ACR Meeting Abstracts

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Abstracts tagged "fibrosis"

  • Abstract Number: 1706 • 2017 ACR/ARHP Annual Meeting

    Dipeptidyl-Peptidase-4 (DPP4) Promotes Fibroblast Activation and Is a Potential Molecular Target for Treatment of Fibrosis

    Alina Soare1, Hermina Györfy1, Alexandru Matei1, Clara Dees1, Chih-Wei Chen1, Andreas Ramming2, Georg Schett3 and Jörg Distler1, 1Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 2Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 3Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany

    Background/Purpose: Dipeptidyl-peptidase-4 (DPP4) has been reported to identify a dermal fibroblast lineage involved in scaring and its inhibition leads to reduced scar formation. Its role…
  • Abstract Number: 1707 • 2017 ACR/ARHP Annual Meeting

    Effect of Anabasum (JBT-101) on Gene Expression in Skin Biopsies from Subjects with Diffuse Cutaneous Systemic Sclerosis (dcSSc) and the Relationship of Baseline Molecular Subsets to Clinical Benefit in the Phase 2 Trial

    Viktor Martyanov1, Yolanda Nesbeth2, Guoshuai Cai1, Tammara A. Wood1, Jake Reder2, Scott Constantine3, Barbara White3, Robert F. Spiera4 and Michael L. Whitfield1, 1Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Celdara Medical, LLC, Lebanon, NH, 3Corbus Pharmaceuticals, Inc., Norwood, MA, 4Rheumatology, Hospital for Special Surgery, New York, NY

    Background/Purpose: Anabasum (JBT-101) is a non-immunosuppressive, synthetic, CB2 agonist that resolves inflammation and fibrosis in animal models of SSc and reduces TGF-β and collagen production…
  • Abstract Number: 1708 • 2017 ACR/ARHP Annual Meeting

    Molecular Imaging Biomarkers for Personalized Medicine Strategies in Systemic Sclerosis-Related Interstitial Lung Disease

    Janine Schniering1, Martina Benesova2,3, Matthias Brunner4, Carol A. Feghali-Bostwick5, Roger Schibli2,3, Oliver Distler6, Cristina Müller2,3 and Britta Maurer6, 1Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 2Department of Chemistry and Applied Biosciences, Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland, Zurich, Switzerland, 3Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Center for Radiopharmaceutical Sciences ETH-PSI-USZ, Paul Scherrer Institute, Villigen-PSI, Switzerland, Villigen PSI, Switzerland, 4Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, Zurich, Switzerland, 5Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC, 6Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Interstitial lung disease (ILD) is a life-threatening complication in SSc. In recent years, distinct genomic and molecular subtypes in SSc-ILD were identified and molecular…
  • Abstract Number: 1718 • 2017 ACR/ARHP Annual Meeting

    The Role and Function of Monocyte-Derived Fibroblast-like Cells in Multi-Organ Fibrosis in Systemic Sclerosis

    Michal Rudnik1, Mara Stellato1, Vincent Milleret2, Przemyslaw Blyszczuk1,3, Britta Maurer1, Karin Klingel4, Joerg C. Henes5, Karl Sotlar6, Martin Ehrbar2, Oliver Distler7 and Gabriela Kania1, 1Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland, 3Department of Clinical Immunology, Jagiellonian University Medical College, Krakow, Poland, 4Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, 5Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, 6Institute of Pathology, Ludwig Maximilians University, Munich, Germany, 7Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Animal studies indicated bone marrow-derived cells as a source of pathological myofibroblasts in fibrosis of multiple organ including lungs, heart, skin and kidney. Monocytes…
  • Abstract Number: 1720 • 2017 ACR/ARHP Annual Meeting

    TGF-ß-Induced Tissue Fibrosis in TBRIcaCol1Cre Transgenic Mice Is Abrogated By the Second Generation Tyrosine Kinase Inhibitor SKI-606 (Bosutinib)

    Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Bosutinib (SKI-606), a second-generation tyrosine kinase inhibitor that blocks the activity of the BCR-ABL kinase responsible for Philadelphia chromosome positive chronic myeloid leukemias, also…
  • Abstract Number: 1721 • 2017 ACR/ARHP Annual Meeting

    Long Noncoding RNA H19X Is a Key Regulator of Apoptosis and Proliferation of Fibroblasts in Systemic Sclerosis and Other TGFβ-Driven Fibrotic Diseases

    Elena Pachera1, Adam Wunderlin1, Shervin Assassi2, Gloria Salazar2, Mojca Frank Bertoncelj1, Rucsandra Dobrota1, Matthias Brock3, Carol A. Feghali-Bostwick4, Gerard Dijkstra5, Gerhard Rogler6, Tobias van Haaften Wouter6, Jörg Distler7, Gabriela Kania1 and Oliver Distler1, 1Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 3Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland, 4Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC, 5Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Switzerland, 6Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland, 7Internal Medicine 3, University of Erlangen, Erlangen, Germany

    Background/Purpose: Long noncoding RNAs (lncRNAs) are a class of transcripts regulating gene expression. We have recently identified a novel lncRNA, H19X, which was upregulated in…
  • Abstract Number: 298 • 2017 ACR/ARHP Annual Meeting

    Anabasum (JBT-101) Enhances Resolution of Inflammation in Humans

    Madhur Motwani1, Fran Bennett1, Mark Tepper2, Barbara White2, Paul Norris3, Raymond MacAllister1, Charles Serhan3 and Derek Gilroy1, 1University College London, London, United Kingdom, 2Corbus Pharmaceuticals, Norwood, MA, 3Harvard Medical School, Cambridge, MA

    Background/Purpose:   Certain rheumatic diseases including systemic sclerosis (SSc) are characterized by chronic activation of innate immune responses, leading to excessive fibrosis.  A normal innate…
  • Abstract Number: 1725 • 2017 ACR/ARHP Annual Meeting

    Insulin-like Growth Factor Binding Protein-4 Exerts Anti-Fibrotic Effects and Its Levels Are Reduced in SSc-Associated Lung Fibrosis

    Yunyun Su1, Stanley Hoffman2 and Carol A. Feghali-Bostwick3, 1Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, charleston, SC, 2Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 3Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC

    Background/Purpose: The Insulin-like growth factor (IGF) system plays an important role in cellular growth, proliferation, differentiation, apoptosis and transformation; IGF binding proteins (IGFBP) exert cell…
  • Abstract Number: 552 • 2017 ACR/ARHP Annual Meeting

    Mast Cells Are Involved in the Pathogenesis of Sjögren  Syndrome By Inducing Tissue Fibrosis

    Shinjiro Kaieda1, Kyoko Fujimoto2, Masaki Okamoto3, Masaki Tominaga2, Tomoaki Hoshino4 and Hiroaki Ida5, 1Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, 2Kurume University School of Medicine, Kurume, Japan, 3Medicine, Kurume University School of Medicine, Kurume, Japan, 4Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, 5Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan

    Background/Purpose: Mast cells have been implicated in many immune-inflammatory disorders. They mediate a variety of inflammatory and fibrotic conditions, but their role in sialadenitis and…
  • Abstract Number: 1924 • 2017 ACR/ARHP Annual Meeting

    The Nuclear Receptor ROR-Alpha As a Key Checkpoint of Tissue Repair

    Rosebeth Kagwiria1, Ruifang Liang2, Chih-Wei Chen3, Thomas Burris4, Georg Schett5 and Jörg Distler6, 1Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 2Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 4Department of pharmacology and physiology, Saint Luis University-school of medicine, Florida, USA, St. Louis, Missouri, MO, 5Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 6Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany

    Background/Purpose: The Retinoic-acid related Orphan Receptor-alpha (RORα) is a member of the nuclear receptor superfamily and a ligand-dependent transcription factor implicated in a wide range…
  • Abstract Number: 731 • 2017 ACR/ARHP Annual Meeting

