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Abstracts tagged "Disease Activity"

  • Abstract Number: 1083 • ACR Convergence 2020

    Alterations of Lipid Profile in IIM Patients Are Associated with Disease Activity, Duration, and Glucocorticoid Treatment

    Sabina Oreska1, Hana Storkanova2, Maja Spiritovic3, Barbora Hermankova4, Michal Vrablik5, Karel Pavelka6, Ladislav Šenolt6, Heřman Mann2, Jiří Vencovský6 and Michal Tomcik7, 1Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Praha 2, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 3Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic,, Prague, Czech Republic, 53rd Department of Internal Medicine, General University Hospital, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 7Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterized by skeletal muscle and organ involvement and chronic course. Systemic inflammation, limited mobility, and glucocorticoid treatment can have…
  • Abstract Number: 1273 • ACR Convergence 2020

    The Impact of the COVID-19 Pandemic on the Fibromyalgia Symptoms of SLE Patients

    Rebecca Sadun1, Jennifer Rogers2, Kai Sun1, Karissa Grier1, Lisa Criscione-Schreiber3, Mithu Maheswaranathan1, Jayanth Doss1 and Megan Clowse4, 1Duke University, Durham, NC, 2Duke, Durham, NC, 3Duke University School of Medicine, Durham, NC, 4Duke University, Chapel Hill, NC

    Background/Purpose: Many patients with SLE experience symptoms of chronic pain and fatigue, often meeting criteria for fibromyalgia (FM). In this study, we sought to examine…
  • Abstract Number: 1538 • ACR Convergence 2020

    Doppler Ultrasound Predicts Successful Discontinuation of Biological DMARDs in Rheumatoid Arthritis Patients in Sustained Clinical Remission

    Lene Terslev1, Cecilie Hegaard Brahe2, Merete Hetland3, Stylianos Georgiadis4, Karen Ellegaard5, Lars Juul6, Uffe Døhn7, Viktoria Fana1, Torsten Møller1, Simon Krabbe1, Lykke Ørnbjerg1, Daniel Glinatsi1, Tuan Khai Huynh8, Natalia Manilo9, Dorte Vendelbo Jensen10, Karsten Asmussen9, Mikael Boesen11, Zoreh Rastiemadabadi12, Lone Morsel-Carlsen12, Jakob Møller13, Henrik Røgind1, Annette Hansen10, Jesper Nørregaard1, Søren Jacobsen14, Niels Steen Krogh15 and Mikkel Østergaard16, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, 2Center for Rheumatology and Spine diseases, Glostrup, Denmark, 3The DANBIO Registry, Rigshospitalet, Glostrup, Denmark, 4Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Glostrup, Denmark, 5The Parker Institute - Frederiksberg og Bispebjerg Hospitaler, Copenhagen, Denmark, 6Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Gentofte, Kobenhavn, Denmark, 7Center for Rheumatology and Spine Diseasesand COPECARE, Copenhagen, Denmark, 8Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 9Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Frederiksberg, Copenhagen, Denmark, 10Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Gentofte, Copenhagen, Denmark, 11department of Radiology, Frederiksberg and Bispebjerg hospitals, Naerum, Denmark, 12Department of Radiology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark, 13Department of Radiology, Herlev and Gentofte Hospital, Herlev, Denmark, 14University of Copenhagen, Copenhagen, Denmark, 15ZiteLab ApS, Frederiksberg, Denmark, 16Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: There is an increasing interest in tapering or even discontinuing biological disease-modifying anti-rheumatic drugs (bDMARDs) in rheumatoid arthritis (RA) patients in sustained remission. The…
  • Abstract Number: 1730 • ACR Convergence 2020

    Comparison of MBDA Score, Patient Global Assessment and Evaluator Global Assessment for Predicting Risk of Radiographic Progression

    Leonard Calabrese1, Michael Weinblatt2, Nancy Shadick2, Cecilie Hegaard Brahe3, Mikkel Østergaard4, Merete Hetland5, Megan Horton6, Darl Flake6 and Eric Sasso7, 1Cleveland Clinic, Cleveland, OH, 2Brigham and Women's Hospital, Boston, MA, 3Center for Rheumatology and Spine diseases, Glostrup, Denmark, 4Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 5The DANBIO Registry, Rigshospitalet, Glostrup, Denmark, 6Myriad Genetics, Inc., Salt Lake City, UT, 7Myriad Autoimmune, South San Francisco, CA

