Abstracts tagged "Disease Activity"

Abstract Number: 2643 • 2018 ACR/ARHP Annual Meeting
Sledai-2K Responder Index-50 Is Effective in Demonstrating Partial Response in a Phase 2, Randomized Placebo-Controlled Study of Ustekinumab in Patients with Active Systemic Lupus Erythematosus
Zahi Touma¹, Murray Urowitz², Dafna D Gladman², Carrie Wagner³, Bei Zhou³, Robert Gordon³, Benjamin Hsu³, Marc Chevrier³ and Shawn Rose³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Krembil Research Institute, U of Toronto, Toronto, ON, Canada, ³Janssen Research & Development, LLC, Spring House, PA
Background/Purpose: Ustekinumab (UST), a monoclonal antibody that targets the shared p40 subunit of the cytokines IL-12 & IL-23, is being investigated in patients (pts) w/…
Abstract Number: 2951 • 2018 ACR/ARHP Annual Meeting
Ustekinumab Treatment Response in SLE Is Associated with Changes in Type II but Not Type I Interferons
Jarrat Jordan¹, Kristen Sweet², Matteo Cesaroni¹, Keying Ma², Carol Franks², Loqmane Seridi², Jessica Schreiter³, Robert Gordon², Peter E. Lipsky⁴, Shawn Rose², Frédéric Baribaud², Matthew Loza² and Kim Campbell², ¹Janssen Research and Development, LLC., Spring House, PA, ²Janssen Research & Development, LLC, Spring House, PA, ³Estrela Lupus Venture, Janssen Research and Development, LLC., Spring House, PA, ⁴AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: We previously reported that treatment with ustekinumab (UST), an anti-IL-12/23 p40 neutralizing monoclonal antibody, improved global and organ-specific measures of disease activity in a…
Abstract Number: 322 • 2018 ACR/ARHP Annual Meeting
Swollen Joint Count Vs. RAPID3: Why a Discrepancy in Remission State?
Gary Craig¹ and Keith Knapp², ¹Discus Analytics LLC., Spokane, WA, ²Discus Analytics LLC, Spokane, WA
Background/Purpose: RA patients (pts) often have multiple comorbidities, and with multiple disease activity (DA) metrics available selecting an appropriate metric is vital. It remains an…
Abstract Number: 592 • 2018 ACR/ARHP Annual Meeting
Improved Response to Etanercept Is Associated with Serum Vitamin D Levels in Rheumatoid Arthritis
W Dankers¹, Pascal HP de Jong², S Heil³, S van den Berg³, A Weel⁴, JMW Hazes⁵, E Colin⁶ and Erik Lubberts⁷, ¹Immunology, Erasmus MC, University Medical Center, Rotterdam, Netherlands, ²Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, ³Clinincal Chemistry, Erasmus MC, Rotterdam, Netherlands, ⁴Rheumatology, Erasmus MC, Rotterdam, Netherlands, ⁵Department of Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, ⁶ZGT Almelo, Deventer, Netherlands, ⁷Erasmus Medical Center, Rheumatology, Rotterdam, Netherlands
Background/Purpose: Although treatment of rheumatoid arthritis (RA) has significantly improved during the past decades, many patients do not adequately respond or become resistant to current…
Abstract Number: 1385 • 2018 ACR/ARHP Annual Meeting
Subjective Well-Being Among Rheumatoid Arthritis Patients
Goichi Kageyama^1,2, Akira Onishi³, Yo Ueda³, Kengo Akashi³, Sho Sendo³, Jun Saegusa³ and Akio Morinobu², ¹Department of Rheumatology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan, ²Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Subjective well-being (SWB) is a psychological construct that is synonymous with happiness. Many variables including age, sex, income, employment, and marital status are related…
Abstract Number: 1617 • 2018 ACR/ARHP Annual Meeting
Influence of Disease Activity in the Physical Activity of Psoriatic Arthritis Patients
M. Vanesa Hernandez-Hernandez¹, Hiurma Sanchez-Perez², Esmeralda Delgado-Frías¹, Iván Ferraz-Amaro³ and Federico Díaz-González⁴, ¹Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, ²Rheumatology, Rheumatology Division, Hospital Universitario de Canarias, La Laguna, Spain, ³Rheumatology Division, Hospital Insular de Gran Canaria, La Laguna, Spain, ⁴University of La Laguna, Hospital Universitario de Canarias, La Laguna, Spain
Background/Purpose: It is generally assumed that patients with chronic arthritis conditions tend to exercise less than what is currently recommended. Although several evidences support this…
