Abstract Number: 621 • 2019 ACR/ARP Annual Meeting
The Use of Microbial Flow Cytometry to Analyze the Intestinal and Oral Microbiota
Background/Purpose: The role of the microbiome in the pathogenesis of autoimmune disorders such as axial spondyloarthritis (SpA) has been well-established through means of describing gross…Abstract Number: 63 • 2018 ACR/ARHP Annual Meeting
TNF-α Blockade Incompletely Reverses Inflammatory Pulmonary Pathology in the TNF-Transgenic Mouse Model of Rheumatoid Arthritis
Background/Purpose: Interstitial lung disease (ILD) is a significant contributor to rheumatoid arthritis (RA) mortality, yet its pathogenesis remains enigmatic. One theory posits that initial inflammatory…Abstract Number: 584 • 2018 ACR/ARHP Annual Meeting
Changes in CD4+ T and B Cell Profile As Indicator of Clinical Remission to TNF Inhibitors in Patients with Rheumatoid Arthritis
Background/Purpose: TNF inhibitors (TNFi) are widely used for the treatment of rheumatoid arthritis (RA). This study aims to analyse the profile of peripheral blood mononuclear…Abstract Number: 849 • 2018 ACR/ARHP Annual Meeting
Constructing a Macrophage Infiltration Timeline in a Murine Model of Osteoarthritis
Background/Purpose: Macrophage infiltration in synovium (SM) and intraarticular fat pads (FP) is common in Osteoarthritis (OA), and can contribute to catabolic cytokine and protease production…Abstract Number: 2116 • 2018 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap Formation Is Dependent on Disease Activity in Systemic Lupus Erythematosus: Determination Using a Flow Cytometry-Based Assay
Background/Purpose: Neutrophil extracellular traps (NETs) are composed of decondensed DNA that is released during an active cell death program is known as NETosis. To date,…Abstract Number: 2328 • 2017 ACR/ARHP Annual Meeting
Characterisation of Lipid Mediator Profile and Immune Cells in Synovial Fluid of Juvenile Idiopathic Arthritis
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is often accompanied by inflammation of the joints. The mechanisms involved in the inflammation in JIA are incompletely understood. Several…Abstract Number: 1170 • 2017 ACR/ARHP Annual Meeting
High Output Flow Cytometry Array Classifies Subjects with Uveitis Due to Behcet’s Disease and Sarcoidosis
Background/Purpose: The information content of multi-parametric flow cytometry-based immune-phenotyping experiments is routinely underexploited given the paucity of adequate tools and strategies for large-scale unbiased data…Abstract Number: 760 • 2016 ACR/ARHP Annual Meeting
Effects of Type I Interferon Inhibition on Blood Leukocyte Subsets in Patients Treated in a Phase IIb Clinical Study of Anifrolumab in SLE
Background/Purpose: A Phase IIb randomized controlled study (NCT01753193) was conducted with anifrolumab, a fully human, anti-interferon (IFN)–α receptor (IFNAR1) specific antibody in adults with moderate…Abstract Number: 918 • 2016 ACR/ARHP Annual Meeting
Anergic B Cells May Preserve Peripheral Tolerance in Lupus-Prone Congenic Mice
Background/Purpose: Anergic autoreactive B cells are thought to play a critical role in systemic lupus erythematosus (SLE), a chronic autoimmune disease where breach of tolerance…Abstract Number: 1201 • 2016 ACR/ARHP Annual Meeting
Deconvolution of Immune Cell Proportions from Whole Blood RNA Using Next-Generation Sequencing
Background/Purpose: Measurements of immune cell proportions from whole blood can be used to detect pharmacodynamic effects, as a marker for prognosis and to aid in…Abstract Number: 1606 • 2016 ACR/ARHP Annual Meeting
Metrotexate Treatment Inmunomodulate the Abnormal Cytokine Expression Present in NaïVe Rheumatoid Arthritis Patients
Background/Purpose: Methotrexate (MTX) is the most commonly used DMARD in rheumatoid arthritis (RA) patients. Since the first reports of the efficacy of low-dose MTX in…Abstract Number: 1638 • 2016 ACR/ARHP Annual Meeting
Antibody Mediated Immunity Drives Response to Methotrexate Treatment in Rheumatoid Arthritis Patients
Background/Purpose: Methotrexate (MTX) is the first line treatment for Rheumatoid Arthritis (RA) in Sweden, but one third of patients do not experience satisfying treatment response.…Abstract Number: 2708 • 2016 ACR/ARHP Annual Meeting
Type 17 Immunity in Spondyloarthritis Is Expanded Across Multiple Lymphocyte Subsets
Background/Purpose: The spondyloarthritides (SpA) are a group of chronic inflammatory disorders involving the axial spine and the peripheral joints. Genetic, functional and clinical trial evidences…Abstract Number: 2929 • 2016 ACR/ARHP Annual Meeting
The Baseline Th17 Lymphocytes Level Is a Predictive Marker of Good Response to Biologics in Rheumatoid Arthritis
Background/Purpose: In clinical daily practice, the response to biologic drugs is unpredictable in patients with rheumatoid arthritis (RA). Thus, there is a crucial need for…Abstract Number: 2055 • 2014 ACR/ARHP Annual Meeting
Are There Immunological Abnormalities in Fibromyalgia Patients: Flow Cytometry Analysis
Background/Purpose: Fibromyalgia is not thought to have an immunological pathogenesis: However, few studies have been done to evaluate immunological abnormalities. We analyzed lymphocyte subsets in…