ACR Meeting Abstracts

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Abstracts tagged "human leukocyte antigens (HLA)"

  • Abstract Number: 040 • 2023 Pediatric Rheumatology Symposium

    HLA DRB1*15 and Eosinophilia Are Common Among Patients with Systemic Juvenile Idiopathic Arthritis

    Alison Lerman1, Shawn Mahmud1, Zineb Alfath2, Benjamin Langworthy3, Patricia Hobday1, Mona Riskalla1 and Bryce Binstadt1, 1Division of Pediatric Rheumatology, Allergy & Immunology, Department of Pediatrics, University of Minnesota and M Health Fairview Masonic Children’s Hospital, Minneapolis, MN, 2University of Minnesota, Minneapolis, 3Division of Biostatistics, School of Public Health and Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN

    Background/Purpose: Over the last two decades, some children with systemic juvenile idiopathic arthritis (SJIA) have developed a severe form of interstitial lung disease (ILD) termed…
  • Abstract Number: 025 • 2020 Pediatric Rheumatology Symposium

    HLA Genetic Signatures Associated with Inflammatory Sub-type in Juvenile Localized Scleroderma

    Christina Schutt1, Emily Mirizio 2, Kaila Schollaert-Fitch 2 and Kathryn Torok 2, 1UPMC Children's Hospital of Pittsburgh, Pittsburgh, 2Pediatric Rheumatology, Univ of Pittsburgh Med Ctr, Pittsburgh

    Background/Purpose: Juvenile localized scleroderma (jLS) is an autoimmune disease of the skin and underlying tissue that is characterized by an earlier inflammatory infiltrate, followed by…
  • Abstract Number: 150 • 2020 Pediatric Rheumatology Symposium

    The Killer Immunoglobulin-like Receptor KIR3DL1 in Combination with HLA-Bw4 Is Associated with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

    Jennifer Frankovich1, Kirstin Anderson 2, Gonzalo Montero-Martin 3, Avis Chan 4, Margo Thienemann 5, Bahare Farhadian 6, Theresa Willett 5, Elizabeth Mellins 7, Alicia Madden 5, Tanya Murphy 8, Susan Swedo 9, Marcelo Fernandez-Vina 3 and Jill Hollenbach 2, 1Stanford, 2University of California San Francisco, San Francisco, California, 3Stanford University, Palo Alto, California, 4Stanford University School of Medicine, Palo Alto, 5Stanford University School of Medicine, Palo Alto, California, 6Stanford Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, 7Stanford University, Stanford, 8University of South Florida, Tampa, Florida, 9National Institute of Mental Health, Bethesda, Maryland

    Background/Purpose: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by abrupt onset of obsessive-compulsive disorder (OCD) and/or food restriction with other specified neuropsychiatric symptoms. Patients with…
  • Abstract Number: 123 • 2019 ACR/ARP Annual Meeting

    Blockade of Antigen-specific T Cell Activation by a Non-Depleting Anti-HLA-DR Monoclonal Antibody with a Unique Binding Epitope

    Fang Shen1, Karen Duffy 1, Stephane Becart 2, Robert Kuhn 1, Melissa Swiecki 1, Brian Jones 1, Yawei Li 1, Jeffrey Hall 1, Ravi Malaviya 1, Nathan Felix 1, Mimi Zhou 2, Sunil Nagpal 1 and Navin Rao 1, 1Janssen R&D, Spring House, PA, 2Janssen R&D, La Jolla, CA

    Background/Purpose: The activation of T helper cells requires cognate recognition of antigen-derived peptides presented by Major Compatibility Complex Class II (MHC II) molecules, which are…
  • Abstract Number: 1998 • 2019 ACR/ARP Annual Meeting

    Major Histocompatibility Antigen HLA-DQB1*0601 Is Associated with Rheumatoid Arthritis Among Indians in a Replication Study: Evidence of Gene-Environment Interaction with LPG Stove Use

