Abstracts tagged "Diagnostic Tests"

Abstract Number: 1926 • 2016 ACR/ARHP Annual Meeting
Indications for Testing and Diagnostic Outcome in Patients with Positive ANCA at a Canadian Tertiary Care Centre
Cyrus Chehroudi^1,2, Ronald Booth^3,4 and Nataliya Milman^4,5,6, ¹Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa, ON, Canada, ³Division of Biochemistry, The Ottawa Hospital, Ottawa, ON, Canada, ⁴Department of Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁵Department of Medicine, University of Ottawa, Ottawa, ON, Canada, ⁶Division of Rheumatology, The Ottawa Hospital, Ottawa, ON, Canada
Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCA) are a hallmark of a subset of small vasculitides collectively termed ANCA-associated vasculitis (AAV). With widespread availability of ANCA testing,…
Abstract Number: 2007 • 2016 ACR/ARHP Annual Meeting
Sensitivity and Specificity of Autoantibodies Against CD74 in Early Axial Spondyloarthritis
Torsten Witte¹, Elke Riechers², Niklas Thomas Baerlecken³, Xenofon Baraliakos⁴, Katrin Achilles-Mehr Bakhsh⁵, Peer Aries⁶, Bettina Bannert⁷, Klaus Becker⁸, Jan Brandt-Juergens⁹, Juergen Braun¹⁰, Boris P. Ehrenstein¹¹, Hartwig Euler¹², Martin Fleck¹³, Reinhard Hein¹⁴, Kirsten Karberg¹⁵, Lars Koehler¹⁶, Torsten Matthias¹⁷, Regina Max¹⁸, Adelheid Melzer¹⁹, Dirk Meyer-Olson²⁰, Juergen Rech²¹, Karin Rockwitz²², Martin Rudwaleit²³, Eva Schweikhard¹⁷, Joachim Sieper²⁴, Carsten Stille¹⁶, Ulrich von Hinüber²⁵, Peter Wagener²⁶, Heike Weidemann²⁷ and Silke Zinke¹⁵, ¹Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ²Medical University Hannover, Hannover, Germany, ³Clinical Immunology and Rheumatology, MD, Hannover, Germany, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵Rheumatology, Hannover, Hannover, Germany, ⁶Rheumatologie im Struenseehaus, Hamburg, Germany, ⁷Department of Internal Medicine, Clinic for Rheumatology and Clinical Immunology, Freiburg, Germany, ⁸Rheumapraxis Blaubeuren, Blaubeuren, Germany, ⁹Praxis Brandt-Juergens/Karberg, Berlin, Germany, ¹⁰Rheumazentrum Ruhrgebiet, Herne, Germany, ¹¹Department of Rheumatology/Clinical Immunology, Asklepios Medical Center, 93077 Bad Abbach, Germany, ¹²Rheumapraxis Hamburg, Hamburg, Germany, ¹³Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany, ¹⁴Rheumapraxis Nienburg, Nienburg, Germany, ¹⁵Rheumapraxis, Berlin, Germany, ¹⁶Rheumapraxis, Hannover, Germany, ¹⁷Aesku.Diagnostics, Wendelsheim, Germany, ¹⁸Dept. of Internal Medicine 5, Division of Rheumatology, University of Heidelberg, Heidelberg, Germany, ¹⁹Rheumapraxis, Seesen, Germany, ²⁰m&i Fachklinik Bad Pyrmont, Bad Pyrmont, Germany, ²¹Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany, ²²Rheumatologic Practice, Goslar, Germany, ²³Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany, ²⁴Rheumatology Department, Charité – University Medicine Berlin, Berlin, Germany, ²⁵Rheumapraxis Hildesheim, Hildesheim, Germany, ²⁶Rheumapraxis, Nienburg, Germany, ²⁷Rheumapraxis Hannover, Hannover, Germany
Background/Purpose: Making the diagnosis of axial spondyloarthritis (axSpA) may be difficult. Antibodies against CD74 have been shown to be present in 2/3 of patients…
Abstract Number: 2075 • 2016 ACR/ARHP Annual Meeting
No Detection of Varicella-Zoster Virus in Temporal Arteries of Patients with Giant Cell Arteritis
