Abstracts tagged "Enthesitis"

Abstract Number: 2878 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety Results of Guselkumab in Patients with Active Psoriatic Arthritis over 56 Weeks from a Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study
Atul A. Deodhar¹, Alice B Gottlieb², Wolf-Henning Boehncke³, Bin Dong⁴, Yuhua Wang⁴, Yanli Zhuang⁴, William Barchuk⁵, Xie L. Xu⁵ and Elizabeth Hsia⁴, ¹Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, ²Department of Dermatology, New York Medical College, Valhalla, NY, ³Geneva University Hospital and University of Geneva, Geneva, Switzerland, ⁴Janssen Research & Development, LLC, Spring House, PA, ⁵Janssen Research & Development, LLC, San Diego, CA
Background/Purpose: Evaluate efficacy and safety of guselkumab (GUS) in patients (pts) with active psoriatic arthritis (PsA) over 56 weeks (wks). Methods: Pts w/active PsA (defined…
Abstract Number: 252 • 2017 ACR/ARHP Annual Meeting
Correlations between Clinical and Ultrasound Scores of Peripheral Enthesitis and Disease Activity Scores in a Cohort of Spondyloarthritis
Assia Haddouche¹, Sabrina Haid², Siham Bencheikh³, Samy Slimani⁴, Amina Abdessemed⁵, Nadjia Brahimi⁶, Aïcha Ladjouz Rezig⁶ and Fella Hanni⁶, ¹of Medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, ²medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, ³EPH HADJOUT, Algiers, Algeria, ⁴Department of Medicine, University of Batna, Batna, Algeria, ⁵Medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, ⁶Department of Medicine, University of Algiers 1, Algiers, Algeria
Background/Purpose: To look correlations between clinical and ultrasound (US) scores of peripheral enthesitis (PE) and disease activity scores of SpAMethods: A prospective study of 208…
Abstract Number: 254 • 2017 ACR/ARHP Annual Meeting
Psoriatic Arthritis Sonographic Enthesitis Scores – Systematic Review of the Literature
Ofir Elalouf¹, Sibel Bakirci², Zahi Touma³, Melanie A Anderson⁴, Gurjit S. Kaeley⁵, Sibel Z. Aydin⁶ and Lihi Eder^7,8, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Fellow in Rheumatology, Antalya, Turkey, ³Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, ⁴Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵University of Florida, Ponte Vedra Beach, FL, ⁶University of Ottawa, Ottawa, ON, Canada, ⁷Medicine, University of Toronto, Toronto, ON, Canada, ⁸Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is a prominent feature of spondyloarthropathy (SpA), including psoriatic arthritis (PsA). The evaluation of enthesitis has conventionally been conducted by clinical exam, a…
Abstract Number: 1515 • 2017 ACR/ARHP Annual Meeting
Improvements in Enthesitis Scores with Certolizumab Pegol Treatment in Males and Females with Active Axial Spondyloarthritis Are Maintained to Week 204
Maxime Dougados¹, Philip J Mease², Joachim Sieper³, Peter C. Taylor⁴, Natasha de Peyrecave⁵, Tommi Nurminen⁶ and Jürgen Braun⁷, ¹Rheumatology Department, Paris-Descartes University and Cochin Hospital, Paris, France, ²Swedish Medical Center and University of Washington, Seattle, WA, ³Charité University Hospital, Berlin, Germany, ⁴Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal, Sciences, Kennedy Institute of Rheumatology, University of Oxford,, Oxford, United Kingdom, ⁵UCB Pharma, Slough, United Kingdom, ⁶UCB Pharma, Monheim, Germany, ⁷Rheumazentrum Ruhrgebiet, Herne, Germany
Background/Purpose: Axial spondyloarthritis (axSpA), characterized by spinal inflammation, is also associated with extra-spinal manifestations including inflammation of the entheses (enthesitis). Enthesitis is equally prevalent throughout…
Abstract Number: 147 • 2016 ACR/ARHP Annual Meeting
Ultrasonographic Evaluation of Subclinical Enthesitis in Patients with Psoriasis
Elzem Bolkan Günaydın¹, Perihan Aladağ², Duygu Tecer¹, Işıl Saadet Yenice¹, Esra Adışen² and Feride Nur Göğüş³, ¹Physical Medicine and Rehabilitation, Division of Rheumatology, Faculty of Medicine, Gazi University, Ankara, Turkey, ²Dermatology, Faculty of Medicine, Gazi University, Ankara, Turkey, ³Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Faculty of Medicine, Gazi University, Ankara, Turkey
