ACR Meeting Abstracts

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Abstracts tagged "flow cytometry"

  • Abstract Number: 621 • 2019 ACR/ARP Annual Meeting

    The Use of Microbial Flow Cytometry to Analyze the Intestinal and Oral Microbiota

    Patrick Stauffer1, Mark Klick 1, Tammy Martin 1, James T. Rosenbaum 2 and Mark Asquith 1, 1Oregon Health and Science University, Portland, OR, 2Devers Eye Institute and Oregon Health & Science University, Portland, OR

    Background/Purpose: The role of the microbiome in the pathogenesis of autoimmune disorders such as axial spondyloarthritis (SpA) has been well-established through means of describing gross…
  • Abstract Number: 2116 • 2018 ACR/ARHP Annual Meeting

    Neutrophil Extracellular Trap Formation Is Dependent on Disease Activity in Systemic Lupus Erythematosus: Determination Using a Flow Cytometry-Based Assay

    Sen Hee Tay1, Olga Zharkova2, Hui Yin Lee3, Shubhita Tripathi4, Wei Yee Ong5, Aisha Lateef6, Paul MacAry7, Lina Lim2, John Edward Connolly8 and Anna-Marie Fairhurst3, 1Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Singapore, 2Physiology, National University of Singapore, Singapore, Singapore, 3Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore, 4National University of Singapore, Singapore, Singapore, 5Institute for Molecular and Cellular Biology, Agency for Science, Technology and Research, Singapore, Singapore, 6Medicine, Division of Rheumatology, National University Hospital of Singapore, Singapore, Singapore, 7Department of Microbiology and Immunology, National University of Singapore, Singapore, Singapore, 8Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore

    Background/Purpose: Neutrophil extracellular traps (NETs) are composed of decondensed DNA that is released during an active cell death program is known as NETosis.  To date,…
  • Abstract Number: 63 • 2018 ACR/ARHP Annual Meeting

    TNF-α Blockade Incompletely Reverses Inflammatory Pulmonary Pathology in the TNF-Transgenic Mouse Model of Rheumatoid Arthritis

    Emily Wu1, Richard Bell2, Edward Schwarz3 and Homaira Rahimi4, 1Department of Immunology, Microbiology, and Virology, University of Rochester, Rochester, NY, 2Center for Musculoskeletal Research, University of Rochester, Rochester, NY, 3Orthopedeatrics, University of Rochester, Rochester, NY, 4Rheumatology, University of Rochester/Golisano Children's Hosp, Rochester, NY

    Background/Purpose: Interstitial lung disease (ILD) is a significant contributor to rheumatoid arthritis (RA) mortality, yet its pathogenesis remains enigmatic. One theory posits that initial inflammatory…
  • Abstract Number: 584 • 2018 ACR/ARHP Annual Meeting

    Changes in CD4+ T and B Cell Profile As Indicator of Clinical Remission to TNF Inhibitors in Patients with Rheumatoid Arthritis

    Borja Hernández-Breijo1,2, Israel Gañán-Nieto3, Cristina Sobrino3, Victoria Navarro-Compán1, Ana Martínez1,2, Carlota García-Hoz3, Javier Bachiller3, María Gema Bonilla Hernán1,4, Garbiñe Roy5, Mónica Vázquez3, Alejandro Balsa1,6, Luisa María Villar3, Dora Pascual-Salcedo1, Eulalia Rodríguez-Martín3 and Chamaida Plasencia1,4, 1Immuno-Rheumatology research group, IdiPaz. La Paz University Hospital, Madrid, Spain, 2Immunology. La Paz University Hospital, Madrid, Spain, 3Immuno-Rheumatology research group, IRYCIS. Ramón y Cajal University Hospital, Madrid, Spain, 4Rheumatology, La Paz University Hospital, Madrid, Spain, 5Immunology. Ramón y Cajal University Hospital and IRYCIS, Madrid, Spain, 6Hospital Universitario La Paz, Madrid, Spain

    Background/Purpose: TNF inhibitors (TNFi) are widely used for the treatment of rheumatoid arthritis (RA). This study aims to analyse the profile of peripheral blood mononuclear…
  • Abstract Number: 849 • 2018 ACR/ARHP Annual Meeting

    Constructing a Macrophage Infiltration Timeline in a Murine Model of Osteoarthritis

