Abstracts tagged "Disease Activity"

Abstract Number: 1664 • 2015 ACR/ARHP Annual Meeting
Switch from Tocilizumab + Methotrexate to Tocilizumab Monotherapy. Maintenance of Response in Patients with Rheumatoid Arthritis at Low Disease Activity.
Jose L. Pablos¹, Navarro Sarabia F², Francisco J. Blanco³, Jose Andres Roman Ivorra⁴, Alberto Alonso⁵, Emilio Martin-Mola⁶ and Miguel Cantalejo-Moreira⁷, ¹Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ²Rheumatologist Service, Hospital. Virgen Macarena, Sevilla, Spain, ³Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁴Rheumatology, H.U. P. La Fe, Valencia, Spain, ⁵H Cruces, Baracaldo, Spain, ⁶H La Paz, Madrid, Spain, ⁷Rheumatology Unit, Hospital de Fuenlabrada, Fuenlabrada, Spain
Background/Purpose: Tocilizumab (TCZ) represents an efficacious alternative for patients with rheumatoid arthritis (RA) with an inadequate clinical response to biological or non-biological disease-modifying anrirheumatic drugs…
Abstract Number: 2468 • 2015 ACR/ARHP Annual Meeting
Antibodies to Histocompatibility Antigens in Juvenile Systemic Lupus Erythematosus Patients
Ana L Rodríguez-Lozano¹, Anne M. Stevens², Jessica M Foster³, Marisa S. Klein-Gitelman⁴, Hermine I. Brunner⁵, Elizabeth Field⁶, Ann M Reed⁷ and Karen Onel⁸, ¹Immunology, Instituto Nacional de Pediatria, Mexico City, Mexico, ²Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, ³Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ⁴Division of Rheumatology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Internal Medicine, University of Iowa, Iowa City, IA, ⁷Department of Pediatrics, Duke University, Durham, NC, ⁸Pediatric Rheumatology, Univ of Chicago, Chicago, IL
Background/Purpose: Microchimerism with HLA mismatched maternal cells can be readily demonstrated in normal individuals and is now established as a normal biological phenomenon. Pediatric SLE…
Abstract Number: 2608 • 2015 ACR/ARHP Annual Meeting
The “Rheumatoid Arthritis Impact of Disease”� Score Correlates with Other Patient Reported Outcomes and with Disease Activity Scores in Patients with RA and Its Patient Acceptable Symptom State Is More Stringent Than DAS28-Remission
Ricardo J.O. Ferreira^1,2, Cátia Duarte^1,3, Sylvie Batista³, Catarina Medeiros³, J.P. Sousa³, Gisela Eugénio¹, Carlos Costa¹, Pedro Carvalho¹, Joana F. Ferreira¹, Margarida Coutinho^1,4, Maria J. Salvador^1,4, Laure Gossec⁵ and J.A.P. da Silva^3,6, ¹Rheumatology, Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal, ²Health Sciences Research Unit: Nursing (UICISA: E), Coimbra, Portugal, ³Faculty of Medicine, Universidade de Coimbra, Coimbra, Portugal, ⁴Clínica Universitária de Reumatologia, Faculty of Medicine, Universidade de Coimbra, Coimbra, Portugal, ⁵Rheumatology, Pitié Salpetriere Hospital, Paris, France, ⁶Centro Hospitalar e Universitário de Coimbra - Hospitais da Universidade de Coimbra, EPE, Coimbra, Portugal
Background/Purpose: The "Rheumatoid Arthritis Impact of Disease" (RAID) score is a Patient Reported Outcome (PRO) that comprises seven domains of disease[1], that may reflect the…
Abstract Number: 2863 • 2015 ACR/ARHP Annual Meeting
Discontinuation of Anti-TNF Therapy in Patients with Axial Spondyloarthritis. a Systematic Literature Review
Victoria Navarro-Compán¹, Chamaida Plasencia-Rodriguez², Eugenio De Miguel¹, Alejandro Balsa³, Emilio Martín-Mola¹, Daniel Seoane-Mato⁴ and Juan D. Cañete⁵, ¹Rheumatology, University Hospital La Paz, Madrid, Spain, ²Rheumatology Department, La Paz University Hospital-Rheumatology Department, Madrid, Spain, ³Rheumatology, La Paz University Hospital-Rheumatology Department, Madrid, Spain, ⁴Research Unit, Spanish Society of Rheumatology, Madrid, Spain, ⁵Rheumatology, Hospital Clinic and IDIBAPS, Barcelona, Spain
