Abstracts tagged "human leukocyte antigens (HLA)"

Abstract Number: 040 • 2023 Pediatric Rheumatology Symposium
HLA DRB1*15 and Eosinophilia Are Common Among Patients with Systemic Juvenile Idiopathic Arthritis
Alison Lerman¹, Shawn Mahmud¹, Zineb Alfath², Benjamin Langworthy³, Patricia Hobday¹, Mona Riskalla¹ and Bryce Binstadt¹, ¹Division of Pediatric Rheumatology, Allergy & Immunology, Department of Pediatrics, University of Minnesota and M Health Fairview Masonic Children’s Hospital, Minneapolis, MN, ²University of Minnesota, Minneapolis, ³Division of Biostatistics, School of Public Health and Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN
Background/Purpose: Over the last two decades, some children with systemic juvenile idiopathic arthritis (SJIA) have developed a severe form of interstitial lung disease (ILD) termed…
Abstract Number: 025 • 2020 Pediatric Rheumatology Symposium
HLA Genetic Signatures Associated with Inflammatory Sub-type in Juvenile Localized Scleroderma
Christina Schutt¹, Emily Mirizio ², Kaila Schollaert-Fitch ² and Kathryn Torok ², ¹UPMC Children's Hospital of Pittsburgh, Pittsburgh, ²Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh
Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue that is characterized by an earlier inflammatory infiltrate, followed by…
Abstract Number: 150 • 2020 Pediatric Rheumatology Symposium
The Killer Immunoglobulin-like Receptor KIR3DL1 in Combination with HLA-Bw4 Is Associated with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)
Jennifer Frankovich¹, Kirstin Anderson ², Gonzalo Montero-Martin ³, Avis Chan ⁴, Margo Thienemann ⁵, Bahare Farhadian ⁶, Theresa Willett ⁵, Elizabeth Mellins ⁷, Alicia Madden ⁵, Tanya Murphy ⁸, Susan Swedo ⁹, Marcelo Fernandez-Vina ³ and Jill Hollenbach ², ¹Stanford, ²University of California San Francisco, San Francisco, California, ³Stanford University, Palo Alto, California, ⁴Stanford University School of Medicine, Palo Alto, ⁵Stanford University School of Medicine, Palo Alto, California, ⁶Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, ⁷Stanford University, Stanford, ⁸University of South Florida, Tampa, Florida, ⁹National Institute of Mental Health, Bethesda, Maryland
Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified neuropsychiatric symptoms. Patients with…
Abstract Number: 123 • 2019 ACR/ARP Annual Meeting
Blockade of Antigen-specific T Cell Activation by a Non-Depleting Anti-HLA-DR Monoclonal Antibody with a Unique Binding Epitope
Fang Shen¹, Karen Duffy ¹, Stephane Becart ², Robert Kuhn ¹, Melissa Swiecki ¹, Brian Jones ¹, Yawei Li ¹, Jeffrey Hall ¹, Ravi Malaviya ¹, Nathan Felix ¹, Mimi Zhou ², Sunil Nagpal ¹ and Navin Rao ¹, ¹Janssen R&D, Spring House, PA, ²Janssen R&D, La Jolla, CA
Background/Purpose: The activation of T helper cells requires cognate recognition of antigen-derived peptides presented by Major Compatibility Complex Class II (MHC II) molecules, which are…
Abstract Number: 1998 • 2019 ACR/ARP Annual Meeting
Major Histocompatibility Antigen HLA-DQB1*0601 Is Associated with Rheumatoid Arthritis Among Indians in a Replication Study: Evidence of Gene-Environment Interaction with LPG Stove Use
Able Lawrence¹, Anshul Dhar ², Swayam Prakash ³, Suvrat Arya ⁴, Amita Aggarwal ⁵ and Suraksha Agrawal ⁶, ¹Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India, ²SGPGIMS, Lucknow, India, ³Cellular and Molecular Immunology Laboratory University of California Irvine, School of Medicine USA, Irvine, CA, ⁴Sanjay Gandhi Postgraduate Institute, Lucknow, India, Lucknow, India, ⁵Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, ⁶SGPGIMS, Lucknow, Uttar Pradesh, India
