Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Determinants of changes in disease activity among patients with juvenile dermatomyositis (JDM) are unknown. Our objective was to develop scores to predict changes in disease activity over the next 6 months among children with active disease at baseline using the CARRA registry.
Methods: The CARRA registry included 658 subjects enrolled between May 2010 and October 2014 with definite or probably JDM defined based on Bohan and Peter criteria, which were modified to include magnetic resonance imaging. Among the 297 subjects with at least one follow-up visit between 4 and 10 months (median 6 months) after baseline, we studied the 65 subjects with active disease at baseline(defined as physician global ≥3 of 10). Linear regression models were used to build risk scores for changes in disease activity adjusted for baseline disease activity, age, sex and disease duration.
Conclusion: Disease characteristics can help identify patients who are less likely to improve over time. Risk scores to predict future changes in disease activity could be used to trigger more aggressive treatment earlier in the disease course.
To cite this abstract in AMA style:Crowson CS, Olazagasti Lourido JM, Niewold TB, Reed AM. Predictors of Changes in Disease Activity Among Children with Juvenile Dermatomyositis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/predictors-of-changes-in-disease-activity-among-children-with-juvenile-dermatomyositis/. Accessed March 23, 2019.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/predictors-of-changes-in-disease-activity-among-children-with-juvenile-dermatomyositis/