Background/Purpose: In patients with axial spondyloarthritis (axSpA), anti-TNF therapy is successful for clinically improving signs and symptoms of the disease. However, there is no clear…
Abstract Number: 3184 • 2015 ACR/ARHP Annual Meeting
Is Treat-to-Target Really Working? a Longitudinal Analysis in Biodam
Sofia Ramiro¹, Robert B.M. Landewé², Désirée van der Heijde¹, Oliver FitzGerald³, Mikkel Østergaard^4,5, Joanne Homik⁶, Ori Elkayam⁷, J Carter Thorne⁸, Margaret Larche⁹, Gianfranco Ferraccioli¹⁰, Marina Backhaus¹¹, Gilles Boire¹², Bernard Combe¹³, Thierry Schaeverbeke¹⁴, Alain Saraux¹⁵, Maxime Dougados¹⁶, Silvano Adami¹⁷, Marcello Govoni¹⁸, Luigi Sinigaglia¹⁹, Alain G. Cantagrel²⁰, Cornelia F. Allaart¹, Cheryl Barnabe²¹, Clifton O. Bingham III²², Paul P. Tak²³, Dirkjan van Schaardenburg²⁴, Hilde Berner Hammer²⁵, Rana Dadashova²⁶, Edna Hutchings²⁶, Joel Paschke²⁶ and Walter Maksymowych²⁷, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, ³Rheumatology, St Vincent's University Hospital, Dublin, Ireland, ⁴Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, ⁵Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Glostrup, Denmark, ⁶Rheumatology, University of Alberta, Edmonton, AB, Canada, ⁷Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁸University of Toronto, Toronto, ON, Canada, ⁹Rheumatology, McMaster University, Hamilton, ON, Canada, ¹⁰Rheumatology and Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy, ¹¹Rheumatology/Immunology, Charite University Hospital, Berlin, Germany, ¹²Department of Medicine/Division of Rheumatology, University of Sherbrooke, Sherbrooke, QC, Canada, ¹³Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France, ¹⁴Rheumatology, Pellegrin University Hospital, Bordeaux, France, ¹⁵Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹⁶Cochin Hospital, Paris Descartes University, Paris, France, ¹⁷University of Verona, Verona, Italy, ¹⁸University of Ferrara, Ferrara, Italy, ¹⁹Department of Rheumatology, Gaetano Pini Institute, Milan, Italy, ²⁰Dept of Rheumatology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France, ²¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²²Rheumatology, Johns Hopkins University, Baltimore, MD, ²³Division of Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center, Amsterdam, Netherlands, ²⁴Rheumatology, Amsterdam Rheumatology and immunology Center, Reade, Amsterdam, Netherlands, ²⁵Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²⁶CaRE Arthritis, Edmonton, AB, Canada, ²⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: A Treat-to-Target approach (T2T), treating patients with RA towards a target, either remission or low disease activity (T2T-REM or T2T-LDA), is nowadays recommended. However…
Abstract Number: 405 • 2015 ACR/ARHP Annual Meeting
Anti-C1q Antibodies As Potential Diagnostic and Prognostic Biomarkers in Juvenile Systemic Lupus Erythematosus
Thaschawee Arkachaisri^1,2, Justin Hung Tiong Tan¹, Manasita Tanya¹, Sook Fun Hoh³, Lena Das⁴ and Jing Yao Leong^5,6, ¹Rheumatology and Immunology, KK Women's and Children's Hospital, Singapore, Singapore, ²Paediatrics, Duke-NUS Graduate Medical School, Singapore, Singapore, ³Nursing, KK Women's and Children's Hospital, Singapore, Singapore, ⁴Dept of Rheumatology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, ⁵Duke-National University of Singapore Graduate Medical School, Singapore, Singapore, ⁶SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore
Background/Purpose: Anti-C1q antibodies (AC1q) were shown to strongly correlate with the occurrence and activity of lupus nephritis in adult SLE. Data of the antibodies in…
Abstract Number: 606 • 2015 ACR/ARHP Annual Meeting