Francesco Muratore¹, Stefania Croci², Ione Tamagnini³, Alessandro Zerbini², Salvatore Bellafiore⁴, Lucia Belloni⁵, Luigi Boiardi⁶, Alessandra Bisagni⁷, Maria Parmeggiani⁸, Alberto Cavazza⁹ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²Clinical Immunology, Allergy and Advanced Biotechnologies Unit,, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ³Pathology Unit, Department of Oncology, Arsicpedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁴Pathology Unit, Department of Oncology, Arcispedale S Maria Nuova, Reggio Emilia, Italy, ⁵Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁶Rheumatology Unit, Arcispedale S.Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁷Pathology Unit, Department of Oncology, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ⁸. Clinical Immunology, Allergy and Advanced Biotechnologies Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, ⁹Pathology Unit, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: Recent studies found an high prevalence of varicella-zoster virus (VZV) infection in temporal arteries (TAs) from both temporal artery biopsy (TAB)-positive and TAB-negative giant…
Abstract Number: 2800 • 2016 ACR/ARHP Annual Meeting
Cell-Bound Complement Activation Products in Multi-Analyte Assay with Algorithm Aid the Diagnosis of Systemic Lupus Erythematosus
James Mossell¹, John A. Goldman², Derren Barken³ and Roberta Alexander⁴, ¹Tift Regional Medical Center, Tifton, GA, ²Medical Quarters #293, Emory St. Joseph’s Hospital, Atlanta, GA, ³Exagen Diagnostics, Vista, CA, ⁴Research & Development, Exagen Diagnostics, Vista, CA
Background/Purpose: Cell-bound complement activation products (CB-CAPs) are sensitive and specific biomarkers in the differential diagnosis of systemic lupus erythematosus (SLE) and other rheumatic diseases, as…
Abstract Number: 2851 • 2016 ACR/ARHP Annual Meeting
An Antigen Microarray to Rule-out Systemic Lupus Erythematosus, the SLE-Key® Rule-out Test, Performs Well As an Aid in Clinical Practice
Donald Massenburg, Justine Oldenberg, Amanda Sell, Tristan Krause and Alvin F. Wells, Rheumatology and Immunotherapy Center, Franklin, WI
Background/Purpose: The SLE-key® test to Rule Out lupus was developed by ImmunArray Ltd using serum samples of 246 SLE patients and 252 self-declared healthy controls.…
Abstract Number: 3106 • 2016 ACR/ARHP Annual Meeting
A Simple Test for Assessing and Monitoring SLE Disease Activity Status
Chaim Putterman¹, Michael Rowe², Joseph Barten Legutki², Theodore M. Tarasow² and Kathryn Sykes², ¹Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, ²HealthTell, Inc, san ramon, CA
Background/Purpose: SLE patients can experience chronically active disease, remissions and flares, or long periods of quiescence. Accurately assessing disease activity is crucial for prescribing appropriate…
Abstract Number: 218 • 2016 ACR/ARHP Annual Meeting
Accuracy of Humasens-Plus Point-of-Care Uric Acid Meter Using Capillary Blood Obtained By Fingertip Puncture
Stephanie Fabre¹, Jean-Marie Launay¹, Jean-François Gautier¹, Adam Platt², Jeffrey N. Miner³, Glen Hughes², Pascal Richette⁴ and Thomas Bardin¹, ¹Hôpital Lariboisière, Paris, France, ²AstraZeneca R&D Alderley Park, Macclesfield, United Kingdom, ³Discovery Biology, Ardea Biosciences, Inc., San Diego, CA, ⁴Fédération de Rhumatologie, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France
Background/Purpose: A key factor in the success of gout management is the long-term lowering of serum uric acid (sUA) levels below predetermined targets (5 or…
Abstract Number: 494 • 2016 ACR/ARHP Annual Meeting
Sensitivity and Specificity of 14-3-3η, Anti-CEP-1 and Anti-Sa Antibodies in a Cohort of Seronegative and Suspected Rheumatoid Arthritis (RA) Patients from a Community Rheumatology Practice
Dmitry Karayev¹, Guoqiu Shen¹, Yvonne Lam¹, Andrew Rimmer¹, Nayan Lal¹, Eugene Karayev¹, Kristine Azarraga¹, Ronald A. Blum¹, Allan L. Metzger¹, Robert I. Morris¹ and Arash A. Horizon², ¹Rheumatology Diagnostics Laboratory, Inc. (RDL), Los Angeles, CA, ²Center for Rheumatology Medical Group, Los Angeles, CA
Background/Purpose: RA is the most common autoimmune inflammatory joint disease, affecting up to 1% of the world population. Detection of antibodies, specifically against IgM rheumatoid…
Abstract Number: 1714 • 2015 ACR/ARHP Annual Meeting
Young Patients with Back Pain and Maximally 1 Spa Feature: Is It Useful to Test HLA-B27 or Image the Sacroiliac Joints?
