ACR Meeting Abstracts

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Abstracts tagged "cytokines"

  • Abstract Number: L07 • ACR Convergence 2020

    Tocilizumab for COVID-19 Infection: A Randomized, Double-Blind, Placebo-Controlled Trial

    John Stone1, 1Massachusetts General Hospital, Boston, MA

    Background/Purpose: The efficacy of interleukin-6 receptor blockade in hospitalized COVID-19 patients not on mechanical ventilation is unclear.Methods: We performed a randomized, double-blind, placebo-controlled trial in…
  • Abstract Number: 0290 • ACR Convergence 2020

    Role of Protein Tyrosine Phosphatase 1B (PTP1B) in Endothelial-to-Mesenchymal Transition (EndoMT) Promoted by Inflammation: Implications for SLE

    Jorge Romo-Tena1, José Esparza-López2, Carmelo Carmona-Rivera3, Luz Blanco4, Mariana Kaplan3 and María de Jesús Ibarra-Sánchez2, 1NIAMS, National Institute of Health, Bethesda, 2INNSZ / UNAM-RAI, Mexico City, Mexico, 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Centreville

    Background/Purpose: The endothelial-to-mesenchymal transition (EndoMT) transdifferentiation process can be promoted by several proinflammatory mediators in many pathological conditions. Recently, it was suggested a crucial role…
  • Abstract Number: 1063 • ACR Convergence 2020

    Spirulina Stimulates Inflammatory Cytokine Production Through the STING and TLR Pathways in Dermatomyositis in Vitro

    Christina Bax1, Yubin Li1, Spandana Maddukuri2, Adarsh Ravishankar3, Jay Patel3, Daisy Yan1, Josef Symon Concha1 and Victoria Werth1, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 2University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Montville, NJ, 3University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia

    Background/Purpose: Spirulina, a popular herbal supplement, stimulates the immune system, as determined by in vitro and in vivo studies. Our recent epidemiologic data suggest that Spirulina…
  • Abstract Number: 1532 • ACR Convergence 2020

    The Non-psychotropic Phytocannabinoids Cannabigerol and Tetrahydrocannabinolic Acid Inhibit Rheumatoid Arthritis Synovial Fibroblast Function by Targeting the Wasabi Receptor TRPA1

    Torsten Lowin1, Matthias Schneider2 and Georg Pongratz3, 1Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, Düsseldorf, Germany, 2Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, Duesseldorf, Germany, 3Department of Rheumatology and Hiller Research Unit Rheumatology, Heinrich Heine University, Duesseldorf, Germany, D�sseldorf, Germany

    Background/Purpose: While medical cannabis is available for german patients since 2017, its use to alleviate symptoms of rheumatic diseases is not recommended due to a…
  • Abstract Number: 0292 • ACR Convergence 2020

    Exhausted pSTAT5-IFNα Signaling Pathways in SLE Patients Are Correlated with Age-associated B Cells and Disease Activity

    Samantha Slight-Webb1, Miles Smith2, Kevin Thomas1, Susan Macwana1, Holden Maecker3, Paul Utz4, Judith James5 and Joel Guthridge1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, 3Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, 4Stanford University School of Medicine, Stanford, CA, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by periods of elevated and suppressed clinical symptoms. Specific cell subsets, such as CD11c+ age-associated…
  • Abstract Number: 1087 • ACR Convergence 2020

    Plasma-derived Extracellular Vesicles Induced STING-mediated Proinflammatory Effects in Dermatomyositis

    Yubin Li1, Christina Bax2, Jay Patel3, Adarsh Ravishankar3, Krisha Desai4, Majid Zeidi4, Muhammad Bashir4 and Victoria Werth1, 1University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, PA, 2University of Pennsylvania, Department of Dermatology, Philadelphia, 3University of Pennsylvania and the Michael J. Crescenz VA Medical Center, Philadelphia, 4University of Pennsylvania, Philadelphia

    Background/Purpose: Dermatomyositis (DM) is an acquired inflammatory myopathy characterized by chronic skin inflammation. The pathogenesis of DM is still unclear. Extracellular vesicles (EVs) are lipid…
  • Abstract Number: 1634 • ACR Convergence 2020

    Etiologies and Management of Hemophagocytic Lymphohistiocytosis: Is It Time for an Updated Protocol and Targeted Treatments?

