Abstracts tagged "gout"

Abstract Number: 1095 • ACR Convergence 2021
Improved Arthrocentesis and Fluid Yield of the Non-Effusive Knee Using Pneumatic Compression
Ahsan Iqbal¹, Sumir Brahmbhatt¹, Maheswari Muruganandam², David Cisneros³, Adnan Kiani², Fatemeh Farshami⁴, Jaren Trost⁵, N. Suzanne Emil², Sharon Nunez¹ and Wilmer Sibbitt², ¹UNM, Albuquerque, NM, ²University of New Mexico, Albuquerque, NM, ³University of New Mexico School of Medicine, Albuquerque, NM, ⁴University of New Mexico, Albuquerque, MD, ⁵Optum, Albuquerque, NM
Background/Purpose: Arthrocentesis is critical for diagnosis and therapy of joint disease; however, it is very difficult to obtain diagnostic fluid from an arthritic but clinically…
Abstract Number: 1580 • ACR Convergence 2021
Whole Blood Gene Expression and eQTL Analysis Implicate GGT7 and FADS2 in Gout Pathogenesis
Richard Reynolds¹, Riku Takei¹, Jeffrey Edberg¹, Nicholas Sumpter¹, Tony Merriman² and Megan Leask¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Dunedin, New Zealand
Background/Purpose: Gene expression studies of whole blood represent a powerful approach for understanding the pathogenesis of gout because differentially expressed transcripts may reflect the activation…
Abstract Number: L08 • ACR Convergence 2020
Long Term Cardiovascular Safety of Febuxostat and Allopurinol in Patients with Chronic Gout: The Febuxostat versus Allopurinol Streamlined Trial (on Behalf of the FAST Investigators)
Thomas MacDonald¹, Isla Mackenzie¹, George Nuki² and Ian Ford³, ¹University of Dundee, Dundee, Scotland, United Kingdom, ²University of Edinburgh, Edinburgh, Scotland, United Kingdom, ³University of Glasgow, Glasgow, Scotland, United Kingdom
Background/Purpose: Febuxostat and allopurinol are uric acid lowering agents. Following concerns about the cardiovascular safety of febuxostat, the European Medicines Agency (EMA) recommended a post-authorization…
Abstract Number: 0648 • ACR Convergence 2020
Dual Energy CT Has Additional Prognostic Value over Clinical Measures in Gout Including Tophi: Best Evidence Synthesis
Sally Stauder¹ and Paul Peloso², ¹Tulane University, Ponte Vedra Beach, FL, ²Horizon Therapeutics plc, Gurnee, IL
Background/Purpose: Dual Energy CT Scan (DECT) can detect monosodium urate crystals in joints and periarticular tissues. EULAR gout guidelines (Richette, 2020) recognized DECT's value in…
Abstract Number: 0665 • ACR Convergence 2020
Trends in Immunomodulation/pegloticase Co-therapy from 2015-2019: A Claims Database Study
Brian LaMoreaux¹, John Botson², Megan Francis-Sedlak¹, Karl Svensson¹ and Robert Holt¹, ¹Horizon Therapeutics plc, Lake Forest, IL, ²Orthopedic Physicians Alaska, Anchorage, AK
Background/Purpose: Pegloticase, a recombinant, PEGylated uricase enzyme, is used to treat uncontrolled gout in patients who do not improve on or are intolerant of oral…
Abstract Number: 0686 • ACR Convergence 2020
Renal Evolution During the First Year of Urate-lowering Therapy According to Sonographic Joint Deposition: Data from the Lille-Alicante Inception Cohort
Irene Calabuig¹, Anne Marty-Ané², Laurène Norberciak³, Jean--Francois Budzik⁴, Agustín Martínez-Sanchis⁵, Mariano Andrés¹ and Tristan Pascart³, ¹Hospital General Universitario de Alicante-ISABIAL and Universidad Miguel Hernández de Elche, Alicante, Spain, ²GHICL, Lille, France, ³GHICL, Lomme, France, ⁴University of Lille, Lille, France, ⁵Hospital General Universitario de Alicante-ISABIAL, Alicante, Spain
Background/Purpose: Gout is associated with chronic kidney disease, but how the kidney function evolves when gout is treated with urate lowering therapy (ULT) is still…
