Abstract Number: 543 • 2015 ACR/ARHP Annual Meeting
The IL-20 Receptor Axis in Early Rheumatoid Arthritis: Novel Inflammation-Independent Links Between Autoantibody Positivity and Radiographic Progression
Background/Purpose: Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs) and bone erosions. Successful treatment can compromise…Abstract Number: 1016 • 2015 ACR/ARHP Annual Meeting
Collagen Antibodies Induce Pain-like Behavior in Mice Independent of Inflammation and Complement Activation but Requires Fcγrs
Background/Purpose: Collagen Antibody Induced Arthritis (CAIA) is an acute mouse model of rheumatoid arthritis (RA). It is induced by an intravenous injection of a cocktail…Abstract Number: 1017 • 2015 ACR/ARHP Annual Meeting
A Novel Mechanism of Arthritis-Induced Pain: Activation of Sensory Neurons By Autoantibodies
Background/Purpose: Joint pain is one of the main reasons for patients with rheumatoid arthritis (RA) to seek medical care. Collagen type II (CII) antibodies (Abs)…Abstract Number: 2577 • 2015 ACR/ARHP Annual Meeting
Ablation of Fc Gamma Receptors Leads to a Decreased Bone Erosion in Experimental Arthritis Not By Altering Osteoclast Numbers within the Inflamed Joint but By Inhibiting Osteoclast Activation
Background/Purpose: Rheumatoid arthritis is characterized by immune complex dependent chronic joint inflammation and severe cartilage and bone destruction. In earlier studies we showed that Fcγ…Abstract Number: 3024 • 2015 ACR/ARHP Annual Meeting
Fcγriiia Mediated Signal Cause Epigenetic Changes in Human Naive CD4+ T-Cells
Background/Purpose: Signals that trigger epigenetic changes in CD4+ T-cells are unknown. To examine a role for FcγRIIIa mediated co-signal in causing epigenetic changes in human…Abstract Number: 989 • 2014 ACR/ARHP Annual Meeting
Fcgamma Receptor IIb Facilitates Rapid Internalisation of Rituximab (type 1 anti-CD20 antibody) in B Cells from Patients with RA and SLE and Contributes to Less Efficient B Cell Lysis Than Type 2 Anti-CD20 Antibodies, in Vitro
Background/Purpose Incomplete B-cell depletion using rituximab (RTX) is associated with poor clinical response in some individuals with RA and SLE, in particular. However, the precise…Abstract Number: 2730 • 2014 ACR/ARHP Annual Meeting
FcγRIIIa Ligation in Human Peripheral CD4+ T-Cells Generate TH17 like Population
Background/Purpose: Cytokines produced during TH17 response, IL-17A and IL17F drive inflammation and autoimmunity. They also act as a bridge between adaptive and innate immunity. Immune…Abstract Number: 1955 • 2014 ACR/ARHP Annual Meeting
Disparity in Internalisation of Monoclonal Antibodies Targeting B Cell Antigens and Regulation By Fc Gamma Receptor IIb: Implications for Targeted Therapy in SLE
Background/Purpose Monoclonal antibodies (mAbs) targeting B cell antigens CD20 and CD22 are used to treat patients with SLE either in the clinic or in clinical…Abstract Number: 1814 • 2014 ACR/ARHP Annual Meeting
RNA-Containing Immune Complexes Shift Human Neutrophils from Phagocytosing Cells to Efficient Releasers of Oxidized DNA in a Process Requiring Crosstalk Between Toll-like Receptors and Fc Gamma Receptor IIa
Background/Purpose Neutrophil extracellular traps (NETs), the extrusion of chromatin to capture microbes, has recently emerged as a possible mechanism that may increase the autoantigenic burden…Abstract Number: 178 • 2013 ACR/ARHP Annual Meeting
Fc-Gamma Receptor Genetic Variation In Kawasaki Disease
Abstract on behalf of the International Kawasaki Disease Genetics Consortium. Background/Purpose: Kawasaki disease (KD) is a pediatric vasculitis of unknown etiology with a substantial genetic…Abstract Number: 1143 • 2013 ACR/ARHP Annual Meeting
Increased Frequency Of Pratroling Monocytes In Experimental Arthritis and Rheumatoid Arthritis Patients In Response To IL6-R Blockade
Background/Purpose: Monocytes represent a heterogeneous circulating population of immune cells that play important roles in the inflammatory response. Two main functional subsets of human monocytes…Abstract Number: 2160 • 2012 ACR/ARHP Annual Meeting
Fcγ Receptor IIIb Polymorphism Is Associated with Injection Reaction to Adalimumab in Patients with Rheumatoid Arthritis
Background/Purpose: Biological agents targeting a specific molecule provide an effective means for therapeutic management of rheumatoid arthritis (RA), but infusion/injection reaction is a major adverse…Abstract Number: 1761 • 2012 ACR/ARHP Annual Meeting
Suppression of Rheumatoid Arthritis B Cells by XmAb5871, an Anti-CD19 Monoclonal Antibody That Co-Engages the B Cell Antigen Receptor and the FcγRIIb Inhibitory Receptor
Background/Purpose: XmAb®5871 is a humanized and Fc-engineered antibody that coengages CD19, part of the B cell receptor (BCR) complex, with the inhibitory receptor FcγRIIb (CD32b).…Abstract Number: 1056 • 2012 ACR/ARHP Annual Meeting
Fc Receptor Gamma-Dependent Autoimmune Endocarditis in K/BxN Mice
Background/Purpose: Arthritis and endocarditis co-exist in several human rheumatic diseases, including systemic lupus erythematosus, rheumatic fever, and rheumatoid arthritis. K/BxN TCR transgenic mice, well known…Abstract Number: 1074 • 2012 ACR/ARHP Annual Meeting
TLR2 Deletion Promotes Arthritis and Joint Destruction Through Reduction of IL-10
Background/Purpose: TLR2 signaling pathway has been suggested as a potential therapeutic target in RA. However, studies with mice deficient in TLR2 (TLR2-/-) and IL-1Ra suggest…