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Abstract Number: 3186

Determinants of Patient-Physician Discordance in Global Assessment in Psoriatic Arthritis and Levels of Discordance According to Disease Activity: A Multicenter European Study

Carole Desthieux1, Benjamin Granger2, Andra Rodica Balanescu3, P Balint4, Jürgen Braun5, Juan Canete6, Turid Heiberg7, Philip S. Helliwell8, Umut Kalyoncu9, Tore K Kvien10, Uta Kiltz5, Dora Niedermayer11, Kati Otsa12, Rossana Scrivo13, Josef Smolen14, Tanja A. Stamm15, Douglas J. Veale16, Kurt de Vlam17, Maarten de Wit18 and Laure Gossec1, 1Rheumatology, Pitié Salpêtrière Hospital, Paris, France, 2Biostatistics, Pitié Salpêtrière Hospital, Paris, France, 3Department of Internal Medicine and Rheumatology “Sf. Maria” Hospital, Bucharest, Romania, 4Rheumatology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, 5Rheumazentrum Ruhrgebiet, Herne, Germany, 6Rheumatology, Hospital Clínic and IDIBAPS, Barcelona, Spain, 7Oslo University Hospital, Oslo, Norway, 8NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 9Hacettepe University, Ankara, Turkey, 10Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 11PsAID taskforce, EULAR, Zurich, Switzerland, 12Rheumatology, Tallinn Central Hospital, Tallinn, EE, 13Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, 14Medical University of Vienna and Hietzing Hospital, Vienna, Austria, 15Internal Medicine III, Vienna Medical University, Vienna, Austria, 16Consultant Rheumatologist, Centre for Arthritis and Rheumatic Disease, St. Vincent’s University Hospital and University College Dublin, Dublin 4, Ireland, 17Katholieke Universiteit Leuven, Leuven, Belgium, 18Medical Humanities, VU Medical Centre, Amsterdam, Netherlands

Meeting: ACR/ARHP Annual Meeting 2016

Date of first publication: September 28, 2016

Keywords: ,

Session Information

Date: Wednesday, November 16, 2016

Title: Epidemiology and Public Health III: Psoriatic Arthritis and More

Session Type: ACR Concurrent Abstract Session

Session Time: 11:00AM-12:30PM

Background/Purpose: In the management of chronic diseases, recommendations insist on the need to work in partnership with the patient. Patient-physician discordance in global assessment of disease activity is frequent but what does it reflect? The objectives of this study were to assess patient-physician discordance in global assessment in psoriatic arthritis (PsA), predictors of discordance (including patient reported domains of health) and the frequency of discordance according to disease activity levels.

Methods: The PsAID cross-sectional multicenter European study of patients with PsA according to expert opinion was analysed. Patient- and Physician-Global Assessment (PGA and PhGA) were rated with a 0-10 numeric rating scale. Discordance was defined as the difference (PGA–PhGA) and as the absolute difference |PGA-PhGA|≥3 points in the whole population and according to Disease Activity index for PSoriatic Arthritis (DAPSA) levels. Determinants of (PGA-PhGA) were assessed by a stepwise multivariate linear regression among 12 physical and psychological aspects of impact (pain, skin problems, fatigue, ability to work/leisure, functional incapacity, feeling of discomfort, sleep disturbance, anxiety/fear, coping, embarrassment/shame, social participation and depressive affects). A sensitivity analysis was also performed with a logistic regression model using the binary variable |PGA-PhGA|≥3 as outcome. There was no imputation of missing data.

Results: In 460 patients (mean age 50.6±12.9 years, 52.2% female, mean disease duration 9.5±9.5 years, mean DAPSA 30.8±32.4), mean PGA was higher than mean PhGA with a mean absolute difference of 1.9±1.8 points. Discordance defined by |PGA-PhGA|≥3 points concerned 134 (29.1%) patients and 115 (85.8% of patients with discordance) had PGA>PhGA. Higher fatigue (β=0.14), lower self-perceived coping (β=0.23) and impaired social participation (β=0.16) were independently associated with a higher difference (PGA-PhGA). The sensitivity analysis using |PGA-PhGA|≥3 as outcome shows that coping (OR=1.34, impaired social participation (OR=1.28) and depressive affects (OR=1.18) were related with discordance. According to DAPSA, more patients with discordance were in remission (30.8%) compared to high disease activity (26.1%).

Conclusion: Discordance concerned 29.1% of these PsA patients, which is less frequent than in rheumatoid arthritis (around 43%). Mean PGA was higher than mean PhGA. Factors associated with discordance were psychological rather than physical domains of health. Unlike most published articles on patient-physician discordance in RA, pain was not a predictive factor in this study, perhaps due to links with other outcomes. The patient’s ability to self-manage seems to be important. Discordance was more frequent in patients in remission, indicating the meaning of remission should be further explored in PsA.

Disclosure: C. Desthieux, None; B. Granger, None; A. R. Balanescu, None; P. Balint, None; J. Braun, None; J. Canete, None; T. Heiberg, None; P. S. Helliwell, None; U. Kalyoncu, None; T. K. Kvien, None; U. Kiltz, None; D. Niedermayer, None; K. Otsa, None; R. Scrivo, None; J. Smolen, None; T. A. Stamm, None; D. J. Veale, None; K. de Vlam, None; M. de Wit, None; L. Gossec, None.

To cite this abstract in AMA style:

Desthieux C, Granger B, Balanescu AR, Balint P, Braun J, Canete J, Heiberg T, Helliwell PS, Kalyoncu U, Kvien TK, Kiltz U, Niedermayer D, Otsa K, Scrivo R, Smolen J, Stamm TA, Veale DJ, de Vlam K, de Wit M, Gossec L. Determinants of Patient-Physician Discordance in Global Assessment in Psoriatic Arthritis and Levels of Discordance According to Disease Activity: A Multicenter European Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/determinants-of-patient-physician-discordance-in-global-assessment-in-psoriatic-arthritis-and-levels-of-discordance-according-to-disease-activity-a-multicenter-european-study/. Accessed .

ACR Meeting Abstracts - https://acrabstracts.org/abstract/determinants-of-patient-physician-discordance-in-global-assessment-in-psoriatic-arthritis-and-levels-of-discordance-according-to-disease-activity-a-multicenter-european-study/