ACR Meeting Abstracts

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Abstracts tagged "fibrosis"

  • Abstract Number: 1044 • 2019 ACR/ARP Annual Meeting

    TGF-β Isoforms Modulate the RNA Cargo of Extracellular Vesicles (Exosomes) Isolated from Cultured Normal Human Lung Microvascular Endothelial Cells: A Mechanistic Link Between Endothelial Cell Dysfunction and the Establishment of a Profibrotic Phenotype in SSc?

    Peter Wermuth1 and Sergio Jimenez 1, 1Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, Philadelphia, PA

    Background/Purpose: Extracellular vesicles (EV) are a diverse assortment of lipid bilayer-bound vesicles of various sizes and origin. Exosomes are a subset of EV arising from…
  • Abstract Number: 1049 • 2019 ACR/ARP Annual Meeting

    Induction of a Profibrotic Phenotype in Normal Dermal Fibroblasts by Expression of PIM1 Kinase and Demonstration of Antifibrotic Effects of Inhibition of PIM Kinases in Systemic Sclerosis Dermal Fibroblasts

    Danielle Pomante 1, Sergio Jimenez 2 and Sonsoles Piera-Velazquez1, 1Thomas Jefferson University, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, Philadelphia, PA

    Background/Purpose: There is an urgent unmet need for effective therapeutic approaches for Systemic Sclerosis (SSc), a systemic autoimmune disease characterized by progressive fibrosis of skin…
  • Abstract Number: 1058 • 2019 ACR/ARP Annual Meeting

    Inhibition of Histone Readers Bromodomain and Extraterminal Domain Proteins Alleviates Scleroderma Fibrosis

    Sirapa Vichaikul 1, Phillip Campbell 2, M. Asif Amin 3, Jeffrey H. Ruth 3, Dallas Rohraff 1, David Fox 4, Dinesh Khanna 5, Amr Sawalha 6 and Pei-Suen Tsou3, 1University of Michigan, Ann Arbor, 2Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 3University of Michigan, Ann Arbor, MI, 4Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence,University of Michigan, Ann Arbor, MI, 5Scleroderma Program, Division of Rheumatology, Department of Internal Medicine, Autoimmunity Center of Excellence, University of Michigan, Ann Arbor, 6University of Pittsburgh & University of Michigan, Pittsburgh, PA

    Background/Purpose: Epigenetic regulation, including histone acetylation, plays an important role in scleroderma (SSc) fibrosis. The binding of the bromodomain and extra-terminal domain proteins (BRDs) to…
  • Abstract Number: 1061 • 2019 ACR/ARP Annual Meeting

    PI3K-Akt Pathway Plays a Crucial Role in Production of Collagen in Fli1 Deficient Condition and Its Inhibitor Has the Therapeutic Potential in Treating Fibrosis

    Yuko Ota1, Atsushi Kitani 2 and Warren Strober 2, 1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 2Mucosal Immunity Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD

    Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis of the skin and internal organs. Previous studies have shown that dermal fibroblast…
  • Abstract Number: 1066 • 2019 ACR/ARP Annual Meeting

    Dysregulated IL-6 Dependent Dermal Adenosine Signaling via Adenosine A2A Receptor May Drive Fibrosis in Systemic Sclerosis

    Christopher Denton 1, Shiwen Xu 2, Sue Verma 3 and Voon Ong4, 1University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom, 2University College London, London, United Kingdom, 3Leadiant Biosciences, London, United Kingdom, 4UCL Medical School, Royal Free Campus, London

    Background/Purpose: Altered generation of adenosine from extracellular nucleotides by ectonucleotidases may orchestrate chronic injury responses and promote fibrosis via the adenosine A2A receptor (ADORA2A). We…
  • Abstract Number: 1073 • 2019 ACR/ARP Annual Meeting

    Identification of Distinct Pro-Fibrotic Monocyte and Macrophage Subsets in Systemic Sclerosis

    Angela Tam1, Lauren Reinke-Breen 2, Glenda Trujillo 2, Shiwen Xu 1, Christopher Denton 3, David Abraham 1, Gabor Jarai 2 and Voon Ong 4, 1University College London, London, United Kingdom, 2Bristol-Myers Squibb, Pennington, 3University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom, 4UCL Medical School, Royal Free Campus, London

    Background/Purpose: Chronic inflammation may modulate the balance of classical, intermediate and non-classical monocyte subsets (defined by CD14/CD16 expression)1.  Monocytes are heterogeneous and subsets can be…
  • Abstract Number: 1231 • 2019 ACR/ARP Annual Meeting

    Improvement in Hepatic Fibrosis Estimated by Fibrosis-4 (FIB-4) Index in Subjects with Chronic Refractory Gout Treated with Pegloticase

    Naomi Schlesinger1, Anthony Yeo 2 and Peter Lipsky 3, 1Division of Rheumatology, Department of Medicine, Rutgers, The State University of New Jersey, New Brunswick, NJ, 2Horizon Therapeutics plc, Lake Forest, IL, 3AMPEL BioSolutions, LLC, Charlottesville, VA

    Background/Purpose: Hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD) (Yang C et al. PlosOne2017; 12:e0177249; Jaruvongvanich V et al. Eur J Gastroenterol Hepatol 2017;…
  • Abstract Number: 2429 • 2019 ACR/ARP Annual Meeting

    Zipcode-Binding Protein 1 (ZBP1) Facilitates Ro60 Surface Translocation, Cellular Growth and Autoimmune Sequelae