    Background/Purpose: To compare the abilities of MBDA score, patient global assessment (PGA) and evaluator global assessment (EGA) to assess risk for radiographic progression (RP), and…
  • Abstract Number: 1827 • ACR Convergence 2020

    Flare Reduction and Oral Corticosteroid Taper in Patients with Active SLE Treated with Anifrolumab in 2 Phase 3 Trials

    Richard Furie1, Eric Morand2, Anca Askanase3, Ed Vital4, Joan Merrill5, Rubana Kalyani6, Gabriel Abreu7, Lilia Pineda6 and Raj Tummala6, 1Zucker School of Medicine at Hofstra/Northwell, Great Neck, 2Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, 3Columbia University College of Physicians and Surgeons, New York, 4University of Leeds; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 5Oklahoma Medical Research Foundation, Oklahoma City, 6BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, 7BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

    Background/Purpose: Objectives of long-term SLE management are not only to reduce disease activity, but also to prevent flares and minimize exposure to oral corticosteroids (OCS),…
  • Abstract Number: 0210 • ACR Convergence 2020

    Long-term Safety and Efficacy of Sarilumab over 5 Years in Patients with Rheumatoid Arthritis Refractory to Tumor Necrosis Factor Inhibitors

    Roy Fleischmann1, Karina Maslova2, Henry Leher3, Amy Praestgaard2 and Gerd Burmester4, 1Southwestern Medical Center, Metroplex Clinical Research Center, Dallas, TX, 2Sanofi, Cambridge, MA, 3Regeneron Pharmaceuticals, Inc, Tarrytown, NY, 4Charité University Hospital Berlin, Berlin, Germany

    Background/Purpose: Sarilumab is a human IL-6 receptor (IL-6R) inhibitor approved for the treatment of adults with moderate to severely active RA. In the TARGET study…
  • Abstract Number: 0358 • ACR Convergence 2020

    Does Smoking Affect Secukinumab Treatment Outcomes and Safety in Patients with Ankylosing Spondylitis? – Real World Data from German Observational Study

    Elke Riechers1, Uta Kiltz2, Jan Brandt-Jürgens3, Peter Kästner4, Daniel Peterlik5 and Hans-Peter Tony6, 1Hannover Medical School, Hannover, Germany, 2Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany, 3Rheumatologische Schwerpunktpraxis Berlin, Berlin, Germany, 4Ambulantes Rheumazentrum, Erfurt, Germany, 5Novartis Pharma GmbH, Nürnberg, Germany, 6Rheumatology/Clinical Immunology, Department of Internal Medicine II, Würzburg, Germany

    Background/Purpose: There is growing body of evidence that smoking is associated with more active and severe disease in patients (pts) with ankylosing spondylitis (AS)1,2. The…
  • Abstract Number: 0744 • ACR Convergence 2020

    Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations with Disease Characteristics, Body Composition, and Physical Functioning

    Patrick Gould1, Babette Zemel2, Elena Taratuta3 and Joshua Baker1, 1University of Pennsylvania, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, 3University of Pennsylvania, Philadelphia

    Background/Purpose: Rheumatoid arthritis (RA) can lead to changes in body composition, including muscle loss and excess adiposity, which are in turn associated with physical disability.…
  • Abstract Number: 0850 • ACR Convergence 2020

    What Does It Mean to Be a BICLA (BILAG-Based Composite Lupus Assessment) Responder? Post Hoc Analysis of the Phase 3 TULIP-1 and TULIP-2 Trials

    Richard Furie1, Eric Morand2, Ian Bruce3, David Isenberg4, Ronald van Vollenhoven5, Gabriel Abreu6, Lilia Pineda7 and Raj Tummala7, 1Zucker School of Medicine at Hofstra/Northwell, Great Neck, 2Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia, 3Centre for Epidemiology Versus Arthritis, The University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, 4Centre for Rheumatology, University College London and Department of Rheumatology, University College Hospital, London, United Kingdom, 5Department of Rheumatology, Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands, 6BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 7BioPharmaceuticals R&D, AstraZeneca, Gaithersburg

    Background/Purpose: BICLA is a validated composite global measure of SLE disease activity that incorporates BILAG, an instrument that distinguishes between partial and complete improvement. BICLA…
  • Abstract Number: 1129 • ACR Convergence 2020