Pauline Bakker¹, Zineb Ez-Zaitouni², Miranda van Lunteren², Manouk de Hooge³, Rosaline van den Berg⁴, Inger Jorid Berg⁵, Robert B. M. Landewé⁶, Maikel van Oosterhout⁷, Roberta Ramonda⁸, Monique Reijnierse⁹, Floris van Gaalen¹ and Désirée van der Heijde¹⁰, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Centre, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Centre, Leiden, Netherlands, ⁴Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Rheumatology, University Hospital Maastricht, Maastricht, Netherlands, ⁷Rheumatology, GHZ Hospital, Gouda, Netherlands, ⁸Cattedra, Voc Rheumatology, University of Padua, Padova, Italy, ⁹Radiology, Leiden University Medical Center, Leiden, Netherlands, ¹⁰University Hospital, Maastricht, Netherlands
Background/Purpose: Axial SpondyloArthritis (axSpA) is a heterogeneous disease. The likelihood of diagnosis varies depending upon the specific findings that are present. However, it is debated…
Abstract Number: 1916 • 2015 ACR/ARHP Annual Meeting
Validation of Novel Biomarker Candidates for Systemic Sclerosis
Johannes Schulte-Pelkum¹, Petra Budde¹, Hans-Dieter Zucht¹, Daniel Wirtz¹, Peter Schulz-Knappe¹, Oliver Distler², Suzana Jordan³, Nicolas Hunzelmann⁴, Matthias Schneider⁵ and Britta Maurer², ¹Protagen AG, Dortmund, Germany, ²Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Dermatology, University of Cologne, Cologne, Germany, ⁵Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease that manifests as progressive fibrosis of the skin and internal organs. SSc is associated with the…
Abstract Number: 2065 • 2015 ACR/ARHP Annual Meeting
Verification of Novel Soluble Biomarkers That Differentiate Patients with Psoriatic Arthritis from Those with Psoriasis without Psoriatic Arthritis
Vinod Chandran¹, Daniela Cretu^2,3, Lisa Gao⁴, Kun Liang⁴, Antoninus Soosaipillai³ and Eleftherios Diamandis^2,3,5, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ³Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada, ⁴Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁵Department of Clinical Biochemistry, University Health Network, Toronto, ON, Canada
Background/Purpose: There is a high prevalence of undiagnosed psoriatic arthritis (PsA) in psoriasis patients. Therefore identifying soluble biomarkers for PsA will help in screening psoriasis…
Abstract Number: 2190 • 2015 ACR/ARHP Annual Meeting
Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION) Core Laboratory Validation Exercise: Comparison of Enzyme-Linked Immunosorbant Assay (ELISA) and Chemiluminescence Immunoassay (CIA)
Maria Laura Bertolaccini¹, Danieli Andrade², Gabriella Lakos³, Rohan Willis⁴, Vittorio Pengo⁵, Alessandra Banzato⁶, Hannah Cohen⁷, Steven Krilis⁸, Doruk Erkan⁹ and on behalf of APS ACTION, ¹Lupus Unit, Rayne Institute, Lupus Research Unit, The Rayne Institute, King's College London School of Medicine, St Thomas' Hospital, London, United Kingdom, ²Rheumatology, University of São Paulo, São Paulo, Brazil, ³INOVA Diagnostics, Inc., San Diego, CA, ⁴Department of Internal Medicine, Antiphospholipid Standardization Laboratory, Division of Rheumatology, Galveston, TX, ⁵Clinical Cardiology, Department of Cardiac Thoracic and Vascular Sciences, University of Padova, Padova, Italy, ⁶Department of Cardiac Thoracic and Vascular Sciences, Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy, ⁷Hematology., University College London, LOndon, United Kingdom, ⁸Immunology, Allergy, and Infectious Diseases, St George Hospital, Kogarah NSW, Australia, ⁹Rheumatology, Barbara Volcker Center for Women and Rheumatic Diseases: Hospital for Special Surgery, New York, NY