Impaired Kidney Function Improves Treatment Response after 6 Months of Methotrexat Treatment in Rheumatoid Arthritis Patients
Paul Studenic¹, Farideh Alasti¹, Josef S. Smolen^2,3, Helmuth Haslacher⁴ and Daniel Aletaha⁵, ¹Department of Internal Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Department of Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria, ³2nd Department of Medicine, Hietzing Hospital, Vienna, Austria, ⁴Laboratory Medicine, Medical University Vienna, Vienna, Austria, ⁵Department of Internal Medicine III; Division of Rheumatology, Medical University Vienna, Vienna, Austria
Background/Purpose: Methotrexate (MTX) and leflunomide are categorized as DMARDs of first choice in treating rheumatoid arthritis patients. MTX should be used cautiously in patients with…
Abstract Number: 997 • 2015 ACR/ARHP Annual Meeting
Feasibility and Influential Factors in Performing Self-Evaluation of DAS28 with Smart System of Disease Management (SSDM) By RA Patient in China
Mu Rong¹, Fei Xiao², Chun Li³, Jianlong Guan⁴, Yan Shen⁴, Dongbao Zhao⁵, Xia Xu⁶, Lindi Jiang⁷, Huiyong Chen⁷, Li Su⁸, Yuhua Jia², Li Zhang², Yuan Liu² and Zhan-Guo Li³, ¹Department of Rheumatology and Immunology, People's Hospital, Beijing University Medical School, Beijing, China, ²Gothic Internet Technology Corporation, Shanghai, China, ³Department of Rheumatology & Immunology, People's Hospital, Beijing University Medical School, Beijing, China, ⁴Huadong Hospital Affiliated to Fudan University, Shanghai, China, ⁵ShangHai ChangHai Hospital, ShangHai ChangHai Hospital, ShangHai, China, ⁶Department of Rheumatology and Immunology, Changhai Hospital,Second Military Medical University,, Shanghai, China, ⁷Zhongshan Hospital, Fudan University, Shanghai, China, ⁸Longhua Hospital Shanghai University of TCM, Shanghai, China
Background/Purpose: Regular evaluations of rheumatoid arthritis (RA) disease activities with disease activity score in 28 joints (DAS28) are critical steps to reach the goal of…
Abstract Number: 1689 • 2015 ACR/ARHP Annual Meeting
Cross Sectional Study Investigating the Effect of the Presence of Fibromyalgia on Common Clinical Disease Activity Indices in Patients with Psoriatic Arthritis
Shay Brikman¹, Victoria Furer², Yonatan Wolman³, Sara Borok Lev-Ran⁴, Ari Polachek⁵, Ofir Elalouf², Amir Sharabi⁶, Ilana Kaufman¹, Daphna Paran⁵ and Ori Elkayam⁶, ¹Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ²Rheumatology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ³Medicine B, Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁴Tel Aviv Sourasky Medical Center, Tel AViv, Israel, ⁵Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁶Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Background/Purpose: To study the effect of the presence of fibromyalgia (FMS) on common clinical disease activity indices in patients with psoriatic arthritis (PsA). Methods: Seventy…
Abstract Number: 2479 • 2015 ACR/ARHP Annual Meeting
The Association Between Social Networks, Disease Activity, and Pain in Rheumatoid Arthritis
Taysir G. Mahmoud¹, Christine Iannaccone², Jing Cui², Yvonne C. Lee³, Michael Weinblatt⁴ and N Shadick⁵, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Boston, MA, ³Rheumatology Immunology & Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Immunology & Allergy, Brigham and Women's Hosp, Boston, MA
The Association between Social Network, Disease Activity, and Pain in Rheumatoid ArthritisBackground/Purpose: Current research suggests that high social network status is related to lower levels…
Abstract Number: 2615 • 2015 ACR/ARHP Annual Meeting
Changes in a Patient-Reported Measure of Physical Function, PF-10a, Are Most Strongly Associated with Changes in the Patient Global Assessment Portion of a Composite Measure of RA Disease Activity