Background/Purpose: Shared epitope smoking interaction does not fully explain MHC association in Rheumatoid Arthritis (RA). We have previously shown HLA-DQB1*0601 (DQ6.1) to be a susceptibility…
Abstract Number: 2308 • 2019 ACR/ARP Annual Meeting
The Interaction Between Human Leukocyte Antigen Class II Alleles and Seroprotection to Seasonal Influenza Vaccination in Patients with Rheumatoid Arthritis: A post-hoc Analysis
Miriam Kim ¹, Jin Kyun Park ², Eun Bong Lee ³ and Kichul Shin⁴, ¹Seoul National University College of Medicine, Seoul, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, ⁴Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea., seoul, Republic of Korea
Background/Purpose: There are few studies that have looked into the role of human leukocyte antigen (HLA) class II alleles in seroprotection to influenza, especially in…
Abstract Number: 83 • 2018 ACR/ARHP Annual Meeting
The Risk of Developing Rheumatoid Arthritis Based on HLA-DQ Genotypes
Sami B. Kanaan¹, Oyku Sensoy² and J. Lee Nelson³, ¹Clinical Research Division, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ²Clinical Research Division, Fred Hutchinson Cancer Research Center, seattle, WA, ³Fred Hutchinson Cancer Research Center, Seattle, WA
Background/Purpose: The strongest genetic risk for rheumatoid arthritis (RA) is contributed from the HLA region. RA-risk associated HLA-DRB1 alleles including *04:01/4/5/8, *01:01, *10:01, and *14:02…
Abstract Number: 1116 • 2018 ACR/ARHP Annual Meeting
Risk of Systemic Sclerosis According to Charge of the HLA-DRβ1 Third Hypervariable Region
Oyku Sensoy¹, Sami B. Kanaan² and J. Lee Nelson³, ¹Clinical Research Division, Fred Hutchinson Cancer Research Center, seattle, WA, ²Clinical Research Division, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ³Fred Hutchinson Cancer Research Center, Seattle, WA
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs and has a predilection for women. The strongest genetic…
Abstract Number: 1345 • 2018 ACR/ARHP Annual Meeting
Association of HLA-DRB1*0301 with Antisynthetase Syndrome in Spanish Patients
Raquel Lopez-Mejías¹, Sara Remuzgo-Martínez¹, Fernanda Genre¹, Verónica Pulito-Cueto¹, Norberto Ortego Centeno², Eva Perez Pampín³, Antonio Mera³, Julia Martínez-Barrio⁴, Francisco Javier López Longo⁴, Verónica Mijares¹, Leticia Lera-Gomez¹, Sonia Fernández Rozas¹, Victor Mora Cuesta⁵, David Iturbe Fernández¹, Jose Manuel Cifrian Martinez¹, Fredeswinda Romero Bueno⁶, Olga Sanchez-Pernaute⁶, Ricardo Blanco¹, Laura Riesco-Dávila⁷, Laura Nuño⁸, María Gema Bonilla Hernán⁹, Alejandro Balsa⁹, Ernesto Trallero-Araguás¹⁰, Albert Selva O'Callaghan¹⁰, Javier Martin¹¹, Javier Llorca¹², Santos Castañeda¹³, Javier Gonzalo Ocejo⁷, Lorenzo Cavagna¹⁴ and Miguel Angel González-Gay^1,15,16, ¹Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, ²Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, ³Rheumatology Division. Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, ⁴Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁵Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santender, Spain, ⁶Rheumatology Division. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ⁷Immunology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, ⁸Rheumatology, Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, ⁹Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, ¹⁰Rheumatology Department. Hospital Universitario Vall d´Hebron, Barcelona, Spain, ¹¹Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain., Granada, Spain, ¹²Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, ¹³Rheumatology, Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, ¹⁴Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ¹⁵School of Medicine, University of Cantabria, Santander, Spain, ¹⁶Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Antisynthetase syndrome (ASSD) is an inflammatory connective tissue disease characterized by the classic triad: arthritis, myositis, and interstitial lung disease (ILD) [1-3]. Raynaud’s phenomenon,…
Abstract Number: 1625 • 2018 ACR/ARHP Annual Meeting
Association of HLA-B Type and Sacroiliitis in Patients with Psoriatic Arthritis
Daniel Kuo¹, Isela Valera², Mihaela Taylor¹, Roy Altman¹, Veena K. Ranganath¹, Thanda Aung¹, James Louie¹ and Suzanne Kafaja¹, ¹Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous disease with strong genetic heritability. Class I major histocompatibility complex (MHC) genes have been associated with PsA phenotype…
Abstract Number: 2787 • 2018 ACR/ARHP Annual Meeting
−21 HLA-Class I Dimorphism Differentiates Psoriatic Arthritis (PsA) from Psoriasis without Psoriatic Arthritis (PsC)
Vinod Chandran¹, Quan Li², Rohan Machhar², Fatima Abji¹, Justine Y. Ye¹, Rajan Nair³, Philip Stuart³, Katerina Oikonomopoulou², James T. Elder⁴, Dafna D Gladman² and Proton Rahman⁵, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Michigan, Ann Arbor, MI, ⁴University of Michigan Medical School, Ann Arbor, MI, ⁵Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada
Background/Purpose: The association between human leukocyte antigen (HLA) class I alleles and psoriatic disease indicates a potential role for the innate immune system in disease…
Abstract Number: 1579 • 2017 ACR/ARHP Annual Meeting
Monocyte-Derived Dendritic Cells (MDDCs) from Spondyloarthritis (SpA) Patients Exhbit a Coordinated Downregulation of the Cholesterol (chol) Biosynthesis Pathway That Relates to Lipid Overload
Maxime Breban¹, Clémence Desjardin², Emmanuel Chaplais³, Alice Talpin³, Felicie Costantino⁴, Christophe Hue³, Aude Jobart-Malfait⁵, Benoit Maury⁶, Stanislas Grassin-Delyle³, Nelly Bonilla⁷, Ariane Leboime⁸, Roula Said Nahal⁹, Franck Letourneur⁷, Sébastien Jacques⁷, Anne Boland¹⁰, Jean-François Deleuze¹⁰, Gilles Chiocchia¹¹ and Henri-Jean Garchon^3,6,12, ¹Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France, ²INSERM UMR1173, Montigny-le-Bretonneux, France, ³Inserm U1173, Montigny-le-Bretonneux, France, ⁴Hôpital Universitaire Ambroise Pare, Paris, France, ⁵INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, ⁶University of Versailles Saint-Quentin, Simone Veil school of Health Sciences, Montigny-le-Bretonneux, France, ⁷Institut Cochin, Inserm U1016, Paris, France, ⁸Ambroise Paré Hospital Division of Rheumatology, Assistance Publique des Hopitaux de Paris, Boulogne-Billancourt, France, ⁹Ambroise Paré Hospital, Boulogne-Billancourt, France, ¹⁰Centre National de Recherche en Génomique Humaine, Evry, France, ¹¹Service d'Immunologie, Ambroise Paré Hospital, University of Versailles Saint-Quentin-en-Yvelines, Boulogne, France, Boulogne-Billancourt, France, ¹²Ambroise Paré Hospital Division of Genetics, AP-HP, Boulogne-Billancourt, France
Background/Purpose: Gene expression studies are useful to investigate the pathogenesis of complex diseases. The critical role of antigen-presenting cells such as dendritic cells (DCs) being…
Abstract Number: 2000 • 2017 ACR/ARHP Annual Meeting
MRI Contributes to Accurate and Early Diagnosis of Non-Radiographic HLA-B27 Negative Axial Spondyloarthritis
