Abstracts tagged "Disease Activity"

Abstract Number: 366 • 2017 ACR/ARHP Annual Meeting
Short-Term Outcomes in Patients with Systemic-Onset Juvenile Idiopathic Arthritis Treated with Either Tocilizumab or Anakinra in a Real-World Setting in the United Kingdom
Lianne Kearsley-Fleet¹, Diederik De Cock¹, Eileen Baildam², Michael W. Beresford³, Helen E. Foster⁴, Taunton R. Southwood⁵, Wendy Thomson^6,7 and Kimme L. Hyrich^1,6, ¹Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²Clinical Academic Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ³Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom, ⁴Institute of Cellular Medicine and Paediatric Rheumatology, Newcastle University and Great North Children's Hospital, Newcastle Upon Tyne, United Kingdom, ⁵Institute of Child Health, University of Birmingham and Birmingham Children's Hospital, Birmingham, United Kingdom, ⁶National Institute of Health Research Manchester Musculoskeletal Biomedical Research Centre, Central Manchester NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁷Arthritis Research UK Centre for Genetics and Genomics, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Juvenile idiopathic arthritis (JIA) comprises 7 ILAR categories, but systemic-onset JIA (sJIA) appears to be distinct in genetic background and pathogenesis from the other…
Abstract Number: 789 • 2017 ACR/ARHP Annual Meeting
Markers of Inflammation and Patient-Reported Measures As Predictors of Relapse in Giant Cell Arteritis
Tanaz A. Kermani¹, Antoine G. Sreih², Gunnar Tomasson³, David Cuthbertson⁴, Renee Borchin⁵, Simon Carette⁶, Lindsy J. Forbess⁷, Nader A. Khalidi⁸, Curry L. Koening⁹, Carol A. McAlear¹⁰, Paul A. Monach¹¹, Larry W. Moreland¹², Christian Pagnoux⁶, Philip Seo¹³, Robert F. Spiera¹⁴, Kenneth J. Warrington¹⁵, Steven R. Ytterberg¹⁵, Carol A. Langford¹⁶ and Peter A. Merkel^17,18, ¹Rheumatology, University of California Los Angeles, Los Angeles, CA, ²Rheumatology, University of Pennsylvania, Philadelphia, PA, ³University of Iceland, Faculty of Medicine, Reykjavik, IS, ⁴Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁵University of South Florida, Tampa, FL, ⁶Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁷Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatology, McMaster University, Hamilton, ON, Canada, ⁹Rheumatology, University of Utah, Salt Lake City, UT, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Boston University School of Medicine, Boston, MA, ¹²Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹³Medicine, Johns Hopkins University, Baltimore, MD, ¹⁴Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁵Rheumatology, Mayo Clinic, Rochester, MN, ¹⁶Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ¹⁷Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁸Biostatistics, Epidemiology, and Bioinformatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose: The significance of increasing erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) in clinically asymptomatic individuals with giant cell arteritis (GCA) is controversial. Patient-reported…
Abstract Number: 1265 • 2017 ACR/ARHP Annual Meeting
Impaired Cardiac Function in Juvenile Mixed Connective Tissue Disease Compared with Controls
Birgit Nomeland Witczak¹, Siri Opsahl Hetlevik², Zoltan Barth^1,3, Thomas Schwartz^4,5, Berit Flatø^2,6, Vibke Lilleby^2,6 and Ivar Sjaastad^1,6,7, ¹Institute for Experimental Medical Research, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ²Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, Oslo, Norway, ³Department of Pathophysiology and Gerontology, Medical School, University of Pècs, Pècs, Hungary, Pècs, Hungary, ⁴Oslo University Hospital and University of Oslo, Institute for Experimental Medical Research, Oslo, Norway, ⁵Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway, Oslo, Norway, ⁶Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway, ⁷Department of Cardiology, Oslo University Hospital, Oslo, Norway, Oslo, Norway
Background/Purpose: Juvenile MCTD (JMCTD) is a heterogenic autoimmune disease, with SLE-, SSc- and PM/DM and RA like manifestations. Cardiac involvement is known in juvenile SLE,…
Abstract Number: 1555 • 2017 ACR/ARHP Annual Meeting
Treatment Changes By Joint Activity and Skin Severity in Patients with Comorbid Psa and Pso
Philip J Mease¹, Carol J. Etzel², Jeffrey Lisse³, April W Armstrong⁴, William J Huster³, Sabrina Rebello², Rhiannon Dodge², Talia M Muram³, Sarah Al Sawah³, Mwangi J Murage³, Jeffrey D Greenberg² and William Malatestinic³, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²Corrona, LLC, Southborough, MA, ³Eli Lilly and Company, Indianapolis, IN, ⁴Keck School of Medicine, University of Southern California, Los Angeles, CA
