Abstracts tagged "Epigenetics"

Abstract Number: 2109 • 2018 ACR/ARHP Annual Meeting
Activation of T Follicular Helper Cells through Epigenetic Regulation By STAT1 and STAT4 in Lupus Patients
Shingo Nakayamada¹, Xiaoxue Ma¹, Satoshi Kubo¹, Yusuke Miyazaki¹, Kaoru Yamagata¹, Kazuhisa Nakano¹ and Yoshiya Tanaka², ¹First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: During the T cell differentiation, signal transducer and activators of transcription (STAT) family transcription factors play pivotal roles in specifying T cell lineages. T…
Abstract Number: 2829 • 2017 ACR/ARHP Annual Meeting
Complete Epigenetic Landscape of Rheumatoid Arthritis Fibroblast-like Synoviocytes Reveals Unanticipated Critical Pathogenic Pathways
Rizi Ai¹, Teresina Laragione², Deepa Hammaker³, David L. Boyle⁴, Andre ‎ Wildberg⁵, Keisuke Maeshima³, Emmanuele Palescandolo⁶, Vinod Krishna⁶, Bryan Linggi⁷, David Pocalyko⁸, John W. Whitaker⁹, Percio S. Gulko², Wei Wang¹⁰ and Gary S. Firestein¹¹, ¹UC San Diego, La Jolla, CA, ²Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, ⁴University of California San Diego, La Jolla, CA, ⁵Chemistry and Biochemistry, UNIVERSITY OF CALIFORNIA SAN DIEGO, LA JOLLA, CA, ⁶Janssen Pharmaceuticals, Spring House, PA, ⁷janssen Pharmaceuticals, Spring House, PA, ⁸Janssen Research, Spring House, PA, ⁹Janssen Pharmaceuticals, La Jolla, CA, ¹⁰Chemistry and Biochemistry, UC San Diego, La Jolla, CA, ¹¹Medicine, University of California San Diego, La Jolla, CA
Background/Purpose: Epigenetics participates in the pathogenesis of rheumatoid arthritis (RA). Epigenetic marks, gene expression and DNA polymorphisms have been investigated but the analyses are limited…
Abstract Number: 66 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Profiling of OA PBMCs Reveals Slowed Epigenetic Aging Among Rapid Radiographic Progressors: Data from the Osteoarthritis Initiative (OAI)
Alexander Rivas¹, Madison Andrews² and Matlock A. Jeffries³, ¹Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Department of Medicine, Division of Rheumatology, Immunology, and Allergy, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Extensive evidence has correlated epigenetic alterations in articular tissues with both the presence and progression of human osteoarthritis. A recent study demonstrated that accelerated…
Abstract Number: 178 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Study in Lupus in an Admixed Mexican Population
Maria Teruel¹, Patrick Coit², Mikhail Dozmorov³, Mario Cardiel⁴, Ignacio Garcia-De La Torre⁵, Marco A Maradiaga-Ceceña Sr.⁶, José Francisco Moctezuma⁷, Maria Teresa Tusié-Luna⁸, Marta Alarcón-Riquelme^9,10 and Amr H Sawalha², ¹GENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, ⁴Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, ⁵Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, ⁶Hospital General de Culiacán, Culiacán, Mexico, ⁷Servicio de Reumatología, Hospital General de Mexico, Ciudad de Mexico, Mexico, ⁸Medicina Genómica y Toxicología Ambiental, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico, ⁹Uppsala University, Uppsala, Sweden, ¹⁰Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain
Background/Purpose: Our knowledge about the pivotal role DNA methylation plays in the pathogenesis of SLE has significantly increased in the last few years. However, we…
Abstract Number: 184 • 2017 ACR/ARHP Annual Meeting
An Epigenome-Guided Approach to Causal Variant Discovery in Autoimmune Disease
Richard C. Pelikan¹, Jennifer A. Kelly², Yao Fu², Caleb Lareau³, Graham B. Wiley¹, Stuart Glenn¹, Martin Aryee^3,4, Courtney Montgomery⁵ and Patrick Gaffney², ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Department of Biostatistics, Harvard T.H. Chan School of Public Health, Charlestown, MA, ⁴Department of Pathology, Harvard Medical School, Boston, MA, ⁵Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Genome-wide association studies have identified thousands of genetic associations with complex human diseases and traits. However, establishing the truly causal regions of risk haplotypes…
Abstract Number: 753 • 2017 ACR/ARHP Annual Meeting
The Histone Demethylase Jumonji Domain-Containing Protein 3 (JMJD3) As Central Mediator of Fibroblast Activation
