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Abstracts tagged "Disease Activity"

  • Abstract Number: 1029 • 2013 ACR/ARHP Annual Meeting

    Quality Of Life In Rheumatoid Arthritis: Cross-National Comparison Study Between US and South Korea

    Yoon-Kyoung Sung1,2, Kazuki Yoshida2,3, Femke H.M. Prince2,4, Michelle A. Frits2, Jung-Yoon Choe5, Won Tae Chung6, Jisoo Lee7, Eun-Mi Koh8, Dae-Hyun Yoo9, Simon M. Helfgott2, Nancy A. Shadick10, Michael E. Weinblatt11, Sang-Cheol Bae1 and Daniel H. Solomon2, 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, 3Department of Rheumatology, Kameda Medical Center, Kamogawa, Japan, 4Pediatric Rheumatology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands, 5Catholic University of Daegu School of Medicine, Daegu, South Korea, 6Division of Rheumatology, Department of Internal Medicine, Dong-A University Hospital, Busan, South Korea, 7Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea, 8Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 9Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 10Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA, 11Division of Rheumatology & Immunology, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Quality of life (QOL) is a well-established outcome for rheumatoid arthritis (RA) trials. To perform trials with QOL as an outcome involving many countries,…
  • Abstract Number: 380 • 2013 ACR/ARHP Annual Meeting

    Active Rheumatoid Arthritis Is An Independent Risk Factor Of Chronic Kidney Disease

    Ryosuke Hanaoka1,2, Kazuhiro Kurasawa3, Ayae Tanaka4 and Harutsugu Okada5, 1Department of Rheumatology, Kamitsuga General Hospital, Kanuma, Japan, 2Department of Rheumatology, Kamitsuga General Hospital, Kanuma, Tochigi, Japan, 3Clinical Immunology, Dokkyo Medical University, Mibu-machi, Shimotsuga-gun, Tochigi-ken, Japan, 4Clinical Immunology, Dokkyo Medical University, Mibu, Tochigi, Japan, 5Clinical Immunology, Dokkyo Medical University, Mibu-machi, Tochigi-ken, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that affects not only joints but also many organs. RA causes vascular damages to contribute to…
  • Abstract Number: 2569 • 2013 ACR/ARHP Annual Meeting

    Serum S100A4 Levels Correlate With Skin Fibrosis and Lung Involvement In Systemic Sclerosis

    Michal Tomcik1, Lucie Andres Cerezo1, Simona Skacelova2, Martin Komarc3, Radim Becvar1, Mariam Grigorian4, Joerg HW Distler5 and Ladislav Senolt1, 1Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Prague, Czech Republic, 3Institute of Biophysics and Informatics of the First Faculty of Medicine, Charles University, Prague, Czech Republic, 4Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark, 5Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Our previous study demonstrated that S100A4 is overexpressed in scleroderma (SSc) skin, fibroblasts and preclinical models of SSc in a TGF-β dependent manner. Furthermore,…
  • Abstract Number: 2251 • 2013 ACR/ARHP Annual Meeting

    Variability in the Classification of Remission Among Disease Activity Indices and Their Correlation: An Analysis From a  Prospective, Observational Registry

    William G. Bensen1, Algis V Jovaisas2, J. Carter Thorne3, Philip Baer4, Majed M. Khraishi5, Sanjay Dixit6, Denis Choquette7, Michael Starr8, Isabelle Fortin9, Dalton E. Sholter10, Emmanouil Rampakakis11,12, John S. Sampalis11,12, Francois Nantel13, Allen J. Lehman14, May Shawi15 and Susan M. Otawa14, 1Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada, 2Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada, 3Southlake Regional Health Centre, Newmarket, ON, Canada, 4Private Practice, Scarborough, ON, Canada, 5Nexus Clinical Research, St John's, NF, Canada, 6McMaster University, Hamilton, ON, Canada, 7Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 8Montreal General Hospital, Montreal, QC, Canada, 9Centre de rhumatologie de l'est du Québec (CREQ), Rimouski, QC, Canada, 10Rheumatology Associates, Edmonton, AB, Canada, 11JSS Medical Research, Montreal, QC, Canada, 12Jewish General Hospital, McGill University, Montreal, QC, Canada, 13Janssen Inc., Toronto, ON, Canada, 14Medical Affairs, Janssen Inc., Toronto, ON, Canada, 15Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada

    Background/Purpose: In recent years, disease remission in rheumatoid arthritis (RA) has been assessed using various disease activity indices such as the DAS28-CRP, SDAI, CDAI, ACR/EULAR-recommended…
  • Abstract Number: 1779 • 2013 ACR/ARHP Annual Meeting