Abstract Number: 1854 • 2018 ACR/ARHP Annual Meeting
SLE Flares during and after Pregnancy Are Mild and Occur at Similar Rates
Julia Davis-Porada¹, Sam Stern², Marta M. Guerra³, Carl Laskin^4,5, Michelle Petri⁶, Michael Lockshin⁷, Lisa R Sammaritano^8,9, David Branch^10,11, Allen D. Sawitzke¹², Joan T. Merrill^13,14, Jill P. Buyon¹⁵, Mimi Kim¹⁶ and Jane E. Salmon^8,9, ¹Research, Hospital for Special Surgery, New York, NY, ²Albert Einstein College of Medicine, New York, NY, ³Department of Medicine and Program in Inflammation and Autoimmunity, Hospital for Special Surgery, New York, NY, ⁴Mount Sinai Hospital Toronto, Toronto, ON, Canada, ⁵Trio Fertility, Toronto, ON, Canada, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Barbara Volcker Center, Hospital for Special Surgery, New York, NY, ⁸Hospital for Special Surgery, New York, NY, ⁹Weill Cornell Medicine, New York, NY, ¹⁰Intermountain Healthcare, Salt Lake City, UT, ¹¹Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT, ¹²Rheumatology, University of Utah Health Sciences Center, Salt Lake City, UT, ¹³University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁴Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Medicine, New York University School of Medicine, New York, NY, ¹⁶Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionally affects women of childbearing age. Low disease activity for 6 months prior to conception leads to the best outcomes;…
Abstract Number: 2466 • 2018 ACR/ARHP Annual Meeting
Prolonged Delay in Presentation to Rheumatologists for Hispanic Patients with Rheumatoid Arthritis Contributes to Later Diagnosis and Treatment
Mariam Riad¹, Daniel Dunham², Jacquelin R. Chua¹, Theodore Pincus¹, Najia Shakoor¹, Sobia Hassan¹, Joel A. Block¹ and Isabel Castrejón¹, ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Division of Internal Medicine, Rush University Medical Center, Chicago, IL
Background/Purpose: Disparities in the initiation of disease modifying anti-rheumatic drugs (DMARDs) in ethnic minorities have been described in rheumatoid arthritis (RA) patients in the US…
Abstract Number: 2651 • 2018 ACR/ARHP Annual Meeting
Patients Characteristics and Patters of Treatment in Refractory Systemic Lupus Erythematosus Patients in the Pre-Biologic Period: Data from a Multiethnic, Multinational Latin American Lupus Cohort
Guillermo J. Pons-Estel^1,2, Marina Scolnik³, Enrique R Soriano³, Guillermina Harvey⁴, Rosana Quintana^5,6, Mercedes Garcia⁷, Verónica Saurit⁸, Cristina Drenkard⁹, Guillermo Berbotto¹⁰, Emilia Sato¹¹, Lilian Costallat¹², Eloisa Bonfa¹³, Eduardo Ferreira Borba¹⁴, Joao C. Tavares Brenol¹⁵, Nilzio A. da Silva¹⁶, Andre Cavalcanti¹⁷, Antonio Iglesias-Gamarra¹⁸, Marlene Guibert-Toledano¹⁹, Gil A. Reyes¹⁹, Loreto Massardo²⁰, Oscar Neira²¹, Mario H Cardiel²², Leonor Barile²³, Mary Carmen Amigo²⁴, Luis H. Silveira²⁵, Ignacio Garcia de la Torre²⁶, Rosa Maria Serrano⁶, Eduardo Acevedo-Vasquez²⁷, Manuel Ugarte-Gil²⁷, Ines Segami²⁸, Viviana Gervasoni⁵, Silvana Conti⁵, Rosa Chacón-Díaz²⁹, Maria H Esteva-Spinetti³⁰ and Bernardo A Pons-Estel⁶, ¹Rheumatology, Hospital Provincial de Rosario, Rosario, Argentina, ²Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario. Argentina, Rosario, Argentina, ³Rheumatology Unit, Internal Medicine Service. Hospital Italiano Buenos Aires. Argentina, Buenos Aires, Argentina, ⁴Escuela de Estadística, Universidad Nacional de Rosario, Rosario, Argentina, ⁵Hospital Provincial de Rosario, Rosario, Argentina, ⁶Centro Regional de Enfermedades Autoinmunes y Reumáticas (GO-CREAR), Rosario, Rosario, Argentina, ⁷Rheumatology, HIGA General San Martin La Plata, La Plata, Argentina, ⁸Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, ⁹Medicine/Rheumatology, Emory University, Atlanta, GA, ¹⁰Sanatorio Británico, Rosario, Argentina, ¹¹Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ¹²Universidade Estadual da Campinas, Campinas, Brazil, ¹³Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ¹⁴Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ¹⁵Hospital da Clinicas da Porto Alegre, Porto Alegre, Brazil, ¹⁶Universidade Federal de