    Francis DiDonato1, Jill Buyon 1 and Robert Clancy 1, 1NYU School of Medicine, New York

    Background/Purpose: Despite the strong association of maternal anti-Ro60 autoantibodies in the development of SS, Neonatal Lupus (NL) and scLE, understanding causality is challenging given that…
  • Abstract Number: 2748 • 2019 ACR/ARP Annual Meeting

    Cracking a Novel Profibrotic Molecular Mechanism: lncRNA H19X and DDIT4L Crosstalk

    Elena Pachera1, Shervin Assassi 2, Gloria Salazar 3, Mojca Frank-Bertoncelj 4, Jörg Distler 5, Gabriela Kania 6 and Oliver Distler 7, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Zurich, Switzerland, 2Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, 3University of Texas McGovern Medical School, Houston, 4University Hospital Zürich, Zürich, Switzerland, 5Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 6Centre of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 7Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland

    Background/Purpose: Long noncoding RNAs (lncRNAs) are an emerging class of noncoding transcripts involved in the regulation of gene expression in health and disease. LncRNAs function…
  • Abstract Number: 2808 • 2019 ACR/ARP Annual Meeting

    Linking Toll-Like Receptor Signaling and Type I Interferons to Inflammation and Fibrosis in a Macrophage/Fibroblast Model of Congenital Heart Block

    Miao Chang1, Robert Clancy 1 and Jill Buyon 1, 1NYU School of Medicine, New York

    Background/Purpose: Since one of the strongest associations with antibodies (abs) to SSA/Ro (Ro60) is the development of congenital heart block (CHB), this model provides an…
  • Abstract Number: 374 • 2019 ACR/ARP Annual Meeting

    The INBUILD Trial of Nintedanib in Patients with Progressive Fibrosing Interstitial Lung Diseases: Subgroup with Autoimmune Diseases

    Eric Matteson1, Clive Kelly 2, Jörg Distler 3, Anna Maria Hoffmann-Vold 4, James Seibold 5, Shikha Mittoo 6, Oliver Distler 7, Rainer-Georg Goeldner 8, Rozsa Schlenker-Herceg 9, Susanne Stowasser 10, Manuel Quaresma 10 and Kevin Flaherty 11, 1Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA, Rochester, 2Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK, Newcastle, United Kingdom, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 4Department of Rheumatology, Oslo University Hospital, Oslo, Norway, Oslo, Norway, 5Scleroderma Research Consultants LLC, Aiken, South Carolina, USA, Aiken, 6University Health Network, Toronto, Ontario, Canada, Toronto, Canada, 7Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland, 8Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, Biberach, Germany, 9Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut, USA, Ridgefield, 10Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany, Ingelheim am Rhein, Germany, 11University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, MI

    Background/Purpose: Some patients with autoimmune disease develop progressive fibrosing interstitial lung disease (ILD) characterized by increasing fibrosis on HRCT, decline in lung function, worsening symptoms…
  • Abstract Number: 384 • 2019 ACR/ARP Annual Meeting

    Prevalence and Predictors of Fibrosis in Rheumatological Patients on Therapy and Risk Factors for Chronic Liver Disease

    Connie Lam 1, Stephen Bloom 2 and Alberta Hoi3, 1School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia, 2Eastern Health Clinical School, Monash University, Melbourne, Victoria, Australia, 3School of Clinical Sciences, Monash University, Meloburne, Victoria, Australia

    Background/Purpose: The assessment of liver stiffness using liver elastography (Fibroscan) has facilitated early diagnosis of hepatic fibrosis in patients with chronic liver disease, but its…
  • Abstract Number: 114 • 2018 ACR/ARHP Annual Meeting

    Antifibrotic Regulation By Response Gene to Complement 32 Protein

    Sergei Atamas, Violeta Rus, Virginia Lockatell, Horea Rus and Irina Luzina, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Pulmonary fibrosis is a serious problem in patients with scleroderma lung disease (SLD). Better therapies for pulmonary fibrosis are urgently needed. Identification of new…
  • Abstract Number: 117 • 2018 ACR/ARHP Annual Meeting

    Hypomorphic A20 Expression Modulates Fibrosis Susceptibility: Implications for Systemic Sclerosis?

    Swati Bhattacharyya1, Wenxia Wang2, Brian M. Jeong2, Hiam Abdala-Valencia3, Roberta Goncalves Marangoni1, Sergejs Berdnikovs Ph.D.4 and John Varga1, 1Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL, 3Northwestern University Feinberg School of Medicine, Chicago, IL, 4Medicine, Northwestern University, Chicago, IL

    Background/Purpose: Mutiple organ fibrosis, a hallmark of systemic sclerosis (SSc), remains poorly understood. Recent GWAS have uncovered consistent genetic linkage between TNFAIP3, encoding the ubiquitin-editing…
  • Abstract Number: 118 • 2018 ACR/ARHP Annual Meeting

    Pharmacological Inhibition of JAK/STAT Signaling By Tofacitinib Prevents Experimental Organ Fibrosis: Novel Therapy for Systemic Sclerosis

    Swati Bhattacharyya1, Wenxia Wang2, Jun Wei3 and John Varga1, 1Northwestern University, Chicago, IL, 2Feinberg School of Medicine, Northwestern University, Chicago, IL, 3Northwestern University, chicago, IL

    Background/Purpose: Synchronous fibrosis in systemic sclerosis (SSc) leads to failure of the skin, lungs and other organs, and has no effective treatments. Myofibroblast activation underlies…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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