    A Randomized Controlled, Clinical, Histological and mRNA Profiling Pilot Study Of Endurance Exercise In Myositis

    Li Alemo Munters1,2, Ingela M. Loell3, Joan Raouf4, Maryam Dastmalchi3, Eva Lindroos5, Christina Ottosson6, Yi-Wen Chen7, Annemarie F van Delden8, Mona Esbjörnsson9, Marina Korotkova10, Helene Alexanderson11, Kanneboyina Nagaraju12 and Ingrid E. Lundberg13, 1Department of Medicine, Rheumatology Unit, , Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, 2Department of Physiotherapy, Rheumatology Unit, Karolinska University Hospital in Solna, Stockholm, Sweden, Stockholm, Sweden, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, 4Department of Medicine, Rheumatology Unit, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, 5Department of Medicine, Rheumatology Unit, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden., Stockholm, Sweden, 6Department of Medicine, Rheumatology Unit, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden., Stockholm, Sweden, 7Research Center for Genetic Medicine, Children’s National Medical Center, Washington DC, USA., Washington DC, DC, 8Department of Medicine,, Rheumatology Unit, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden., Stockholm, Sweden, 9Department of Physiology, Karolinska Institutet, Huddinge, Sweden, 10Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, 11Department of Neurobiology, Care Science and Society, Division of Physiotherapy, Division of Physiotherapy, Karolinska Institutet, Huddinge, Stockholm, Sweden, 12Research Center for Genetic Medicine, Children’s National Medical Center, Washington DC, DC, 13Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: This pilot study is a hypothesis-driven exploratory part of a larger randomized controlled trial evaluating effects of a supervised 12-week endurance exercise program (EG)…
  • Abstract Number: 1359 • 2013 ACR/ARHP Annual Meeting

    Does Rheumatoid Arthritis Disease Activity Correlate With Weather Conditions?

    Eimear Savage1, David McCormick1, Stephen McDonald1, Michael Stevenson2, Owen Moore3 and Andrew Cairns4, 1Rheumatology, Belfast Hospitals Trust, Musgrave Park Hospital, Belfast BT9 7JB, Northern Ireland, 2Medical Statistics, Centre for Public Health., Queens University, Belfast. School of Medicine, Dentistry and Biomedical Sciences., Belfast BT12 6BJ, Northern Ireland, 3Rheumatology, St. Vincent’s Hospital, Melbourne, Australia, 4Rheumatology, Belfast Hospitals Trust, Musgrave Park Hospital, Belfast, United Kingdom

    Background/Purpose: Rheumatoid Arthritis is a common inflammatory joint condition affecting up to 1% of the Northern Ireland population.  Patients often report increasing joint pain with…
  • Abstract Number: 942 • 2013 ACR/ARHP Annual Meeting

    CXCL13 Is a Marker Of Joint Involvement In Early Rheumatoid Arthritis

    Stinne Greisen1, Tue Rasmussen1, Karen Schelde1, Kristian Stengaard-Pedersen2, Merete Lund Hetland3, Kim Hørslev-Petersen4, Bent Deleuran5 and Malene Hvid6, 1Dept of Biomedicine, Aarhus University, Aarhus, Denmark, 2Arhus University Hospital, Aarhus, Denmark, 3Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Danish Rheumatologic Database (DANBIO), Glostrup Hospital., Copenhagen, Denmark, 4Institute of Regional Health Services Research, University of Southern Denmark, Graasten, Denmark, 5Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 6Dept. of Clinical Medicine, Aarhus University, Aarhus, Denmark

    Background/Purpose: CXCL13 is central in the formation of lymphoid follicles in secondary and tertiary lymphoid tissue. It attracts CXCR5-expressing B cells and follicular helper T…
  • Abstract Number: 392 • 2013 ACR/ARHP Annual Meeting

    Prevalence Of Cardiovascular Risk Factors and Cardiovascular Disease In Rheumatoid Arthritis Patients Across International Regions: A Comparison Of The Corrona International and Corrona United States Registries