    Able Lawrence1, Anshul Dhar 2, Swayam Prakash 3, Suvrat Arya 4, Amita Aggarwal 5 and Suraksha Agrawal 6, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India, 2SGPGIMS, Lucknow, India, 3Cellular and Molecular Immunology Laboratory University of California Irvine, School of Medicine USA, Irvine, CA, 4Sanjay Gandhi Postgraduate Institute, Lucknow, India, Lucknow, India, 5Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India, 6SGPGIMS, Lucknow, Uttar Pradesh, India

    Background/Purpose: Shared epitope smoking interaction does not fully explain MHC association in Rheumatoid Arthritis (RA). We have previously shown HLA-DQB1*0601 (DQ6.1) to be a susceptibility…
  • Abstract Number: 2308 • 2019 ACR/ARP Annual Meeting

    The Interaction Between Human Leukocyte Antigen Class II Alleles and Seroprotection to Seasonal Influenza Vaccination in Patients with Rheumatoid Arthritis: A post-hoc Analysis

    Miriam Kim 1, Jin Kyun Park 2, Eun Bong Lee 3 and Kichul Shin4, 1Seoul National University College of Medicine, Seoul, Republic of Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, 4Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea., seoul, Republic of Korea

    Background/Purpose: There are few studies that have looked into the role of human leukocyte antigen (HLA) class II alleles in seroprotection to influenza, especially in…
  • Abstract Number: 1625 • 2018 ACR/ARHP Annual Meeting

    Association of HLA-B Type and Sacroiliitis in Patients with Psoriatic Arthritis

    Daniel Kuo1, Isela Valera2, Mihaela Taylor1, Roy Altman1, Veena K. Ranganath1, Thanda Aung1, James Louie1 and Suzanne Kafaja1, 1Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, 2Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Psoriatic arthritis (PsA) is a heterogeneous disease with strong genetic heritability. Class I major histocompatibility complex (MHC) genes have been associated with PsA phenotype…
  • Abstract Number: 2787 • 2018 ACR/ARHP Annual Meeting

    −21 HLA-Class I Dimorphism Differentiates Psoriatic Arthritis (PsA) from Psoriasis without Psoriatic Arthritis (PsC)

    Vinod Chandran1, Quan Li2, Rohan Machhar2, Fatima Abji1, Justine Y. Ye1, Rajan Nair3, Philip Stuart3, Katerina Oikonomopoulou2, James T. Elder4, Dafna D Gladman2 and Proton Rahman5, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3University of Michigan, Ann Arbor, MI, 4University of Michigan Medical School, Ann Arbor, MI, 5Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada

    Background/Purpose: The association between human leukocyte antigen (HLA) class I alleles and psoriatic disease indicates a potential role for the innate immune system in disease…
  • Abstract Number: 83 • 2018 ACR/ARHP Annual Meeting

    The Risk of Developing Rheumatoid Arthritis Based on HLA-DQ Genotypes

    Sami B. Kanaan1, Oyku Sensoy2 and J. Lee Nelson3, 1Clinical Research Division, Fred Hutchinson Cancer Research Center, SEATTLE, WA, 2Clinical Research Division, Fred Hutchinson Cancer Research Center, seattle, WA, 3Fred Hutchinson Cancer Research Center, Seattle, WA

    Background/Purpose: The strongest genetic risk for rheumatoid arthritis (RA) is contributed from the HLA region. RA-risk associated HLA-DRB1 alleles including *04:01/4/5/8, *01:01, *10:01, and *14:02…
  • Abstract Number: 1116 • 2018 ACR/ARHP Annual Meeting

    Risk of Systemic Sclerosis According to Charge of the HLA-DRβ1 Third Hypervariable Region