Christina Bergmann¹, Amelie Brandt¹, Clara Dees², Yun Zhang³, Chih-Wei Chen⁴, Tatjana Mallano⁵, Thomas Wohlfahrt⁶, Ruifang Liang⁷, Rosebeth Kagwiria¹, Aline Bozec⁸, Ralf Rieker⁹, David Abraham¹⁰, Andreas Ramming¹¹, Oliver Distler¹², Georg Schett¹³ and Jörg Distler¹⁴, ¹Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ²Department of Internal Medicine 3 and Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ³Department of Internal Medicine 3 and Institute for Clinical Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁵Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁶Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁷Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁸Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ⁹Department of Pathology, University Clinic Erlangen, Erlangen, Germany, ¹⁰Centre for Rheumatology and Connective Tissue, UCL School of Life and Medical Sciences, London, London, United Kingdom, ¹¹Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ¹²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹³Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ¹⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany
Background/Purpose: Epigenetic modifications are key drivers of chronic fibroblast activation. Trimethylation of histone 3 at lysine residue K27 (H3K27me3) is a repressive modification, that is…
Abstract Number: 755 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells: Identification of Epigenetically Affected Key Genes and Pathways
Shadia Nada¹, Ibtissam Gad², Ali Alqahtani³, Ahmad Assaly², Sadik Khuder⁴, Yongqing Wang⁵, Bashar Kahaleh¹ and Nezam Altorok¹, ¹Medicine/Rheumatology, University of Toledo, Toledo, OH, ²University of Toledo, Toledo, OH, ³Internal Medicine, University of Toledo, Toledo, OH, ⁴Department of Medicine, University of Toledo, Toledo, OH, ⁵Medicine, University of Toledo, Toledo, OH
Background/Purpose: The etiology of systemic sclerosis (SSc) is not clear, but there is evidence suggesting a critical role for epigenetic alterations in disease pathogenesis and…
Abstract Number: 767 • 2017 ACR/ARHP Annual Meeting
Elevated MeCP2 Expression in Diffuse Cutaneous Systemic Sclerosis Dermal Fibroblasts Is Associated with Anti-Fibrotic Effects
Ye He¹, Pei-Suen Tsou², Dinesh Khanna³ and Amr H Sawalha², ¹Rheumatology, University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic Sclerosis (SSc) is a multisystem autoimmune connective tissue disorder characterized by vascular injury and fibrosis of the skin and internal organs. Methyl-CpG-binding protein…
Abstract Number: 903 • 2017 ACR/ARHP Annual Meeting
Increased Expression of CCN4/WISP1 in Osteoarthritic Articular Cartilage Is Epigenetically Regulated and Disrupts Cartilage Homeostasis
Martijn H. van den Bosch¹, Yolande F. Ramos², Wouter den Hollander², Nils Bömer², Rob G. Nelissen³, Judith V. Bovée⁴, Peter L. van Lent¹, Arjen B. Blom¹, Peter M. van der Kraan¹ and Ingrid Meulenbelt², ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Department of Orthopedics, Leiden University Medical Center, Leiden, Netherlands, ⁴Department of Pathology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Previously, we described increased expression of Wnt-1-induced signaling protein 1 (Wisp1) in murine synovium and cartilage after induction of experimental osteoarthritis (OA) models. WISP1…
Abstract Number: 1017 • 2017 ACR/ARHP Annual Meeting
Investigation of Differential Methylation As a Potential Biomarker of Methotrexate Response in Patients with Rheumatoid Arthritis
Nisha Nair¹, Darren Plant^2,3, Suzanne M Verstappen¹, John D Isaacs⁴, Ann W. Morgan⁵, Kimme L. Hyrich⁶, Anne Barton⁷ and Anthony G. Wilson⁸, ¹Arthritis Research UK Centre of Genetics and Genomics and Centre of Epidemiology, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Manchester, United Kingdom, ³NIHR Manchester Musculoskeletal BRU, Central Manchester Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁴Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁶National Institute of Health Research Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁷Arthritis Research UK, Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom, ⁸UCD School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
Background/Purpose: Methotrexate (MTX) is the first-line disease modifying anti-rheumatic drug for the treatment of rheumatoid arthritis (RA). However, many patients do not respond adequately or…
Abstract Number: 1660 • 2017 ACR/ARHP Annual Meeting
Prolactin Induces an Interferon Signature in Monocytes and Drives IRF1-HAT Interactions
