Abstracts tagged "Fibroblasts"

Abstract Number: 891 • 2012 ACR/ARHP Annual Meeting
Fatty Acids Promote Secretion of Proinflammatory and Prodestructive Factors by Synovial Fibroblasts
Klaus W. Frommer¹, Andreas Schäffler², Stefan Rehart³, Angela Lehr⁴, Ulf Müller-Ladner⁵ and Elena Neumann⁶, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Department of Internal Medicine III, Endocrinology, Diabetes, Metabolism, Justus-Liebig-University of Giessen, Giessen, Germany, ³Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁴Dept Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Bad Nauheim, Germany, ⁶Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Due to their role in inflammatory metabolic diseases, we hypothesized that free fatty acids (FFA) are also involved in primary inflammatory joint diseases including…
Abstract Number: 2294 • 2012 ACR/ARHP Annual Meeting
The Histone Deacetylase SIRT1 Is Anti-Fibrotic and Mediates Resveratrol Effects
Roberta G. Marangoni¹, Archit Ghosh¹, Jun Wei² and John Varga³, ¹Medicine, Rheumatolgoy, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Fibrosis in scleroderma is associated with increased collagen synthesis driven by TGF-β and associated epigenetic modifications. The Class III histone deacetylase SIRT1 has anticancer…
Abstract Number: 784 • 2012 ACR/ARHP Annual Meeting
Neutralization of Plasminogen Activator Inhibitor-1 Resolves Skin Fibrosis and Vascular Injury in a Murine Model of Human Scleroderma
Raphael Lemaire¹, Tim Burwell¹, Tracy Delaney¹, Cindy Chen², Julie Bakken¹, Lily Cheng¹, Philip Brohawn¹, Isabelle de Mendez³, Dominic Corkill³, Anthony Coyle⁴, Ronald Herbst² and Jane Connor¹, ¹Research, MedImmune LLC, Gaithersburg, MD, ²Respiration, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, ³Research, Medimmune, LLC, Cambridge, England, ⁴Centers for Therapeutic Innovation, Pfizer, Inc., Cambridge (formerly at MedImmune LLC, Gaithersburg, MD, USA), MA
Background/Purpose: Scleroderma is a systemic autoimmune disease in which thrombosis and fibrosis contribute to skin pathology. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of…
Abstract Number: 2297 • 2012 ACR/ARHP Annual Meeting
Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: DNA methylation is one of the best-characterized epigenetic modifications that have been implicated in numerous biologic and pathologic processes. It is initiated by DNA…
Abstract Number: 787 • 2012 ACR/ARHP Annual Meeting
Aberrant Adipogenesis in the Pathogenesis of Scleroderma
Roberta Goncalves Marangoni¹, Jun Wei², Monique E. Hinchcliff¹, Feng Fang³, Warren Tourtellotte⁴ and John Varga⁵, ¹Division of Rheumatology, Northwestern University Medical School, Chicago, IL, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Rheumatology Division, Northwestern University Medical School, Chicago, IL, ⁴Pathology, Northwestern University Medical School, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Skin fibrosis in systemic sclerosis (SSc) is associated with loss of subcutaneous adipose tissue (SCAT) and reduction in adiponectin. The mechanism underlying SCAT atrophy…
Abstract Number: 2300 • 2012 ACR/ARHP Annual Meeting
The Effects of Salvianolic Acid B in Fibrotic Models in Vivo and in Vitro
Qingmei Liu¹, Wenyu Wu², Wenzheng Tu³, Haiyan Chu¹, Yanyun Ma¹, Hejian Zou⁴, Xiaodong Zhou⁵ and Jiu-Cun Wang¹, ¹Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, ²Huashan Hospital, Shanghai, China, ³Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, China, ⁴Rheumatology, Huashan Hospital, Shanghai, China, ⁵Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: , Methods: , Results: and Conclusion: Background: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs. Salvianolic acid…
Abstract Number: 419 • 2012 ACR/ARHP Annual Meeting
Epigenome Analysis of Rheumatoid Arthritis Synovial Fibroblasts Revealed TBX-5 As a Novel Transcription Factor in Chemokine Regulation
Emmanuel Karouzakis¹, Michelle Trenkmann², Renate E. Gay¹, Beat A. Michel¹, Steffen Gay¹ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Changes in DNA methylation and histone marks have been associated with diseases such as cancer, rheumatoid arthritis (RA) and systemic lupus erythematosus. Previously, we…
Abstract Number: 2302 • 2012 ACR/ARHP Annual Meeting
Secreted Frizzled-Related Protein 4 Induces a Profibrotic Phenotype in Systemic Sclerosis Fibroblasts by Activating a Non-Canonical WNT Signaling Pathway