    Dimitrios A. Pappas1, Kathy Lampl2, Joel M. Kremer3, Sebastião C. Radominski4, Janos Gal5, Fredrik Nyberg6, Anand N. Malaviya7, Aimée Whitworth8, Oscar Luis Rillo9, Allan Gibofsky10, Tatiana Popkova11, Meilien Ho12, Ieda Laurindo13, George W. Reed8, Eduardo Mario Kerzberg14, Laura Horne15, Roman Záhora16, Katherine C. Saunders17, Bernado Pons-Estel18, Alina U. Onofrei19 and Jeffrey D. Greenberg20, 1Columbia University, New York, NY, 2AstraZeneca R&D Wilmington, Wilmington, DE, 3Center for Rheumatology, Albany Medical College, Albany, NY, 4Universidade Federal do Paraná, Curitiba, Brazil, 5Rheumatology, County Hospital, Kecskemet, Hungary, 6AstraZeneca R&D, Mölndal, Sweden, 7Rheumatology, Consultant Rheumatologist, ISIC Superspeciality Hospital, New Delhi-11007-, India, 8CORRONA, Inc., Southborough, MA, 9Hospital Tornú, Capital Federal, Argentina, 10Medicine and Public Health, Hospital for Special Surgery, New York, NY, 11Research Institute of Rheumatology -Russian Academy of Medical Science, Moscow, Russia, 12AstraZeneca R&D Alderley Park, Macclesfield, United Kingdom, 13Rheumatology, Universidade de São Paulo, São Paulo, Brazil, 14Rheumatology, J. M. Ramos Mejía Hospital, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina, 15AstraZeneca, Wilmington, DE, 16Revmatologická ambulance, Terezin, Czech Republic, 17Corrona, LLC., Southborough, MA, 18Hospital Provincial de Rosario, Rosario, Argentina, 19University of Massachusetts Medical School, Worcester, MA, 20Rheumatology, NYU Hospital for Joint Diseases, New York, NY

    Background/Purpose: Cardiovascular disease (CVD) is a major comorbidity in patients (pts) with rheumatoid arthritis (RA). We explored variations in the prevalence of cardiovascular (CV) risk…
  • Abstract Number: 2545 • 2013 ACR/ARHP Annual Meeting

    Active Systemic Lupus Erythematosus: Cytokines and Soluble Tumor Necrosis Factor Receptors Response To Moderate/Intense Exercise

    Luiz A. Perandini1, Diego Sales-de-Oliveira1, Suzana B.V. Mello2, Niels O Camara3, Fernanda R. Lima1, Eduardo F. Borba2, Eloisa Bonfa2, Ana Lucia Sá-Pinto1, Hamilton Roschel4 and Bruno Gualano5, 1University of Sao Paulo, Rheumatology Division, Sao Paulo, Brazil, 2University of Sao Paulo, Rheumatology Division, São Paulo, Brazil, 3Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil, 4Universidade de São Paulo, Faculdade de Educação Física e Esporte, São Paulo, Brazil, 5University of Sao Paulo, School of Physical Education and Sport, Sao Paulo, Brazil

    Background/Purpose: Systemic lupus erythematosus (SLE) is a rheumatic autoimmune condition characterized by altered lipoprotein profile, physical dysfunction and increased risk of cardiovascular disease. Exercise is,…
  • Abstract Number: 2256 • 2013 ACR/ARHP Annual Meeting

    Analysis of the Factors That Contribute to the Differences Between DAS28-ESR and DAS28-CRP

    Toshihiro Matsui1, Hirotaka Tsuno2, Jinju Nishino3, Yoshiaki Kuga4, Atsushi Hashimoto5 and Shigeto Tohma6, 1Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Kanagawa, Japan, 2Department of Rheumatology, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan, 3Nishino Clinic, Orthopedics and Rheumatology, Tokyo, Japan, 4Wakaba Hospital, Saitama, Japan, 5Department of Rheumatology, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan, 6Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan

    Background/Purpose: It is widely accepted that the remission rate of DAS28-CRP is larger than that of DAS28-ESR, SDAI, and CDAI in patients with rheumatoid arthritis.…
  • Abstract Number: 1787 • 2013 ACR/ARHP Annual Meeting

    Does Age At Disease Onset Influence Disease Activity and Function In Rheumatoid Arthritis Patients? Results From The Ontario Best Practices Research Initiative (OBRI) Registry

    Thanu Nadarajah1, Binu Jacob2, Pooneh Akhavan3, Bindee Kuriya4, Edward C. Keystone5 and Claire Bombardier6, 1Department of Medicine, University of Toronto, Toronto, ON, Canada, 2University Health Network, Toronto General Research Institute, Toronto, ON, Canada, 3Medicine, Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, 4Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 5Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 6Rheumatology, University of Toronto, Toronto, ON, Canada

