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Abstracts tagged "Experimental Arthritis"

  • Abstract Number: 1020 • ACR Convergence 2021

    Enhancing Endothelial Cell Barrier Function via Sphingosine -1 Phosphate Receptor 1 (S1PR1) – a Novel Treatment for Experimental Arthritis

    Nathalie Burg, Ryan Malpass, Carl Blobel and Jane Salmon, Hospital for Special Surgery, New York, NY

    Background/Purpose: S1PR1 signaling plays critical roles in EC barrier function and vascular health, but until now, research on S1PR1 modulation in autoimmune rheumatic disease has…
  • Abstract Number: 0450 • ACR Convergence 2020

    In Vitro Characterization of Inflammatory Arthritis Associated with Immune Check Point Inhibition

    Anne Sofie Sørensen1, Morten Nørgaard Andersen1, Kristian Juul-Madsen2, Cæcilie Deisting Skejø1, Henrik Schmidt1, Thomas Vorup-Jensen1 and Tue Wenzel Kragstrup1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University, Aarhus, Midtjylland, Denmark

    Background/Purpose: During treatment with immune checkpoint inhibitors (ICI) such as the anti-PD-1 antibody pembrolizumab, 2-4% of cancer patients develop inflammatory arthritis as an immune-related adverse…
  • Abstract Number: 0741 • ACR Convergence 2020

    Constitutive Inhibitor Kappa B (IκB) Kinase 2 (IKK2) Activation Induces an Inflammatory State in Fibroblast-Like Synoviocytes

    Sergio Ramirez-Perez1, Umesh Gangishetti1, Kyle Jones1 and Pallavi Bhattaram2, 1Department of Orthopaedics, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, 2EMORY UNIVERSITY, Atlanta, GA

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are key players involved in the production of inflammatory mediators that trigger joint tissue damage in inflammatory arthritis (IA). The most…
  • Abstract Number: 0967 • ACR Convergence 2020

    Absence of Thy1 Associated with Severe Bone Loss in the TNF-transgenic (TNF-Tg) Mice Arthritis Model

    Ananta Paine1, Maria de la Luz Garcia-Hernandez2, Marc Nuzzo3, Stacey Duemmel3, Benjamin Korman1 and Christopher Ritchlin1, 1Department of Medicine, University of Rochester Medical Center, Rochester, NY, 2Department of Medicine, University of Rochester Medical Center, West Henrietta, NY, 3Department of Medicine, University of Rochester Medical Center, Rochester

    Background/Purpose: Thy1 (CD90) is a glycosylated, glycophosphatidylinositol (GPI)-anchored membrane protein noted to be expressed on many cells including T lymphocytes, stem cells, osteoblasts and fibroblasts.…
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ACR Pediatric Rheumatology Symposium 2020

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