    Cheng Zhou1,2, Vu Nguyen1,3, Nisha Sambamurthy1,2, Michael Dodge1,4 and Carla Scanzello1,2, 1Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, 2Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 3University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 4Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

    Background/Purpose: Macrophage infiltration in synovium (SM) and intraarticular fat pads (FP) is common in Osteoarthritis (OA), and can contribute to catabolic cytokine and protease production…
  • Abstract Number: 1170 • 2017 ACR/ARHP Annual Meeting

    High Output Flow Cytometry Array Classifies Subjects with Uveitis Due to Behcet’s Disease and Sarcoidosis

    Johannes Nowatzky1, Ezra Resnick2, Julia Manasson3, Cristy Stagnar1 and Olivier Manches4, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2Google Inc., New York, NY, 3Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 4EFS Rhône-Alpes-Auvergne "Immunobiology and Immunotherapy in Chronic Diseases", INSERM - French National Institute of Health and Medical Research, Grenoble, France

    Background/Purpose: The information content of multi-parametric flow cytometry-based immune-phenotyping experiments is routinely underexploited given the paucity of adequate tools and strategies for large-scale unbiased data…
  • Abstract Number: 2328 • 2017 ACR/ARHP Annual Meeting

    Characterisation of Lipid Mediator Profile and Immune Cells in Synovial Fluid of Juvenile Idiopathic Arthritis

    Johannes Hendrick von Hegedus1, Q. S. R. Madari2, P.C.E. Hissink Muller3, M. Kloppenburg4, REM Toes4, Martin Giera5, TWJ Huizinga4, Rebecca ten Cate6 and A. Ioan-Facsinay4, 1Department of Rheumatology, LUMC, Leiden, Netherlands, 2LUMC, Leiden, Netherlands, 3Willem-Alexander Children's Hospital, LUMC, Leiden, Netherlands, 4Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands, 6Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is often accompanied by inflammation of the joints. The mechanisms involved in the inflammation in JIA are incompletely understood. Several…
  • Abstract Number: 760 • 2016 ACR/ARHP Annual Meeting

    Effects of Type I Interferon Inhibition on Blood Leukocyte Subsets in Patients Treated in a Phase IIb Clinical Study of Anifrolumab in SLE

    Geoffrey Stephens1, Rong Zeng2, Xiang Guo2, Steve Eck3, Yuling Wu3, Liangwei Wang3, Gabor Illei3 and Wendy White2, 1Cellcion, Clarksburg, MD, 2Translational Sciences, MedImmune, LLC, Gaithersburg, MD, 3MedImmune, LLC, Gaithersburg, MD

    Background/Purpose: A Phase IIb randomized controlled study (NCT01753193) was conducted with anifrolumab, a fully human, anti-interferon (IFN)–α receptor (IFNAR1) specific antibody in adults with moderate…
  • Abstract Number: 918 • 2016 ACR/ARHP Annual Meeting

    Anergic B Cells May Preserve Peripheral Tolerance in Lupus-Prone Congenic Mice

    Kieran Manion1,2, Yuriy Baglaenko1,2, Nan-Hua Chang2, Nafiseh Talaei3 and Joan Wither4, 1Immunology, University of Toronto, Toronto, ON, Canada, 2Genetics and Development, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Genetics and Development, Krembil Research Institute, Toronto, ON, Canada, 4Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose:  Anergic autoreactive B cells are thought to play a critical role in systemic lupus erythematosus (SLE), a chronic autoimmune disease where breach of tolerance…
  • Abstract Number: 1201 • 2016 ACR/ARHP Annual Meeting

    Deconvolution of Immune Cell Proportions from Whole Blood RNA Using Next-Generation Sequencing

    Omar Jabado1, Sarah Hu2, Julie Carman3, Suzanne Suchard3, Deborah Lee4, Zhenhao Qi5, Stefan Kirov6, Ryan Golhar7, Aiqing He7, Cate Speake8, Peter S. Linsley8, Steven G. Nadler9 and Somnath Bandyopadhyay2, 13551 Lawrenceville Princeton, Bristol-Myers Squibb, Princeton, NJ, 2Bristol-Myers Squibb, Princeton, NJ, 3Discovery Translational Sciences Group, Bristol-Myers Squibb, Princeton, NJ, 4Discovery Immunoscience, Bristol-Myers Squibb, Princeton, NJ, 5Exploratory Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, 6Genetically Defined Diseased & Genomics, Bristol-Myers Squibb, Princeton, NJ, 7Genetically Defined Diseases & Genomics, Bristol-Myers Squibb, Princeton, NJ, 8Systems Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, 9Immunosciences Translational Research, Bristol-Myers Squibb, Princeton, NJ