    Background/Purpose: The population of elderly individuals with rheumatoid arthritis (RA) is increasing. The aim of this study was to assess whether age at disease onset…
  • Abstract Number: 1361 • 2013 ACR/ARHP Annual Meeting

    Stringent Therapies Improve Clinical, Radiographic and Magnetic Resonance Imaging Outcome In Early-Stage Rheumatoid Arthritis Patients From Japanese Population: Longitudinal Study From Nagasaki Early Arthritis Cohort

    Mami Tamai1,2, Yoshikazu Nakashima3, Junko Kita4, Ayuko Takatani4, Ayako Nishino3, Takahisa Suzuki3, Yoshiro Horai3, Akitomo Okada5, Shin-ya Kawashiri3,6, Naoki Iwamoto3, Kunihiro Ichinose3, Kazuhiko Arima6, Hideki Nakamura3, Tomoki Origuchi7, Masataka Uetani8, Katsumi Eguchi9 and Atsushi Kawakami3, 1Center for Health & Community Medicine, Nagasaki University, Nagasaki, Japan, 2Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 4Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan, 6Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 7Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 8Department of Radiology and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 9Sasebo City General Hospital, Sasebo, Nagasaki, Japan

    Background/Purpose: Prognosis of the patients with rheumatoid arthritis (RA) nowadays is supposed to become better by treat-to-target (T2T) strategy. Osteitis determined by magnetic resonance imaging…
  • Abstract Number: 882 • 2013 ACR/ARHP Annual Meeting

    Association Of a Neutrophil Gene Signature Comprised Of Low Density Granulocyte (LDG)-Enriched Genes With Both Future Systemic Lupus Erythematosus Disease Activity and Poor Longterm Outcomes

    Michelle Petri1, Laurence S. Magder2, Hong Fang1, Jadwiga Bienkowska3, Andrea Dearth4, Norm Allaire5 and Ann Ranger4, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, 3Translational Medicine, Biogen Idec Inc., Cambridge, MA, 4Biogen Idec Inc, Cambridge, MA, 5Biogen Idec Inc., Cambridge, MA

    Background/Purpose: Neutrophils and neutrophil death (NETosis) have a role in the pathogenesis of SLE. A neutrophil gene signature (NGS) exists in SLE, although its association…
  • Abstract Number: 345 • 2013 ACR/ARHP Annual Meeting

    Prevalence Of Peri-Articular Manifestations (Enthesitis and Dactylitis) and Disease Activity In Psoriatic Arthritis Patients: Impact Of Treatment With TNF Inhibitors In a Real-World Canadian Population

    Proton Rahman1, Denis Choquette2, William G. Bensen3, Majed M. Khraishi4, Isabelle Fortin5, Andrew Chow6, Maqbool K. Sheriff7, Julie Vaillancourt8, John S. Sampalis8, Susan M. Otawa9, Allen J. Lehman9 and May Shawi10, 1Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, 2Rheumatology, Institut de rhumatologie de Montréal (IRM), Montréal, QC, Canada, 3Department of Medicine, Division of Rheumatology, Clinical Professor, McMaster University, Hamilton, ON, Canada, 4Nexus Clinical Research, St John's, NF, Canada, 5Centre de rhumatologie de l'est du Québec (CREQ), Rimouski, QC, Canada, 6University of Toronto, McMaster University, Credit Valley Rheumatology, Mississauga, ON, Canada, 7Nanaimo Regional General Hospital, Nanaimo, BC, Canada, 8JSS Medical Research, Montreal, QC, Canada, 9Medical Affairs, Janssen Inc., Toronto, ON, Canada, 10Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada

    Background/Purpose: To determine the point prevalence of peri-articular manifestations (PAMs) in psoriatic arthritis (PsA) patients treated with anti-TNF in a real-world, Canadian, routine clinical practice…
  • Abstract Number: 2512 • 2013 ACR/ARHP Annual Meeting

    Smoking Is Associated With More Severe Skin Disease In Subjects With Moderate To Severe Systemic Lupus Erythematosus (SLE)

    Victoria P. Werth1, Munther A. Khamashta2, Gabor G. Illei3, Stephen Yoo3, Liangwei Wang4 and Warren Greth3, 1Department of Dermatology, Veteran Affairs Medical Center, Philadelphia, PA, 2Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, 3Clinical Development, MedImmune, LLC, Gaithersburg, MD, 4Biostatistics, MedImmune, LLC, Gaithersburg, MD

    Background/Purpose: The influence of smoking on the severity of cutaneous manifestations in adults with moderate to severe SLE was assessed in an ongoing international, multi-center,…
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