Session Type: Abstract Submissions (ACR)
Background/Purpose: Fibromyalgia is not thought to have an immunological pathogenesis: However, few studies have been done to evaluate immunological abnormalities. We analyzed lymphocyte subsets in fibromyalgia syndrome (FMS) patients and compared the results to established normal values in healthy controls.
Methods: 25 Patients (22 female and 3 male) with fibromyalgia meeting 2010 ACR criteria and followed in a rheumatology office practice had their blood analyzed by flow cytometry. Normal values for healthy controls were established by the University of Miami Immunology Laboratory where the analyses were performed.
Results: The following immunologic tests were abnormal in fibromyalgia patients
Conclusion: CD4+CD38+ helper Tcells were elevated in the FMS patients. CD8+CD38+, CD8+CD95+ and CD8+CD11a were reduced in FMS compared to normal healthy levels. This suggests possible increased T helper cell function and reduced CD8 cytotoxic/suppressor T cells in this group of fibromyalgia patients.)
The immune system could play a yet undetermined role in fibromyalgia.
R. S. Katz,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/are-there-immunological-abnormalities-in-fibromyalgia-patients-flow-cytometry-analysis/