Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: The indirect immunofluorescence (IIF) pattern observed in the antinuclear antibody (ANA) test provides an initial assessment of autoantibody responses in candidate patients who have or may be at risk of developing systemic autoimmune rheumatic diseases (SARD). Despite its wide clinical use, a universal nomenclature to describe ANA IIF patterns has not been adopted. The
Methods: A working committee addressed collective issues on ANA nomenclature that were raised by participants representing research, clinical, and diagnostic laboratories. Post-workshop exchanges were held with the goal of reaching consensus on key issues.
Results: ANA IIF patterns were separated into three major categories (nuclear, cytoplasmic, and mitotic patterns) and each pattern was defined and described in detail. Consensus was achieved for 28 IIF patterns that were designated with an alpha-numeric code (AC-1 to AC-28) and summarized under a nomenclature and classification tree (ANApatterns.org). Important findings include, e.g., the Homogeneous and Coarse Speckled nuclear patterns are linked to autoantibodies strongly associated with SARD whereas the
Conclusion: ICAP has provided a common platform to address issues that are of great interest to the community. The establishment of a consensus on ANA reporting will require interaction with committees in charge of establishing disease classification and diagnostic criteria. Future goals include building collaborative data on ANA IIF patterns, selection of new consensus patterns, and establishment of an interpretative clinical description for each AC pattern for clinical use. The 3rd and 4th ICAP workshops are planned for Kyoto (October 2016) and Dresden (September 2017).
To cite this abstract in AMA style:Chan EKL, Damoiseaux J, Carballo G, Conrad K, de Melo Cruvinel W, Francescantonio P, Fritzler MJ, Garcia-De La Torre I, Herold M, Mimori T, Satoh M, Von Muhlen C, Andrade LEC. The International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns (ICAP) Initiative – Update and Its Impact [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/the-international-consensus-on-standardized-nomenclature-of-antinuclear-antibody-hep-2-cell-patterns-icap-initiative-update-and-its-impact/. Accessed September 21, 2019.
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