    Therese Posas-Mendoza1, Cara McLeod1, William Davis2 and Robert Quinet2, 1Ochsner Medical Center, New Orleans, LA, 2Dept of Rheumatology, Ochsner Medical Center, New Orleans, LA

    Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease characterized by immune-overstimulation and a hyperinflammatory response resulting in cytokine storm and multi-organ failure.1 Secondary HLH…
  • Abstract Number: 0300 • ACR Convergence 2020

    Exposure to Topical Antimicrobials Reduces Inflammatory Gene Expression in Cutaneous Lupus Lesional Skin

    Sirisha Sirobhushanam1, Allison Billi2, Alex Tsoi2, Celine Berthier2, Johann Gudjonsson3 and J. Michelle Kahlenberg4, 1University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann Arbor, 3University of Michigan, Ann ArborUniversity of Michigan, 4Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Lupus lesional skin has elevated interferon expression, is highly colonized with Staphylococcus aureus (50%) and has no FDA-approved treatment options. S. aureus is known…
  • Abstract Number: 1209 • ACR Convergence 2020

    The Strength of IL-6/STAT3 Signal Inhibition by SAR S.c q2w Showed Significantly Higher Level Than That of TCZ S.c q2w but Lower Than TCZ S.c q1w

    Shuntaro Saito1, Katsuya Suzuki2, Keiko Yoshimoto2, Yasushi Kondo2, Jun Kikuchi2, Kotaro Otomo2, Hironari Hanaoka2, Yuko Kaneko2 and Tsutomu Takeuchi3, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Division of Rheumatology, Department of internal Medicine, School of Medicine, Keio University, Tokyo, Japan

    Background/Purpose: Interleukin-6 (IL-6) is a key cytokine in the pathogenesis of rheumatoid arthritis (RA). Tocilizumab (TCZ) and Sarilumab (SAR) are monoclonal antibodies that bind to…
  • Abstract Number: 1803 • ACR Convergence 2020

    Ability of Innate, Adaptive, and TNF-Superfamily Immune Pathways to Characterize Disease Activity and Inform a Refined Lupus Disease Activity Immune in a Confirmatory Cohort of SLE Patients

    Melissa Munroe1, Wade DeJager2, Susan Macwana2, Ly Tran2, Joel Guthridge2, Eldon Jupe3, Daniele DeFreese3, Ryan Newhardt3, Mohan Purushothaman3, Sanjiv Sharma3, Nancy Redinger2, Teresa Aberle2, Stan Kamp2, Cristina Arriens2, Eliza Chakravarty2, Joan Merrill4 and Judith James5, 1Oklahoma Medical Research Foundation/Progentec Diagnostics, Inc., Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Progentec Diagnostics, Inc., Oklahoma City, OK, 4Oklahoma Medical Research Foundation, Oklahoma City, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease driven by complex immune dysregulation, involving altered immune mediators and accumulation of autoantibody (AutoAb) specificities.…
  • Abstract Number: 0458 • ACR Convergence 2020

    Rapid Implementation of a Multidisciplinary COVID-19 Cytokine Storm Syndrome Task Force

    Bibi Ayesha1, Anand Kumthekar1, Ruchi Jain2, Sneha Patel3, Manish Ramesh1, Denisa Ferastraoaru4, Golda Hudes4, Merhunisa Karagic4, Sheema Zafar1, Rachel Bartash4, Natalia Vasquez-Canizares5, Elizabeth Kitsis6, Clement Tagoe7, Dawn Wahezi5, Tamar Rubinstein8 and Anna Broder3, 1Montefiore Medical Center, Bronx, NY, 2Montefiore Medical Center, Irvington, NY, 3Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 4Montefiore Medical Center, Bronx, 5Albert Einstein College of Medicine, Bronx, NY, 6Albert Einstein College of Medicine, New York, NY, 7Albert Einstein College of Medicine, Fresh Meadows, NY, 8Albert Einstein College of Medicine / Montefiore Medical Center, White Plains, NY