    Oyku Sensoy1, Sami B. Kanaan2 and J. Lee Nelson3, 1Clinical Research Division, Fred Hutchinson Cancer Research Center, seattle, WA, 2Clinical Research Division, Fred Hutchinson Cancer Research Center, SEATTLE, WA, 3Fred Hutchinson Cancer Research Center, Seattle, WA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs and has a predilection for women. The strongest genetic…
  • Abstract Number: 1345 • 2018 ACR/ARHP Annual Meeting

    Association of HLA-DRB1*0301 with Antisynthetase Syndrome in Spanish Patients

    Raquel Lopez-Mejías1, Sara Remuzgo-Martínez1, Fernanda Genre1, Verónica Pulito-Cueto1, Norberto Ortego Centeno2, Eva Perez Pampín3, Antonio Mera3, Julia Martínez-Barrio4, Francisco Javier López Longo4, Verónica Mijares1, Leticia Lera-Gomez1, Sonia Fernández Rozas1, Victor Mora Cuesta5, David Iturbe Fernández1, Jose Manuel Cifrian Martinez1, Fredeswinda Romero Bueno6, Olga Sanchez-Pernaute6, Ricardo Blanco1, Laura Riesco-Dávila7, Laura Nuño8, María Gema Bonilla Hernán9, Alejandro Balsa9, Ernesto Trallero-Araguás10, Albert Selva O'Callaghan10, Javier Martin11, Javier Llorca12, Santos Castañeda13, Javier Gonzalo Ocejo7, Lorenzo Cavagna14 and Miguel Angel González-Gay1,15,16, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santander, Spain, 2Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 3Rheumatology Division. Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain, 4Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 5Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, IDIVAL, Santander, Spain, Santender, Spain, 6Rheumatology Division. Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, 7Immunology Division, Hospital Universitario Marqués de Valdecilla, Santander, Spain, Santander, Spain, 8Rheumatology, Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, 9Rheumatology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain, 10Rheumatology Department. Hospital Universitario Vall d´Hebron, Barcelona, Spain, 11Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain., Granada, Spain, 12Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain, 13Rheumatology, Rheumatology Department, Hospital Universitario de La Princesa, IIS-IP, Madrid, Spain, 14Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, 15School of Medicine, University of Cantabria, Santander, Spain, 16Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: Antisynthetase syndrome (ASSD) is an inflammatory connective tissue disease characterized by the classic triad: arthritis, myositis, and interstitial lung disease (ILD) [1-3]. Raynaud’s phenomenon,…
  • Abstract Number: 271 • 2017 ACR/ARHP Annual Meeting

    The Trend of Incidence Rate, Frequency and HLA Phenotype of Reactive Arthritis and Uveitis in Japanese Patients with Bladder Cancer Following Intravesical BCG Therapy: A 20-Year, Two-Center Retrospective Study

    Yoshinori Taniguchi1, Satoshi Inotani2, Hirofumi Nishikawa2, Kosuke Inoue3, Taro Horino2, Takashi Karashima4, Yasuhiko Yoshinaga5 and Yoshio Terada3, 1Endocrinology, Metabolism,Nephrology and Rheumatology, Kochi University, Kochi, Japan, 2Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School, Nankoku, Japan, 3Kochi University, Nankoku, Japan, 4Urology, Kochi University, Nankoku, Japan, 5Kurashiki Medical Center, Kurashiki, Japan

    Background/Purpose: Intravesical instillation of Bacillus Calmette-Guerin (iBCG) is used as an effective immunotherapy of bladder cancer. However it may have, as adverse event, a reactive…
  • Abstract Number: 1102 • 2017 ACR/ARHP Annual Meeting

    Choosing Unwisely: HLA-B27 Testing and Adherence to Choosing Wisely Practices in a Large Integrated Academic Healthcare System

    Marc W. Nolan1,2, Morgan M. Brown3 and Elie Gertner1,2, 1Section of Rheumatology, Regions Hospital, St. Paul, MN, 2Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, 3HealthPartners Institute, St. Paul, MN