    Prediction of Progression of Interstitial Lung Disease in Patients with Systemic Sclerosis

    Wanlong Wu1, Suzana Jordan2, Mike Oliver Becker3, Rucsandra Dobrota3, Shuang Ye4, Britta Maurer5 and Oliver Distler2, 1Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich; Department of Rheumatology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Zurich, Switzerland, 2Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 4Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 5Department of Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: No data are available to distinguish between progressive and stable patients when mild lung fibrosis is diagnosed in systemic sclerosis (SSc) patients. This study…
  • Abstract Number: 1925 • 2017 ACR/ARHP Annual Meeting

    TGFβ Promotes Fibrosis By MYST1-Dependent Epigenetic Regulation of Autophagy

    Ariella Zehender1, Neng-Yu Lin2, Adrian Stefanica3, Chih-Wei Chen4, Alina Soare5, Thomas Wohlfahrt6, Simon Rauber6, Christina Bergmann7, Andreas Ramming8, Oliver Distler9, Georg Schett10 and Jörg Distler5, 11Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 2Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 31Department of Internal Medicine 3 – Rheumatology and Immunology, University of Erlangen, Erlangen, Germany, 4Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 5Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, 6Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 7Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, 8Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, 9Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 10Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany

    Background/Purpose: Autophagy (Atg) is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Aberrant activation of Atg has been implicated into the pathogenesis…
  • Abstract Number: 742 • 2017 ACR/ARHP Annual Meeting

    Quantitative CT Evalutation in Diffuse Interstitial Lung Involvement in Systemic Sclerosis: Usefulness of Lung Texture Analysis to Predict the Functional Change over Time

    Silvia Bosello1, Maria Elena Occhipinti2, Giovanni Canestrari1, Enrico De Lorenzis1, Federico Parisi1, Gerlando Natalello3, Grazia Leuconeo4, Anna Rita larici4, Chiara De Waure4, Gianfranco Ferraccioli5 and Elisa Gremese6, 1Division of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, 2University of Florence, Florence, Italy, 3Division of Rhematology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, 4Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, 5Institute of Rheumatology, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy, 6Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Università Cattolica - Fondazione Policlinico Universitario A.Gemelli, Rome, Italy

    Background/Purpose: The prognosis of patients with scleroderma and interstitial lung involvement (SSc-ILD) can be evaluated by combining data of pulmonary function tests (PFTs) and high-resolution…
  • Abstract Number: 1926 • 2017 ACR/ARHP Annual Meeting

    Cardiac Remodeling in Systemic Sclerosis: TGF-β/Fra2-Dependent Autophagy As a Novel Target for Heart Fibrosis

    Mara Stellato1, Michal Rudnik1, Florian Renoux1, Elena Pachera1, Karl Sotlar2, Karin Klingel3, Joerg C. Henes4, Przemyslaw Blyszczuk1,5, Oliver Distler1 and Gabriela Kania1, 1Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Institute of Pathology, Ludwig Maximilians University, Munich, Germany, 3Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, 4Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, 5Department of Clinical Immunology, Jagiellonian University Medical College, Krakow, Poland

    Background/Purpose: SSc patients frequently suffer from primary cardiac involvement. The main histological feature is fibrosis, but the mechanisms responsible for the heart failure remain unclear.…
  • Abstract Number: 763 • 2017 ACR/ARHP Annual Meeting

    Mechanisms of Insulin-like Growth Factor-II-Mediated Fibrosis

    Sara Garrett1, Justin Thomas2, Eileen Hsu3 and Carol A. Feghali-Bostwick4, 1Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 2Eisenhower Medical Center, Rancho Mirage, CA, 3Kaiser Permanente Medical Group, Mclean, VT, 4Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC

    Background/Purpose: Previous work has shown that insulin-like growth factor (IGF)-II is increased in fibrosing lung diseases, including idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis (SSc)-associated…
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