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Abstract Number: 2457

Anti-Major Histocompatibility Complex Class I-Related Chain a (MICA) Antibodies in Rheumatoid Arthritis Patients with Interstitial Lung Disease

Hiroshi Furukawa1, Shomi Oka1, Kota Shimada2, Akiko Komiya1, Naoshi Fukui1, Naoyuki Tsuchiya3 and Shigeto Tohma1, 1Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, 2Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, 3Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: autoantibodies, human leukocyte antigens (HLA), interstitial lung disease and rheumatoid arthritis (RA)

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Session Information

Session Title: Rheumatoid Arthritis - Human Etiology and Pathogenesis

Session Type: Abstract Submissions (ACR)

Background/Purpose: Interstitial lung disease (ILD) is frequently associated with rheumatoid arthritis (RA), and is designated RA-associated ILD (RA-ILD) that influences the prognosis of the disease. Transfusion related acute lung injury is defined as an acute lung injury associated with blood transfusion; one of its causes is thought to be anti-HLA antibody. Here, we investigated the anti-HLA antibody profiles to determine whether they may be useful for diagnosing RA-ILD.

Methods: Anti-HLA antibody levels were analyzed using the Lambda Array Beads Multi-Analyte System (LABScreen Mixed Assay, One Lambda, Canoga Park, CA), using a LabScan 100 system (Luminex, Austin, TX),  in 34 RA patients with or without RA-ILD. This study was reviewed and approved by the ethics committees of each participating institute. Informed consent was provided by all subjects.

Results: Average anti-major histocompatibility complex class I-related chain A (MICA) antibody levels were higher in RA patients with ILD than in those without (P=0.0013, Mann-Whitney’s U test). Average anti-HLA class I or class II antibody levels were not significantly different between RA patients with or without ILD (P=0.6419 and 0.2486, respectively). The ratio of (average anti-MICA antibody levels) / (average anti-HLA class I antibody levels) was increased in RA patients with ILD than in those without (P=4.47X10-5). The area under the curve value of receiver operating characteristic curves of the ratio was 0.912. The optimized cut-off level of the ratio was determined for RA-ILD, and the specificity and the sensitivity were 88.2% and 82.4%, respectively.

Conclusion: To the best of our knowledge, this is the first report of anti-HLA antibody profiles in RA-ILD. The ratio of (average anti-MICA antibody levels) / (average anti-HLA class I antibody levels) could be a better marker for diagnosing RA-ILD. Further large-scale studies would provide a possibility of generating better markers for RA-ILD.


Disclosure:

H. Furukawa,

The Japan Research Foundation for Clinical Pharmacology,

2,

The Takeda Science Foundation ,

2,

The Nakatomi Foundation,

2,

The Daiwa Securities Health Foundation ,

2,

Mitsui Sumitomo Insurance Welfare Foundation,

2;

S. Oka,
None;

K. Shimada,
None;

A. Komiya,
None;

N. Fukui,
None;

N. Tsuchiya,
None;

S. Tohma,

Pfizer Japan Inc., Eisai Co., Ltd, and Chugai Pharmaceutical Co., Ltd,

2.

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