    Discordance in Patient and Physician Assessment of Disease Activity in Relapsing Polychondritis

    Emily Rose1, Marcela Ferrada1, Kaitlin Quinn2, Wendy Goodspeed1, Laurent Arnaud3 and Peter C. Grayson4, 1Systemic Autoimmunity Branch, Vasculitis Translational Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Washington, DC, 3Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, Alsace, France, 4Systemic Autoimmunity Branch, National Institutes of Health, NIAMS, Bethesda, MD

    Background/Purpose: Relapsing polychondritis (RP) is a rare chronic disabling inflammatory condition primarily affecting cartilage tissue. Self-reported patient outcome measures, which have not been evaluated in…
  • Abstract Number: 1277 • ACR Convergence 2020

    Low Cost Composite Markers to Differentiate Infection from Disease Activity in a Febrile Patient with Systemic Lupus Erythematosus

    Pankti Mehta1, Komal Singh1, Amita Aggarwal1 and Seema Sharma1, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

    Background/Purpose: Patients with Systemic Lupus Erythematosus (SLE) are at an increased risk of infection owing to immunosuppressive therapy along with coexistent immune dysregulation. It is…
  • Abstract Number: 1540 • ACR Convergence 2020

    Association Between Disease Activity and Left Ventricular Systolic Function in Patients with Rheumatoid Arthritis: A Case-Control Study

    Elías Abraham Rodríguez1, Dionicio Ángel Galarza-Delgado2, José Ramón Azpiri López3, Iris Jazmín Colunga Pedraza4, Salvador Lugo Pérez3, Itzel Corina Zárate Salinas3, Paola Fernanda Frausto Lerma4, Alejandra Pérez Villar4, Mayra Alejandra Reyes Soto4 and Raymundo Vera5, 1Hospital Universitario "José Eleuterio González", Monterrey, Mexico, 2Rheumatology Service, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma Nuevo León, Monterrey, Nuevo Leon, Mexico, 3Cardiology Service, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma Nuevo León, Monterrey, Mexico, 4Rheumatology service, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma Nuevo León, Monterrey, Mexico, 5Cardiology Service Hospital Universitario "José Eleuterio González", Monterrey, Mexico

    Background/Purpose: Patients with Rheumatoid Arthritis(RA) have a higher prevalence of Cardiovascular Disease (CVD), which is the most common cause of death in this group. Disease…
  • Abstract Number: 1731 • ACR Convergence 2020

    Development of a Disease Activity Index for Rheumatoid Arthritis Patients Using the HandScan

    Maxime Verhoeven1, Paco Welsing1, Janneke Tekstra1, Jacob van Laar1, Floris Lafeber1, Johannes Jacobs1 and Anton Westgeest2, 1UMC Utrecht, Utrecht, Netherlands, 2Máxima MC Eindhoven, Eindhoven, Netherlands

    Background/Purpose: Disease activity in rheumatoid arthritis (RA) patients is usually measured by an index like DAS28,1 a composite measure consisting of 28 swollen and/or tender…
  • Abstract Number: 1829 • ACR Convergence 2020

    Lupus Disease Activity After Cessation of Anifrolumab Treatment During the Phase 2b MUSE Trial Follow-up Period

    Richard Furie1, Kenneth Kalunian2, Joan Merrill3, Gabriel Abreu4 and Raj Tummala5, 1Zucker School of Medicine at Hofstra/Northwell, Great Neck, 2School of Health Sciences, University of California, La Jolla, 3Oklahoma Medical Research Foundation, Oklahoma City, 4BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, 5BioPharmaceuticals R&D, AstraZeneca, Gaithersburg

    Background/Purpose: In the randomized, double-blind, phase 2b MUSE trial, anifrolumab reduced disease activity vs placebo across multiple endpoints in patients with moderately to severely active…
  • Abstract Number: 0247 • ACR Convergence 2020

    Lupus Low Disease Activity State Achievement Is Important for Reducing Adverse Outcomes in Pregnant Patients with Systemic Lupus Erythematosus

    Ji-Won Kim1, Ju-Yang Jung1, Hyoun-Ah Kim1 and Chang-Hee Suh1, 1Ajou university school of medicine, Suwon, Republic of Korea

    Background/Purpose: This study aimed to examine the frequency and risk factors of complications during pregnancy in women with systemic lupus erythematosus (SLE).Methods: The medical records…
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