Background/Purpose: APS ACTION International Clinical Database and Repository was created to study the natural course of disease over 10 years in persistently aPL-positive patients with/without…
Abstract Number: 2231 • 2015 ACR/ARHP Annual Meeting
Vitamin D Deficiency States Can be Actively Prevented. Results from a Cross-Sectional Study of over 3000 Patients with Rheumatic Diseases
Elena Nikiphorou¹, Pekka Hannonen¹, Paula Väre¹, Arto Kokko², Tuomas Rannio^3,4 and Tuulikki Sokka-Isler⁴, ¹Jyvaskyla Central Hospital, Jyvaskyla, Finland, ²Jyvaskyla Central Hospital, Jyväskylä, Finland, ³Kuopio University Hospital, Kuopio, Finland, ⁴Rheumatology, Jyvaskyla Central Hospital, Jyvaskyla, Finland
Background/Purpose: Vitamin D (D25) deficiency has been an ongoing matter of concern, especially in countries at northern latitudes. The effects of D25 deficiency in patients…
Abstract Number: 2598 • 2015 ACR/ARHP Annual Meeting
Neutrophil Extracellular Trap Levels Measured By Cell Free Nucleosome ELISA in Serum Are Highly Specific and Sensitive for Rheumatoid Arthritis
Paul Hasler¹, Stavros Giaglis¹, Ulrich A. Walker², Erik Deman¹, Christoph Hemmeler¹, Christina Ryser¹, Samuel Kretzschmar¹, Guenther Schaefer³, Juliane Franz¹ and Sinuhe Hahn⁴, ¹Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, ²Rheumatology, University Hospital, Basel, Basel, Switzerland, ³Dept. of Biomedicine, Laboratory of Prenatal Medicine, University Hospital Basel, Basel, Switzerland, ⁴Dept. of Biomedicine, Laboratory for Prenatal Medicine, University Hospital Basel, Basel, Switzerland
Background/Purpose: Rheumatoid factor (RF) or anti-citrullinated peptide antibody (ACPA) detection have limited clinical utility for the diagnosis of rheumatoid arthritis (RA), as the specificity and…
Abstract Number: 2614 • 2015 ACR/ARHP Annual Meeting
Single Academic Center Experience with 14-3-3 Eta in the Evaluation of Inflammatory Arthritis
Lance Feller¹, Paul Tuttle IV², Austin M. Dalrymple³, Srikanth Bathula⁴, Katherine Temprano⁵, Reema H. Syed⁶, Rama Bandlamudi⁷, Kathryn Coulson⁸, Peri Pepmueller⁹ and Terry Moore¹⁰, ¹Internal Medicine/Rheumatology, Saint Louis University, Saint Louis, MO, ²Saint Louis University, Saint Louis, MO, ³Pediatric Rheumatology, St. Louis University, St. Louis, MO, ⁴Rheumatology, Saint Louis University, Saint Louis, MO, ⁵Medicine/Rheumatology, Saint Louis University, St. Louis, MO, ⁶IM-Rheumatology, Saint Louis University, St. Louis, MO, ⁷Internal Medicine/Rheumatology, St. Louis Univ Health Sciences, St. Louis, MO, ⁸Rheumatology/ 213A, St. Louis University, St. Louis, MO, ⁹Rheumatology, Saint Louis University, St. Louis, MO, ¹⁰Division of Rheumatology and Pediatric Rheumatology, Saint Louis University School of Medicine, St Louis, MO
Background/Purpose: 14-3-3 proteins are chaperonins found in all eukaryotic cells. There are multiple isoforms which are thought to be involved in intracellular signaling and transcription…

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