ACR Meeting Abstracts

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Abstracts tagged "Fc receptors"

  • Abstract Number: L14 • 2018 ACR/ARHP Annual Meeting

    Top-Line Results of a Phase 2, Double-Blind, Randomized, Placebo-Controlled Study of a Reversible B Cell Inhibitor, XmAb®5871, in Systemic Lupus Erythematosus (SLE)

    Joan T. Merrill1, Joshua June2, Fotios Koumpouras3, Wambui Machua4, Mohammad Faisal Khan5, Anca Askanase6, Arezou Khosroshahi7, Saira Sheikh8, Paul A. Foster9 and Debra J. Zack9, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Joshua June, DO, Lansing, MI, 3Internal Medicine, Rheumatology, Yale University School of Medicine, New Haven, CT, 4Internal Medicine, Piedmont Atlanta Hospital, Atlanta, GA, 5Arthritis & Rheumatology Center of Oklahoma, PLLC, Oklahoma City, OK, 6Director, Columbia University Lupus Center, Columbia University Medical Center, Bronx, NY, 7Department of Medicine, Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, 8Medicine, University of North Carolina, Chapel Hill, NC, 9Xencor, Inc., San Diego, CA

    Background/Purpose: XmAb5871 is a humanized anti-CD19 antibody Fc-engineered for increased affinity to FcgRIIb. Co-ligation of CD19 and FcgRIIb inhibits B lineage cells key to SLE…
  • Abstract Number: 1986 • 2018 ACR/ARHP Annual Meeting

    Adalimumab:TNF Complexes Are Cleared More Efficiently By Human Osteoclasts Than Those with Etanercept through Fcg-Receptor Binding and Internalization

    Bohdan P. Harvey, Joel Cohen-Solal and Zehra Kaymakcalan, Biologics, AbbVie Bioresearch Center, Worcester, MA

    Background/Purpose: TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis (OCgenesis) independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast…
  • Abstract Number: 2037 • 2018 ACR/ARHP Annual Meeting

    CTLA4 Signaling Down-Regulates Fcγ Receptor I Expression on Circulating Monocytes: A Potential Mechanism of Action of Abatacept for RA

    Ryosuke Fukue, Yuka Okazaki and Masataka Kuwana, Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Abatacept is a recombinant fusion protein comprising cytotoxic T lymphocyte antigen 4 (CTLA4) and Fc region of immunoglobulin (Ig), which is efficacious against rheumatoid…
  • Abstract Number: 59 • 2016 ACR/ARHP Annual Meeting

    Novel Agents for Blocking the Interaction of Immune Complexes with the Activatory FcγRIIIa Receptor

    James Robinson1, Euan Baxter1, Darren Tomlinson2, Richard Foster3, Robin Owen4, Stephanie Win1, Joanne Nettleship5, Christian Tiede2, Jayakanth Kankanala2, Raymond Owens5, Colin Fishwick3, Michael McPherson2 and Ann Morgan6, 1NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 2Astbury Centre, School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom, 3School of Chemistry, University of Leeds, Leeds, United Kingdom, 4Harwell Science and Innovation Campus, Diamond Light Source, Didcot, United Kingdom, 5Research Complex at Harwell, Oxford Protein Production Facility - UK, Oxford, United Kingdom, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, Great Britain

    Background/Purpose: Protein-protein interactions are essential for the control of cellular functions and critical for regulation of the immune system. One example is the binding of…
  • Abstract Number: 1006 • 2016 ACR/ARHP Annual Meeting

    Immune Complex-Mediated TLR8 Activation Shifts Neutrophils from Phagocytosis to Netosis through Furin-Dependent Shedding of Fcgriia

    Christian Lood1, Sabine Arve2, Laura Durcan2, Jeffrey Ledbetter2 and Keith B. Elkon1, 1Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2University of Washington, Seattle, WA

    Background/Purpose:  Neutrophils, isolated from healthy individuals, were incubated with RNA-ICs and analyzed for phagocytosis and NETosis by flow cytometry and fluorimetry, respectively, in the presence…
  • Abstract Number: 1569 • 2016 ACR/ARHP Annual Meeting

    Increased Circulating CD14brightCD16+ Intermediate Monocytes Are Regulated By Interleukin-10 in Patients with Rheumatoid Arthritis

    Masako Tsukamoto1, Noriyuki Seta2, Keiko Yoshimoto1, Katsuya Suzuki1, Kunihiro Yamaoka1 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Department of Internal Medicine, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan

    Background/Purpose:  The study enrolled 35 untreated RA patients and 14 healthy volunteers. DAS28-ESR was evaluated and peripheral blood samples were obtained at baseline and following…
  • Abstract Number: 2065 • 2016 ACR/ARHP Annual Meeting

    Platelet FcγRIIa Polymorphism H131R Associates with Subclinical Atherosclerosis and Increased Platelet Activity in SLE

    Sara Rasmussen1, Harmony Reynolds2, Jill P. Buyon3, Sokha Nhek4, Jonathan Newman3, Jeffrey Berger5 and Robert M Clancy1, 1Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2Cardiology, New York University School of Medicine, New York, NY, 3Medicine, New York University School of Medicine, New York, NY, 4New York University School of Medicine, New York, NY, 5Medicine, Division of Cardiology, New York University School of Medicine, New York, NY

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by heterogeneity of presentation, an undulating course, and elevated risk for premature cardiovascular disease.…
  • Abstract Number: 2263 • 2016 ACR/ARHP Annual Meeting

    Apolipoprotein E Regulates Inflammation and Joint Destruction during Antigen-Induced Arthritis (AIA)

