Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Serum cytokines play an important role in the pathogenesis of myositis by initiating and perpetuating various cellular and humoral autoimmune processes. The aim of this study was to measure interferon (IFN)-inducible chemokines (IFNCK), Th1, Th2, Th17, innate, and regulatory cytokines in patients with adult dermatomyositis (DM) and juvenile dermatomyositis (JDM) at multiple visits to identify biomarkers predictive of changes in disease activity.
Conclusion: IFNCK and other cytokine scores may be useful biomarkers to predict changes in disease activity among myositis patients. Differing associations for JDM and DM may indicate biological differences between diseases that warrant specific biomarkers for each to best predict changes in disease activity.
To cite this abstract in AMA style:Crowson CS, Olazagasti Lourido JM, Hein MS, Pendegraft RS, Strausbauch MA, Niewold TB, Ernste FC, Wampler Muskardin TL, Peterson EJ, Gillespie EC, Reed AM. Interferon Chemokine Score and Other Cytokine Measures Predict Changes in Disease Activity in Patients with Juvenile and Adult Dermatomyositis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/interferon-chemokine-score-and-other-cytokine-measures-predict-changes-in-disease-activity-in-patients-with-juvenile-and-adult-dermatomyositis/. Accessed October 20, 2020.
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