Abstract Number: 1607 • ACR Convergence 2020
Effectiveness of Dietary Counseling on Gout Management and Risk Factors for Metabolic Syndrome in Gout Patients
Juliana Chang¹, Jonathan Tsui² and Maida Wong³, ¹Division of Rheumatology, Department of Medicine, University of California Irvine, Irvine, CA, ²Geisinger Medical Center, Danville, PA, ³Division of Rheumatology, Department of Medicine, VA Long Beach Healthcare System, Long Beach, CA
Background/Purpose: Gout is the most prevalent inflammatory arthritis globally. Despite treatment advances, the prevalence of gout has continued to increase over the last several decades.…
Abstract Number: 0649 • ACR Convergence 2020
A Multicenter, Open-Label, Efficacy and Safety Study of Pegloticase in Patients with Uncontrolled Gout Who Have Undergone Kidney Transplantation: Early Data Report
Abdul Abdellatif¹, Lin Zhao², Paul Peloso³, Katya Cherny², Brad Marder², John Scandling⁴ and Kenneth Saag⁵, ¹Baylor College of Medicine, Division of Nephrology, Houston, TX, ²Horizon Therapeutics plc, Lake Forest, IL, ³Horizon Therapeutics plc, Gurnee, IL, ⁴Stanford Medicine, Department of Nephrology, Stanford, CA, ⁵University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, AL
Background/Purpose: Gout’s high prevalence in kidney transplant (KT) recipients has been associated with heavy residual urate burden, decreased urate excretion related to reduced renal function,…
Abstract Number: 0667 • ACR Convergence 2020
Gout Management Beyond Prescription Writing: The Role of the Pharmacist
Emma Dorris¹, Paul Ryan², Mariosa Kieran³, Nicola Dalbeth⁴ and Geraldine McCarthy⁵, ¹School of Medicine, Dublin, Dublin, Ireland, ²Mayfield Family Practice, Cork, Cork, Ireland, ³Pharmacy Department, Dublin, Dublin, Ireland, ⁴University of Auckland, Auckland, New Zealand, ⁵University College Dublin, Dublin, Dublin, Ireland
Background/Purpose: Urate lowering therapy (ULT) is recommended for long-term gout management. However, gout flares are common at the time of starting ULT, and these flares…
Abstract Number: 0688 • ACR Convergence 2020
The Discontinuation of Allopurinol in the Inpatient Setting and the Risk of Gout Flare: A Community-Hospital Experience
Artem Minalyan¹, Waqas Ullah², Shristi Khanal³, Bikash Basyal⁴ and Qian Zhang³, ¹Department of Medicine/Abington Hospital - Jefferson Health, Jenkintown, PA, ²Department of Medicine/Abington Hospital - Jefferson Health, Horsham, ³Department of Medicine/Abington Hospital - Jefferson Health, Jenkintown, ⁴Department of Medicine/Abington Hospital - Jefferson Health, Abington
Background/Purpose: The discontinuation of urate-lowering therapy (ULT) in the outpatient setting increases the risk of gout flare. It was reported that in hospitalized patients with…
Abstract Number: 1628 • ACR Convergence 2020
Management of Gout After Pegloticase; Observations of US Clinical Practice from Trio Health and the American Rheumatology Network (ARN)
Nehad Soloman¹, Mona Amin², Simon Helfgott³, Alexander Hu⁴, Kent Kwas Huston⁵, Jordan Leonard⁶, Kelsey Milligan⁷, Scott Milligan⁷, Jasvinder Singh⁸, John Tesser⁹ and Colin Edgerton¹⁰, ¹Arizona Arthritis & Rheumatology Associates, P.C., Peoria, AZ, ²Arizona Arthritis & Rheumatology Associates, P.C., Scottsdale, AZ, ³BWH- HMS, Boston, MA, ⁴Arizona Arthritis & Rheumatology Associates, P.C., New Orleans, LA, ⁵Kansas City Physician Partners, Kansas City, MO, ⁶Arizona Arthritis & Rheumatology Associates, P.C., Phoenix, AZ, ⁷Trio Health, Louisville, CO, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, ¹⁰Articularis Healthcare, Summerville, SC