    Background/Purpose: Measurements of immune cell proportions from whole blood can be used to detect pharmacodynamic effects, as a marker for prognosis and to aid in…
  • Abstract Number: 1606 • 2016 ACR/ARHP Annual Meeting

    Metrotexate Treatment Inmunomodulate the Abnormal Cytokine Expression Present in NaïVe Rheumatoid Arthritis Patients

    Jorge Monserrat Sanz1, Ana Maria Gómez Lahoz1, Maria Dolores Sosa Reina1, Cristina Bohórquez Heras2, Atusa Movasat2, Ana Pérez Gómez2, Lucía Ruiz Gutiérrez2, Ana Sánchez Atrio2, Eduardo Cuende Quintana2, M José León2, David Diaz3, Fernando Albarrán Hernández2 and Melchor Alvarez-Mon2,3, 1Medicine and Medical Specialities, Laboratory of Immune System Diseases, Department of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain, 2University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, 3Laboratory of Immune System Diseases, Department of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain

    Background/Purpose: Methotrexate (MTX) is the most commonly used DMARD in rheumatoid arthritis (RA) patients. Since the first reports of the efficacy of low-dose MTX in…
  • Abstract Number: 1638 • 2016 ACR/ARHP Annual Meeting

    Antibody Mediated Immunity Drives Response to Methotrexate Treatment in Rheumatoid Arthritis Patients

    Boel Brynedal1, Helga Westerlind2, Lasse Folkersen3,4, Leonid Padyukov5, Nancy Vivar5, Anca I Catrina6, Lars Klareskog5 and Louise Berg5, 1Section of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Karolinska, Sweden, 2Section of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 3Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 4Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark, 5Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden, 6Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

    Background/Purpose: Methotrexate (MTX) is the first line treatment for Rheumatoid Arthritis (RA) in Sweden, but one third of patients do not experience satisfying treatment response.…
  • Abstract Number: 2708 • 2016 ACR/ARHP Annual Meeting

    Type 17 Immunity in Spondyloarthritis Is Expanded Across Multiple Lymphocyte Subsets

    Davide Simone1, Hussein Al Mossawi1, Anna Ridley2, Jelle De Wit1, Takuya Sekine1, Nuha Ansar1, Karen Doig1 and Paul Bowness1, 1Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom

    Background/Purpose: The spondyloarthritides (SpA) are a group of chronic inflammatory disorders involving the axial spine and the peripheral joints. Genetic, functional and clinical trial evidences…
  • Abstract Number: 2929 • 2016 ACR/ARHP Annual Meeting

    The Baseline Th17 Lymphocytes Level Is a Predictive Marker of Good Response to Biologics in Rheumatoid Arthritis

    Sarah Salomon1, Caroline Guignant2, Pierre Morel3, Brigitte Gubler4, Patrice Fardellone5, Jean-Pierre Marolleau6 and Vincent Goeb7, 1Rheumatology, University Hospital of Amiens, Amiens, France, 2Immunology Laboratory, University Hospital of Amiens, Amiens, France, 3Hematology, University Hospital of Amiens, Amiens, France, 4Immunology, University Hospital of Amiens, Amiens, France, 5Department of Rheumatology, Amiens University hospital, Amiens, France, 6hematology, University Hospital of Amiens, Amiens, France, 7Rheumatology, Amiens University Hospital, Amiens, France

    Background/Purpose: In clinical daily practice, the response to biologic drugs is unpredictable in patients with rheumatoid arthritis (RA). Thus, there is a crucial need for…
  • Abstract Number: 2055 • 2014 ACR/ARHP Annual Meeting

    Are There Immunological Abnormalities in Fibromyalgia Patients: Flow Cytometry Analysis

    Robert S. Katz1, Hannah Bond2 and Daniel Pickrell2, 1Rush Medical College, Chicago, IL, 2Rheumatology Associates, Chicago, IL

    Background/Purpose:  Fibromyalgia is not thought to have an immunological pathogenesis: However, few studies have been done to evaluate immunological abnormalities.   We analyzed lymphocyte subsets in…
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