Abstracts tagged "Diagnostic Tests"

Abstract Number: 1334 • 2016 ACR/ARHP Annual Meeting
Contribution of Diagnostic Investigations in the Management of Uveitis: Retrospective Analysis of 300 Patients
Jérôme Hadjadj¹, Thibault Chapron², Manal Assala¹, Sawsen Salah², Bertrand Dunogue¹, Matthieu Groh³, Philippe Blanche¹, Luc Mouthon⁴, Dominique Monnet², Claire Le Jeunne⁴, Antoine Brezin² and Benjamin Terrier³, ¹Internal Medicine, Cochin Hospital, Paris, France, ²Ophtalmology, Cochin Hospital, Paris, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁴Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France
Background/Purpose: Uveitis represents a diagnostic and therapeutic challenge, as well as an economic one, due to its heterogeneous presentation, multiple underlying causes and lack of…
Abstract Number: 1518 • 2016 ACR/ARHP Annual Meeting
Immunoglobulin Binding Protein (BiP), an Antigen for CCP Sero-Positive Rheumatoid Arthritis Patients, Can Result in a False Positive Quantiferon-Gold Tuberculosis Test
JoAnn Ball¹, Kelsy Greenwald¹, Atul A. Deodhar² and Kevin L. Winthrop³, ¹Rheumatology, Desert Medical Advances, Palm Desert, CA, ²Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, ³Oregon Health and Sciences University, Portland, OR
Background/Purpose: Citrullinated BiP is a newly described target for cyclic citrullinated peptide(CCP). BiP in both serum and synovial fluid is over-expressed in RA patients and…
Abstract Number: 1892 • 2016 ACR/ARHP Annual Meeting
Immunosignature Technology Differentiates Patients with Systemic Sclerosis and Internal Organ Involvement
Lorinda Chung¹, David Fiorentino², Robert Gerwien³, Kathleen Jia⁴, Joseph Barten Legutki³, Antonio Valenzuela Vergara⁴, Lisa Zhu⁴, Theodore M. Tarasow³ and Kathryn Sykes³, ¹Rheumatology, Stanford University Medical Center, Palo Alto, CA, ²Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, ³HealthTell, Inc, san ramon, CA, ⁴Stanford University Medical Center, Palo Alto, CA
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease (CTD) characterized by fibrosis, vascular complications, and inflammation affecting both skin and internal organs. Diagnosis of…
Abstract Number: 1902 • 2016 ACR/ARHP Annual Meeting
Detecting the Pulmonary Vascular Involvement and the Changes in Gene Activation Profiles at Early Stage of Systemic Sclerosis in Patients with Raynaud Phenomenon
Yoshinobu Koyama¹, Soichiro Fuke², Yoshiharu Sato³ and Toshie Higuchi⁴, ¹Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan, ²Department of Cardiology, Japan Red Cross Okayama Hospital, Okayama, Japan, ³DNA Chip Research Inc, Yokohama, Japan, ⁴Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan
Background/Purpose: Raynaud phenomenon (RP) is known to precede other disease manifestations of systemic sclerosis (SSc), and classically viewed as reversible vasospasm due to functional changes…
Abstract Number: 1926 • 2016 ACR/ARHP Annual Meeting
Indications for Testing and Diagnostic Outcome in Patients with Positive ANCA at a Canadian Tertiary Care Centre
Cyrus Chehroudi^1,2, Ronald Booth^3,4 and Nataliya Milman^4,5,6, ¹Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Division of Biochemistry, The Ottawa Hospital, Ottawa, ON, Canada, ⁴Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁵Department of Medicine, University of Ottawa, Ottawa, ON, Canada, ⁶Division of Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada
Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCA) are a hallmark of a subset of small vasculitides collectively termed ANCA-associated vasculitis (AAV). With widespread availability of ANCA testing,…
Abstract Number: 2007 • 2016 ACR/ARHP Annual Meeting
Sensitivity and Specificity of Autoantibodies Against CD74 in Early Axial Spondyloarthritis
Torsten Witte¹, Elke Riechers², Niklas Thomas Baerlecken³, Xenofon Baraliakos⁴, Katrin Achilles-Mehr Bakhsh⁵, Peer Aries⁶, Bettina Bannert⁷, Klaus Becker⁸, Jan Brandt-Juergens⁹, Juergen Braun¹⁰, Boris P. Ehrenstein¹¹, Hartwig Euler¹², Martin Fleck¹³, Reinhard Hein¹⁴, Kirsten Karberg¹⁵, Lars Koehler¹⁶, Torsten Matthias¹⁷, Regina Max¹⁸, Adelheid Melzer¹⁹, Dirk Meyer-Olson²⁰, Juergen Rech²¹, Karin Rockwitz²², Martin Rudwaleit²³, Eva Schweikhard¹⁷, Joachim Sieper²⁴, Carsten Stille¹⁶, Ulrich von Hinüber²⁵, Peter Wagener²⁶, Heike Weidemann²⁷ and Silke Zinke¹⁵, ¹Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ²Medical University Hannover, Hannover, Germany, ³Clinical Immunology and Rheumatology, MD, Hannover, Germany, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵Rheumatology, Hannover, Hannover, Germany, ⁶Rheumatologie im Struenseehaus, Hamburg, Germany, ⁷Department of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, Freiburg, Germany, ⁸Rheumapraxis Blaubeuren, Blaubeuren, Germany, ⁹Praxis Brandt-Juergens/Karberg, Berlin, Germany, ¹⁰Rheumazentrum Ruhrgebiet, Herne, Germany, ¹¹Department of Rheumatology/Clinical Immunology, Asklepios Medical Center, 93077 Bad Abbach, Germany, ¹²Rheumapraxis Hamburg, Hamburg, Germany, ¹³Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany, ¹⁴Rheumapraxis Nienburg, Nienburg, Germany, ¹⁵Rheumapraxis, Berlin, Germany, ¹⁶Rheumapraxis, Hannover, Germany, ¹⁷Aesku.Diagnostics, Wendelsheim, Germany, ¹⁸Dept. of Internal Medicine 5, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany, ¹⁹Rheumapraxis, Seesen, Germany, ²⁰m&i Fachklinik Bad Pyrmont, Bad Pyrmont, Germany, ²¹Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ²²Rheumatologic Practice, Goslar, Germany, ²³Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, ²⁴Rheumatology Department, Charité – University Medicine Berlin, Berlin, Germany, ²⁵Rheumapraxis Hildesheim, Hildesheim, Germany, ²⁶Rheumapraxis, Nienburg, Germany, ²⁷Rheumapraxis Hannover, Hannover, Germany
Background/Purpose: Making the diagnosis of axial spondyloarthritis (axSpA) may be difficult. Antibodies against CD74 have been shown to be present in 2/3 of patients…
Abstract Number: 2075 • 2016 ACR/ARHP Annual Meeting
No Detection of Varicella-Zoster Virus in Temporal Arteries of Patients with Giant Cell Arteritis
Francesco Muratore¹, Stefania Croci², Ione Tamagnini³, Alessandro Zerbini², Salvatore Bellafiore⁴, Lucia Belloni⁵, Luigi Boiardi⁶, Alessandra Bisagni⁷, Maria Parmeggiani⁸, Alberto Cavazza⁹ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²Clinical Immunology, Allergy and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ³Pathology Unit, Department of Oncology, Arsicpedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁴Pathology Unit, Department of Oncology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁶Rheumatology Unit, Arcispedale S.Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁷Pathology Unit, Department of Oncology, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁸. Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁹Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: Recent studies found an high prevalence of varicella-zoster virus (VZV) infection in temporal arteries (TAs) from both temporal artery biopsy (TAB)-positive and TAB-negative giant…