Yiu Tak Leung¹, Lihua Shi², Kelly Maurer², Li Song³ and Kathleen E. Sullivan⁴, ¹Temple University, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Pediatrics, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Epigenetic changes in systemic lupus erythematosus (SLE) offer a potential explanation for the chronicity of disease. We previously found that interferon regulatory factor-1(IRF1) binding…
Abstract Number: 1727 • 2017 ACR/ARHP Annual Meeting
Genome-Wide DNA Methylation Analysis in Systemic Sclerosis Reveals Hypomethylation of Interferon-Associated Genes in CD4+ and CD8+ T Cells
Weilin Pu¹, Weifeng Ding², Lei Wang³, Shuai Jiang⁴, Wenzhen Tu³, Shicheng Guo⁵, Qingmei Liu⁶, Yanyun Ma⁴, Sidi Chen⁷, Wenyu Wu⁶, Xiaodong Zhou⁸, Maureen D. Mayes⁹, Shervin Assassi⁹, John D. Reveille⁹, Li Jin¹⁰ and Jiucun Wang¹⁰, ¹State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, ²Medical Laboratory Center, Medical Laboratory Center, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China, Nantong, China, ³Division of Rheumatology, Division of Rheumatology, Shanghai TCM-integrated Hospital, Shanghai, China, Shanghai, China, ⁴Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, Shanghai, China, ⁵Department of Bioengineering, Department of Bioengineering, University of California at San Diego, CA, USA, San Diego, CA, ⁶Department of Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China, Shanghai, China, ⁷State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences,, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China, ⁸Internal Medicine-Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁹University of Texas McGovern Medical School, Houston, TX, ¹⁰State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai, China
Background/Purpose: Systemic sclerosis (SSc) is a complex systemic autoimmune disease caused by complicated interaction between genetic, epigenetic and environmental risk factors. Evidence showed epigenetic modifications,…
Abstract Number: 1791 • 2017 ACR/ARHP Annual Meeting
TET1 Is an Important Transcriptional Activator of the Tnfa Locus in Macrophages
Emmanuel Karouzakis¹, Fangfang Sun², Agnieszka Pajak¹, Shuang Ye², Steffen Gay¹, Oliver Distler³ and Michel Neidhart¹, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Activated macrophages are found in the inflamed and hyperplastic synovial RA tissue. Macrophages are the main producers of high levels of pro-inflammatory cytokines such…
Abstract Number: 1925 • 2017 ACR/ARHP Annual Meeting
TGFβ Promotes Fibrosis By MYST1-Dependent Epigenetic Regulation of Autophagy
Ariella Zehender¹, Neng-Yu Lin², Adrian Stefanica³, Chih-Wei Chen⁴, Alina Soare⁵, Thomas Wohlfahrt⁶, Simon Rauber⁶, Christina Bergmann⁷, Andreas Ramming⁸, Oliver Distler⁹, Georg Schett¹⁰ and Jörg Distler⁵, ¹1Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ²Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ³1Department of Internal Medicine 3 – Rheumatology and Immunology, University of Erlangen, Erlangen, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, ⁵Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁶Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁷Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany, ⁸Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ¹⁰Department of Internal Medicine 3 – Rheumatology and Immunology, Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University of Erlangen-Nuremberg and University Hospital Erlangen, Erlangen, Germany
Background/Purpose: Autophagy (Atg) is catabolic process allowing cells to degrade unnecessary or dysfunctional cellular organelles. Aberrant activation of Atg has been implicated into the pathogenesis…
Abstract Number: 2654 • 2017 ACR/ARHP Annual Meeting
Treatment-Associated DNA Methylation Patterns in Systemic Lupus Erythematosus
Juliana Imgenberg-Kreuz^1,2, Jonas Carlsson Almlöf¹, Dag Leonard³, Gunnel Nordmark², Maija-Leena Eloranta³, Leonid Padyukov⁴, Iva Gunnarsson⁴, Elisabet Svenungsson⁴, Christopher Sjöwall⁵, Lars Rönnblom², Ann-Christine Syvänen¹ and Johanna K Sandling^1,2, ¹Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ²Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ³Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden, ⁴Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁵Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping University, Linköping, Sweden, Linköping, Sweden
Background/Purpose: DNA methylation has emerged as an important contributing factor in the pathogenesis of systemic lupus erythematosus (SLE). SLE typically requires continuous treatment to control…

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