Chun-Chi Lu¹, Guo-Shu Hunag², Tony Szu-Hsien Lee³, En Chao⁴, Hsiang-Cheng Chen², Shi-Jye Chu², Feng-Cheng Liu², San-Yuan Kao², Tsung-Yun Hou², Chen-Hung Chen⁵, Sin-Yi Lyu⁶ and Deh-Ming Chang⁷, ¹University of Washington; Tri-Service General Hopsital, National Defense Medical Center, Seattle, WA, ²Tri-Service General Hopsital, National Defense Medical Center, Taipei, Taiwan, ³National Taiwan Normal University, Taipei, Taiwan, ⁴Tri-Service General Hospital Songshan branch, National Defense Medical Center, Taipei, Taiwan, ⁵Taipei Tzu Chi Hospital, Taipei, Taiwan, ⁶Taoyuan General Hospital, Ministry of Health and Welfare, Taipei, Taiwan, ⁷Tri-Service General Hospital, National Defense Medical Center; Taipei Veteran General Hospital, Taipei, Taiwan
Background/Purpose: According to the ASAS classification criteria for axial spondyloarthritis (SpA), the presence of structure changes of sacroiliac (SI) joints such as sclerosis, bone erosion,…
Abstract Number: 2037 • 2017 ACR/ARHP Annual Meeting
HLA-B27 Testing in Patients >= 45 Years of Age and Subsequent Diagnosis of Late Onset Spondyloarthritis
Marc W. Nolan^1,2, Morgan M. Brown³ and Elie Gertner^1,2, ¹Section of Rheumatology, Regions Hospital, St. Paul, MN, ²Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ³HealthPartners Institute, St. Paul, MN
Background/Purpose: In 2015, the Canadian Rheumatology Association published their Choosing Wisely recommendations regarding HLA-B27 testing. One of the criteria that triggers testing is inflammatory back…
Abstract Number: 2136 • 2017 ACR/ARHP Annual Meeting
Association of HLA-DQA1*05 with the Presence of Interstitial Lung Disease Independent of Autoantibody Status in Caucasian Patients with Polymyositis and Dermatomyositis
Adam Schiffenbauer¹, Sara Faghihi-Kashani², Terrance P. O'Hanlon¹, Willy Flegel³, Sharon Adams³, Ira N. Targoff⁴, Chester V. Oddis^5,6, Rohit Aggarwal^7,8, Lisa G Rider¹, Steven R. Ytterberg⁹, Lisa Christopher-Stine¹⁰, Sonye K. Danoff¹¹, Paul F. Dellaripa^12,13, Ejaz Shamim¹⁴, Andrew Mammen¹⁵ and Frederick W Miller¹⁶, ¹Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ²Environmental Autoimmunity Group, National Institute of Environmental Health, Bethesda, MD, ³Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD, ⁴VA Medical Center, University of Oklahoma Health Sciences Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Rheumatology/Clinical Immunology, Unviersity of Pittsburgh/University of Pittsburgh Medical Center, Pittsburgh, PA, ⁶Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁷Pediatria II, Reumatologia, PRINTO, Istituto Giannina Gaslini, Genoa, Italy, ⁸Department of Medicine / Rheumtology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁹Rheumatology, Mayo Clinic, Rochester, MN, ¹⁰Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, ¹¹Medicine/Pulmonary, Johns Hopkins University, Baltimore, MD, ¹²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ¹³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ¹⁴9. Department of Neurology, Mid-Atlantic Permanente Research Institute, Kaiser Permanente, Rockville, MD, ¹⁵Muscle Diseases Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases. National Institutes of Health, Bethesda, MD, ¹⁶Clinical Research Branch / Environmental Autoimmunity Group, NIH, Bethesda, MD
Background/Purpose: Interstitial lung disease (ILD) is a frequent complication and a major contributor to mortality and morbidity in polymyositis and dermatomyositis (PM/DM). Prior studies have…

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