    Background/Purpose: The ACR in 2013 and the Canadian Rheumatology Association (CRA) in 2015 published their respective Choosing Wisely recommendations to promote evidence-based care and reduce…
  • Abstract Number: 1579 • 2017 ACR/ARHP Annual Meeting

    Monocyte-Derived Dendritic Cells (MDDCs) from Spondyloarthritis (SpA) Patients Exhbit a Coordinated Downregulation of the Cholesterol (chol) Biosynthesis Pathway That Relates to Lipid Overload

    Maxime Breban1, Clémence Desjardin2, Emmanuel Chaplais3, Alice Talpin3, Felicie Costantino4, Christophe Hue3, Aude Jobart-Malfait5, Benoit Maury6, Stanislas Grassin-Delyle3, Nelly Bonilla7, Ariane Leboime8, Roula Said Nahal9, Franck Letourneur7, Sébastien Jacques7, Anne Boland10, Jean-François Deleuze10, Gilles Chiocchia11 and Henri-Jean Garchon3,6,12, 1Rheumatology, Ambroise Paré Hospital (AP-HP), Versailles Saint Quentin en Yvelines University, INSERM UMR1173, Boulogne-Billancourt, France, 2INSERM UMR1173, Montigny-le-Bretonneux, France, 3Inserm U1173, Montigny-le-Bretonneux, France, 4Hôpital Universitaire Ambroise Pare, Paris, France, 5INSERM-U1173, University of Versailles Saint-Quentin-en-Yvelines, France, Montigny-le-Bretonneux, France, 6University of Versailles Saint-Quentin, Simone Veil school of Health Sciences, Montigny-le-Bretonneux, France, 7Institut Cochin, Inserm U1016, Paris, France, 8Ambroise Paré Hospital Division of Rheumatology, Assistance Publique des Hopitaux de Paris, Boulogne-Billancourt, France, 9Ambroise Paré Hospital, Boulogne-Billancourt, France, 10Centre National de Recherche en Génomique Humaine, Evry, France, 11Service d'Immunologie, Ambroise Paré Hospital, University of Versailles Saint-Quentin-en-Yvelines, Boulogne, France, Boulogne-Billancourt, France, 12Ambroise Paré Hospital Division of Genetics, AP-HP, Boulogne-Billancourt, France

    Background/Purpose: Gene expression studies are useful to investigate the pathogenesis of complex diseases. The critical role of antigen-presenting cells such as dendritic cells (DCs) being…
  • Abstract Number: 2000 • 2017 ACR/ARHP Annual Meeting

    MRI Contributes to Accurate and Early Diagnosis of Non-Radiographic HLA-B27 Negative Axial Spondyloarthritis

    Chun-Chi Lu1, Guo-Shu Hunag2, Tony Szu-Hsien Lee3, En Chao4, Hsiang-Cheng Chen2, Shi-Jye Chu2, Feng-Cheng Liu2, San-Yuan Kao2, Tsung-Yun Hou2, Chen-Hung Chen5, Sin-Yi Lyu6 and Deh-Ming Chang7, 1University of Washington; Tri-Service General Hopsital, National Defense Medical Center, Seattle, WA, 2Tri-Service General Hopsital, National Defense Medical Center, Taipei, Taiwan, 3National Taiwan Normal University, Taipei, Taiwan, 4Tri-Service General Hospital Songshan branch, National Defense Medical Center, Taipei, Taiwan, 5Taipei Tzu Chi Hospital, Taipei, Taiwan, 6Taoyuan General Hospital, Ministry of Health and Welfare, Taipei, Taiwan, 7Tri-Service General Hospital, National Defense Medical Center; Taipei Veteran General Hospital, Taipei, Taiwan

    Background/Purpose: According to the ASAS classification criteria for axial spondyloarthritis (SpA), the presence of structure changes of sacroiliac (SI) joints such as sclerosis, bone erosion,…
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