Abstracts tagged "Disease Activity"

Abstract Number: 1484 • 2016 ACR/ARHP Annual Meeting
Exploring the Link Between RA Disease Activity, Lipid Levels, and Cardiovascular Disease in an Early Inflammatory Arthritis Cohort
Saurash Reddy, Xiaobo Meng and Carol Hitchon, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: Rheumatoid arthritis (RA) has been established as a risk factor for cardiovascular disease (CVD), with systemic inflammation being linked with atherosclerosis. Traditional CVD risk…
Abstract Number: 1702 • 2016 ACR/ARHP Annual Meeting
Baseline Patient Characteristics Associated with Response to Biologic Therapy in Patients with Psoriatic Arthritis Enrolled in the Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry
Philip J Mease¹, Chitra Karki², Mei Liu², Arthur Kavanaugh³, Christopher T. Ritchlin⁴, Doquyen H. Huynh³, Renganayaki Pandurengan², Jacqueline B. Palmer⁵ and Jeffrey D. Greenberg^2,6, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²Corrona, LLC, Southborough, MA, ³University of California San Diego, La Jolla, CA, ⁴Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶New York University School of Medicine, New York, NY
Background/Purpose: The objective of this analysis was to investigate differences in baseline demographic and clinical characteristics of patients with psoriatic arthritis (PsA) who responded to…
Abstract Number: 2152 • 2016 ACR/ARHP Annual Meeting
S100A11 Protein Is Increased in Rheumatoid Arthritis and Is Associated with Disease Activity and Inflammation
Lucie Andres Cerezo¹, Barbora Šumová¹, Klára Prajzlerová¹, David Veigl², Karel Pavelka¹, Jiří Vencovský³ and Ladislav Senolt³, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, ²1st Orthopaedic Clinic, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ³Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
Background/Purpose: Calgizzarin (S100A11) is a member of the S100 protein family that acts in different tumors via regulating number of biologic functions. Recent data suggest…
Abstract Number: 2539 • 2016 ACR/ARHP Annual Meeting
Analysis of Joints Susceptible to Rheumatoid Arthritis (RA) and Their Recovery Sequence Based on DAS28 and Physical Function Based on HAQ with Smart System of Disease Management (SSDM) in China：a Prospective Cohort Study
Rong Mu¹, Jing Yang², Hongzhi Wang³, Xinwang Duan⁴, Jianling Dong², Fengxiao Zhang⁵, Wenqiang Fan⁶, Huifang Guo⁷, Tong Xie⁸, Fei Xiao⁹, Hui Xiao⁹, Yuhua Jia⁹, Minjun Wang⁹, Yuan Liu⁹, Bing Wu⁹ and Zhanguo Li¹⁰, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, ³The First Hospital of Jiaxing, Jiaxing, China, ⁴Department of rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, China, ⁵Department of rheumatology, Hebei General Hospital, Shijiazhuang, China, ⁶Department of rheumatology, Central Hospital of XinXiang, Henan, XinXiang, China, ⁷The Second Hospital of Hebei Medical University, Shijiazhuang, China, ⁸Affiliated hospital of Guangdong medical University, Zhanjiang, China, ⁹Gothic Internet Technology Corporation, Shanghai, China, ¹⁰Peking University People's Hospital, Beijing, China
Background/Purpose: The disease activity score in 28 joints (DAS28) and health assessment questionnaire (HAQ) serve as guides for the treatment of rheumatoid arthritis (RA). Smart…
Abstract Number: 2811 • 2016 ACR/ARHP Annual Meeting
Predictors of Persistent Disease Activity and Persistent Remission in Systemic Lupus Erythematosus – Results from the Hopkins Lupus Cohort
Ioanna Giannakou¹, Katerina Chatzidionysiou², Noémi Györi³, Laurence S Magder⁴, Ronald F. van Vollenhoven^5,6 and Michelle Petri⁷, ¹Department of Medicine, Karolinska Institute, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska Institute, Stockholm, Sweden, ²Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska Institute, Stockholm, Sweden, ³Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁴Epidemiology and Public Health, Division of Rheumatology, School of Medicine, Johns Hopkins University, Baltimore, MD, ⁵Rheumatology Unit, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), Department of Medicine, Karolinska Institute, Stockholm, Sweden, ⁶Amsterdam Rheumatology and Immunology Center (ARC), Amsterdam, Netherlands, ⁷Rheumatology Division, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by a variability of disease expression, both between individuals and within individuals, over time. The aim of this…
Abstract Number: 3081 • 2016 ACR/ARHP Annual Meeting
Prognostic Factors of Death in a Cohort of 116 Adults with Hemophagocytic Syndrome: Impact of Underlying Disease and Laboratory Parameters