Justin Gillespie¹, Paul Emery² and Francesco Del Galdo³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is a chronic fibrotic disease involving autoimmune activation, fibroproliferative vasculopathy and tissue fibrosis of skin and multiple internal organs. Several studies…
Abstract Number: 408 • 2012 ACR/ARHP Annual Meeting
Alpha-Enolase Facilitates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Kichul Shin¹, Ji Ah Park², Seyeon Bae³, Jae Seung Kang³ and Yeong Wook Song⁴, ¹Rheumatology, College of Medicine, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine,, Seoul National Hospital, Seoul, South Korea, ³Department of Anatomy and Tumor Immunity Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea
Background/Purpose:Alpha-enolase (ENO1) is a multifunctional glycolytic enzyme ubiquitously expressed in the cytoplasm. Citrullinated ENO1 is reported to be a candidate autoantigen in rheumatoid arthritis (RA),…
Abstract Number: 1793 • 2012 ACR/ARHP Annual Meeting
The Cyclooxygenase/Prostaglandin-E₂ Pathway Is Critical for Autocrine IL-17A Production by Th17 Cells Upon Synovial Fibroblast Interaction
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar³, Patrick S. Asmawidjaja³, Johanna M.W. Hazes⁴ and Erik Lubberts³, ¹Immunology, Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Recently, we have shown that Th17, but not Th1 cells, from patients with early rheumatoid arthritis (RA) are potent activators of RA synovial fibroblasts…
Abstract Number: 39 • 2012 ACR/ARHP Annual Meeting
SDF-1 Induces Osteoclastogenesis in Rheumatoid Arthritis by Upregulating of RANKL Expression in Synovial Fibroblasts and CD4+ T Cells
Hae-Rim Kim¹, Kyoung-Woon Kim², Bo-Mi Kim¹, Mi La Cho³ and Sang-Heon Lee⁴, ¹Division of Rheumatology, Konkuk University School of Medicine, Seoul, South Korea, ²Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ³Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁴Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea
Background/Purpose: Stromal cell-derived factor (SDF)-1 is involved in bone destructive process in rheumatoid arthritis (RA) and bony metastasis in malignancy, through inducing angiogenesis, producing matrix-degrading…
Abstract Number: 1775 • 2012 ACR/ARHP Annual Meeting
The Phosphoinositide 3-Kinase Pathway Regulates Fibroblast-Like Synoviocyte Invasion
Beatrix Bartok¹, Deepa Hammaker² and Gary S. Firestein³, ¹Rheumatology, UCSD, La Jolla, CA, ²MC 0656, Univ of California San Diego, La Jolla, CA, ³Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Cartilage destruction mediated by invasive fibroblast-like synoviocytes (FLS) plays a central role in pathogenesis of RA. Increased cell migration and degradation of extracellular matrix…
Abstract Number: 1659 • 2012 ACR/ARHP Annual Meeting
Ptpome Profile of Rheumatoid Arthritis Fibroblast-Like Synoviocytes: A Novel Role for the Tyrosine Phosphatase SHP-2 As a Modulator of Invasion and Survival
Stephanie Stanford¹, Michael Maestre², Beatrix Bartok³, David L. Boyle⁴, Heather Arnett⁵, Tomas Mustelin⁶, Gary S. Firestein⁷ and Nunzio Bottini², ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, ⁵Amgen, Inc., Seattle, WA, ⁶Sanford-Burnham Institute for Medical Research, La Jolla, CA, ⁷Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). These cells assume a…
Abstract Number: 1610 • 2012 ACR/ARHP Annual Meeting
The DNA Methylation Signature in Fibroblast-Like Synoviocytes (FLS) Defines Critical Pathogenic Pathways in Rheumatoid Arthritis (RA)
David L. Boyle¹, Robert Shoemaker², David W. Anderson³, Wei Wang⁴ and Gary S. Firestein⁵, ¹Div of Rheum, UCSD School of Medicine, La Jolla, CA, ²NexDx, Inc., San Diego, CA, ³Research and Development, NexDx, Inc., San Diego, CA, ⁴Chemistry, UCSD, La Jolla, CA, ⁵Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: A DNA methylation signature has been characterized that distinguishes RA FLS from osteoarthritis (OA) and normal (NL) FLS. The presence of epigenetic changes in…
Abstract Number: 1517 • 2012 ACR/ARHP Annual Meeting
TLR9 Signaling in Fibroblasts Promotes Pro-Fibrotic Responses Via TGF-Beta
Yang Yang¹, Feng Fang², Lei Liu¹, Junjie Shangguan³, Boping Ye¹ and John Varga³, ¹School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Division of Rheumatology, Northwestern University, Chicago, IL
Background/Purpose: Systemic sclerosis (SSc) is associated with progressive fibrosis and transforming growth factor β (TGF-β) is implicated in its pathogenesis. Toll-like receptors (TLR) respond to…

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