ACR Meeting Abstracts

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Abstracts tagged "cytokines"

  • Abstract Number: 1071 • 2015 ACR/ARHP Annual Meeting

    Single-Cell RNA Sequencing of Human Podocytes, Endothelial Cells, and Tubular Cells Identifies Markers and Gene Profiles Differentiating Class IV and Class V Renal Disease in Lupus Nephritis

    Evan Der1, Kemal Akat2, Robert Clancy3, Beatrice Goilav4, Anna R. Broder5, H. Michael Belmont6, Peter M. Izmirly7, Nicole Jordan8, Tao Wang9, James Pullman10, Daniel Schwartz10, Ming Wu11, Thomas Tuschl2, Jill P. Buyon3 and Chaim Putterman12, 1Albert Einstein College of Medicine, Bronx, NY, 2Rockefeller University, New York, NY, 3Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 4Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, 5Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 6Hosp for Joint Disease, New York, NY, 7Rheumatology, NYU School of Medicine, New York, NY, 8Montefiore Medical Center, New York, NY, 9Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, 10Pathology, Albert Einstein College of Medicine, Bronx, NY, 11Pathology, New York University School of Medicine, New York, NY, 12Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY

    Background/Purpose: Currently, classification and treatment decisions in lupus nephritis (LN) are largely based on renal histology. Transcriptome analysis may accurately differentiate types of renal involvement,…
  • Abstract Number: 2076 • 2015 ACR/ARHP Annual Meeting

    Development of Lupus Nephritis: Preclinical Evaluation of Patients Who Subsequently Develop Systemic Lupus Erythematosus Demonstrate Elevation of Select Soluble Mediators Prior to and at Disease Classification in Patients with Nephritis

    Melissa E. Munroe1, Jourdan R. Anderson1, Julie M. Robertson1, Timothy B. Niewold2, George C. Tsokos3, Michael P. Keith4, Joan T. Merrill5, Jill P. Buyon6, John B. Harley7 and Judith A. James8, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 3Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4Walter Reed National Military Medical Center, Bethesda, MD, 5Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 7Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 8Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: SLE is a heterogeneous autoimmune disease marked by immune dysregulation and a spectrum of pathogenic autoantibodies. Why some patients have only moderate symptoms and…
  • Abstract Number: 1104 • 2015 ACR/ARHP Annual Meeting

    Mouse B Cells Require Glucose and Free Fatty Acids As Carbon Sources for Cytokine and Chemokine Secretion

    Doujiao Wu1, Dongyue Huang2, Edward Pearce1 and Alfred Kim2, 1Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO, 2Rheumatology, Washington University School of Medicine, Saint Louis, MO

    Background/Purpose: B cells contribute to disease pathophysiology through several mechanisms, including cytokine and chemokine secretion. A wide variety of stimuli can activate B cells including…
  • Abstract Number: 2205 • 2015 ACR/ARHP Annual Meeting

    Inhibition of Dickkopf1 Dampens Anti Osteogenic Effect of Fibroblast-like Synoviocytes

    Eiji Sugiyama, Yusuke Yoshida and Satoshi Yamasaki, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose:   Fibroblast-Like Synoviocytes (FLS) play important roles in RA progression. Previous studies have revealed importance of FLS in osteoclast activation, however, the roles of…
  • Abstract Number: 1139 • 2015 ACR/ARHP Annual Meeting

    Differential Inflammatory Profile in Experimental Models of Arthritis

    Ana C. Ortiz1, Anne Crilly1, Lynette Dunning1, Carmen Huesa1, C. S. Goodyear2, John C. Lockhart1, William R. Ferrell2 and Iain B. McInnes2, 1Institute of Biomedical and Environmental Health Research, University of the West of Scotland, Paisley, United Kingdom, 2Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: While osteoarthritis (OA) in humans is characterized by cartilage degradation, osteophyte formation and joint remodeling, inflammation and synovitis are now recognized to contribute to…
  • Abstract Number: 2465 • 2015 ACR/ARHP Annual Meeting

    Cytokine Profile Comparison of Monogenic and Complex Conditions with Interferon-Regulated Gene Signatures in Chronic Atypical Neutrophilic Dermatosis with Lipodsytrophy and Elevated Temperature (CANDLE), SAVI, Aicardi-Goutieres Syndrome, JDM, and SLE