    Background/Purpose: Coronavirus disease (COVID-19) infected patients present with a state of ongoing inflammation and an exaggerated inflammatory state due to unregulated cytokine release called the…
  • Abstract Number: 1217 • ACR Convergence 2020

    Effects of JAK Inhibitors Against JAK2-mediated Signaling in Innate Immune Cells

    Yuya Fujita1, Naoki Matsuoka1, Makiko Furuya-Yashiro2, Jumpei Temmoku2, Yuki Kuroiwa3, Masaru Tanaka4, Tomoyuki Asano2, Shuzo Sato5, Haruki Matsumoto2, Hiroshi Watanabe2, Hideko Kuzuru6, Hiroshi Yatsuhashi7, Atsushi Kawakami8 and Kiyoshi Migita9, 1Fukushima Medical University School of Medicine, Department of Rheumatology, Fukushima, Fukushima, Japan, 2Fukushima Medical University School of Medicine, Department of Rheumatology, Fukushima, Japan, 3Eli Lilly Japan K.K., Tokyo, 4Eli Lilly Japan K.K., Tokyo, Japan, 5Fukushima Medical University School of Medicine, Department of Rheumatology, Fukushima, Japan, 6NHO Nagasaki Medical Center, Clinical Research Center, Omura, Japan, 7NHO Nagasaki Medical Center, Clinical Research Center, Omura, Nagasaki, Japan, 8Nagasaki University Graduate School of Biomedical Sciences, Unit of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki, Nagasaki, Japan, 9Fukushima Medical University School of Medicine, Department of Rheumatology, Fukushima, Fukushima, Japan

    Background/Purpose: Janus kinase (JAK) family is comprised of JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2). JAKs form homo- or hetero-complexes, the combination of which…
  • Abstract Number: 1809 • ACR Convergence 2020

    Serum Cytokine Profiling in Systemic Lupus Erythematosus, Analysed Using Unsupervised Machine Learning, Reveals Clinically Relevant Clusters

    Fabien Vincent1, Jannina Ong1, Alberta Hoi2, Sarah Boyd1, Hieu Nim1 and Eric Morand3, 1Monash University, Clayton, Victoria, Australia, 2Monash University, Melbourne, Victoria, Australia, 3Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Australia

    Background/Purpose: SLE is a heterogeneous disease, where a better understanding of molecular differences between patients is needed in order to direct therapy. Existing approaches generally…
  • Abstract Number: 0473 • ACR Convergence 2020

    Characterization of DOCK8 as a Novel Gene Associated with Cytokine Storm Syndrome

    Mingce Zhang1, Remy Cron2, Devin Absher3, Prescott Atkinson1, Winn Chatham1 and Randy Cron1, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, 3HudsonAlpha Institute for Biotechnology, Huntsville, AL

    Background/Purpose: Cytokine storm syndrome (CSS), also known as macrophage activation syndrome (MAS) or secondary hemophagocytic lymphohistiocytosis (HLH), is a life threatening condition that commonly presents…
  • Abstract Number: 1225 • ACR Convergence 2020

    Targeting to IL-6 or Specific JAKs for RA Treatment: Seeking a Rationale for Switching Each Other If One of These Treatments Resulted in Lack of Efficacy

    Yoshinobu Koyama1, Yoshiharu Sato2, Hiroshi Iijima2, Moe Sakamoto3 and Toshie Higuchi3, 1Okayama Red Cross Hospital, Japanese Red Cross Society, Okayama, Japan, 2DNA Chip Research Inc, Tokyo, Japan, 3Division of Rheumatology, Okayama Red Cross Hospital, Japanese Red Cross Society, Okayama, Japan

    Background/Purpose: Inhibition of IL-6 signaling is one of the most established strategies for RA treatment. Tocilizumab (TCZ) is the pioneer which blocks IL-6 signaling by…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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