Goiás, Goiânia, Brazil, ¹⁷Novartis, Sao Paulo, Brazil, ¹⁸Clinical Development, Nordic Bioscience, Herlev, Denmark, ¹⁹Centro de Investigaciones Médico-Quirúrgicas (CIMEQ), Havana, Cuba, ²⁰GLADEL, Santiago, Chile, ²¹Rheumatology Section., Hospital del Salvador, Universidad de Chile., Santiago, Chile, ²²Centro de Investigación Clínica de Morelia, Morelia, Mexico, ²³Hospital Ángeles del Pedregal, Mexico, Mexico, ²⁴Rheumatology, Centro Medico ABC, Mexico, Mexico, ²⁵Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, ²⁶Hospital General de Occidente, Guadalajara, Mexico, ²⁷Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²⁸Hospital Edgardo Rebagliati Martins. EsSalud, Lima, Peru, ²⁹Servicio de Reumatología, Hospital Universitario de Caracas, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, ³⁰Hospital Central de San Cristóbal, San Cristóbal, Venezuela, San Cristóbal, Venezuela (Bolivarian Republic of)
Background/Purpose: Over the last few years, the importance of treating patients with systemic lupus erythematosus (SLE) towards achieving Remission or Low Disease Activity State has…
Abstract Number: 2963 • 2018 ACR/ARHP Annual Meeting
Improving Clinically Inactive Disease in Patients with Juvenile Idiopathic Arthritis- a Quaternary Center Experience
Cagri Yildirim-Toruner¹, Ohoud AlAhmed², Fatima Barbar-Smiley³, Karla Jones³, Melanie Kohlheim⁴, Stephanie Lemle⁵, Darby MacDonald², Evan Mulvihill⁶, Edward Oberle², Aliese Sarkissian², Vidya Sivaraman⁷, Bethanne Thomas², Kelly Wise⁸ and Stacy P. Ardoin¹, ¹Division of Rheumatology, Nationwide Children’s Hospital, Columbus, OH, ²Pediatric Rheumatology, Nationwide Children's Hospital, Columbus, OH, ³Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁴Pediatric Rheumatology Care and Outcomes Improvement Network, Cincinnati, OH, ⁵Nationwide Children's Hospital, Columbus, OH, ⁶Pediatrics and Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁷Division of Rheumatology, Nationwide Children's Hospital, Columbus, OH, ⁸Specialty Pharmacy/Rheumatology, Nationwide Children's Hospital, Columbus, OH
Background/Purpose: Juvenile idiopathic arthritis (JIA), the most common pediatric rheumatologic diagnosis, influences many aspects of a child’s life. Although there is no known cure, disease…
Abstract Number: 323 • 2018 ACR/ARHP Annual Meeting
Impact of Gains in Rheumatoid Arthritis Disease Activity Documentation on Outcomes over Time
Jing Li¹, Julie Gandrup¹, Laura Trupin¹, Zara Izadi², Jinoos Yazdany¹ and Gabriela Schmajuk³, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ³San Francisco VA Medical Center, San Francisco, CA
Background/Purpose: Despite significant interest in using health information technology (IT) to improve processes of care such as documentation of disease activity in RA, few studies…
Abstract Number: 597 • 2018 ACR/ARHP Annual Meeting
Characteristics of Patients and Predictors of Composite Disease Activity Scores for Switching to Monotherapy Vs Continuing TNF Inhibitor and Methotrexate Combination Therapy in RA: A Retrospective Analysis of the Brigham and Women’s Rheumatoid Arthritis Sequential Study Registry
Nancy A. Shadick¹, Michael E Weinblatt¹, Christine K Iannaccone², Michelle Frits³, Tigwa Davis⁴, Christopher Young⁴, David H. Collier⁵, Mahdi Gharaibeh⁵ and Bradley S. Stolshek⁶, ¹Brigham and Women's Hospital, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Health Analytics, LLC, Columbia, MD, ⁵Amgen Inc., Thousand Oaks, CA, ⁶Amgen, Inc., Thousand Oaks, CA
Background/Purpose: Biologics in combination with methotrexate (MTX) are being incorporated earlier in rheumatoid arthritis (RA) therapy to prevent long-term damage and maintain patient function. While…
Abstract Number: 1396 • 2018 ACR/ARHP Annual Meeting
Factors Associated with Specific Quality of Life Evolution in SLE Patients: A French Prospective Longitudinal Multicenter Study