Pilar Brito-Zerón¹, Pedro Moral Moral², Belchin Kostov³, Luis Caminal-Montero⁴, Guadalupe Fraile⁵, Eva Fonseca⁶, Patricia Pérez Guerrero⁷, Angel Robles⁸, Antonio J. Chamorro⁹, María Andrés Calvo¹⁰, José Ramón Larrañaga¹¹, Maria José Forner¹², Mónica Rodriguez Carballeira¹³, Manuel Ruiz Muñoz¹⁴, Roberto Hurtado García¹⁵, Luis Fernando Viejo Llorente¹⁶, Sergio Prieto-González¹⁷, Pedro Castro¹⁸, Aleida Martínez Zapico⁴, María Vaquero Herrero⁹, Angela Ruiz de Temiño de la Peña¹⁰, Soledad Retamozo^1,19, Manuel Ramos-Casals²⁰ and REGHEM-GEAS-SEMI Spanish Cohort, ¹Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, ²Department of Internal Medicine, Hospital La Fé, Valencia, Valencia, Spain, ³Research Group in Primary Care, IDIBAPS, ABS Les Corts, CAPSE, Barcelona, Spain, ⁴Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain, ⁵Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain, Madrid, Spain, ⁶Department of Internal Medicine, Hospital de Cabueñes, Gijón, Gijón, Spain, ⁷Department of Internal Medicine, Hospital Universitario Puerta del Mar, Cádiz, Cadiz, Spain, ⁸Department of Internal Medicine, Hospital La Paz, Madrid, Madrid, Spain, ⁹Department of Internal Medicine, Complejo Asistencial Universitario de Salamanca, Salamanca, Spain, ¹⁰Department of Internal Medicine, Hospital Rio Hortega, Valladolid, Valladolid, Spain, ¹¹Department of Internal Medicine, Hospital Xeral, Vigo, Vigo, Spain, ¹²Department of Internal Medicine, Hospital Clínico de Valencia, Valencia, Spain, ¹³Department of Internal Medicine, Hospital Mutua de Terrasa, Terrasa, Spain, ¹⁴Department of Internal Medicine, Hospital Universitario Fundacion Alcorcón, Madrid, Spain, ¹⁵Department of Internal Medicine, Hospital Vega Baja, Orihuela, Orihuela, Spain, ¹⁶Department of Internal Medicine, Hospital Virgen de la Salud, Toledo, Toledo, Spain, ¹⁷Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona, Barcelona, Spain, ¹⁸Medical Intensive Care Unit, ICMiD, Hospital Clínic, Barcelona, Barcelona, Spain, ¹⁹Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Argentina, Córdoba, Argentina, ²⁰Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain
Background/Purpose: To analyze the potential use of the main features at diagnosis (epidemiological, clinical, laboratory) as prognostic factors and to estimate the risk of death…
Abstract Number: 86 • 2016 ACR/ARHP Annual Meeting
Optimizing the Efficiency of Patient Data Capture Using Smartphone Technology: Evaluation of the Correlation Between Promis Instruments for PRO Data Capture
Huifeng Yun¹, Jennifer Beaumont², Shuo Yang³, James Willig⁴, W. Ben Nowell⁵, Seth D. Ginsberg⁶, Kelly V. Clayton⁷, Shantana Hazel^7,8, Carole Wiedmeyer⁵ and Jeffrey Curtis⁹, ¹Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, ²Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Med - Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, ⁵CreakyJoints/Global Health Living Foundation, Upper Nyack, NY, ⁶Global Healthy Living Foundation, CreakyJoints, Upper Nyack, NY, ⁷Global Healthy Living Foundation, Upper Nyack, NY, ⁸Sister Girl Foundation, Inc., Upper Nyack, NY, ⁹Division Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Patient-reported outcomes (PROs) are key to enabling the comprehensive assessment of patient-centered benefits in comparative effectiveness research (CER). However, the relationships between different PROMIS…
Abstract Number: 519 • 2016 ACR/ARHP Annual Meeting
Greater Fatigue at Baseline and Female Gender Predict Worse Disability in Early RA Despite Treatment to Target: A Comparison of Two Observational Cohort Studies from the United Kingdom
Sarah Twigg¹, Elizabeth M.A. Hensor², Jane E. Freeston¹, Ai Lyn Tan¹, Alan Tennant³, Paul Emery⁴, Ann Morgan⁵ and YEAR consortium, IACON consortium , ¹NIHR Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ³Swiss Paraplegic Research,, Nottwil, Switzerland, ⁴NIHR Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom
Background/Purpose: Although disability is part of the ‘core set’ of outcomes for RA research recommended by OMERACT (1), current therapeutic strategies focus on inflammation. The…
Abstract Number: 772 • 2016 ACR/ARHP Annual Meeting
Effect of HMG-CoA Reductase Inhibitor Drugs (Statins) on Systemic Lupus Erythematosus Disease Activity: A Systematic Review and Meta-Analysis
Givenchy Maree Garcia, Annalyn Urbano and Evelyn Salido, Section of Rheumatology, University of the Philippines - Philippine General Hospital, Manila, Philippines