Elizabeth R. Wahl^1,2, Andrew Gross², Vladimir Chernitskiy², Patricia P. Katz² and Jinoos Yazdany³, ¹Medicine/Rheumatology, San Francisco Veterans Affairs Medical Center, San Francisco, CA, ²Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ³University of California, San Francisco, San Francisco, CA
Background/Purpose: A brief patient-reported measure of physical function, the PROMIS PF-10a, is sensitive to changes in disease activity among patients with rheumatoid arthritis (RA). However,…
Abstract Number: 2878 • 2015 ACR/ARHP Annual Meeting
Treating Axial Spondyloarthritis to Target: Influence of the Population Characteristics and Comorbidities in Reaching Ankylosing Spondylitis Disease Activity Score (ASDAS) Inactive Disease in a Cohort of Patients Treated with Tnfalpha Inhibitors Agents
Sara Monti, Veronica Codullo, Vittorio Grosso, Silvia Breda, Carlomaurizio Montecucco and Roberto Caporali, Division of Rheumatology, University of Pavia, IRCCS Foundation Policlinico S. Matteo, Pavia, Italy
Background/Purpose: The treat to target strategy (T2T), aiming at inactive disease (ID), has become the recommended approach also in the field of axial-SpA (axSpA) (1). …
Abstract Number: 3185 • 2015 ACR/ARHP Annual Meeting
A Cluster-Randomized Trial of a Behavioral Intervention to Incorporate a Treat-to-Target Approach in the Clinical Care of Rheumatoid Arthritis Patients in the United States
Leslie Harrold^1,2, George W. Reed^1,2, J. Timothy Harrington³, Christine J. Barr¹, Katherine C. Saunders¹, Allan Gibofsky⁴, Eric M. Ruderman⁵, Tmirah Haselkorn⁶, Jeffrey D. Greenberg^1,7, Ani John⁶ and Joel M. Kremer⁸, ¹Corrona, LLC, Southborough, MA, ²University of Massachusetts Medical School, Worcester, MA, ³Joiner Associates, LLC, Madison, WI, ⁴Hospital for Special Surgery, New York, NY, ⁵Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Genentech, Inc, South San Francisco, CA, ⁷NYU School of Medicine, New York, NY, ⁸Albany Medical College and The Center for Rheumatology, Albany, NY
Background/Purpose: We report the results of a cluster-randomized behavioral intervention trial designed to assess the impact of implementing a treat-to-target (T2T) approach vs usual care…
Abstract Number: 409 • 2015 ACR/ARHP Annual Meeting
Disease Activity, Disease Damage and Predictive Factors in Juvenile Onset Mixed Connective Tissue Disease – a Norwegian Nationwide Study
Siri Opsahl Hetlevik¹, Berit Flatø^1,2, Marite Rygg^3,4, Ellen Berit Nordal⁵ and Vibke Lilleby⁶, ¹Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, ³Department of Pediatrics, St Olav University Hospital, Trondheim, Norway, ⁴Department of Laboratory Medicine, Children's and Women's health, Norwegian University of Science and Technology, Trondheim, Norway, ⁵Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway, ⁶Rheumatology, Oslo University Hospital, Oslo, Norway
Background/Purpose: Mixed Connective Tissue Disease (MCTD) is a rare rheumatic disease with overlapping features from Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc) and Polymyositis. Juvenile…
Abstract Number: 620 • 2015 ACR/ARHP Annual Meeting
Evaluation of Patients from the Non-Biologic Arms of Inflammatory Arthritis Clinical Trials Identifies Several Predictors of Remission, As Well As, Distinct Responder Subgroups
Brian Tom¹ and Deborah P.M. Symmons², ¹Biostatistics Unit, Medical Research Council, Cambridge, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
Background/Purpose: The RA-MAP consortium is a UK flagship industry-academic partnership investigating clinical and biological predictors of disease outcome in patients with rheumatoid arthritis (RA). Methods:…

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