Background/Purpose: Pegloticase is approved for severe gout in patients that are intolerant to, or whose disease is ineffectively controlled by, other uric acid lowering therapies…
Abstract Number: 0650 • ACR Convergence 2020
Risk of Vertebral Fractures at Lateral Chest Radiographies in Patients with Gout
Marco Ferrández-Jiménez¹, Irene Calabuig², Maria Luisa Peral², Miguel Gómez-Garberí¹ and Mariano Andrés², ¹Universidad Miguel Hernández de Elche, Alicante, Spain, ²Hospital General Universitario de Alicante-ISABIAL and Universidad Miguel Hernández de Elche, Alicante, Spain
Background/Purpose: Osteoporosis causes significant morbidity and mortality through the development of fragility fractures, including vertebral fractures (VF). Patients with gout may show an increased risk…
Abstract Number: 0669 • ACR Convergence 2020
Calcium Pyrophosphate Crystal Deposition in Gouty Tophi
Hang-Korng Ea¹, Alan Gauffenic², Quand Nguyen³, Nhu Pham³, Oceane Olivier², Vincent Frochot⁴, Dominique Bazin⁵, Nghia Le³, Caroline Marty², Agnès Ostertag², Martine Cohen-Solal¹, Jean-Denis Laredo⁶, Pascal Richette⁷ and Thomas Bardin⁸, ¹Université de Paris, INSERM UMR 1132, BIOSCAR, AP-HP, DMU Locomoteur, Paris, France, ²Université de Paris, INSERM UMR 1132, BIOSCAR, Paris, France, ³Vien Gut Medical Center and French-Vietnamese research center on gout and chronic diseases, Ho Chi Ming, Vietnam, ⁴Hôpital Tenon, Service des explorations fonctionnelles multidisciplinaires, Sorbonne université, UMR_S1155, Paris, France, ⁵Institut de Chimie Physique, Université Paris-Saclay et CNRS - UMR8000, Orsay, France, ⁶AP-HP Université de Paris, Paris, ⁷Department of Rheumatology, Lariboisière Hospital, AP-HP Université de Paris, INSERM U1132, Paris, ⁸Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France
Background/Purpose: The coexistence of calcium pyrophosphate (CPP) and monosodium urate crystals is rarely reported in gouty tophi. We investigated CPP crystal deposits in a series…
Abstract Number: 0689 • ACR Convergence 2020
The Changing Epidemiology of Inpatient Gout and Associated Mortality: A 17-year National Study
Jasvinder Singh¹ and John Cleveland¹, ¹University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Knowledge gaps exist regarding time-trends for the main causes (Cardiac/renal disease vs. infections) hospitalizations in gout. Therefore, we examined whether specific causes (cardiovascular, renal,…
Abstract Number: 1629 • ACR Convergence 2020
Management of Gout with Pegloticase; Real-World Utilization and Outcomes from Trio Health and the American Rheumatology Network (ARN)
Nehad Soloman¹, Mona Amin², Kimmi Cox³, Simon Helfgott⁴, Alexander Hu⁵, Kent Kwas Huston⁶, Jordan Leonard⁷, Scott Milligan³, Jasvinder Singh⁸, John Tesser⁹ and Colin Edgerton¹⁰, ¹Arizona Arthritis & Rheumatology Associates, P.C., Peoria, AZ, ²Arizona Arthritis & Rheumatology Associates, P.C., Scottsdale, AZ, ³Trio Health, Louisville, CO, ⁴BWH- HMS, Boston, MA, ⁵Arizona Arthritis & Rheumatology Associates, P.C., New Orleans, LA, ⁶Kansas City Physician Partners, Kansas City, MO, ⁷Arizona Arthritis & Rheumatology Associates, P.C., Phoenix, AZ, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, ¹⁰Articularis Healthcare, Summerville, SC
Background/Purpose: Infusion reactions and other adverse events associated with pegloticase may lead to discontinuation of treatment in patient populations that have already failed or are…

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