Abstract Number: 2800 • 2016 ACR/ARHP Annual Meeting
Cell-Bound Complement Activation Products in Multi-Analyte Assay with Algorithm Aid the Diagnosis of Systemic Lupus Erythematosus
James Mossell¹, John A. Goldman², Derren Barken³ and Roberta Alexander⁴, ¹Tift Regional Medical Center, Tifton, GA, ²Medical Quarters #293, Emory St. Joseph’s Hospital, Atlanta, GA, ³Exagen Diagnostics, Vista, CA, ⁴Research & Development, Exagen Diagnostics, Vista, CA
Background/Purpose: Cell-bound complement activation products (CB-CAPs) are sensitive and specific biomarkers in the differential diagnosis of systemic lupus erythematosus (SLE) and other rheumatic diseases, as…
Abstract Number: 776 • 2015 ACR/ARHP Annual Meeting
Sensitivity of Antinuclear Antibody By Immunofluorescence Testing for Detection of Anti-Ro/SSA Antibodies
Ivan Alcantara-Arreola¹, Nina Tello-Winniczuk² and Alejandro Diaz-Borjon³, ¹Hospital Angeles Lomas, Huixquilucan, Mexico, ²Division of Internal Medicine / Rheumatology, Hospital Angeles Lomas, Huixquilucan, Mexico, ³Med/Div of Rheumatology, Hospital Angeles Lomas, Huixquilucan, Mexico
Background/Purpose: A positive ANA test is a diagnostic criterion for several rheumatic diseases, although it may appear in other autoimmune disorders and healthy individuals. An…
Abstract Number: 2961 • 2015 ACR/ARHP Annual Meeting
Reliability and Validity of the Total Joint Count and Swollen Joint Count in Early Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Veronica J. Berrocal², Gandikota Girish³, Meng Zhang⁴, Chris Hatzis¹, Shervin Assassi⁵, Elana J. Bernstein⁶, Robyn T. Domsic⁷, Faye N. Hant⁸, Monique E. Hinchcliff⁹, Elena Schiopu¹⁰, Virginia D. Steen¹¹, Tracy M. Frech¹² and Dinesh Khanna¹³, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Div of Rheumatology, University of Michigan, Ann Arbor, MI, ³Radiology, University of Michigan, Ann Arbor, MI, ⁴Epidemiology and Biostatistics, Hospital for Special Surgery, New York, NY, ⁵Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁶Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁷Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁸Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁹Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ¹⁰University of Michigan, Ann Arbor, MI, ¹¹Rheumatology, Georgetown University Medical Center, Washington, DC, ¹²Div of Rheumatology, University of Utah, Salt Lake City, UT, ¹³Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Arthropathy and tendinopathy in Systemic Sclerosis (SSc) contribute to disability and are associated with disease progression. Clinical trials in SSc sometimes include the tender…
Abstract Number: 777 • 2015 ACR/ARHP Annual Meeting
SLE-KeyTM Rule-out Test to Assess Lupus in Anti-Nuclear Antibody Positive Subjects Using the Immunarray iCHIP®
D. Scott Batty¹, I.R. Cohen², Chaim Putterman³, Nicole Jordan⁴, Keren Jakobi⁵, Rachel Sorek⁵, Yakov Blumenstein⁵, Pennina Safer⁵ and David Pisetsky⁶, ¹ImmunArray Inc., Richmond, VA, ²Weizmann Institute of Science, Rehovot, Israel, ³Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁴Montefiore Medical Center, New York, NY, ⁵ImmunArray LTD, Rehovot, Israel, ⁶Duke University Medical Center and Durham VAMC, Durham, NC
Background/Purpose: SLE is associated with a broad spectrum of autoantibodies, but currently there is no single serologic test to diagnose SLE definitively. Diagnosis is thus…