Background/Purpose: Psoriasis is a diseases with diverse skeletal manifestations of which enthesistis is the primary lesion. However, enthesitis may often develop without any symptoms or…
Abstract Number: 165 • 2016 ACR/ARHP Annual Meeting
The Apparent Diffusion Coefficient As a Quantitative Imaging Biomarker of Therapeutic Response in Enthesitis-Related Arthritis
Timothy Bray¹, Kanimozhi Vendhan¹, Nicola Ambrose², David Atkinson¹, Shonit Punwani¹, Corinne Fisher², Debajit Sen², Yiannis Ioannou² and Margaret Hall-Craggs¹, ¹Centre for Medical Imaging, UCL, London, United Kingdom, ²Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom
Background/Purpose : Early treatment in enthesitis-related arthritis (ERA) may have a disease-modifying effect with consequently improved outcomes. However, disease activity may be difficult to assess,…
Abstract Number: 385 • 2016 ACR/ARHP Annual Meeting
Safety of Adalimumab in Pediatric Patients with Polyarticular Juvenile Idiopathic Arthritis, Enthesitis-Related Arthritis, Psoriasis, and Crohn’s Disease
Gerd Horneff¹, Marieke M. B. Seyger², Dilek Arikan³, Jasmina Kalabic⁴, Jaclyn K. Anderson³, Andreas Lazar⁵, David A. Williams³, Chen Wang³, Rita Tarzynski-Potempa³ and Jeffrey S. Hyams⁶, ¹Asklepios Kliniken GmbH, Hamburg, Germany, ²Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³AbbVie Inc., North Chicago, IL, ⁴AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁵AbbVie Deutschland GmbH & Co. KG, North ChicagoLudwigshafen, IL, Germany, ⁶Connecticut Children’s Medical Center, Hartford, CT
Background/Purpose: Adalimumab (ADA) is a tumor necrosis factor (TNF) inhibitor used for treatment of chronic immune diseases. The safety of ADA treatment in pediatric patients…
Abstract Number: 386 • 2016 ACR/ARHP Annual Meeting
Long-Term Efficacy and Safety of Adalimumab in Pediatric Patients with Enthesitis Related Arthritis
Rubén Burgos-Vargas¹, Shirley M.L. Tse², Gerd Horneff³, Kristina Unnebrink⁴ and Jaclyn K. Anderson⁵, ¹Hospital General de Mexico, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico, ²University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada, ³Asklepios Clinc Sankt Augustin, Sankt Augustin, Germany, ⁴AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁵AbbVie Inc., North Chicago, IL
Background/Purpose: Enthesitis-related arthritis (ERA) is a JIA category primarily affecting entheses and peripheral joints but can involve the axial skeleton. Disease activity and structural change…
Abstract Number: 959 • 2016 ACR/ARHP Annual Meeting
Efficacy and Safety of Ixekizumab in Patients with Active Psoriatic Arthritis: 52 Week Results from a Phase 3 Study
Philip J Mease¹, Masato Okada², Mitsumasa Kishimoto², Catherine L. Shuler³, Hilde Carlier³, Chen-Yen Lin³, Jiani Mou³, Susan R Moriarty³, Chin H. Lee³ and Dafna D Gladman⁴, ¹Rheumatology and Internal Medicine, Swedish Medical Center and University of Washington, Seattle, WA, ²Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, ³Eli Lilly and Company, Indianapolis, IN, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose: Ixekizumab (IXE) is an IgG4 monoclonal antibody that binds with high affinity and specificity to the proinflammatory cytokine IL-17A. In this phase 3 study…
Abstract Number: 960 • 2016 ACR/ARHP Annual Meeting
Ultrasonographic Improvement of Peripheral Subclinical Enthesopathy in Therapy-Naive Patients Treated with Ustekinumab for Chronic Plaque Psoriasis: A 52-Week, Prospective, Open Label, Controlled Cohort Study
Laura Savage¹, Mark Goodfield², Elizabeth M.A. Hensor³, Paul Emery³ and Dennis McGonagle⁴, ¹NIHR Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ²Department of Dermatology, Leeds Centre for Dermatology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom
Background/Purpose: Subclinical enthesopathy is recognised in up to 50% of psoriasis patients and is thought to precede inflammatory PsA. It is not known if effective…
Abstract Number: 1312 • 2016 ACR/ARHP Annual Meeting