Background/Purpose: Treatment of both joint and skin symptoms is important for overall disease management of patients with psoriatic arthritis and comorbid psoriasis1,2. The objective of…
Abstract Number: 1879 • 2017 ACR/ARHP Annual Meeting
Majority of Rheumatoid Arthritis Patients in Clinical Remission As Defined By DAS-28, CDAI, SDAI and RAPID-3 Have No Signal on Ultrasound Power Doppler
Allen P. Anandarajah¹, Andreea Coca² and Ralf G. Thiele³, ¹Dept of Rheumatology, Univ of Rochester Medical Ctr, Rochester, NY, ²University of Rochester Medical Center, Rochester, NY, ³Medicine, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Remission in rheumatoid arthritis (RA) is often assessed using the following indices: disease activity scores (DAS-28), clinical disease activity index (CDAI), Simplified Disease Activity…
Abstract Number: 2374 • 2017 ACR/ARHP Annual Meeting
Obesity Impacts ESR and Not Other Measures of Rheumatoid Arthritis Disease Activity
Ana Maheshwari¹, Oumoul Barry¹ and MJ Bergman², ¹Internal Medicine, Mercy Catholic Medical Center, Darby, PA, ²Medicine, Drexel University College of Medicine, Philadelphia, PA
Background/Purpose: Disease activity measurement is a cornerstone to treat to target strategy. The impact of body mass index (BMI) on disease activity in rheumatoid arthritis…
Abstract Number: 2641 • 2017 ACR/ARHP Annual Meeting
Immune Complex-Driven Neutrophil Activation in Systemic Lupus Erythematosus – Novel Biomarkers of Disease Activity and Severity
Hsin-Hsuan Juo¹, Edward Chiou², Keith B. Elkon³ and Christian Lood⁴, ¹Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Department of Medicine & Immunology, University of Washington, Seattle, WA, ⁴Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Neutrophil activation is linked to inflammation and autoimmune diseases, including systemic lupus erythematosus (SLE) where nucleic acid-containing immune complexes (ICs) drive inflammation through engagement…
Abstract Number: 2968 • 2017 ACR/ARHP Annual Meeting
Less Fatigue in Psoriatic Arthritis after High Intensity Interval Training. a Randomized Controlled Trial
Ruth Stoklund Thomsen¹, Tom Ivar Lund Nilsen², Glenn Haugeberg³, Anja Bye³, Arthur Kavanaugh⁴ and Mari Hoff⁵, ¹Faculty of Medicine, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, ²Faculty of medicine, Department of public health and nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, ³NTNU, Norwegian University of Science and Technology, Trondheim, Norway, ⁴Medicine, University of California, San Diego, La Jolla, CA, ⁵Rheumatolgy, University Hospital, St. Olavs Hospital, NTNU, Trondheim, Norway
Background/Purpose: Patients with psoriatic arthritis (PsA) have a high disease burden with increased pain and more fatigue than the general population. Physical exercise is recommended…
Abstract Number: 417 • 2017 ACR/ARHP Annual Meeting
Improvement in Overall Work Productivity Among Biologic-NaïVe Patients with Rheumatoid Arthritis Treated with Tocilizumab Subcutaneous Injection: A Prospective, Real World, Observational Study in Japan
Yoshiya Tanaka¹, Hideto Kameda², Kazuyoshi Saito³, Yuko Kaneko⁴, Eiichi Tanaka⁵, Shinsuke Yasuda⁶, Naoto Tamura⁷, Keishi Fujio⁸, Takao Fujii⁹, Toshihisa Kojima¹⁰, Tatsuhiko Anzai¹¹, Chikuma Hamada¹², Yoshihisa Fujino¹³, Shinya Matsuda¹³ and Hitoshi Kohsaka¹⁴, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, ²Division of Rheumatology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan, ³Tobata General Hospital, Fukuoka, Japan, ⁴Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ⁵Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ⁶Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, ⁷Department of Internal Medicine and Rheumatology, Juntedo University School of Medicine, Tokyo, Japan, ⁸Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan, ⁹Department of Rheumatism and Collagen Disease, Wakayama Medical University, Wakayama, Japan, ¹⁰Nagoya Univ. Grad. Schl. of Med., Nagoya, Japan, ¹¹Data Science Division, Statistics Analysis Department 1, EPS Corporation, Tokyo, Japan, ¹²Department of Information and Computer Technology, Tokyo University of Science, Tokyo, Japan, ¹³Department of Preventive Medicine and Community Health, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ¹⁴Department of Rheumatology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan
Background/Purpose: This is the first study assessing the effect of subcutaneous tocilizumab (TCZ-SC) and/or conventional synthetic DMARDs (csDMARDs) on work productivity and activity impairment (WPAI)…
