocrinopathy.  Etiology involves complex environmental, genetic and genomic influences driving innate and adaptive autoimmune responses.  This…
  • Abstract Number: 1875 • 2013 ACR/ARHP Annual Meeting

    A Dense Mapping Of Human Leukocyte Antigen Region For Study Of Interaction With Smoking In The Development Of Rheumatoid Arthritis

    Xia Jiang1, Henrik Källberg1, Lisbeth Ärlestig2, Solbritt M. Rantapää-Dahlqvist3, Lars Klareskog4, Leonid Padyukov5 and Lars Alfredsson6, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, 3Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden, 4Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 5Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 6Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
  • Abstract Number: 1635 • 2013 ACR/ARHP Annual Meeting

    Identification Of Novel Genetic Associations Within Major Histocompatibility Complex (MHC) Class I and Class II In Systemic Lupus Erythematosus (SLE) Patients:  An Examination Of Epitopes Of Early Autoimmunity

    Gerard Dumancas1, Chee Paul Lin2, Indra Adrianto1, Jennifer A. Kelly1, Stuart B. Glenn1, Jourdan Anderson2, John B. Harley3,4, Timothy J. Vyse5, Robert P. Kimberly6, Marta E. Alarcon-Riquelme7, Carl D. Langefeld8, Betty P. Tsao9, Lindsey A. Criswell10, Chaim O. Jacob11, Patrick M. Gaffney12, Kathy Sivils12, Judith A. James12,13 and Courtney Montgomery2, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 4US Department of Veterans Affairs Medical Center, Cincinnati, OH, 5Medical & Molecular Genetics, King's College London, London, United Kingdom, 6Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 7Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, 8Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, 9Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, 10Department of Medicine, University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, San Francisco, CA, 11Division of Rheumatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 12Oklahoma Medical Research Foundation, Oklahoma City, OK, 13College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production, multiple organ involvement, strong genetic predisposition and specifically, to be associated with…
  • Abstract Number: 176 • 2013 ACR/ARHP Annual Meeting

    Identification Of Major Histocompatibility Complex Class II Alleles Associated With Systemic Sclerosis Through Imputation Strategy

    Jose Ezequiel Martin1, Carmen P. Simeón2, Norberto Ortego-Centeno3, Patricia Carreira4, Miguel A. Gonzalez-Gay5,6, Nicolas Hunzelmann7, Shervin Assassi8, Filemon K. Tan8, Frank C. Arnett8, Xiaodong Zhou8, T.R.D.J. Radstake9,10, Maureen D. Mayes11, Paul de Bakker12,13, Javier Martin1,14 and B. P. C. Koeleman13, 1Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 2Department of Internal Medicine, Hospital Valle de Hebron, Barcelona, Spain, 3Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 4Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, 5Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain, 6Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 7Department of Dermatology, University of Cologne, Cologne, Germany, 8Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 9Laboratory for Translational Immunology, UMC Utrecht, Utrecht, Netherlands, 10Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 11University of Texas Health Science Center at Houston, Houston, TX, 12Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 13Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, 14Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain

    Background/Purpose: Different alleles of MHC class II molecules have been associated either with risk to systemic sclerosis (SSc) or its subphenotypes. Due to the high…
  • Abstract Number: 522 • 2012 ACR/ARHP Annual Meeting

    Genetic Variation in the NCR3 Locus Is Associated with Anti-SSA⁄SSB Positive Primary Sjögren′s Syndrome in Scandinavian Samples

    Gunnel Nordmark1, Maija-Leena Eloranta1, Per Eriksson2, Elke Theander3, Helena Forsblad-d'Elia4, Roald Omdal5, Marie Wahren-Herlenius6, Roland Jonsson7 and Lars Rönnblom1, 1Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 2Rheumatology/AIR, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, 3Dept of Rheumatology, Skane University Hospital, Lund University, Malmö, Sweden, 4Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, 5Department of Internal Medicine, Stavanger university Hospital, Stavanger, Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, 6Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, 7Broegelmann Research Laboratory, the Gade Institute, University of Bergen, Bergen, Norway

    Background/Purpose: Candidate gene studies in primary Sjögren’s syndrome (pSS) have identified polymorphisms in genes involved in the type I interferon (IFN) system and the type…
  • Abstract Number: 978 • 2012 ACR/ARHP Annual Meeting

    A Genome-Wide Interaction Study with Smoking Suggests New Risk Loci for Two Different Subsets of Rheumatoid Arthritis; Results From Swedish Epidemiological Investigation of Rheumatoid Arthritis Study

    Xia Jiang1, Henrik Källberg1, Leonid Padyukov2, Lars Klareskog3 and Lars Alfredsson1, 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Rheumatoid arthritis (RA) is believed to have a multifactorial etiology, involving both genetic and environmental components, and can be divided into two major subsets…
  • Abstract Number: 1197 • 2012 ACR/ARHP Annual Meeting

    Porphyromonas Gingivalis and the Pathogenesis of Rheumatoid Arthritis: Analysis of the Synovial Tissue and of Other Compartments

    Michele C. Totaro1, Sara D'Onghia2, Elisa Gremese1, Luca Petricca1, Simona Marchetti2, Silvia Canestri1, Barbara Tolusso1, Stefano Alivernini1, Paola Cattani2 and Gianfranco Ferraccioli1, 1Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, 2Laboratory of Clinical Analyses CIC, Catholic University of the Sacred Heart, Rome, Italy

    Background/Purpose: Porphyromonas gingivalis (Pg), a periodontal anaerobic intracellular pathogen, has been recently associated to rheumatoid arthritis (RA) and the pathogenesis of the disease, due to…
  • Abstract Number: 1359 • 2012 ACR/ARHP Annual Meeting

    Comparison of Sacroiliac MRI Evaluation Versus Sacroiliac x-Rays in Peripheral Psoriatic Arthritis: Evidence of Silent Disease and Lack of Association to HLA-B27

    Jose Luis Fernandez-Sueiro1, JA Pinto1, S. Pertega-Diaz2, E. Gonzalez3 and Francisco J. Blanco V4, 1Rheumatology Division, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, 2Epidemiology and Statistics, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, 3Rheumatology, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain, 4Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain

    Background/Purpose: Although there are no consensus on how to define spinal involvement in axial psoriatic artritis (axPsA), our data suggest that the presence of spinal…
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