Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: To evaluate the incidence of reactive arthritis (ReA), uveitis and conjunctivitis in Japanese patients with bladder cancer following intravesical BCG therapy (iBCG).
Methods: The clinical symptoms, laboratory, and imaging findings of Japanese patients who received iBCG (n=555 (250 and 305 in Kochi Medical School Hospital (KMSH) and Kurashiki Medical Center (KMC), respectively)) for bladder cancer from March 1997 to February 2016 (for 20 years) were retrospectively assessed. Especially, the patients with ReA and conjunctivitis/uveitis were examined.
Results: The backgrounds of patients received iBCG were followings; age 73±10 and 70±11; male/female 198/52 and 240/65 in KMSH and KMC, respectively. ReA was revealed in 5/250 (2.0%) and 6/305 (2.0%), uveitis in 3/250 (1.2%) and 1/305 (0.3%), and conjunctivitis in 18/250 (7.2%) and 15/305 (4.9%) in KMSH and KMC, respectively. As the total evaluation, ReA, uveitis and conjunctivitis were revealed in 11/555 (2.0%), 4/555 (0.7%) and 33/555(5.9%), respectively. All ReA were developed after 3-times of iBCG. Clinical, ultrasound and FDG-PET/CT findings of ReA induced by iBCG showed asymmetric polyarthritis/polyenthesitis. Laboratory examinations showed high CRP (>10mg/dl) in all cases. Notably, there were significant increased frequencies of HLA-B27, B35, B39 and B51 alleles in ReA patients (16.7%, 33.3%, 33.3% and 66.7%, respectively) when compared with healthy subjects (0.3%, 17.0%, 6.0% and 16.0%, respectively).
Conclusion: Despite the positive rate of HLA-B27 in ReA induced by iBCG in our study was 16.7% suggesting lower frequency than 51 to 55% in the Western countries, the incidence of ReA induced by iBCG in Japanese population was 2.0 % which could be more than in the Western countries (0.5 to 1%) from previous reports. High positivity 66.7% and 33.3% of HLA-B51 and B39 in our study might raise the possibility that HLA-B51 or B39, besides B27, also may be associated with ReA induced by iBCG in Japan.
To cite this abstract in AMA style:Inotani S, Taniguchi Y, Karashima T, Yoshinaga Y, Nishikawa H, Maeda N, Fujimoto S, Terada Y. Incidence of Reactive Arthritis, Uveitis and Conjunctivitis in Japanese Patients with Bladder Cancer Following Intravesical BCG Therapy: A 20 Years’ Two-Center Retrospective Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/incidence-of-reactive-arthritis-uveitis-and-conjunctivitis-in-japanese-patients-with-bladder-cancer-following-intravesical-bcg-therapy-a-20-years-two-center-retrospective-study/. Accessed November 28, 2020.
« Back to 2016 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/incidence-of-reactive-arthritis-uveitis-and-conjunctivitis-in-japanese-patients-with-bladder-cancer-following-intravesical-bcg-therapy-a-20-years-two-center-retrospective-study/