    Hanna Kim1, Yin Liu2, Adriana Almeida de Jesus1, Robert Wesley3, Yan Huang1, Gina A. Montealegre Sanchez1, Dawn C. Chapelle1, Wanxia L. Tsai4, Massimo G. Gadina4, Frederick W. Miller5, Sarfaraz Hasni6, Adeline Vanderver7, Lisa G Rider5 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Diseases Section, NIAMS, NIH, Bethesda, MD, 2Scientific Review Branch, NIAMS, NIH, Bethesda, MD, 3Clinical Center, National Institutes of Health, Bethesda, MD, 4Translational Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, 5Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 6National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 7Pediatric Neurology, Children's National Medical Center, Washington, DC

    Background/Purpose: An Interferon (IFN) Regulated Gene Signature (IRS) was previously reported in patients with two complex autoimmune diseases, juvenile systemic lupus (JSLE)1  and juvenile dermatomyositis…
  • Abstract Number: 1156 • 2015 ACR/ARHP Annual Meeting

    Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis

    MIN-YOUNG JUNG1, Hae-Rim Kim2, HYUN-SOOK KIM3, HO-YOUN KIM1 and Sang Heon Lee4, 1Konkuk university hospital, Seoul, South Korea, 2Division of Rheumatology, Konkuk University School of Medicine, Seoul, South Korea, 3Soonchenhyang university school of medicine, Seoul, South Korea, 4Konkuk University Hospital, Seoul, South Korea

    Background/Purpose: This study aimed to determine the regulatory effect of Th17 cytokines on osteoclastogenesis in rheumatoid arthritis (RA). Methods: The expression of interleukin (IL)-17 and…
  • Abstract Number: 2518 • 2015 ACR/ARHP Annual Meeting

    Does the Cytokine Pattern, Including the IL23 – IL17 Immune Axis, Change in Pregnant Women with Psoriatic Arthritis?

    Andrea Pluma-Sanjurjo1, Peter M. Villiger2 and Frauke Förger3, 1Rheumatology, University Hospital Vall d'Hebron, Barcelona, Spain, 2Professor & Head, Bern, Switzerland, 3Rheumatology, Clinical Immunology and Allergology, Inselspital-University Hospital, Bern, Switzerland

    Background/Purpose: During pregnancy, most patients with Psoriatic Arthritis (PsA) experience a natural improvement of their symptoms. This might be due to the immunological changes that…
  • Abstract Number: 13 • 2015 ACR/ARHP Annual Meeting

    Altered Soluble Mediators, Autoantibodies, and Lupus-Specific Connective Tissue Disease Questionnaire Scores Distinguish Blood Relatives with Incomplete Lupus from Unaffected Relatives and Relatives with Classified SLE

    Melissa E. Munroe1, Kendra A. Young2, Jill M. Norris3, Teresa Aberle1, Virginia C. Roberts1, Joel M. Guthridge1, Diane L. Kamen4, Gary S. Gilkeson5, Michael H. Weisman6, Mariko L. Ishimori6, Daniel J Wallace7, David R. Karp8, Kathy L. Sivils9, John B. Harley10 and Judith A. James11, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Epidemiology, University of Colorado Denver, Aurora, CO, 3University of Colorado Denver, Aurora, CO, 4Medicine, Medical University of South Carolina, Charleston, SC, 5Department of Rheumatology, Medical University of South Carolina, Charleston, SC, 6Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 7Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 8Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, 9Oklahoma Medical Research Foundation, Oklahoma City, OK, 10Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 11Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Blood relatives (Rel) of lupus patients have increased risk of SLE. Some have autoantibodies and SLE clinical features, but do not meet ≥ 4…
  • Abstract Number: 1161 • 2015 ACR/ARHP Annual Meeting

    Synovial Th9 Cells Prolong Neutrophil Survival and Functionally Enhance the Infiltrating T Cells in Rheumatoid Arthritis

    Dipendra Kumar Mitra1 and Kaustav Chowdhury2, 1Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, Delhi, India, 2TRANSPLANT IMMUNOLOGY AND IMMUNOGENETICS, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, New Delhi, India