    Giuliana Ascone1, Irene Di Ceglie1, Wouter de Munter1, Birgitte Walgreen2, Annet Sloetjes1, Peter M. van der Kraan1, Ernst Lindhout3, Mike Martens3 and Peter L. E. M. van Lent1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimental, Radboud university medical center, Nijmegen, Netherlands, 3Future Diagnostics Solutions (FDs), Wijchen, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease largely driven by immune complexes and their interaction with FcγRs present on macrophages within the synovium.…
  • Abstract Number: 543 • 2015 ACR/ARHP Annual Meeting

    The IL-20 Receptor Axis in Early Rheumatoid Arthritis: Novel Inflammation-Independent Links Between Autoantibody Positivity and Radiographic Progression

    Tue Wenzel Kragstrup1,2,3, Stinne Greisen1, Morten Aagaard Nielsen1, Chris Rhodes2, Kristian Stengaard-Pedersen3, Merete Lund Hetland4, Kim Hørslev-Petersen5, Peter Junker6, Mikkel Østergaard7, Malene Hvid1,8, Thomas Vorup-Jensen1, William H. Robinson2,9, Jeremy Sokolove2,10 and Bent Deleuran1,3,8, 1Department of Biomedicine, Aarhus University, Aarhus, Denmark, 2VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, 3Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 4DANBIO, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 5Rheumatology, Rheumatology King Christian X's Hospital, Graasten, Denmark, 6University of Southern Denmark, Odense, Denmark, 7Copenhagen University Hospital Glostrup, Copenhagen, Denmark, 8Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 9Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 10Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPAs) and bone erosions. Successful treatment can compromise…
  • Abstract Number: 3024 • 2015 ACR/ARHP Annual Meeting

    Fcγriiia Mediated Signal Cause Epigenetic Changes in Human Naive CD4+ T-Cells

    Ye Bi1, Chen Chen2, Terry Moore3 and Anil K. Chauhan4, 1Internal Medicine, Saint Louis University, St. Louis, MO, 2Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Division of Rheumatology and Pediatric Rheumatology, Saint Louis University School of Medicine, St Louis, MO, 4Internal Medicine-Rheumatology, Saint Louis University, St Louis, MO

    Background/Purpose: Signals that trigger epigenetic changes in CD4+ T-cells are unknown. To examine a role for FcγRIIIa mediated co-signal in causing epigenetic changes in human…
  • Abstract Number: 2577 • 2015 ACR/ARHP Annual Meeting

    Ablation of Fc Gamma Receptors Leads to a Decreased Bone Erosion in Experimental Arthritis Not By Altering Osteoclast Numbers within the Inflamed Joint but By Inhibiting Osteoclast Activation

    Irene Di Ceglie1, Sjef Verbeek2, Peter van der Kraan1, Wim van den Berg1 and Peter van Lent1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Human Genetic, Human Genetic, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis is characterized by immune complex dependent chronic joint inflammation and severe cartilage and bone destruction. In earlier studies we showed that Fcγ…
  • Abstract Number: 1017 • 2015 ACR/ARHP Annual Meeting

    A Novel Mechanism of Arthritis-Induced Pain: Activation of Sensory Neurons By Autoantibodies

    Duygu Bas1, Alex Bersellini Farinotti1, Jon Sinclair2, Gustaf Wigerblad3, Kutty Selva Nandakumar4, Rikard Holmdahl5, Bo Rydqvist2 and Camilla Svensson3, 1Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, Sweden, 3Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, 4Department of Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 5Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Joint pain is one of the main reasons for patients with rheumatoid arthritis (RA) to seek medical care. Collagen type II (CII) antibodies (Abs)…
  • Abstract Number: 1016 • 2015 ACR/ARHP Annual Meeting

    Collagen Antibodies Induce Pain-like Behavior in Mice Independent of Inflammation and Complement Activation but Requires Fcγrs

    Gustaf Wigerblad1, Katalin Sandor1, Kutty Selva Nandakumar2, Rikard Holmdahl3 and Camilla Svensson1, 1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, 2Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden, 3Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Collagen Antibody Induced Arthritis (CAIA) is an acute mouse model of rheumatoid arthritis (RA). It is induced by an intravenous injection of a cocktail…
  • Abstract Number: 2730 • 2014 ACR/ARHP Annual Meeting

    FcγRIIIa Ligation in Human Peripheral CD4+ T-Cells Generate TH17 like Population

    Anil K. Chauhan1, Terry Moore2 and Chen Chen3, 1Rheumatology, Saint Louis University, St. Louis, MO, 2Rheumatology/Immunology, St Louis University, Saint Louis, MO, 3Rheumatology/Internal Medicine, Saint Louis University, St. Louis, MO

    Background/Purpose: Cytokines produced during TH17 response, IL-17A and IL17F drive inflammation and autoimmunity. They also act as a bridge between adaptive and innate immunity. Immune…
  • Abstract Number: 1955 • 2014 ACR/ARHP Annual Meeting

    Disparity in Internalisation of Monoclonal Antibodies Targeting B Cell Antigens and Regulation By Fc Gamma Receptor IIb: Implications for Targeted Therapy in SLE

    Venkat Reddy1, Geraldine Cambridge2, David A. Isenberg3, Mark Cragg4 and Maria J. Leandro2, 1Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, 2Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 3Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 4Antibody and Vaccine group, Cancer Sciences Unit, Faculty of Medicine, Southampton University, Southampton, United Kingdom

    Background/Purpose Monoclonal antibodies (mAbs) targeting B cell antigens CD20 and CD22 are used to treat patients with SLE either in the clinic or in clinical…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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