Abstract Number: 3127 • 2015 ACR/ARHP Annual Meeting
Serologic Diagnosis of Human Neuropsychiatric Lupus Using the Immunarray ICHIP®
Chaim Putterman¹, D. Scott Batty², I.R. Cohen³, Nicole Jordan⁴, Debbie Rybak¹, Tamar Rubinstein¹, Keren Jakobi⁵, Rachel Sorek⁵, Anat Reiner-Benaim⁵, Yakov Blumenstein⁵ and Pennina Safer⁵, ¹Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ²ImmunArray Inc., Richmond, VA, ³Weizmann Institute of Science, Rehovot, Israel, ⁴Montefiore Medical Center, New York, NY, ⁵ImmunArray LTD, Rehovot, Israel
Background/Purpose: Peripheral neurologic syndromes and central nervous system (CNS) manifestations are recognized as primary disease manifestations in systemic lupus erythematosus (SLE). Neuropsychiatric SLE (NPSLE) involves…
Abstract Number: 1095 • 2015 ACR/ARHP Annual Meeting
Identification of Carbamylated Alpha-1-Anti-Trypsin (A1AT) As an Antigenic Target of Anti-Carp Antibodies in Patients with Rheumatoid Arthritis
Marije K. Verheul¹, Alvin Yea², Andrea Seaman², Robert A. Cordfunke³, Jan W. Drijfhout⁴, George M. Janssen⁴, Arnoud de Ru³, Peter A. van Veelen⁴, René E. M. Toes⁵, Michael Mahler² and Leendert A. Trouw¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Inova Diagnostics, San Diego, CA, ³IHB, Leiden University Medical Center, Leiden, Netherlands, ⁴Immunohematology and Bloodbank, Leiden University Medical Center, Leiden, Netherlands, ⁵Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Antibodies targeting carbamylated proteins (anti-CarP) were recently identified in serum samples from patients with rheumatoid arthritis (RA). The presence of anti-CarP antibodies was associated…
Abstract Number: 1354 • 2015 ACR/ARHP Annual Meeting
Whipple’s Disease: The Diagnostic Utility of Synovial Fluid Tropheryma Whipplei Polymerase Chain Reaction
Zoran Kvrgic¹, Kelly Cawcutt², Robin Patel³, Abinash Virk², Clement J. Michet Jr.⁴, Eric L. Matteson⁵ and Tim Bongartz¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Infectious Diseases, Mayo Clinic, Rochester, MN, ³Medicine, Mayo Clinic, Rochester, MN, ⁴Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Department of Internal Medicine and Department of Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: Inflammatory arthritis is a common, non-specific symptom of Whipple’s disease. Recovery of the organism by conventional culture is often unsuccessful. Synovial fluid polymerase chain…
Abstract Number: 1714 • 2015 ACR/ARHP Annual Meeting
Young Patients with Back Pain and Maximally 1 Spa Feature: Is It Useful to Test HLA-B27 or Image the Sacroiliac Joints?
Pauline Bakker¹, Zineb Ez-Zaitouni², Miranda van Lunteren², Manouk de Hooge³, Rosaline van den Berg⁴, Inger Jorid Berg⁵, Robert B. M. Landewé⁶, Maikel van Oosterhout⁷, Roberta Ramonda⁸, Monique Reijnierse⁹, Floris van Gaalen¹ and Désirée van der Heijde¹⁰, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Centre, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Rheumatology, University Hospital Maastricht, Maastricht, Netherlands, ⁷Rheumatology, GHZ Hospital, Gouda, Netherlands, ⁸Cattedra, Voc Rheumatology, University of Padua, Padova, Italy, ⁹Radiology, Leiden University Medical Center, Leiden, Netherlands, ¹⁰University Hospital, Maastricht, Netherlands
Background/Purpose: Axial SpondyloArthritis (axSpA) is a heterogeneous disease. The likelihood of diagnosis varies depending upon the specific findings that are present. However, it is debated…

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