Incidence of Reactive Arthritis, Uveitis and Conjunctivitis in Japanese Patients with Bladder Cancer Following Intravesical BCG Therapy: A 20 Years’ Two-Center Retrospective Study
Satoshi Inotani^1,2,3,4, Yoshinori Taniguchi⁵, Takashi Karashima⁶, Yasuhiko Yoshinaga⁷, Hirofumi Nishikawa⁸, Natsuki Maeda⁹, Shimpei Fujimoto⁸ and Yoshio Terada¹⁰, ¹internal medicine, Chikamori Hospital, Kochi, Japan, ²Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi medical school, Nankoku, Japan, ³Urology, Kochi medical school, Nankoku, Japan, ⁴Rheumatic Disease Center, Kurashiki Medical Center, Kurashiki, Japan, ⁵Endocrinology, Metabolism,Nephrology and Rheumatology, Kochi University, Kochi, Japan, ⁶Urology, Kochi University, Nankoku, Japan, ⁷Kurashiki Medical Center, Kurashiki, Japan, ⁸Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School, Nankoku, Japan, ⁹Endocrinology,Metabolism,Nephrology and Rheumatology, Kochi Medical School, Nankoku, Japan, ¹⁰Kochi University, Nankoku, Japan
Background/Purpose: To evaluate the incidence of reactive arthritis (ReA), uveitis and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy (iBCG). Methods: The…
Abstract Number: 1325 • 2016 ACR/ARHP Annual Meeting
Musculoskeletal Manifestations in Ebola Survivors
Duane Pearson¹, Lisa Davis², John Frankhauser³ and Liron Caplan⁴, ¹Division of Rheumatology, University of Colorado, Aurora, CO, ²Div of Rheumatology, Denver Health, Denver, CO, ³Serving In Mission, Monrovia, Liberia, ⁴Div of Rheumatology, Denver VA and University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Musculoskeletal complaints are common among survivors of Ebola Virus Disease (EVD) and can have clinical impacts beyond two years post-convalescence. The frequency of these…
Abstract Number: 2743 • 2016 ACR/ARHP Annual Meeting
Do Specific Entheseal Points in Spa Patients Impact Patient Reported Outcomes? Implications for Clinical Practice
John Kelsall¹, Pauline Boulos², Regan Arendse³, Michelle Teo⁴, Anna Jaroszynska⁵, Michael Starr⁶, Alexander Tsoukas⁷, Emmanouil Rampakakis⁸, Eliofotisti Psaradellis⁹, Karina Maslova¹⁰, Cathy Tkaczyk¹¹, Francois Nantel¹², Brendan Osborne¹¹ and Allen J Lehman¹⁰, ¹Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²Rheumatology, McMaster University, Hamilton, ON, Canada, ³University of Saskatchewan, Saskatoon, SK, Canada, ⁴Rheumatology, Penticton Regional Hospital, Penticton, BC, Canada, ⁵Private practice, Burlington, ON, Canada, ⁶Rheumatology, Mcgill University, Pointe-Claire,, QC, Canada, ⁷McGill University, Montreal, QC, Canada, ⁸JSS Medical Research, St-Laurent, QC, Canada, ⁹JSS Medical Research, Montreal, QC, Canada, ¹⁰Janssen Inc., Toronto, ON, Canada, ¹¹Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹²19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Previous studies have shown associations between swelling or tenderness of specific joints in RA patients and patient pain. This analysis aimed to describe the…
Abstract Number: 3157 • 2016 ACR/ARHP Annual Meeting
The Association Between Sonographic Enthesitis and Radiographic Damage in Psoriatic Arthritis
Ari Polachek¹, Dafna D Gladman², Richard J. Cook³, Vinod Chandran⁴ and Lihi Eder⁵, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto, ON, Canada, ⁵Medicine, University of Toronto, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is a common clinical finding and a key pathogenic feature in psoriatic arthritis (PsA). Ultrasound is emerging as a preferred method to assess…
Abstract Number: 3161 • 2016 ACR/ARHP Annual Meeting
The Association Between HLA Genetic Susceptibility Markers and Sonographic Enthesitis in Psoriatic Arthritis
Ari Polachek¹, Richard J. Cook², Vinod Chandran¹, Fatima Abji¹, Dafna D Gladman³ and Lihi Eder⁴, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, University of Toronto, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is an important pathophysiologic component in psoriatic arthritis (PsA). Ultrasound is emerging as an optimal method to evaluate enthesitis. HLA genes are implicated…

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