Background/Purpose: Statins have been shown to have anti-inflammatory and immunomodulatory effects. In vitro studies show that these drugs inhibit inflammatory cells, decrease the expression of…
Abstract Number: 1226 • 2016 ACR/ARHP Annual Meeting
Evaluation of the Association Between C-Reactive Protein and Anti-Citrullinated Protein Antibody in Rheumatoid Arthritis: Analysis of Two Clinical Practice Data Sets
E Alemao¹, Z Guo¹, L Burns¹, M Frits², Jonathan Coblyn², Michael Weinblatt² and NA Shadick², ¹Bristol-Myers Squibb, Princeton, NJ, ²Brigham and Women’s Hospital, Boston, MA
Background/Purpose: The association between inflammatory markers such as CRP or ESR and joint damage has been widely established in RA. Autoantibodies such as RF and…
Abstract Number: 1514 • 2016 ACR/ARHP Annual Meeting
Symptoms of Depression and Anxiety Predict Worse Disease Activity and Functional Disability in a Cohort of Established Rheumatoid Arthritis Patients
Christine Iannaccone¹, Taysir G. Mahmoud², Jing Cui³, Michael Weinblatt¹ and NA Shadick⁴, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology Immunology & Allergy, Brigham & Women's Hosp, Boston, MA
Background/Purpose: Depression and anxiety disorders are common in RA patients, with the most recent prevalence estimates indicating that 16.8% of RA patients have a diagnosis…
Abstract Number: 1741 • 2016 ACR/ARHP Annual Meeting
Patients with Active Psoriatic Arthritis Achieving Minimal Disease Activity with Secukinumab Treatment Demonstrate Sustained Improvement of Function and Quality of Life
Laura C. Coates¹, Philip J Mease², Laure Gossec³, Bruce Kirkham⁴, Lawrence Rasouliyan⁵, Shephard Mpofu⁶, Steffen Jugl⁶, Chetan Karyekar⁷ and Kunal Gandhi⁷, ¹University of Leeds, Leeds, United Kingdom, ²Rheumatology and Internal Medicine, Swedish Medical Center and University of Washington, Seattle, WA, ³Rheumatology Department, Hôpital Pitié Salpêtrière, Paris 06 University, Paris, France, ⁴Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom, ⁵RTI Health Solutions, Barcelona, Spain, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Secukinumab, a fully human anti–IL-17A monoclonal antibody, previously demonstrated higher minimal disease activity (MDA)1 response rates and sustained improvements in patient reported outcomes2 among…
Abstract Number: 2159 • 2016 ACR/ARHP Annual Meeting
Allopurinol Use Is Associated with Lower Risk of Peripheral Vascular Disease in the US Elderly
Jasvinder A. Singh¹ and John Cleveland², ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Rheumatology, University of Alabama at Birmingham (UAB), Birmingham, AL
Background/Purpose: Gout is associated with higher cardiovascular disease risk. Based on our previous work, there is evidence that allopurinol use reduces the risk of myocardial…
Abstract Number: 2578 • 2016 ACR/ARHP Annual Meeting
Plasma Levels of Bone Morphogenetic Protein (BMP) Subgroups and Their Inhibitors (noggin, sclerostin) in Rheumatoid Arthritis Patients and Correlation with Disease Activity, Clinical and Radiographic Progression
Ozge Kockara¹, Merve Sibel Gungoren², Erdem Karabulut³, Sebnem Ataman⁴ and Filiz Akbiyik², ¹Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ²Medical Biochemistry, Hacettepe University Faculty of Medicine, Ankara, Turkey, ³Biostatistics, Hacettepe University Faculty of Medicine, Ankara, Turkey, ⁴Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Progressive bone destruction occurs in rheumatoid arthritis (RA) due to imbalance of osteoblast/osteoclast activity. Bone morphogenetic proteins (BMPs) regenerate bone damage by stimulating the…
Abstract Number: 2814 • 2016 ACR/ARHP Annual Meeting
Immunofluorescence Pattern and Titer of the Antinuclear Antibody Test Correlate with Disease Activity in Patients with Systemic Lupus Erythematosus
Mônica Simon Prado¹, Alessandra Dellavance², Sílvia H. Rodrigues³ and Luis Eduardo C. Andrade^4,5, ¹Rheumatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, UNIFESP-EPM, São Paulo, Brazil, ²Research and Development Department, Fleury Medicine and Health Laboratories, São Paulo, Brazil, ³Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, UNIFESP-EPM, Sao Paulo, Brazil, ⁴Rheumatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, UNIFESP-EPM, Sao Paulo, Brazil, ⁵Fleury Health and Medicine, Sao Paulo, Brazil
Background/Purpose: Antinuclear antibody (ANA) indirect immunofluorescence (IIF) assay on HEp-2 cells (HEp-2-ANA) is an important element for diagnosis and classification of Systemic Lupus Erythematosus (SLE),…

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