Abstracts tagged "Fibroblasts"

Abstract Number: 1496 • 2012 ACR/ARHP Annual Meeting
Downregulated Expression of Metallothionein Genes in Response to the Gadolinium Contrast Agent Omniscan in Normal Human Differentiated Macrophages and Dermal Fibroblasts
Peter J. Wermuth¹, Francesco Del Galdo², Sankar Addya³, Paolo Fortina³ and Sergio A. Jimenez¹, ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Metallothioneins bind heavy metals with high affinity and can serve as storage proteins for labile Zn2+ which in turn can regulate immune system activity…
Abstract Number: 2289 • 2012 ACR/ARHP Annual Meeting
Adiponectin Has Potent Anti-Fibrotic Effects Mediated Via AMP Kinase: Novel Target for Fibrosis Therap
Feng Fang¹, Lei Liu², Yang Yang², Jun Wei¹, Swati Bhattacharyya³, Ross Summer⁴, Boping Ye² and John Varga³, ¹Rheumatology Division, Northwestern University, Chicago, IL, ²School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, ³Division of Rheumatology, Northwestern University, Chicago, IL, ⁴Pulmonary Center, Boston University, Boston, MA
Background/Purpose: Fibrosis in scleroderma is associated with transforming growth factor-β (TGF-β) signaling activation, collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ) inhibits…
Abstract Number: 1193 • 2012 ACR/ARHP Annual Meeting
Podoplanin Expression in Rheumatoid Stroma Correlates with Lymphoid Neogenesis and Is Downregulated by Anti-TNF-α Therapy
Regina Faré¹, Elena Izquierdo¹, Manuel J. Del Rey¹, Raquel Celis², Alicia Usategui¹, Juan D. Cañete³ and Jose L. Pablos¹, ¹Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, ²Arthritis Unit, Rheumatology Department, Arthritis Unit, Rheumatology Dpt, Hospital Clinic of Barcelona and IDIBAPS, Barcelona, Spain, ³Rheumatology, Hospital Clínic of Barcelona. IDIBAPS. University of Barcelona, Barcelona, Spain
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts (SF) expand and undergo phenotypic changes that contribute to chronic inflammation and joint destruction. Podoplanin (Pdp) is a…
Abstract Number: 2293 • 2012 ACR/ARHP Annual Meeting
Interleukin-17A Positive Cells Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated to Skin Thickness
Marie-Elise Truchetet¹, Nicolò Costantino Brembilla¹, Elisa Montanari¹, Paola Lonati², Pier Luigi Meroni³ and Carlo Chizzolini¹, ¹University hospital of Geneva, Geneva, Switzerland, ²Division of Rheumatology, Istituto G. Pini, University of Milan, Milan, Italy, ³Division of Rheumatology, Istituto G. Pini, University of Milan, Milano, Italy
Background/Purpose: T cell producing IL-17A are increased in the peripheral blood of individuals affected by systemic sclerosis (SSc). We asked the question whether IL-17A-producing cells…
Abstract Number: 891 • 2012 ACR/ARHP Annual Meeting
Fatty Acids Promote Secretion of Proinflammatory and Prodestructive Factors by Synovial Fibroblasts
Klaus W. Frommer¹, Andreas Schäffler², Stefan Rehart³, Angela Lehr⁴, Ulf Müller-Ladner⁵ and Elena Neumann⁶, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Department of Internal Medicine III, Endocrinology, Diabetes, Metabolism, Justus-Liebig-University of Giessen, Giessen, Germany, ³Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁴Dept Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Bad Nauheim, Germany, ⁶Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Due to their role in inflammatory metabolic diseases, we hypothesized that free fatty acids (FFA) are also involved in primary inflammatory joint diseases including…
Abstract Number: 2294 • 2012 ACR/ARHP Annual Meeting
The Histone Deacetylase SIRT1 Is Anti-Fibrotic and Mediates Resveratrol Effects
Roberta G. Marangoni¹, Archit Ghosh¹, Jun Wei² and John Varga³, ¹Medicine, Rheumatolgoy, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Fibrosis in scleroderma is associated with increased collagen synthesis driven by TGF-β and associated epigenetic modifications. The Class III histone deacetylase SIRT1 has anticancer…
Abstract Number: 784 • 2012 ACR/ARHP Annual Meeting
Neutralization of Plasminogen Activator Inhibitor-1 Resolves Skin Fibrosis and Vascular Injury in a Murine Model of Human Scleroderma
Raphael Lemaire¹, Tim Burwell¹, Tracy Delaney¹, Cindy Chen², Julie Bakken¹, Lily Cheng¹, Philip Brohawn¹, Isabelle de Mendez³, Dominic Corkill³, Anthony Coyle⁴, Ronald Herbst² and Jane Connor¹, ¹Research, MedImmune LLC, Gaithersburg, MD, ²Respiration, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, ³Research, Medimmune, LLC, Cambridge, England, ⁴Centers for Therapeutic Innovation, Pfizer, Inc., Cambridge (formerly at MedImmune LLC, Gaithersburg, MD, USA), MA
Background/Purpose: Scleroderma is a systemic autoimmune disease in which thrombosis and fibrosis contribute to skin pathology. Plasminogen activator inhibitor-1 (PAI-1) is the major inhibitor of…
Abstract Number: 2297 • 2012 ACR/ARHP Annual Meeting
Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype
Bashar Kahaleh¹ and Yongqing Wang², ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²Medicine, University of Toledo, Toledo, OH
Background/Purpose: DNA methylation is one of the best-characterized epigenetic modifications that have been implicated in numerous biologic and pathologic processes. It is initiated by DNA…
Abstract Number: 787 • 2012 ACR/ARHP Annual Meeting
Aberrant Adipogenesis in the Pathogenesis of Scleroderma
Roberta Goncalves Marangoni¹, Jun Wei², Monique E. Hinchcliff¹, Feng Fang³, Warren Tourtellotte⁴ and John Varga⁵, ¹Division of Rheumatology, Northwestern University Medical School, Chicago, IL, ²Rheumatology Division, Northwestern University, Chicago, IL, ³Rheumatology Division, Northwestern University Medical School, Chicago, IL, ⁴Pathology, Northwestern University Medical School, Chicago, IL, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Skin fibrosis in systemic sclerosis (SSc) is associated with loss of subcutaneous adipose tissue (SCAT) and reduction in adiponectin. The mechanism underlying SCAT atrophy…
Abstract Number: 2300 • 2012 ACR/ARHP Annual Meeting
The Effects of Salvianolic Acid B in Fibrotic Models in Vivo and in Vitro
Qingmei Liu¹, Wenyu Wu², Wenzheng Tu³, Haiyan Chu¹, Yanyun Ma¹, Hejian Zou⁴, Xiaodong Zhou⁵ and Jiu-Cun Wang¹, ¹Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, ²Huashan Hospital, Shanghai, China, ³Shanghai Traditional Chinese Medicine-Integrated Hospital, Shanghai, China, ⁴Rheumatology, Huashan Hospital, Shanghai, China, ⁵Rheumatology, University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: , Methods: , Results: and Conclusion: Background: Scleroderma or systemic sclerosis (SSc) is characterized by the fibrosis of skin and visceral organs. Salvianolic acid…
Abstract Number: 419 • 2012 ACR/ARHP Annual Meeting
Epigenome Analysis of Rheumatoid Arthritis Synovial Fibroblasts Revealed TBX-5 As a Novel Transcription Factor in Chemokine Regulation
Emmanuel Karouzakis¹, Michelle Trenkmann², Renate E. Gay¹, Beat A. Michel¹, Steffen Gay¹ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Changes in DNA methylation and histone marks have been associated with diseases such as cancer, rheumatoid arthritis (RA) and systemic lupus erythematosus. Previously, we…
Abstract Number: 2302 • 2012 ACR/ARHP Annual Meeting
Secreted Frizzled-Related Protein 4 Induces a Profibrotic Phenotype in Systemic Sclerosis Fibroblasts by Activating a Non-Canonical WNT Signaling Pathway
Justin Gillespie¹, Paul Emery² and Francesco Del Galdo³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Systemic Sclerosis (SSc) is a chronic fibrotic disease involving autoimmune activation, fibroproliferative vasculopathy and tissue fibrosis of skin and multiple internal organs. Several studies…
Abstract Number: 408 • 2012 ACR/ARHP Annual Meeting
Alpha-Enolase Facilitates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
Kichul Shin¹, Ji Ah Park², Seyeon Bae³, Jae Seung Kang³ and Yeong Wook Song⁴, ¹Rheumatology, College of Medicine, Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine,, Seoul National Hospital, Seoul, South Korea, ³Department of Anatomy and Tumor Immunity Medical Research Center, College of Medicine, Seoul National University, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea
Background/Purpose:Alpha-enolase (ENO1) is a multifunctional glycolytic enzyme ubiquitously expressed in the cytoplasm. Citrullinated ENO1 is reported to be a candidate autoantigen in rheumatoid arthritis (RA),…
Abstract Number: 1793 • 2012 ACR/ARHP Annual Meeting
The Cyclooxygenase/Prostaglandin-E₂ Pathway Is Critical for Autocrine IL-17A Production by Th17 Cells Upon Synovial Fibroblast Interaction
Sandra M.J. Paulissen¹, Jan Piet van Hamburg², Nadine Davelaar³, Patrick S. Asmawidjaja³, Johanna M.W. Hazes⁴ and Erik Lubberts³, ¹Immunology, Erasmus Medical Center, Immunology, Rotterdam, Netherlands, ²Rheumatology, Erasmus MC, Rotterdam, Netherlands, ³Rheumatology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands
Background/Purpose: Recently, we have shown that Th17, but not Th1 cells, from patients with early rheumatoid arthritis (RA) are potent activators of RA synovial fibroblasts…
Abstract Number: 39 • 2012 ACR/ARHP Annual Meeting
SDF-1 Induces Osteoclastogenesis in Rheumatoid Arthritis by Upregulating of RANKL Expression in Synovial Fibroblasts and CD4+ T Cells
Hae-Rim Kim¹, Kyoung-Woon Kim², Bo-Mi Kim¹, Mi La Cho³ and Sang-Heon Lee⁴, ¹Division of Rheumatology, Konkuk University School of Medicine, Seoul, South Korea, ²Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ³Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ⁴Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea
Background/Purpose: Stromal cell-derived factor (SDF)-1 is involved in bone destructive process in rheumatoid arthritis (RA) and bony metastasis in malignancy, through inducing angiogenesis, producing matrix-degrading…

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