Hervé Devilliers¹, Marie Corneloup², Francois Maurier³, Denis Wahl^4,5, Geraldine Muller⁶, Olivier Aumaître⁷, Pascal Sève⁸, Gilles Blaison⁹, Jean-Loup Pennaforte¹⁰, Thierry Martin¹¹, Nadine Magy¹², Sabine Berthier¹³, Laurent Arnaud¹⁴, Abderrahmane Bourredjem¹⁵ and Zahir Amoura¹⁶, ¹Service de Médecine Interne et Maladies Systémiques, CHU de Dijon, Dijon, France, ²Clinical epidemiology, Clinical investigation center, INSERM CIC-EC 1432, Dijon University Hospital, 21000 Dijon, France, ³Médecine interne, Hôpitaux Privés de Metz, Metz, France, ⁴CHU de Nancy, Vascular Medicine Division and Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, Nancy, F-54000, France; Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France, Nancy, France, ⁵CHU de Nancy, Vascular Medicine Division and Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases; and UMR_S U1116 Research Unit, Nancy, France, ⁶Department of Internal Medicine and Systemic Diseases, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, ⁷CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, ⁸Internal medicine, Internal medicine department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France, ⁹Internal medicine departement, Colmar Hospital, Colmar, France, ¹⁰Internal Medicine, Internal medicine departement, CHU de Reims, Reims, France, ¹¹Cnrs UPR9021, Department of Clinical Immunology and Internal Medicine, Strasbourg University Hospital, IBMC CNRS UPR9021, Strasbourg, France, ¹²Internal Medecine, CHRU Besançon, Besancon, France, ¹³Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ¹⁴Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ¹⁵Clinical investigation center, INSERM CIC-EC 1432, Dijon University Hospital, Dijon, France, ¹⁶Université Pierre et Marie Curie, Paris, France
Background/Purpose: To analyze variables associated with evolution of disease-specific health related quality of life (HRQoL) in systemic lupus erythematosus (SLE) patients. Methods: We conducted a…
Abstract Number: 1619 • 2018 ACR/ARHP Annual Meeting
Patterns and Outcomes on As Patients Disease Activity Using Smart System of Disease Management (SSDM): Analysis of T2T Pattern Shift and the Correlation between Disease Activity and Mental Health
Jing Xue¹, Hui Song², Jing Yang³, Zhenchun Zhang⁴, Chun Li⁵, Hongbin Li⁶, Zhenbiao Wu⁷, Hua Wei⁸, Jianlin Huang⁹, Hongzhi Wang¹⁰, Yasong Li¹¹, Xiaohan Wang¹², Henglian Wu¹³, Miaojia Zhang¹⁴, Yuhua Jia¹⁵, Hui Xiao¹⁵, Fei Xiao¹⁵ and Huaxiang Wu¹⁶, ¹88 Jiefang Road, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, ²Department of Rheumatology, Beijing Jishuitan Hospital, Beijing, China, ³Department of rheumatology, Central Hospital of MianYang, Sichuan, Mian Yang, China, ⁴People's Hospital of Linyi, Shandong, Linyi, China, ⁵Peking University People's Hospital, Beijing, China, ⁶The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China, ⁷The First Affiliated Hospital of The Fourth Military Medical University, Xi'an, China, ⁸Northern Jiangsu People's Hospital, Yangzhou, China, ⁹Department of rheumatology, The Sixth Hospital Affiliated to Sun yat-sen University, Guangzhou, China, ¹⁰The First Hospital of Jiaxing, Jiaxing, China, ¹¹Department of Rheumatology and Immunology, Zhejiang Provincal People's Hospital, Hangzhou, China, ¹²Department of Rheumatology and Immunology, Anyang district hospital, Anyang, China, ¹³Dongguan Donghua Hospital, Dongguan, China, ¹⁴Department of Rheumatology and Immunology, Jiangsu Province Hospital, Nanjing, China, ¹⁵Shanghai Gothic Internet Technology Co., Ltd., Shanghai, China, ¹⁶The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
Background/Purpose: Ankylosing Spondylitis Disease Activity Score (ASDAS) was adopted to evaluate the degree of disease activity and the inflammatory response in AS patients. ASDAS score…
Abstract Number: 1860 • 2018 ACR/ARHP Annual Meeting
Development and Validation of a Microrna Panel to Differentiate between Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Control Subjects
Michelle J. Ormseth, Joseph F. Solus, Quanhu Sheng, Fei Ye, Qiong Wu, Yan Guo, Annette M. Oeser, Ryan Allen, Kasey Vickers and C Michael Stein, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: MicroRNAs (miRNAs) are short non-coding RNAs that regulate genes and have utility as disease biomarkers. Use of small RNA (sRNA) sequencing along with unbiased…

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