    Background/Purpose: Th-9 cells are distinct T cell subset secreting IL-9 and associated with allergic and parasitic diseases and produced by Th9 cells. Contribution of these…
  • Abstract Number: 2611 • 2015 ACR/ARHP Annual Meeting

    Circulating Monocyte Count Is Significantly Associated with Interstitial Pneumonia in Biologic-Naive Patients with Rheumatoid Arthritis: A Single-Center Prospective Cohort Study (Keio First-Bio Cohort Study)

    Keisuke Izumi1, Misato Hashizume2, Yuko Kaneko3, Keiko Yoshimoto1 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Product Research Department, Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, 3Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose : Interstitial pneumonia (IP) is one of the most critical complications in rheumatoid arthritis (RA). Severe IP is developed in zymosan-treated SKG mice, and…
  • Abstract Number: 18 • 2015 ACR/ARHP Annual Meeting

    Epigallocatechin-3-Gallate (EGCG) Facilitates TAK1 Nuclear Translocation and Its Interaction with p300 to Inhibit Histone Acetylation in Human RA Synovial Fibroblasts

    Anil Singh1,2, Mukesh Chourasia3 and Salahuddin Ahmed4, 1Department of Pharmaceutical Science, Washington State University, Spokane, WA, 2Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, 3Department of Pharmacoinformatics,, National lnstitute of Pharmaceutical Education and Research, Hajipur,, India, 4Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA

    Background/Purpose: TAK1 is one of the most important proteins in IL-1β signaling cascade that mediates downstream p38/JNK and NF-κB activation. In the present study, we…
  • Abstract Number: 1165 • 2015 ACR/ARHP Annual Meeting

    Age-Dependent Effects of HLA-B27/β2m Expression on Host Immunity and the Intestinal Microbiota

    Mark Asquith1, Phoebe Lin2, Sean Davin3, Patrick Stauffer4, Stephen R. Planck5 and James T. Rosenbaum6, 1OHSU, Portland, OR, 2Casey Eye Institute, Oregon Health and Science University, Portland, OR, 3Oregon Health and Science University, Portland, OR, 4Oregon Health & Science University, Portland, OR, 5Casey Eye Institute, Oregon Health & Science University, Portland, OR, 6Devers Eye Institute, Legacy Hospital system, Portland, OR

    Background/Purpose: The HLA-B27/β2m transgenic rat is a leading model of Anklylosing Spondylitis (AS) and other B27-associated spondyloarthopathies. The development of both bowel and joint inflammation…
  • Abstract Number: 2699 • 2015 ACR/ARHP Annual Meeting

    Muscle Inflammation Relates to Disease Activity and Disability but Not Insulin Resistance in Rheumatoid Arthritis

    Ryan Jessee1, Rachel Narowski2, Monica Hubal3, Janet Huebner4, Virginia Kraus5, William Kraus6 and Kim Huffman2,7, 1Internal Medicine, Duke University Medical Center, Durham, NC, 2Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, 3Research and Education, George Washington University School of Medicine and Health Sciences, Washington, DC, 4Duke Molecular Physiology Institute,, Duke University Medical Center, Durham, NC, 5Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 6Division of Cardiology, Duke University Medical Center, Durham, NC, 7Durham Veterans Affairs Medical Center, Durham, NC

    Background/Purpose: Rheumatoid arthritis (RA) is associated with increased cardiovascular disease, insulin resistance, and disability. Our objectives were to analyze levels of skeletal muscle inflammatory cytokines…
  • Abstract Number: 2350 • 2014 ACR/ARHP Annual Meeting

    A Humanized Monoclonal Antibody Raised Against a Heat Shock Protein Epitope Suppresses Autoimmune Inflammatory Diseases By Skewing the Immune System Selectively Towards an Anti-Inflammatory Response

    Yaakov Naparstek1, Rina Ulmansky2, Galia Katzavian3, Ronit Meyuhas3, Eli Moallem4, Shira Yair3, Dorit Landstein3 and Virginie Loeb3, 1Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, 2Hadassah - Hebrew University Medical Center, Jerusalem, Israel, 3ProtAb Ltd., Jerusalem, Israel, 4Dept. of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel

    Background/Purpose We have previously shown that resistance to Adjuvant Arthritis (AA) is due to the presence of anti-heat shock protein (HSP) antibodies, directed at peptide-6,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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