Abstract Number: 825 • 2017 ACR/ARHP Annual Meeting
Radiological Disease Activity Is the Major Determinant for Physicians While Deciding Active Disease in Takayasu Arteritis
Gokce Kenar¹, Sedanur Karaman², Pinar Cetin³, Handan Yarkan⁴, Berrin Zengin¹, Gercek Can¹, Merih Birlik⁵ and Fatos Onen¹, ¹Rheumatology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey, ²Internal Medicine, Dokuz Eylul Universty, izmir, Turkey, ³Rheumatology, Dumlupınar University School of Medicine, Kutahya, Turkey, ⁴Rheumatology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, ⁵Rheumatology, Dokuz Eylul University Faculty of Medicine, izmir, Turkey
Background/Purpose:There are no valid followup parameters in the assessment of disease activity in Takayasu arteritis(TA).We investigated the impact of incorporation of vascular imaging into ITAS…
Abstract Number: 1340 • 2017 ACR/ARHP Annual Meeting
Is Depression in Patients with Rheumatoid Arthritis Associated with Disease Activity? Comparative Study between Germany and Brazil
Harriet Morf¹, Olga Seifert², Geraldo Castelar-Pinheiro³, Ana Beatriz Vargas-Santos⁴ and C Baerwald⁵, ¹Department of Internal Medicine, University Hospital, Erlangen, Germany, ²University of Leipzig, Leipzig, Germany, ³Universidade do Estado do Rio de Janeiro - UERJ, Rio de Janeiro, Brazil, ⁴Internal Medicine - Rheumatology, State University of Rio de Janeiro, Rio de Janeiro, Brazil, ⁵Department of Rheumatology, University of Leipzig, Germany, Leipzig, Germany
Background/Purpose: Rheumatoid Arthritis (RA) can be associated with psychologic disorders and especially depression. About 13–20% of patients have clinical significant depression (Matcham F et al,…
Abstract Number: 1565 • 2017 ACR/ARHP Annual Meeting
Depression and Fatigue in Patients with Ankylosing Spondylitis
Ji Hui Shin¹, Sun Ju Ahn² and Tae-Hwan Kim³, ¹rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Medical Research Coordinator, Hanyang Univerity Hospital for Rheumatic Disease Research Center, Seoul, Korea, Republic of (South), ³Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South)
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease that leads to bony ankyloses. The disease occurs in early adulthood, a critical stage in life,…
Abstract Number: 1916 • 2017 ACR/ARHP Annual Meeting
The Interferon Gamma Release Assay Is a Novel Predictor of Disease Activity in Systemic Lupus Erythematosus
Jenna Thomason¹, Christian Lood² and Grant Hughes³, ¹Medicine, University of Washington, Seattle, WA, ²Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ³Medicine/Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Interferon gamma (IFN-G) is critical cytokine for defense against intracellular pathogens; it is also involved in the pathogenesis of systemic lupus erythematosus (SLE). The…
Abstract Number: 2432 • 2017 ACR/ARHP Annual Meeting
Longitudinal Changes in Gene Expression Associated with Disease Activity during Pregnancy and Post-Partum Among Women with Rheumatoid Arthritis
Dana E. Goin^1,2, Mette Smed³, Nicholas Jewell², Lior Pachter^2,4, J. Lee Nelson^5,6, Hanne Kjaergaard³, Jørn Olsen⁷, Merete Lund Hetland^8,9, Bent Ottesen³, Vibeke Zoffmann³ and Damini Jawaheer^1,7,10, ¹UCSF Benioff Children's Hospital Oakland/CHORI, Oakland, CA, ²University of California, Berkeley, Berkeley, CA, ³Juliane Marie Center, Copenhagen, Denmark, ⁴California Institute of Technology, Pasadena, CA, ⁵Fred Hutchinson Cancer Research Center, Seattle, WA, ⁶University of Washington, Seattle, WA, ⁷Aarhus University, Aarhus, Denmark, ⁸The DANBIO registry and the Danish Departments of Rheumatology, Glostrup, Denmark, ⁹University of Copenhagen, Copenhagen, Denmark, ¹⁰University of California, San Francisco, San Francisco, CA
Background/Purpose: Many women with rheumatoid arthritis (RA) experience an improvement in disease activity during pregnancy, and a predictable flare in the months after they give…
Abstract Number: 2642 • 2017 ACR/ARHP Annual Meeting
Lupus Serum Induces Glomerular Endothelial Cell Neutrophil Adhesion in Association with Soluble Mediators of Chemotaxis and Adhesion
Dayvia Russell¹, Margaret Markiewicz² and Jim C. Oates^3,4, ¹Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, ²Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁴Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is associated with endothelial dysfunction, which can accelerated inflammation. Ingress of neutrophils into tissue requires chemotaxis and adhesion to endothelial…

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